prednisone and Orbital Pseudotumor studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Orbital Pseudotumor: A nonspecific tumor-like inflammatory lesion in the ORBIT of the eye. It is usually composed of mature LYMPHOCYTES; PLASMA CELLS; MACROPHAGES; LEUKOCYTES with varying degrees of FIBROSIS. Orbital pseudotumors are often associated with inflammation of the extraocular muscles (ORBITAL MYOSITIS) or inflammation of the lacrimal glands (DACRYOADENITIS).

Research Excerpts

Excerpt	Relevance	Reference
"Four patients had orbital myositis of one extraocular muscle at the initial episode and recurrent myositis of a different extraocular muscle on the contralateral orbit."	2.48	Relapsing migratory idiopathic orbital inflammation: six new cases and review of the literature. ( Avni-Zauberman, N; Ben Simon, GJ; Rosen, N; Tripathy, D, 2012)
"Concurrent orbital pseudotumor and Crohn's disease, although rare, have been described."	2.38	Acute dacryoadenitis and Crohn's disease: findings and management. ( Cartwright, MJ; Dutt, S; Nelson, CC, 1992)
"Coexistence of idiopathic orbital inflammatory pseudotumor (IOIP) and thyroid-associated ophthalmopathy (TAO) is extremely rare."	1.42	Concomitant Idiopathic Orbital Inflammatory Pseudotumor and Thyroid-Associated Ophthalmopathy. ( Chen, J; Lin, J; Liu, R; Shen, T; Yan, J, 2015)
"A patient diagnosed with necrotizing scleritis, c-ANCA+ an orbital pseudotumour, and possible multiple sclerosis in 2003 was treated with oral cyclophosphamide and steroids with partial response."	1.40	[C-ANCA positive necrotising scleritis and multiple sclerosis compatible with ocular Wegener: treatment with rituximab]. ( Aldasoro-Cáceres, I; Aldasoro-Cáceres, V; Ibáñez-Bosch, R; Murié-Fernández, M; Pérez-Moreiras, JV, 2014)
"Orbital pseudotumor is a benign, idiopathic, non-infectious and non-neoplastic clinical syndrome characterized by the presence of an inflammatory mass at orbital level with no identifiable cause."	1.37	Orbital pseudotumor in a child: diagnostic implications and treatment strategies. ( Ciracì, L; Dammacco, R; Di Leo, E; Guerriero, S; Piscitelli, D; Sborgia, C; Vacca, A, 2011)

Research

Studies (43)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants Achieving Treatment Success After Switching to Other Medication (Phase II, 0-6 Months)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	16 (37.21)	18.2507
2000's	12 (27.91)	29.6817
2010's	14 (32.56)	24.3611
2020's	1 (2.33)	2.80

