pregabalin and Diabetic-Retinopathy

Patients with POAG have lower corneal endothelial cell density than healthy controls of the same age. This may be attributed to mechanical damage from elevated IOP and toxicity of glaucoma medications.. Mycophenolic acid was detected in all cats. The dose 10 mg/kg given q12h for 1 week was tolerated (n = 3). The efficacy of MMF as an immunosuppressant and long-term safety in cats of this dosage regimen is unknown.. T

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Pregabalin is the first drug to receive FDA approval for treating diabetic neuropathic pain. This study investigated the neuroprotective effect of pregabalin in an experimental model of diabetic retinopathy and tested some possible mechanisms underlying the putative neuroprotective effect. Male Wistar rats received streptozotocin (45 mg/kg) to induce type 1 diabetes mellitus. After two weeks, a course of pregabalin (3, 10 and 30 mg/kg) has been launched for five consecutive weeks. Retinal expression of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) was estimated by real-time PCR and retinal glutamate content was also estimated. Further, retinal caspase-3 immunoblotting and DNA fragmentation assays determined the degree of apoptosis. Pregabalin improved histopathological abnormalities in diabetic retinas and suppressed the diabetes-enhanced retinal expression of IL-1β, TNF-α, CD

Topics: Analgesics; Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Gene Expression; Glial Fibrillary Acidic Protein; Glutamic Acid; Glutathione; Interleukin-1beta; Male; Microglia; Neuroprotection; Neuroprotective Agents; Oxidative Stress; Pregabalin; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Retina; Tumor Necrosis Factor-alpha

Charles Bonnet syndrome is a condition characterised by the presence of visual hallucinations in patients having visual impairment most commonly reported in the seventh decade. We describe a case of a 55-year-old lady who had developed retinopathy causing significant visual loss secondary to diabetes mellitus. She had started seeing images of men for the past 2 months which made her feel uncomfortable and seek psychiatric help. She was aware that the hallucinations were not real but a part of her imagination. A detailed history did not reveal any psychopathology but the patient had several medical complications due to her uncontrolled diabetes. Pregabalin, which was started for her neuropathy, dramatically remitted her symptoms within 2 days.

Topics: Analgesics; Diabetic Neuropathies; Diabetic Retinopathy; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Middle Aged; Pregabalin; Syndrome; Vision Disorders

To report the role of retinal hypoxia in development of diabetic macular edema and its management--a new concept.. A 24-year-old diabetic female was seen with bilateral visual blurring for 3 weeks, associated with marked diabetic macular edema, diabetic retinopathy, and non-arteritic anterior ischemic optic neuropathy (NA-AION) in both eyes. She was taking three blood pressure lowering drugs for diabetic neuropathy and nephropathy. Stopping two of those arterial hypotensive drugs, without any of the conventional treatments for diabetic macular edema, resulted in rapid improvement of visual acuity from counting fingers to 20/50 in the right eye, and from 20/80 to 20/25 in the left eye, and complete resolution of macular edema and improvement of retinopathy. Similarly, visual field defects in both eyes improved to almost normal.. The evidence from this diabetic patient suggests that hypoxia caused by fall in perfusion pressure in the retinal capillaries may be playing an important role in the development of diabetic macular edema in some, perhaps many, of these cases.

Topics: Adult; Blood Pressure; Diabetic Nephropathies; Diabetic Retinopathy; Female; Fluorescein Angiography; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Hypoxia; Insulin; Lisinopril; Macular Edema; Optic Neuropathy, Ischemic; Pregabalin; Proteinuria; Retinal Diseases; Tomography, Optical Coherence; Tramadol; Vision Disorders; Visual Acuity; Visual Field Tests; Visual Fields

Topics: Blood Pressure; Diabetic Retinopathy; Fluorescein Angiography; gamma-Aminobutyric Acid; Humans; Hypoxia; Insulin; Lisinopril; Macular Edema; Optic Neuropathy, Ischemic; Pregabalin; Proteinuria; Retinal Diseases; Retinal Vein Occlusion; Tomography, Optical Coherence; Tramadol; Vision Disorders; Visual Acuity; Visual Fields