pregna-4-17-diene-3-16-dione has been researched along with Choline-Deficiency* in 1 studies
1 other study(ies) available for pregna-4-17-diene-3-16-dione and Choline-Deficiency
Article | Year |
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Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation.
Alisol B 23-acetate (AB23A) is a natural triterpenoid isolated from the traditional Chinese medicine rhizoma alismatis, which exhibits a number of pharmacological activities, including anti-hepatitis virus, anti-cancer and antibacterial effects. In this study we examined whether AB23A protected against non-alcoholic steatohepatitis (NASH) in mice, and the mechanisms underlying the protective effects. NASH was induced in mice fed a methionine and choline-deficient (MCD) diet for 4 weeks. The mice were simultaneously treated with AB23A (15, 30, and 60 mg·kg Topics: Animals; Chenodeoxycholic Acid; Cholestenones; Choline Deficiency; Dose-Response Relationship, Drug; Fibrosis; Gene Expression; Hepatocytes; Lipid Metabolism; Lipogenesis; Liver; Male; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Pregnenediones; Primary Cell Culture; Protective Agents; Receptors, Cytoplasmic and Nuclear | 2017 |