pregabalin and Neuroectodermal-Tumors--Primitive

This case describes a young adult male patient diagnosed and treated for a primitive neuroectodermal tumour (PNET) at 3 years of age. Chemotherapy and radiation therapy used following surgical treatment of this tumour have known neurotoxic complications, some of which have delayed onset. In this case, the patient exhibited sudden onset, persistent bilateral and deep ear pain that was consistent with a neuropathy of the glossopharyngeal nerve occurring 17 years after the completion of therapy for PNET. Treatment with pregabalin was successful with near-complete resolution of the complaint. The diagnostic certainty in this case is discussed in relation to the current diagnostic criteria for neuropathic pain.

Topics: Analgesics; Antineoplastic Protocols; Child, Preschool; Combined Modality Therapy; Diagnosis, Differential; Glossopharyngeal Nerve; Humans; Male; Neuralgia; Neuroectodermal Tumors, Primitive; Pregabalin; Treatment Outcome; Young Adult