pregabalin and Demyelinating-Diseases

Multiple sclerosis (MS)-induced neuropathic pain deteriorates quality of life in patients but is often refractory to treatment. In experimental autoimmune encephalomyelitis (EAE), a rodent model of MS, animals develop neuropathy and inflammation-induced tissue acidosis, which suggests the involvement of acid-sensing ion channels (ASICs). Also, peripheral neuropathy is reported in MS patients. However, the involvement of the peripheral nervous system (PNS) in MS neuropathic pain remains elusive. This study investigated the contribution of ASICs and peripheral neuropathy in MS-induced neuropathic pain. Elicited pain levels were as high in Asic1a

Topics: Acid Sensing Ion Channels; Analgesics; Animals; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Ganglia, Spinal; Gray Matter; Hyperalgesia; Lumbar Vertebrae; Mice, Knockout; Microglia; Motor Activity; Myelin Sheath; Neuralgia; Peptides; Peripheral Nervous System; Pregabalin; Sensory Receptor Cells