Page last updated: 2024-08-23

pregnanolone and Aging

pregnanolone has been researched along with Aging in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19907 (15.56)18.7374
1990's7 (15.56)18.2507
2000's16 (35.56)29.6817
2010's14 (31.11)24.3611
2020's1 (2.22)2.80

Authors

AuthorsStudies
Farley, JA; Logan, S; Owen, DB; Parks, EE; Sonntag, WE; Yeganeh, A1
Bedin, R; Biagini, G; Giovannini, G; Lucchi, C; Meletti, S; Monti, G; Rustichelli, C; Trenti, T1
Aoyama, B; Eguchi, S; Iwata, H; Kawano, T; Locatelli, FM; Nishigaki, A; Shigematsu-Locatelli, M; Tateiwa, H; Yamanaka, D; Yokoyama, M1
Darbra, S; Llidó, A; Mòdol, L; Pallarès, M1
Casarosa, E; Genazzani, AD; Genazzani, AR; Petignat, P; Pluchino, N; Santoro, A; Wenger, JM1
Eckert, A; Grimm, A; Lang, UE; Mensah-Nyagan, AG; Schmitt, K1
Belelli, D; Brown, AR; Herd, MB; Lambert, JJ1
Bartolomé, I; Darbra, S; Llidó, A; Pallarès, M1
Diaz-Granados, JL; Matthews, DB; Novier, A; Ornelas, LC1
Afroz, S; Shen, H; Smith, SS1
De Sarro, G; Dore, R; Maciocco, E; Mostallino, MC; Mura, ML; Pisu, MG; Russo, E; Serra, M1
Darbra, S; Pallarès, M1
Mares, P; Stehlíková, M1
George, O; Le Moal, M; Mayo, W; Piazza, PV; Vallée, M; Vitiello, S1
Berry, RB; Chin, VS; Diaz-Granados, J; Kirk, RE; Matthews, DB; Van Skike, CE1
Brinton, RD; Chen, S; Henry, S; Irwin, RW; Liu, L; Singh, C; Thompson, RF; Wang, JM; Yao, J1
Akwa, Y; Baulieu, EE; David, JP; Delacourte, A; Eychenne, B; Liere, P; Pianos, A; Sazdovitch, V; Schumacher, M; Weill-Engerer, S1
Bancel, F; Dayanithi, G; Leng, G; Ludwig, M; Widmer, H1
Gulinello, M; Smith, SS1
Harrison, MB; Kapur, J; Mtchedlishvili, Z; Sun, CS1
Bernardi, F; Casarosa, E; Genazzani, AD; Genazzani, AR; Luisi, M; Luisi, S; Palumbo, M; Puccetti, S; Stomati, M1
Bernardi, F; Casarosa, E; Gabbanini, M; Genazzani, AD; Genazzani, AR; Luisi, M; Palumbo, M; Picciarelli, G; Pieri, M; Pluchino, N1
George, O; Le Moal, M; Mayo, W; Vallée, M1
Dudek, BC; Frye, CA; Harney, JP; Lydon, JP; O'Malley, BW; Pfaff, DW; Rhodes, ME; Sumida, K1
Cerny, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Pouzar, V; Stárka, L; Vrbíková, J1
Brinton, RD; Wang, JM1
Alexaki, VI; Castanas, E; Charalampopoulos, I; Dermitzaki, E; Gravanis, A; Lasaridis, I; Margioris, AN; Minas, V; Stournaras, C; Tsatsanis, C; Vardouli, L1
Brinton, RD; Chen, S; Irwin, RW; Liu, L; Wang, JM1
Matsumoto, K; Nagareda, T; Takeyama, M1
Drayer, NM; Nagel, GT; van der Ploeg, KR; Volmer, M; Wolthers, BG1
Beyer, C; Fernandez-Guasti, A; Gonzalez-Mariscal, G1
Fries, U; Iglauer, F; Kunze, K; Stuerenburg, HJ1
Borodinsky, LN; Fiszman, ML; Pesce, G; Pomata, P1
Bernardi, F; Casarosa, E; Genazzani, AR; Lanzone, A; Luisi, S; Nappi, RE; Petraglia, F; Purdy, RH; Salvestroni, C1
Cavarretta, I; Magnaghi, V; Martini, L; Melcangi, RC; Piva, F1
Bernardi, F; Casarosa, E; Genazzani, AR; Luisi, M; Luisi, S; Nappi, RE; Palumbo, M; Petraglia, F; Purdy, RH; Salvestroni, C; Tonetti, A1
Bovolin, P; Cavarretta, I; D'Urso, D; Magnaghi, V; Martini, L; Melcangi, RC; Zucchi, I1
Bernardi, F; Bernasconi, S; Casarosa, E; Fadalti, M; Ferrari, E; Genazzani, AR; Luisi, M; Luisi, S; Petraglia, F; Saggese, G1
Beart, PM; Crossley, KJ; Hirst, JJ; Walker, DW1
Bernardi, F; Casarosa, E; Cobellis, L; Genazzani, AR; Luisi, M; Luisi, S; Monteleone, P; Petraglia, F; Stomati, M1
Frisone, DF; Frye, CA; Zimmerberg, B1
Baird, MB; Birnbaum, LS1
Chang, MC; Lau, IF; Parkening, TA; Saksena, SK1
Bäckström, T; Norberg, L; Wahlström, G1
Mannan, MA; O'Shaughnessy, PJ1