Authors	Studies
Bachman Groth, JA	1
Harris, GJ	1
Khochtali, S	1
Zayani, M	1
Ksiaa, I	1
Ben Meriem, I	1
Zaouali, S	1
Jelliti, B	1
Khairallah, M	1
Albitar, HAH	1
Carmona, EM	1
Herrera, I	1
Kam, Y	1
Whittaker, TJ	1
Champion, M	1
Ajlan, RS	1
Li, Y	1
Lip, G	1
Chong, V	1
Yuan, J	1
Ding, Z	1
Kalapesi, FB	1
Garrott, HM	1
Moldovan, C	1
Williams, M	1
Ramanan, A	1
Herbert, HM	1
Aldasoro-Cáceres, V	1
Aldasoro-Cáceres, I	1
Pérez-Moreiras, JV	1
Murié-Fernández, M	1
Ibáñez-Bosch, R	1
Yan, J	2
Wu, P	1
Heidari, P	1
Verdijk, RM	1
van den Bosch, WA	1
Paridaens, D	1
Shen, T	1
Chen, J	1
Lin, J	1
Liu, R	1
Patel, A	1
Modjtahedi, BS	1
Freitag, SK	1
Sobrin, L	1
Kazlas, MA	1
Nieto, JC	1
Kim, N	1
Lucarelli, MJ	1
Seth, A	1
Anderson, DP	1
Albiani, DA	1
Barton, JJ	1
Chappelow, AV	1
McMahon, JT	1
Jones, CL	1
Kosmorsky, G	1
Guerriero, S	1
Di Leo, E	1
Piscitelli, D	1
Ciracì, L	1
Vacca, A	1
Sborgia, C	1
Dammacco, R	1
Avni-Zauberman, N	1
Tripathy, D	1
Rosen, N	1
Ben Simon, GJ	1
Elhoudzi, J	1
Rome, A	1
Padovani, L	1
Gentet, JC	1
André, N	1
Foley, MR	1
Moshfeghi, DM	1
Wilson, MW	1
Haik, BG	1
Pappo, AS	1
Hill, DA	1
Subramanian, PS	1
Kerrison, JB	1
Calvert, PC	1
Miller, NR	1
Kawasaki, A	1
Borruat, FX	1
Mulvihill, A	1
Smith, CR	1
Buncic, JR	1
Foroozan, R	1
Thorne, JE	1
Jabs, DA	1
Qazi, FA	1
Nguyen, QD	1
Kempen, JH	1
Dunn, JP	1
Mora-de-Oñate, J	1
Pascual-Pérez-Alfaro, R	1
Izquierdo-Vázquez, C	1
González-Ruiz, M	1
Aguirrebeña-Olmos, A	1
Díez-Villalba, R	1
Smith, RR	1
Phillips, PM	1
Newman, SA	1
Raskin, EM	1
McCormick, SA	1
Maher, EA	1
Della Rocca, RC	1
Cheung, MK	1
Martin, DF	1
Chan, CC	1
Callanan, DG	1
Cowan, CL	1
Nussenblatt, RB	1
Du, Y	1
Zheng, Y	1
Jiang, R	1
Kurtz, S	1
Moisseiev, J	1
Gutman, I	1
Blumenthal, M	1
Simcock, PR	1
Rauz, S	1
Barnes, E	1
Kinnear, P	1
Pollard, ZF	1
Monfort-Gouraud, M	1
Chokre, R	1
Dubiez, M	1
Ratsimihah, T	1
Hamza, A	1
Sauvageon, G	1
Mombaerts, I	1
Schlingemann, RO	1
Goldschmeding, R	1
Koornneef, L	1
Matesanz, JL	1
García Alonso, A	1
Gracia Chapullé, A	1
Llaneza Ruiz, J	1
Bittar, MS	1
Garcia, ML	1
Marchiori, PE	1
Peterson, EA	1
Hymas, DC	1
Pratt, DV	1
Mortenson, SW	1
Anderson, RL	1
Mamalis, N	1
Gonzales, GR	1
Stidham, DB	1
Sondhi, N	1
Plager, D	1
Helveston, E	1
de Heide, LJ	1
Talsma, MA	1
Hwang, IP	1
Jordan, DR	1
Acharya, V	1
Dutt, S	1
Cartwright, MJ	1
Nelson, CC	1
Li, JT	1
Garrity, JA	1
Kephart, GM	1
Gleich, GJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Myfortic (Enteric-coated Mycophenolate Sodium) for the Treatment of Non-infectious Intermediate Uveitis - a Prospective, Controlled, Randomized Multicenter Trial[NCT01092533]	Phase 3	44 participants (Actual)	Interventional	2010-03-31	Completed
First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial[NCT01829295]	Phase 3	216 participants (Actual)	Interventional	2013-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Controlled ocular inflammation (≤ 0.5+ anterior chamber cells, ≤ 0.5+ vitreous haze, no active retinal/choroidal lesions in both eyes) with 7.5 mg/day of oral prednisone and ≤ 2 drops/day of topical 1% prednisolone acetate for patients who crossed over to other medication following treatment failure at 6 months (or earlier). (NCT01829295)
Timeframe: 6 Months

Number of Participants Achieving Treatment Success at 12 Months on Same Medication (Phase I, 6-12 Months)

Intervention	Participants (Count of Participants)
Switched Over to Methotrexate	20
Switched Over to Mycophenolate Mofetil	7

