pregabalin and Epilepsy--Reflex

pregabalin has been researched along with Epilepsy--Reflex* in 1 studies

Other Studies

1 other study(ies) available for pregabalin and Epilepsy--Reflex

Article	Year
Carboxylate bioisosteres of pregabalin. Bioorganic & medicinal chemistry letters, 2006, Jul-01, Volume: 16, Issue:13 Several beta-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the alpha(2)-delta protein examined. Two select compounds with potent affinity for alpha(2)-delta, 8a and 16a, were subsequently tested in vivo in an audiogenic seizure model and found to elicit protective effects. Topics: Amines; Animals; Anticonvulsants; Binding Sites; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy, Reflex; Gabapentin; gamma-Aminobutyric Acid; Mice; Mice, Inbred DBA; Molecular Structure; Pregabalin; Protein Subunits; Stereoisomerism; Structure-Activity Relationship	2006

Article

Year

Bioorganic & medicinal chemistry letters, 2006, Jul-01, Volume: 16, Issue:13

Several beta-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the alpha(2)-delta protein examined. Two select compounds with potent affinity for alpha(2)-delta, 8a and 16a, were subsequently tested in vivo in an audiogenic seizure model and found to elicit protective effects.

Topics: Amines; Animals; Anticonvulsants; Binding Sites; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy, Reflex; Gabapentin; gamma-Aminobutyric Acid; Mice; Mice, Inbred DBA; Molecular Structure; Pregabalin; Protein Subunits; Stereoisomerism; Structure-Activity Relationship

2006