pregabalin has been researched along with Teratogenesis* in 2 studies
2 other study(ies) available for pregabalin and Teratogenesis
| Article | Year |
|---|---|
Pregabalin alters reproductive performance in male mice and causes congenital anomalies in offspring.
Pregabalin is an anticonvulsant drug with analgesic activity for the treatment of neuropathic pain.. To valuate the toxicity of pregabalin in reproductive parameters, spermatogenesis, and teratogenicity in the offspring of mice.. Twenty male mice were randomly distributed into two groups: PGB group and group C (n =10 per group). The animals in the PGB group received, via gavage, 200mg/kg of pregabalin diluted in distilled water daily, for a period of 45days. Group C received distilled water under the same experimental design.. In the paternal parameters of the PGB group, there was a significant increase in the size of the testicles, morphological alterations in the spermatozoa, a decrease in the Johnsen score, an increase in the Leydig cells, and a decrease in the serum level of testosterone. In the intrauterine development parameters of females mated with males from the PGB group, a significant decrease in placental weight, weight and length of fetuses, and fetal viability rate was observed. There was a significant increase in the number of resorptions and post-implantation losses. The significant anomalies observed in the offspring were alteration in the size of the kidneys, absent metacarpals and phalanges, alteration in the sternum, and supernumerary thoracic vertebrae.. Results suggest that pregabalin had toxic effects on the reproductive function of male mice and teratogenic potential.. The findings of this study may provide new hypotheses, taking into account the risk-benefit ratio for male reproduction and offspring health. Topics: Analgesics; Animals; Female; Male; Mice; Placenta; Pregabalin; Pregnancy; Reproduction; Teratogenesis; Water | 2023 |
Pregabalin does not Cause Midline Closure Defect but is not as Innocent as It is Thought.
To investigate the effects of pregabalin on neural tube closure, and other potential effects on other organ systems in a chick embryo model.. Fertilized chicken eggs were divided into groups, and different doses of pregabalin was administered. All embryos were harvested in the 8th day of incubation, and investigated both macroscopically and microscopically against any developmental malformations caused by Pregabalin.. Macroscopically not any malformations were detected but macrosomia was statistically significant in medium and high dose groups. Microscopically, vertebral lamina ossification was delayed in some embryos in high dose group but not interpreted as midline closure defect and also not statistically significant. Decrease in the number of renal glomerulus and increase in the tubular damage was statistically significant in medium and high dose groups. Cardiomegaly was also found in some embryos in middle and high dose groups but not statistically significant.. The use of pregabalin does not cause neural tube closure defect in the embryo unless not exceed recommended maximum dose. Causing macrosomia instead of developmental retardation by Pregabalin is in conflict with the literature. This study revealed that Pregabalin causes fetal nephrotoxicity and macrosomia. These findings indicate that the use of Pregabalin in pregnancy still needs to be accounted as suspicious. Topics: Animals; Chick Embryo; Chickens; Dose-Response Relationship, Drug; Embryonic Development; Neural Tube; Neural Tube Defects; Pregabalin; Teratogenesis; Toxicity Tests | 2021 |