Controlled ocular inflammation (≤ 0.5+ anterior chamber cells, ≤ 0.5+ vitreous haze, no active retinal/choroidal lesions in both eyes) with 7.5 mg/day of oral prednisone and ≤ 2 drops/day of topical 1% prednisolone acetate in patients who were a treatment success at the primary outcome of 6 months. (NCT01829295)
Timeframe: 12 Months

Number of Participants Achieving Treatment Success at 6 Months (Phase I, 0-6 Months)

Article	Year
Relapsing migratory idiopathic orbital inflammation: six new cases and review of the literature. The British journal of ophthalmology, 2012, Volume: 96, Issue:2 Topics: Adolescent; Adult; Biopsy; Eyelid Diseases; Female; Glucocorticoids; Humans; Injections, Intralesion	2012
[Anterior uveitis as the form of presentation of orbital pseudotumor in a child]. Revista clinica espanola, 1997, Volume: 197, Issue:1 Topics: Administration, Oral; Child; Diagnosis, Differential; Female; Humans; Orbital Pseudotumor; Prednison	1997
Acute dacryoadenitis and Crohn's disease: findings and management. Ophthalmic plastic and reconstructive surgery, 1992, Volume: 8, Issue:4 Topics: Acute Disease; Adolescent; Crohn Disease; Dacryocystitis; Humans; Male; Orbital Pseudotumor; Prednis	1992

