pregnanolone has been researched along with Acute Post-Traumatic Stress Disorder in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 16 (69.57) | 24.3611 |
| 2020's | 4 (17.39) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, KD; Pineles, SL; Pinna, G; Rasmusson, AM | 1 |
| Ding, ZC; Fang, XX; Guo, Y; Jiang, XY; Li, YF; Ran, YH; Shang, C; Sun, LJ; Wang, HL; Yao, JQ; Zhang, LM | 1 |
| Almeida, FB; Barros, HMT; Pinna, G | 2 |
| Cusin, C; Farfel, GM; Geracioti, TD; Hamner, MB; Jain, S; Lang, AJ; Lohr, J; Marx, CE; Naylor, JC; Raman, R; Rasmusson, AM; Rosse, R; Stein, MB; Summerall, L; Sun, X; Tsai, J | 1 |
| Kawada, T | 1 |
| Arditte Hall, KA; Hauger, R; Irvine, J; Miller, MW; Nillni, YI; Orr, SP; Pineles, SL; Pinna, G; Rasmusson, AM; Resick, PA; Webb, A | 1 |
| Anderson, GM; Gregor, K; Hamouda, M; King, MW; Nillni, YI; Pineles, SL; Pinna, G; Rasmusson, AM; Scioli-Salter, E; Valovski, I | 1 |
| Locci, A; Pinna, G | 1 |
| Hauger, RL; Inslicht, SS; Madden, E; Metzler, TJ; Neylan, TC; O'Donovan, A; Rao, MN; Richards, A; Rucker, E; Talbot, LS | 1 |
| Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP | 1 |
| Chen, JS; He, JL; Liu, CY; Ma, JC; Qiu, ZK; Shen, D; Shen, YG; Zeng, J; Zhang, GH | 1 |
| Dunn, CE; Hamer, RM; Keefe, FJ; Kilts, JD; Marx, CE; Morey, RA; Naylor, JC; Shampine, LJ; Strauss, JL; Szabo, ST; Tupler, LA; Wagner, HR | 1 |
| Chen, HX; Chen, XF; Li, YF; Qiu, ZK; Xue, R; Yang, RF; Zhang, LM; Zhang, YZ; Zhao, N | 1 |
| Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Zeng, J | 1 |
| Acca, GM; Jin, J; Maren, S; Mathew, AS; Nagaya, N | 1 |
| Liang, JJ; Locci, A; Marx, CE; Nillni, YI; Pineles, SL; Pinna, G; Rasmusson, AM; Scioli-Salter, ER | 1 |
| Pinna, G | 1 |
| Forman, DE; Rasmusson, AM; Schnurr, PP; Scioli, E; Zukowska, Z | 1 |
| Pinna, G; Rasmusson, AM | 1 |
| Girdler, SS; Klatzkin, RR; Light, KC; Morrow, AL; Pedersen, CA | 1 |
| Charney, D; Gottschalk, C; Guidotti, A; Krystal, J; Paliwal, P; Pinna, G; Rasmusson, AM; Weisman, D | 1 |
| Costa, E; Guidotti, A; Nelson, M; Pibiri, F; Pinna, G | 1 |
7 review(s) available for pregnanolone and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
A role for deficits in GABAergic neurosteroids and their metabolites with NMDA receptor antagonist activity in the pathophysiology of posttraumatic stress disorder.
Topics: Female; Humans; Hypothalamo-Hypophyseal System; Male; Neurosteroids; Pituitary-Adrenal System; Pregnanolone; Progesterone; Receptors, N-Methyl-D-Aspartate; Stress Disorders, Post-Traumatic | 2022 |
Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD?
Topics: Animals; Biomarkers; Brain; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Humans; Nerve Growth Factors; Neurosteroids; Pregnanolone; Stress Disorders, Post-Traumatic | 2021 |
The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Depressive Disorder, Major; Feedback, Physiological; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Male; Models, Biological; Pituitary-Adrenal System; Pregnanolone; Receptors, GABA-A; Sex Characteristics; Stress Disorders, Post-Traumatic; Stress, Physiological; Stress, Psychological | 2021 |
Neuroactive steroids and PTSD treatment.
Topics: Animals; Dehydroepiandrosterone; Estradiol; Glucocorticoids; Humans; Pregnanolone; Steroids; Stress Disorders, Post-Traumatic; Stress, Psychological | 2017 |
In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis.
Topics: Animals; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Fluoxetine; Humans; Mice; Pregnanolone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress Disorders, Post-Traumatic | 2010 |
Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome.
