pregabalin and Musculoskeletal-Pain

Polymyalgia rheumatism and fibromyalgia are clinically similar. As there are no specific diagnostic markers, they are difficult to distinguish. A 92-year-old woman with a 3-month history of general pain, including left hip pain, was referred to our hospital. Her medical history included polymyalgia rheumatism that had been treated with prednisolone for 18 years. We found 14 of 18 symmetrical tender points. We diagnosed fibromyalgia based on two physical examinations and her personal history of general pain. Pregabalin was prescribed, and her pain gradually disappeared. About a month later, she complained of returned buttock pain and fever. She was diagnosed with exacerbation of polymyalgia rheumatism by various examinations and was treated with prednisolone. We found 3 of 18 asymmetrical tender points. No symptoms had recurred at the 1-month follow-up visit. Her case provides an opportunity to highlight the possible pitfalls when diagnosing geriatric general pain.

Topics: Aged, 80 and over; Diagnosis, Differential; Female; Fibromyalgia; Geriatric Assessment; Humans; Musculoskeletal Pain; Pain Management; Pain Measurement; Polymyalgia Rheumatica; Pregabalin; Risk Assessment; Severity of Illness Index; Treatment Outcome

The aim of this study was to clarify the mechanism of disuse-induced muscle hyperalgesia through the evaluation of the pharmacological behaviour of muscle hyperalgesia profiles in chronic post-cast pain (CPCP) rats with acute and chronic-phase mirror-image muscle hyperalgesia treated with diclofenac (NSAID), pregabalin (an inhibitor of Ca

Topics: Animals; Chronic Pain; Diclofenac; Disease Models, Animal; Duloxetine Hydrochloride; Humans; Muscle, Skeletal; Muscular Disorders, Atrophic; Musculoskeletal Pain; Pain Measurement; Pain Threshold; Pregabalin; Rats; Rats, Sprague-Dawley