Compounds > pregna-4-17-diene-3-16-dione--(17z)-isomer

pregna-4-17-diene-3-16-dione--(17z)-isomer and Prostatic-Neoplasms

pregna-4-17-diene-3-16-dione--(17z)-isomer has been researched along with Prostatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for pregna-4-17-diene-3-16-dione--(17z)-isomer and Prostatic-Neoplasms

Article	Year
Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis. Bioorganic & medicinal chemistry letters, 2012, Jul-15, Volume: 22, Issue:14 Two new stigmastane-type steroids, stigmasta-5,22E-diene-3β,11α-diol (1) and stigmasta-5,22E-diene-3β,7α,11α-triol (2), together with eight known compounds, were isolated from the resinous exudates of Commiphora mukul. Their structures were established by extensive analysis of their HR-MS, 1D- and 2D-NMR (COSY, HMQC, HMBC and NOESY) spectra. The isolates were evaluated for their antiproliferative activities against four human cancer cell lines. Compound 2 demonstrated inhibitory effects with IC(50) values of 5.21, 9.04, 10.94 and 16.56 μM, respectively, against K562, MCF-7, PC3 and DU145 human cancer cell lines. Further study showed that 2 was able to enforce the PC3 cell cycle arrest in the G2/M phase, and induce the apoptosis of PC3 cells by activation of Bax, caspases 3 and 9, and by inhibition of Bcl-2. It was also found that 1 inhibited proliferation of PC3 cells via G0/G1 phase arrest of the cell cycle. Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Commiphora; Humans; Male; Models, Molecular; Molecular Structure; Prostatic Neoplasms; Steroids; Structure-Activity Relationship	2012

Article

Year

Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis.

Bioorganic & medicinal chemistry letters, 2012, Jul-15, Volume: 22, Issue:14

Two new stigmastane-type steroids, stigmasta-5,22E-diene-3β,11α-diol (1) and stigmasta-5,22E-diene-3β,7α,11α-triol (2), together with eight known compounds, were isolated from the resinous exudates of Commiphora mukul. Their structures were established by extensive analysis of their HR-MS, 1D- and 2D-NMR (COSY, HMQC, HMBC and NOESY) spectra. The isolates were evaluated for their antiproliferative activities against four human cancer cell lines. Compound 2 demonstrated inhibitory effects with IC(50) values of 5.21, 9.04, 10.94 and 16.56 μM, respectively, against K562, MCF-7, PC3 and DU145 human cancer cell lines. Further study showed that 2 was able to enforce the PC3 cell cycle arrest in the G2/M phase, and induce the apoptosis of PC3 cells by activation of Bax, caspases 3 and 9, and by inhibition of Bcl-2. It was also found that 1 inhibited proliferation of PC3 cells via G0/G1 phase arrest of the cell cycle.

Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Commiphora; Humans; Male; Models, Molecular; Molecular Structure; Prostatic Neoplasms; Steroids; Structure-Activity Relationship

2012