Topics: Adaptation, Physiological; Animals; Dehydroepiandrosterone; Female; Glucocorticoids; Humans; Hydrocortisone; Male; Metabolic Syndrome; Mice; Models, Biological; Neuropeptide Y; Pregnanolone; Risk Factors; Stress Disorders, Post-Traumatic; Stress, Physiological; Testosterone | 2010 |
Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Fluoxetine; Mice; Neurotransmitter Agents; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Up-Regulation | 2012 |
1 trial(s) available for pregnanolone and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
A randomized controlled trial of ganaxolone in posttraumatic stress disorder.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Pregnanolone; Proof of Concept Study; Stress Disorders, Post-Traumatic; Treatment Outcome | 2017 |
15 other study(ies) available for pregnanolone and Acute Post-Traumatic Stress Disorder
| Article | Year |
|---|---|
Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: Emphasis on brain GABA, neurosteroids and HPA axis function.
Topics: Animals; Behavior, Animal; Carrier Proteins; Corticosterone; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Hypothalamo-Hypophyseal System; Imidazoles; Male; Prefrontal Cortex; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Sertraline; Stress Disorders, Post-Traumatic | 2020 |
Effect of ganaxolone in patients with posttraumatic stress disorder.
Topics: Anticonvulsants; Humans; Pregnanolone; Stress Disorders, Post-Traumatic | 2018 |
PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma.
Topics: 5-alpha-Dihydroprogesterone; Adult; Female; Follicular Phase; GABA Agents; Humans; Hydroxysteroid Dehydrogenases; Luteal Phase; Menstrual Cycle; Neurotransmitter Agents; Pregnanolone; Progesterone; Receptors, GABA; Receptors, GABA-A; Stress Disorders, Post-Traumatic | 2018 |
Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD.
Topics: 5-alpha-Dihydroprogesterone; Adult; Cholestenone 5 alpha-Reductase; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depressive Disorder, Major; GABAergic Neurons; Gas Chromatography-Mass Spectrometry; Humans; Hydroxysteroid Dehydrogenases; Male; Middle Aged; Neurosteroids; Pregnanolone; Progesterone; Severity of Illness Index; Stress Disorders, Post-Traumatic | 2019 |
Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior.
Topics: Amides; Animals; Anxiety; Disease Models, Animal; Emotions; Ethanolamines; Fear; Hippocampus; Male; Mice; Palmitic Acids; PPAR alpha; Pregnanolone; Social Isolation; Stress Disorders, Post-Traumatic | 2019 |
Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder.
Topics: Adrenocorticotropic Hormone; Adult; Enzyme Inhibitors; Feedback, Physiological; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Metyrapone; Neurotransmitter Agents; Pituitary-Adrenal System; Pregnanolone; Progesterone; Sex Characteristics; Stress Disorders, Post-Traumatic; Young Adult | 2014 |
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Hypnotics and Sedatives; Pregnanolone; Psychiatric Status Rating Scales; Receptors, GABA-A; Saccades; Stress Disorders, Post-Traumatic; Young Adult | 2016 |
Free and Easy Wanderer Plus (FEWP) improves behavioral deficits in an animal model of post-traumatic stress disorder by stimulating allopregnanolone biosynthesis.
Topics: Animals; Behavior, Animal; Drugs, Chinese Herbal; Fear; Male; Maze Learning; Motor Activity; Pregnanolone; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic | 2015 |
Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.
Topics: Adult; Afghan Campaign 2001-; Afghanistan; Biomarkers; Female; Headache; Humans; Iraq; Iraq War, 2003-2011; Male; Middle Aged; Pain; Pregnanolone; Self Report; Stress Disorders, Post-Traumatic; Veterans | 2016 |
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Isoquinolines; Male; Motor Activity; Prefrontal Cortex; Pregnanolone; Purines; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic | 2016 |
Anti-PTSD-like effects of albiflorin extracted from Radix paeoniae Alba.
Topics: Amygdala; Animals; Bridged-Ring Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fear; Hippocampus; Male; Maze Learning; Paeonia; Prefrontal Cortex; Pregnanolone; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic | 2017 |
Allopregnanolone induces state-dependent fear via the bed nucleus of the stria terminalis.
Topics: Acoustic Stimulation; Amygdala; Animals; Anxiety; Association Learning; Conditioning, Classical; Fear; Male; Pregnanolone; Rats; Septal Nuclei; Stress Disorders, Post-Traumatic | 2017 |
Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women.
Topics: Adult; Demography; Depression; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Luteinizing Hormone; Pregnanolone; Premenstrual Syndrome; Progesterone; Prospective Studies; Radioimmunoassay; Stress Disorders, Post-Traumatic; Stress, Psychological | 2006 |
Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder.
Topics: 5-alpha-Dihydroprogesterone; Adult; Affect; Analysis of Variance; Dehydroepiandrosterone; Female; Humans; Menstrual Cycle; Pregnanolone; Progesterone; Receptors, GABA-A; Reference Values; Stress Disorders, Post-Traumatic | 2006 |
Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Brain Chemistry; Cerebral Cortex; Fear; Fluoxetine; Gene Expression Regulation; Limbic System; Mice; Models, Animal; Pregnanolone; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress Disorders, Post-Traumatic | 2008 |