Page last updated: 2024-08-23

pregnanolone and Age-Related Memory Disorders

pregnanolone has been researched along with Age-Related Memory Disorders in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's6 (50.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Bae, MA; Cho, SH; Hwang, KS; Kim, JL; Kim, KT; Kim, SS; Park, HC1
Bernedo, MM; Cabrera, R; Escudero, C; Giuliani, F; Yunes, R1
Cohen, SJ; Finn, DA; Rabinowitz, A; Stackman, RW1
Bäckström, T; Bengtsson, SK; Johansson, M1
Bäckström, T; Kask, K; Nilsson, LG; Sundström-Poromaa, I1
Bradford, DW; Buchanan, RW; Dunn, L; Hamer, RM; Keefe, RS; Kilts, JD; Leimone, LA; Lieberman, JA; Marx, CE; Morrow, AL; Naylor, JC; Payne, VM; Porcu, P; Savitz, AJ; Shampine, LJ; Strauss, JL1
George, O; Le Moal, M; Mayo, W; Piazza, PV; Vallée, M; Vitiello, S1
Cervantes, M; Espinosa-García, C; Hernández-Morales, L; Monfil, T; Montes, P; Moralí, G1
Bazzocchini, V; Cabrera, R; Casas, S; Escudero, C; García, S; Giuliani, F; Yunes, R1
George, O; Le Moal, M; Mayo, W; Vallée, M1
Aszalós, Z1
Bäckström, T; Birzniece, V; Johansson, IM; Lindblad, C; Olsson, T1

Reviews

2 review(s) available for pregnanolone and Age-Related Memory Disorders

ArticleYear
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: Acetylcholine; Aging; Animals; Brain Stem; Dehydroepiandrosterone Sulfate; Humans; Memory; Memory Disorders; Pregnanolone; Pregnenolone; Prosencephalon; Sleep; Sleep Wake Disorders

2006
[Neurological and psychiatric aspects of some endocrine diseases. The role of neurosteroids and neuroactive steroids].
    Orvosi hetilap, 2007, Oct-14, Volume: 148, Issue:41

    Topics: Addison Disease; Adrenal Cortex Hormones; Androgens; Anxiety; Cognition Disorders; Cushing Syndrome; Depression; Endocrine System Diseases; Estrogens; Fear; Fetal Organ Maturity; Gonadal Steroid Hormones; Humans; Memory Disorders; Mental Disorders; Mood Disorders; Muscle Weakness; Nervous System Diseases; Pain; Pregnanolone; Progesterone

2007

Trials

2 trial(s) available for pregnanolone and Age-Related Memory Disorders

ArticleYear
Allopregnanolone impairs episodic memory in healthy women.
    Psychopharmacology, 2008, Volume: 199, Issue:2

    Topics: Adult; Double-Blind Method; Estradiol; Female; Gonadal Steroid Hormones; Humans; Memory; Memory Disorders; Memory, Short-Term; Middle Aged; Neuropsychological Tests; Pregnanolone; Progesterone; Psychomotor Performance

2008
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:8

    Topics: Adult; Aged; Brain; Brain Chemistry; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Placebos; Pregnanolone; Pregnenolone; Schizophrenia; Treatment Outcome; Up-Regulation

2009

Other Studies

8 other study(ies) available for pregnanolone and Age-Related Memory Disorders

ArticleYear
Chronic exposure to butyl-paraben causes photosensitivity disruption and memory impairment in adult zebrafish.
    Aquatic toxicology (Amsterdam, Netherlands), 2022, Volume: 251

    Topics: Animals; Hydrocortisone; Ligands; Memory Disorders; Neurosteroids; Neurotransmitter Agents; Parabens; Pregnanolone; Water Pollutants, Chemical; Zebrafish

2022
Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release.
    Journal of neural transmission (Vienna, Austria : 1996), 2019, Volume: 126, Issue:10

    Topics: Animals; Estrogens; Female; Locomotion; Memory Disorders; Ovariectomy; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists

2019
The neurosteroid allopregnanolone impairs object memory and contextual fear memory in male C57BL/6J mice.
    Hormones and behavior, 2014, Volume: 66, Issue:2

    Topics: Animals; Cues; Dose-Response Relationship, Drug; Fear; GABA Agonists; Gonadal Steroid Hormones; Hippocampus; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Microinjections; Pregnanolone; Receptors, GABA-A; Recognition, Psychology

2014
Long-term continuous allopregnanolone elevation causes memory decline and hippocampus shrinkage, in female wild-type B6 mice.
    Hormones and behavior, 2016, Volume: 78

    Topics: Animals; Behavior, Animal; Female; Hippocampus; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Neurotransmitter Agents; Organ Size; Pregnanolone

2016
Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats.
    Biological psychiatry, 2010, Nov-15, Volume: 68, Issue:10

    Topics: Aging; Animals; Behavior, Animal; Brain; Disease Models, Animal; Indomethacin; Male; Memory Disorders; Pregnanolone; Rats; Rats, Sprague-Dawley; Sleep Disorders, Circadian Rhythm; Steroids

2010
Neuroprotective effects of progesterone and allopregnanolone on long-term cognitive outcome after global cerebral ischemia.
    Restorative neurology and neuroscience, 2011, Volume: 29, Issue:1

    Topics: Animals; Brain Ischemia; Cognition; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Pregnanolone; Progesterone; Random Allocation; Rats; Rats, Sprague-Dawley; Swimming; Time Factors; Treatment Outcome

2011
Allopregnanolone prevents memory impairment: effect on mRNA expression and enzymatic activity of hippocampal 3-α hydroxysteroid oxide-reductase.
    Brain research bulletin, 2012, Feb-10, Volume: 87, Issue:2-3

    Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); Analysis of Variance; Animals; Avoidance Learning; Disease Models, Animal; Drug Administration Schedule; Estradiol; Exploratory Behavior; Female; Gene Expression Regulation, Enzymologic; Hippocampus; Inhibition, Psychological; Memory Disorders; Motor Activity; Ovariectomy; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; RNA, Messenger

2012
Allopregnanolone inhibits learning in the Morris water maze.
    Brain research, 2002, May-03, Volume: 934, Issue:2

    Topics: Anesthetics; Animals; Brain; Corticosterone; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Learning Disabilities; Male; Maze Learning; Memory Disorders; Neural Inhibition; Neurons; Orientation; Pregnanolone; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Space Perception; Swimming; Synaptic Transmission

2002