pregabalin has been researched along with Premature-Birth* in 3 studies
1 review(s) available for pregabalin and Premature-Birth
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Prenatal exposure to pregabalin, birth outcomes and neurodevelopment - a population-based cohort study in four Nordic countries.
Pregabalin is an antiepileptic drug frequently prescribed to pregnant women. Risks of adverse birth and postnatal neurodevelopmental outcomes following prenatal exposure to pregabalin are uncertain.. To investigate the association between prenatal exposure to pregabalin and the risks of adverse birth and postnatal neurodevelopmental outcomes.. This study was conducted using population-based registries in Denmark, Finland, Norway, and Sweden (2005-2016). We compared pregabalin exposure against no exposure to antiepileptics and against active comparators lamotrigine and duloxetine. We obtained pooled propensity score-adjusted estimates of association using fixed-effect and Mantel-Haenszel (MH) meta-analyses.. The total number of pregabalin-exposed births was 325/666,139 (0.05%) in Denmark, 965/643,088 (0.15%) in Finland, 307/657,451 (0.05%) in Norway, and 1275/1,152,002 (0.11%) in Sweden. The adjusted prevalence ratios (aPRs) with 95% confidence interval (CI) following pregabalin exposure versus no exposure were 1.14 (0.98-1.34) for major congenital malformations and 1.72 (1.02-2.91) for stillbirth, which attenuated to 1.25 (0.74-2.11) in MH meta-analysis. For the remaining birth outcomes, the aPRs were close to or attenuated toward unity in analyses using active comparators. Adjusted hazard ratios (95% CI) contrasting prenatal pregabalin exposure versus no exposure were 1.29 (1.03-1.63) for ADHD and attenuated when using active comparators, 0.98 (0.67-1.42) for autism spectrum disorders, and 1.00 (0.78-1.29) for intellectual disability.. Prenatal exposure to pregabalin was not associated with low birth weight, preterm birth, small for gestational age, low Apgar score, microcephaly, autism spectrum disorders, or intellectual disability. On the basis of the upper value of the 95% confidence interval, increased risks greater than 1.8 were unlikely for any major congenital malformation and ADHD. For stillbirth and most groups of specific major congenital malformations, the estimates attenuated in MH meta-analysis. Topics: Anticonvulsants; Cohort Studies; Female; Humans; Infant, Newborn; Intellectual Disability; Pregabalin; Pregnancy; Premature Birth; Prenatal Exposure Delayed Effects; Scandinavian and Nordic Countries; Stillbirth | 2023 |
2 other study(ies) available for pregabalin and Premature-Birth
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Adverse pregnancy outcomes in women exposed to gabapentin and pregabalin: data from a population-based study.
Topics: Abortion, Induced; Abortion, Spontaneous; Adult; Anticonvulsants; Congenital Abnormalities; Female; Gabapentin; Heart Septal Defects, Ventricular; Humans; Infant, Newborn; Infant, Small for Gestational Age; Italy; Pregabalin; Pregnancy; Premature Birth; Risk Factors | 2018 |
A common medication for neuropsychiatric illnesses may cause common problems in pregnancy.
Topics: Abnormalities, Drug-Induced; Calcium Channel Blockers; Female; Humans; Mental Disorders; Pain; Pregabalin; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Premature Birth | 2016 |