Article	Year
Case Report: Idiopathic Sclerosing Orbital Inflammation. Optometry and vision science : official publication of the American Academy of Optometry, 2021, 04-01, Volume: 98, Issue:4 Topics: Administration, Oral; Female; Glucocorticoids; Humans; Infusions, Intravenous; Methylprednisolone; M	2021
[Idiopathic orbital inflammatory syndrome: Report of 24 cases]. Journal francais d'ophtalmologie, 2018, Volume: 41, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Biopsy; Female; Humans; Immunosuppressive Agents;	2018
48-Year-Old Man With Bilateral Mediastinal Lymphadenopathy, Orbital Pseudotumors, Kidney Masses, and Acute Pancreatitis. Mayo Clinic proceedings, 2019, Volume: 94, Issue:3 Topics: Acute Disease; Diagnosis, Differential; Glucocorticoids; Humans; Immunoglobulin G; Immunoglobulin G4	2019
Bisphosphonate-induced orbital inflammation in a patient on chronic immunosuppressive therapy. BMC ophthalmology, 2019, Feb-14, Volume: 19, Issue:1 Topics: Administration, Oral; Bone Density Conservation Agents; Cyclosporine; Female; Glucocorticoids; Human	2019
Idiopathic orbital inflammation syndrome with retro-orbital involvement: a retrospective study of eight patients. PloS one, 2013, Volume: 8, Issue:2 Topics: Adult; Aged; Carotid Artery, Internal; Cavernous Sinus; Cranial Fossa, Middle; Female; Humans; Magne	2013
IgG4 orbital inflammation in a 5-year-old child presenting as an orbital mass. Orbit (Amsterdam, Netherlands), 2013, Volume: 32, Issue:2 Topics: Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Hypergammaglob	2013
[C-ANCA positive necrotising scleritis and multiple sclerosis compatible with ocular Wegener: treatment with rituximab]. Archivos de la Sociedad Espanola de Oftalmologia, 2014, Volume: 89, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Muri	2014
Idiopathic orbital myositis. The Journal of craniofacial surgery, 2014, Volume: 25, Issue:3 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Child; China; Dexamethasone; Female; Humans; Male;	2014
Biopsy-proven recurrence of unilateral IgG4-related orbital inflammation after 20 years. Orbit (Amsterdam, Netherlands), 2014, Volume: 33, Issue:5 Topics: Administration, Oral; Adult; Azathioprine; Biopsy; Drug Therapy, Combination; Female; Glucocorticoid	2014
Concomitant Idiopathic Orbital Inflammatory Pseudotumor and Thyroid-Associated Ophthalmopathy. The Journal of craniofacial surgery, 2015, Volume: 26, Issue:6 Topics: Adult; Anti-Inflammatory Agents; Blepharoptosis; Dexamethasone; Female; Follow-Up Studies; Glucocort	2015
Idiopathic Orbital Inflammation Presenting with Bilateral Panuveitis. Journal of pediatric ophthalmology and strabismus, 2016, Apr-23, Volume: 53 Online Topics: Adolescent; Fluorescein Angiography; Glucocorticoids; Humans; Magnetic Resonance Imaging; Male; Orbi	2016
Dacryoadenitis and orbital myositis associated with lyme disease. Archives of ophthalmology (Chicago, Ill. : 1960), 2008, Volume: 126, Issue:8 Topics: Aged; Anti-Bacterial Agents; Blepharoptosis; Dacryocystitis; Doxycycline; Drug Therapy, Combination;	2008
Orbital inflammation and optic neuropathy with zoledronic acid for metastatic prostate cancer. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2009, Volume: 44, Issue:4 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Diphosphonates; Dru	2009
Granulomatous orbital inflammation associated with intraorbital titanium-impregnated acetate fiber. Orbit (Amsterdam, Netherlands), 2010, Volume: 29, Issue:3 Topics: Biopsy, Needle; Blood Chemical Analysis; Contrast Media; Exophthalmos; Follow-Up Studies; Granuloma,	2010
Orbital pseudotumor in a child: diagnostic implications and treatment strategies. Clinical and experimental medicine, 2011, Volume: 11, Issue:1 Topics: Adolescent; Anti-Inflammatory Agents; Azathioprine; Biopsy; Female; Head; Histocytochemistry; Humans	2011
Metronomic scheduling of anticancer agents for a refractory orbital pseudotumor in a child. Journal of pediatric hematology/oncology, 2013, Volume: 35, Issue:8 Topics: Administration, Metronomic; Anti-Inflammatory Agents; Antineoplastic Agents; Celecoxib; Child; Cyclo	2013
Orbital inflammatory syndromes with systemic involvement may mimic metastatic disease. Ophthalmic plastic and reconstructive surgery, 2003, Volume: 19, Issue:4 Topics: Blepharoptosis; Bone Diseases; Child; Diagnosis, Differential; Exophthalmos; Female; Glucocorticoids	2003
Orbital inflammatory disease after pamidronate treatment for metastatic prostate cancer. Archives of ophthalmology (Chicago, Ill. : 1960), 2003, Volume: 121, Issue:9 Topics: Aged; Anti-Inflammatory Agents; Antineoplastic Agents; Bone Neoplasms; Diphosphonates; Humans; Male;	2003
An unusual presentation of herpes zoster ophthalmicus: orbital myositis preceding vesicular eruption. American journal of ophthalmology, 2003, Volume: 136, Issue:3 Topics: Acyclovir; Anti-Inflammatory Agents; Antiviral Agents; Diplopia; Drug Therapy, Combination; Female;	2003