Reviews

6 review(s) available for pregnanolone and Aging

ArticleYear
Advances in neurosteroids: role in clinical practice.
    Climacteric : the journal of the International Menopause Society, 2013, Volume: 16 Suppl 1

    Topics: Affect; Aging; Behavior; Brain Injuries; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Male; Menopause; Neurotransmitter Agents; Postpartum Period; Pregnancy; Pregnanolone; Premenstrual Syndrome; Progesterone; Reproduction

2013
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: Acetylcholine; Aging; Animals; Brain Stem; Dehydroepiandrosterone Sulfate; Humans; Memory; Memory Disorders; Pregnanolone; Pregnenolone; Prosencephalon; Sleep; Sleep Wake Disorders

2006
Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent.
    Current Alzheimer research, 2006, Volume: 3, Issue:3

    Topics: Aging; Alzheimer Disease; Animals; Brain; Cell Differentiation; Mice; Mice, Transgenic; Nerve Regeneration; Neurons; Pregnanolone; Stem Cell Transplantation; Stem Cells

2006
Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging.
    Annals of the New York Academy of Sciences, 2006, Volume: 1088

    Topics: Aging; Animals; Apoptosis; Dehydroepiandrosterone; Humans; Neuroimmunomodulation; Neurons; Pregnanolone

2006
Regenerative potential of allopregnanolone.
    Brain research reviews, 2008, Volume: 57, Issue:2

    Topics: Aging; Alzheimer Disease; Animals; Brain; Humans; Nerve Regeneration; Pregnanolone

2008
Clinical implications of circulating neurosteroids.
    International review of neurobiology, 2001, Volume: 46

    Topics: Aging; Alzheimer Disease; Dehydroepiandrosterone; Female; Humans; Male; Menopause; Menstrual Cycle; Pregnanolone

2001

Other Studies

39 other study(ies) available for pregnanolone and Aging

ArticleYear
Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice.
    Journal of lipid research, 2020, Volume: 61, Issue:10

    Topics: Aging; Animals; Brain; Cognition; Interleukin-6; Male; Mice; Pregnanolone

2020
Low levels of progesterone and derivatives in cerebrospinal fluid of patients affected by status epilepticus.
    Journal of neurochemistry, 2018, Volume: 147, Issue:2

    Topics: 5-alpha-Dihydroprogesterone; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Retrospective Studies; Status Epilepticus; Steroids; Tandem Mass Spectrometry; Young Adult

2018
Role of neurosteroid allopregnanolone on age-related differences in exercise-induced hypoalgesia in rats.
    Journal of pharmacological sciences, 2019, Volume: 139, Issue:2

    Topics: Aging; Animals; Behavior, Animal; Brain; Male; Pain; Pain Threshold; Physical Conditioning, Animal; Pregnanolone; Progesterone; Rats, Wistar; Reflex; Spinal Cord

2019
Interaction between neonatal allopregnanolone administration and early maternal separation: effects on adolescent and adult behaviors in male rat.
    Hormones and behavior, 2013, Volume: 63, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Anxiety; Anxiety, Separation; Body Weight; Exploratory Behavior; Gonadal Steroid Hormones; Male; Maternal Deprivation; Pregnanolone; Rats; Reflex, Startle

2013
Improvement of neuronal bioenergetics by neurosteroids: implications for age-related neurodegenerative disorders.
    Biochimica et biophysica acta, 2014, Volume: 1842, Issue:12 Pt A

