prednisone has been researched along with alpha 1-Antitrypsin Deficiency in 11 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
alpha 1-Antitrypsin Deficiency: Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The pharmacokinetic comparability of Prolastin-C to Prolastin was assessed in subjects with AAT deficiency." | 2.75 | Pharmacokinetic comparability of Prolastin®-C to Prolastin® in alpha₁-antitrypsin deficiency: a randomized study. ( Brantly, ML; Campos, MA; Chapman, KR; Kueppers, F; Sandhaus, RA; Stocks, JM; Strange, C; Turino, G; Wang-Smith, L, 2010) |
| "The differential diagnosis of spinal cord compression in a patient who has had a transplant should include primary presentation of PTLD." | 1.35 | Extradural thoracic spinal cord compression: unusual initial presentation of post-transplant lymphoproliferative disorder. ( Bakker, NA; Coppes, MH; Slart, RH; van Dijk, JM; van Imhoff, GW; Verschuuren, EA, 2008) |
| "Sarcoidosis was diagnosed on account of hypercalcemia (3." | 1.27 | [A patient with type ZZ alpha 1-antitrypsin deficiency and hypercalcemia caused by sarcoidosis]. ( Borstlap, R; van Collenburg, JJ; van Lookeren Campagne, JG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, Q | 1 |
| D'Urzo, AD | 1 |
| Kohn, R | 1 |
| Margolis, ML | 1 |
| Bakker, NA | 1 |
| van Dijk, JM | 1 |
| Slart, RH | 1 |
| Coppes, MH | 1 |
| van Imhoff, GW | 1 |
| Verschuuren, EA | 1 |
| Stocks, JM | 1 |
| Brantly, ML | 1 |
| Wang-Smith, L | 1 |
| Campos, MA | 1 |
| Chapman, KR | 1 |
| Kueppers, F | 1 |
| Sandhaus, RA | 1 |
| Strange, C | 1 |
| Turino, G | 1 |
| Kolts, BE | 1 |
| Spindel, E | 1 |
| Johnston, RF | 1 |
| Mondschein, FJ | 1 |
| Pittelkow, MR | 2 |
| Smith, KC | 2 |
| Su, WP | 2 |
| Stock, PG | 1 |
| Ascher, NL | 1 |
| Najarian, JS | 1 |
| Borstlap, R | 1 |
| van Lookeren Campagne, JG | 1 |
| van Collenburg, JJ | 1 |
| Lonchampt, F | 1 |
| Blanc, D | 1 |
| Terrasse, F | 1 |
| Humbert, P | 1 |
| Kienzler, JL | 1 |
| Agache, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multi-center, Randomized, Double-blind, Crossover Trial to Evaluate the Pharmacokinetic Comparability of Alpha-1 MP to Prolastin in Subjects With Alpha1-antitrypsin Deficiency.[NCT00295061] | Phase 3 | 24 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The primary objective of this study was to demonstrate the pharmacokinetic comparability (geometric least square mean ratio of AUC between the Alpha-1 MP vs. Prolastin®, 90% confidence interval falls within 0.80-1.25, FDA Guidance as being bioequivalent between two treatments) of Alpha-1 MP to Prolastin® in subjects with alpha-1-anti-trypsin (AAT) deficiency by comparing AUC from Day 0 to Day 7 of plasma Alpha1-PI measured by the functional activity (potency) assay. AUC from Day 0 to Day 7 was calculated at steady state at the end of the first and second 8-week treatment periods during the 16-week double-blind, crossover phase." (NCT00295061)
Timeframe: Day 0 to Day 7
| Intervention | mg*h/mL (Number) |
|---|---|
| Alpha-1 MP | 155.9 |
| Prolastin | 152.4 |
2 reviews available for prednisone and alpha 1-Antitrypsin Deficiency
| Article | Year |
|---|---|
Chronic active hepatitis.
Topics: alpha 1-Antitrypsin Deficiency; Autoimmune Diseases; Azathioprine; Diagnosis, Differential; Drug The | 1984 |
Panniculitis associated with severe alpha 1-antitrypsin deficiency. Treatment and review of the literature.
Topics: Adipose Tissue; Adult; Aged; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Biopsy; Blood Prot | 1987 |
1 trial available for prednisone and alpha 1-Antitrypsin Deficiency
| Article | Year |
|---|---|
Pharmacokinetic comparability of Prolastin®-C to Prolastin® in alpha₁-antitrypsin deficiency: a randomized study.
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Antineoplastic Combined Chemotherapy Protocols; | 2010 |
8 other studies available for prednisone and alpha 1-Antitrypsin Deficiency
| Article | Year |
|---|---|
Challenge of α
Topics: Administration, Inhalation; Administration, Oral; Adult; alpha 1-Antitrypsin Deficiency; Bronchodila | 2016 |
Localized Pulmonary Densities in a Patient with α1-Antitrypsin Deficiency.
Topics: alpha 1-Antitrypsin Deficiency; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Diagno | 2015 |
Extradural thoracic spinal cord compression: unusual initial presentation of post-transplant lymphoproliferative disorder.
Topics: Adult; alpha 1-Antitrypsin Deficiency; Antineoplastic Combined Chemotherapy Protocols; Cyclophospham | 2008 |
Chronic bronchitis and pulmonary emphysema.
Topics: alpha 1-Antitrypsin Deficiency; Bronchitis; Bronchodilator Agents; Chronic Disease; Diagnosis, Diffe | 1981 |
Alpha-1-antitrypsin deficiency and panniculitis. Perspectives on disease relationship and replacement therapy.
Topics: Adult; Aged; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Blood Proteins; Dapsone; Debrideme | 1988 |
Pediatric liver transplantation using combination immunosuppressive therapy.
Topics: Actuarial Analysis; alpha 1-Antitrypsin Deficiency; Azathioprine; Biliary Atresia; Child; Child, Pre | 1987 |
[A patient with type ZZ alpha 1-antitrypsin deficiency and hypercalcemia caused by sarcoidosis].
Topics: alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Child; Genotype; Humans; Hypercalcemia; Male; P | 1986 |
[Weber-Christian disease associated with familial alpha-1-antitrypsin deficiency. Apropos of a case].
Topics: alpha 1-Antitrypsin Deficiency; Female; Humans; Metabolism, Inborn Errors; Middle Aged; Panniculitis | 1985 |