Pediatric orbital pseudotumour presenting as a painless orbital and periocular mass. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2004, Volume: 39, Issue:1 Topics: Child; Exophthalmos; Female; Glucocorticoids; Humans; Magnetic Resonance Imaging; Orbital Pseudotumo	2004
Combined central retinal artery and vein occlusion from orbital inflammatory pseudotumour. Clinical & experimental ophthalmology, 2004, Volume: 32, Issue:4 Topics: Adult; Exophthalmos; Fluorescein Angiography; Glucocorticoids; Humans; Magnetic Resonance Imaging; M	2004
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
[Painful ophthalmoplegia (pseudotumor of the orbit and Tolosa-Hunt syndrome)]. Archivos de la Sociedad Espanola de Oftalmologia, 2007, Volume: 82, Issue:8 Topics: Anti-Inflammatory Agents; Diagnosis, Differential; Female; Glucocorticoids; Humans; Magnetic Resonan	2007
The wayward eye. The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha, 2007,Autumn, Volume: 70, Issue:4 Topics: Anecdotes as Topic; Anti-Inflammatory Agents; Cataract Extraction; Humans; Lens Implantation, Intrao	2007
Orbital inflammatory disease after intravenous infusion of zoledronate for treatment of metastatic renal cell carcinoma. Archives of ophthalmology (Chicago, Ill. : 1960), 2008, Volume: 126, Issue:1 Topics: Administration, Oral; Bone Density Conservation Agents; Bone Neoplasms; Carcinoma, Renal Cell; Dipho	2008
Granulomatous idiopathic orbital inflammation. Ophthalmic plastic and reconstructive surgery, 1995, Volume: 11, Issue:2 Topics: Adult; Biopsy; Exophthalmos; Female; Humans; Male; Middle Aged; Orbit; Orbital Pseudotumor; Predniso	1995
Diagnosis of reactive lymphoid hyperplasia by chorioretinal biopsy. American journal of ophthalmology, 1994, Oct-15, Volume: 118, Issue:4 Topics: Antigens, CD; Biopsy; Choroid; Fluorescein Angiography; Fundus Oculi; Humans; Hyperplasia; Male; Mid	1994
[Application of A-scan ultrasonography in the diagnosis and treatment of myositis of extraocular muscles (with a report of four cases)]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1994, Volume: 16, Issue:1 Topics: Adult; Diagnosis, Differential; Female; Humans; Male; Oculomotor Muscles; Orbital Pseudotumor; Predn	1994
Orbital pseudotumor presenting as acute glaucoma with choroidal and retinal detachment. German journal of ophthalmology, 1993, Volume: 2, Issue:1 Topics: Acute Disease; Aged; Choroid Diseases; Female; Glaucoma; Humans; Intraocular Pressure; Orbital Pseud	1993
Orbital myositis. Eye (London, England), 1995, Volume: 9 ( Pt 5) Topics: Adult; Anti-Inflammatory Agents; Autoantibodies; Female; Humans; Orbital Pseudotumor; Prednisone; To	1995
Acute rectus muscle palsy in children as a result of orbital myositis. The Journal of pediatrics, 1996, Volume: 128, Issue:2 Topics: Acute Disease; Anti-Inflammatory Agents; Cellulitis; Child; Child, Preschool; Diagnosis, Differentia	1996
[Inflammatory pseudotumor of the orbit and suspected sarcoidosis]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:7 Topics: Adolescent; Humans; Male; Orbital Pseudotumor; Prednisone; Sarcoidosis	1996
Idiopathic granulomatous orbital inflammation. Ophthalmology, 1996, Volume: 103, Issue:12 Topics: Acute Disease; Adult; Aged; Child, Preschool; Chronic Disease; Female; Glucocorticoids; Humans; Male	1996
Acute orbital myositis. Case report. Arquivos de neuro-psiquiatria, 1997, Volume: 55, Issue:1 Topics: Acute Disease; Adult; Female; Glucocorticoids; Humans; Orbital Pseudotumor; Prednisone; Respiratory	1997
Sarcoidosis with orbital tumor outside the lacrimal gland: initial manifestation in 2 elderly white women. Archives of ophthalmology (Chicago, Ill. : 1960), 1998, Volume: 116, Issue:6 Topics: Aged; Aged, 80 and over; Female; Glucocorticoids; Humans; Lymphatic Diseases; Magnetic Resonance Ima	1998
Pain in Tolosa-Hunt syndrome. Journal of pain and symptom management, 1998, Volume: 16, Issue:3 Topics: Aged; Anti-Inflammatory Agents; Female; Humans; Magnetic Resonance Imaging; Orbital Pseudotumor; Pai	1998
Presumed isolated inflammation of the superior oblique muscle in idiopathic orbital myositis. Ophthalmology, 1998, Volume: 105, Issue:12 Topics: Humans; Intraocular Pressure; Male; Middle Aged; Oculomotor Muscles; Orbital Pseudotumor; Prednisone	1998
Giant-cell arteritis presenting as an orbital pseudotumor. The Netherlands journal of medicine, 1999, Volume: 55, Issue:4 Topics: Aged; Diagnosis, Differential; Female; Follow-Up Studies; Giant Cell Arteritis; Glucocorticoids; Hum	1999
Lacrimal gland inflammation as the presenting sign of Crohn's disease. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2001, Volume: 36, Issue:4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Dacryocystitis; Drug Therapy, Combina	2001
Refractory periorbital edema in a 29-year-old man. Annals of allergy, 1992, Volume: 69, Issue:2 Topics: Adult; Angioedema; Diagnosis, Differential; Eosinophils; Humans; Magnetic Resonance Imaging; Male; O	1992

prednisone and Orbital Pseudotumor