    Topics: Adenosine Triphosphate; Aging; Androstane-3,17-diol; Animals; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Energy Metabolism; Estradiol; Estrone; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Neurodegenerative Diseases; Neurons; Neurotransmitter Agents; Oxygen Consumption; Pregnanolone; Progesterone; Reactive Oxygen Species; Superoxide Dismutase; Testosterone

2014
Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.
    The Journal of physiology, 2015, Jan-01, Volume: 593, Issue:1

    Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 5-alpha-Dihydroprogesterone; Aging; Animals; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pregnanolone; Receptors, GABA-A; Synaptic Transmission; Thalamus

2015
Effects of neonatal allopregnanolone manipulations and early maternal separation on adult alcohol intake and monoamine levels in ventral striatum of male rats.
    Hormones and behavior, 2016, Volume: 82

    Topics: 5-alpha Reductase Inhibitors; Aging; Alcohol Drinking; Animals; Animals, Newborn; Biogenic Monoamines; Ethanol; Exploratory Behavior; Female; Hippocampus; Male; Maternal Deprivation; Pregnanolone; Rats; Rats, Wistar; Ventral Striatum

2016
Differences in Behavioral Responding in Adult and Aged Rats Following Chronic Ethanol Exposure.
    Alcoholism, clinical and experimental research, 2016, Volume: 40, Issue:7

    Topics: Aging; Animals; Ethanol; Male; Maze Learning; Motor Activity; Pregnanolone; Rats; Substance Withdrawal Syndrome

2016
α4βδ GABA
    Neuroscience, 2017, 04-07, Volume: 347

    Topics: Aging; Animals; CA1 Region, Hippocampal; Dendritic Spines; Female; GABA-A Receptor Agonists; Isoxazoles; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Pregnanolone; Receptors, GABA-A; Spatial Learning

2017
Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy.
    Journal of neurochemistry, 2008, Volume: 106, Issue:6

    Topics: Aging; Animals; Animals, Genetically Modified; Brain; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Disease Models, Animal; Down-Regulation; Epilepsy, Absence; gamma-Aminobutyric Acid; Male; Neuronal Plasticity; Pregnanolone; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Stress, Psychological; Synapses; Synaptic Transmission; Thalamus; Up-Regulation

2008
Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood.
    Psychoneuroendocrinology, 2010, Volume: 35, Issue:4

    Topics: 5-alpha Reductase Inhibitors; Aging; Animals; Animals, Newborn; Anti-Anxiety Agents; Brain; Enzyme Inhibitors; Exploratory Behavior; Female; Finasteride; Male; Midazolam; Neural Inhibition; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Reflex, Startle; Sexual Maturation

2010
Anticonvulsant doses of ganaxolone do not compromise motor performance in immature rats.
    Neuroscience letters, 2010, Jan-29, Volume: 469, Issue:3

    Topics: Aging; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electric Stimulation; Epilepsy; Male; Motor Activity; Neuropsychological Tests; Pregnanolone; Rats; Rats, Wistar; Seizures; Time Factors

2010
Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats.
    Biological psychiatry, 2010, Nov-15, Volume: 68, Issue:10

    Topics: Aging; Animals; Behavior, Animal; Brain; Disease Models, Animal; Indomethacin; Male; Memory Disorders; Pregnanolone; Rats; Rats, Sprague-Dawley; Sleep Disorders, Circadian Rhythm; Steroids

2010
Effect of acute ethanol and acute allopregnanolone on spatial memory in adolescent and adult rats.
    Alcohol (Fayetteville, N.Y.), 2011, Volume: 45, Issue:5

    Topics: Aging; Animals; Ethanol; Hippocampus; Male; Maze Learning; Memory; Pregnanolone; Rats; Rats, Sprague-Dawley; Space Perception

2011
Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice.
    Neurobiology of aging, 2012, Volume: 33, Issue:8

    Topics: Aging; Alzheimer Disease; Animals; Cell Survival; Hippocampus; Learning; Memory; Mice; Mice, Knockout; Neurons; Pregnanolone; Recovery of Function; Stem Cells; Treatment Outcome

2012
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Brain Chemistry; Cerebellum; Corpus Striatum; Dehydroepiandrosterone Sulfate; Female; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Hippocampus; Humans; Hypothalamus; Male; Pregnanolone; Pregnenolone; Progesterone; Protein Structure, Secondary; Steroids; tau Proteins

2002
Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus.
    The Journal of physiology, 2003, Apr-01, Volume: 548, Issue:Pt 1

    Topics: Aging; Animals; Calcium; Dose-Response Relationship, Drug; Estradiol; Female; GABA Agonists; GABA Antagonists; Neurons; Neurotransmitter Agents; Oxytocin; Pituitary Gland, Posterior; Pregnanolone; Presynaptic Terminals; Progesterone; Rats; Rats, Wistar; Receptors, GABA-A; Sodium; Steroids; Supraoptic Nucleus; Vasopressins

2003
Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:2

    Topics: Acoustic Stimulation; Aging; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; Female; Flumazenil; GABA Modulators; Lorazepam; Male; Pregnanolone; Progesterone; Rats; Rats, Long-Evans; Receptors, GABA-A; Reflex, Startle; Sex Characteristics

2003
Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development.
    Neuroscience, 2003, Volume: 118, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Dentate Gyrus; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Male; Membrane Potentials; Neural Inhibition; Neurons; Pregnanolone; Pregnenolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Steroids; Up-Regulation

2003
Conjugated equine estrogens reverse the effects of aging on central and peripheral allopregnanolone and beta-endorphin levels in female rats.
    Fertility and sterility, 2004, Volume: 81 Suppl 1

    Topics: Adrenal Glands; Aging; Animals; beta-Endorphin; Brain; Dose-Response Relationship, Drug; Estrogens; Estrogens, Conjugated (USP); Estrus; Female; Hippocampus; Hypothalamus; Ovariectomy; Pituitary Gland; Pregnanolone; Rats; Rats, Wistar; Tissue Distribution

2004
Tibolone, transdermal estradiol or oral estrogen-progestin therapies: effects on circulating allopregnanolone, cortisol and dehydroepiandrosterone levels.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2005, Volume: 20, Issue:3

    Topics: Administration, Cutaneous; Adrenal Glands; Aging; Dehydroepiandrosterone; Estradiol; Estrogen Replacement Therapy; Estrogens; Estrogens, Conjugated (USP); Female; Humans; Hydrocortisone; Hysterectomy; Medroxyprogesterone Acetate; Middle Aged; Norethindrone; Norethindrone Acetate; Norpregnenes; Ovariectomy; Postmenopause; Pregnanolone; Progesterone; Progestins

2005
Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; gamma-Aminobutyric Acid; Hippocampus; Mice; Mice, Knockout; Motor Activity; Motor Skills; Pregnanolone; Progesterone; Receptors, Progesterone

2006
Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age.
    The Journal of clinical endocrinology and metabolism, 2006, Volume: 91, Issue:8

    Topics: Adult; Aging; Dehydroepiandrosterone; Estradiol; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Isomerism; Luteal Phase; Pregnanolone; Pregnenolone; Progesterone; Receptors, GABA-A

2006
Deficiency of 5 alpha-steroid formation in guinea pig ovaries compared with immature rat and hamster ovaries.
    Journal of steroid biochemistry, 1984, Volume: 21, Issue:4

    Topics: Aging; Animals; Cricetinae; Female; Guinea Pigs; Mesocricetus; Ovary; Oxidoreductases; Pregnanes; Pregnanolone; Progesterone; Rats; Rats, Inbred Strains; Sexual Maturation; Species Specificity; Steroids

1984
The diagnosis of 21-hydroxylase deficiency in a prematurely born infant on the basis of the urinary steroid excretion pattern.
    Clinica chimica acta; international journal of clinical chemistry, 1982, Apr-23, Volume: 120, Issue:3

    Topics: Adrenal Hyperplasia, Congenital; Aging; Androstanes; Chromatography, Gas; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Infant, Newborn; Infant, Premature; Male; Pregnanes; Pregnanetriol; Pregnanolone; Pregnenes; Steroid Hydroxylases; Steroids; Tetrahydrocortisone

1982
Anesthetic pregnanes counteract androgen-induced defeminization.
    Neuroendocrinology, 1982, Volume: 34, Issue:5

    Topics: Aging; Anesthetics; Animals; Animals, Newborn; Anovulation; Female; Male; Pregnanediones; Pregnanes; Pregnanolone; Progesterone; Rats; Testosterone

1982
Effect of age on synthesis of the GABAergic steroids 5-alpha-pregnane-3,20-dione and 5-alpha-pregnane-3-alpha-ol-20-one in rat cortex in vitro.
    Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:2-3

    Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Aging; Animals; Buffers; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Male; Oxidoreductases; Pregnanediones; Pregnanolone; Rats; Rats, Inbred Strains

1997
Neurosteroid modulation of GABAA receptors in the developing rat brain cortex.
    Neurochemistry international, 1997, Volume: 31, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Embryo, Mammalian; Embryonic and Fetal Development; Muscimol; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Steroids

1997
Aging is associated with changes in allopregnanolone concentrations in brain, endocrine glands and serum in male rats.
    European journal of endocrinology, 1998, Volume: 138, Issue:3

    Topics: Adrenal Glands; Aging; Animals; Brain Chemistry; Cerebral Cortex; Cohort Studies; Corticosterone; Cross Reactions; Endocrine Glands; Hypothalamus; Immune Sera; Male; Pituitary Gland; Pregnanolone; Radioimmunoassay; Rats; Rats, Wistar; Sheep; Testis; Testosterone

1998
Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives.
    Neuroscience, 1998, Volume: 85, Issue:2

    Topics: 20-alpha-Dihydroprogesterone; Aging; Animals; Animals, Newborn; Blotting, Northern; Cells, Cultured; Gene Expression Regulation; Male; Myelin Basic Protein; Myelin P0 Protein; Oligodendroglia; Pregnanolone; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve

1998
Circulating levels of allopregnanolone in humans: gender, age, and endocrine influences.
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:6

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aged; Aging; Corticotropin-Releasing Hormone; Dehydroepiandrosterone; Female; Follicular Phase; Gonadotropin-Releasing Hormone; Humans; Luteal Phase; Male; Menopause; Menstruation; Middle Aged; Ovary; Pregnanolone; Progesterone; Sex Characteristics

1998
Progesterone derivatives are able to influence peripheral myelin protein 22 and P0 gene expression: possible mechanisms of action.
    Journal of neuroscience research, 1999, May-15, Volume: 56, Issue:4

    Topics: 20-alpha-Dihydroprogesterone; Aging; Animals; Blotting, Northern; Cells, Cultured; Gene Expression Regulation; Male; Myelin P0 Protein; Myelin Proteins; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schwann Cells; Sciatic Nerve

1999
Changes of serum allopregnanolone levels in the first 2 years of life and during pubertal development.
    Pediatric research, 1999, Volume: 46, Issue:3

    Topics: Adolescent; Aging; Child; Female; Humans; Hypothalamo-Hypophyseal System; Infant; Male; Pregnanolone; Puberty

1999
Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Brain; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Fetus; Frontal Lobe; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Picrotoxin; Pregnancy; Pregnanolone; Receptors, GABA-A; Sheep; Sulfur Radioisotopes

2000
Social isolation stress during the third week of life has age-dependent effects on spatial learning in rats.
    Behavioural brain research, 2002, Jan-22, Volume: 128, Issue:2

    Topics: Aging; Animals; Body Weight; Female; Hydrocortisone; Male; Maze Learning; Memory, Short-Term; Pregnanolone; Rats; Rats, Long-Evans; Social Isolation; Stress, Psychological

2002
Induction of hepatic mixed function oxidases in senescent rodents.
    Experimental gerontology, 1978, Volume: 13, Issue:5

    Topics: Aging; Animals; Benzopyrene Hydroxylase; Benzphetamine; Biotransformation; Cytochrome P-450 Enzyme System; Cytochromes; Enzyme Induction; Ethylmorphine-N-Demethylase; Liver; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnanolone; Rats

1978
Circulating plasma levels of pregnenolone, progesterone, estrogen, luteinizing hormone, and follicle stimulating hormone in young and aged C57BL/6 mice during various stages of pregnancy.
    Journal of gerontology, 1978, Volume: 33, Issue:2

    Topics: Aging; Animals; Embryo Implantation; Estrogens; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Litter Size; Luteinizing Hormone; Maternal Age; Mice; Mice, Inbred C57BL; Pregnancy; Pregnancy, Animal; Pregnanolone; Steroids; Time Factors

1978
The anaesthetic potency of 3 alpha-hydroxy-5 alpha-pregnan-20-one and 3 alpha-hydroxy-5 beta-pregnan-20-one determined with an intravenous EEG-threshold method in male rats.
    Pharmacology & toxicology, 1987, Volume: 61, Issue:1

    Topics: Aging; Anesthesia, Intravenous; Anesthetics; Animals; Dose-Response Relationship, Drug; Electroencephalography; Male; Pregnanes; Pregnanolone; Rats

1987
Ovarian steroid metabolism during post-natal development in the normal mouse and in the adult hypogonadal (hpg) mouse.
    Journal of reproduction and fertility, 1988, Volume: 82, Issue:2

    Topics: 20-alpha-Dihydroprogesterone; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aging; Androstenedione; Animals; Female; Hypogonadism; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Ovary; Pregnanolone; Progesterone

1988