prednisone has been researched along with Optic Neuritis in 126 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Optic Neuritis: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The regimen of glucocorticoid therapy was oral prednisone, starting with 160 mg daily followed by reducing the dosage by 20 mg every three days until 40 mg per day was attained and then tapering the dosage at 70 mg every other day until stoppage of the drug." | 5.30 | [Treatment of acute optic neuritis with high dose of prednisone]. ( Ai, F; Hu, T; Jiang, R; Liu, Q; Zhang, M, 1998) |
| " Recurrences were more frequent in patients with multiple sclerosis and in those treated with oral prednisone alone." | 5.08 | Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group. ( , 1997) |
| "We conducted a multicenter study in which 389 patients with acute optic neuritis (and without known multiple sclerosis) were randomly assigned to receive intravenous methylprednisolone (250 mg every six hours) for 3 days followed by oral prednisone (1 mg per kilogram of body weight) for 11 days, oral prednisone (1 mg per kilogram) alone for 14 days, or placebo for 14 days." | 5.07 | The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group. ( Beck, RW; Brown, CH; Cleary, PA; Kaufman, DI; Kupersmith, MJ; Paty, DW; Trobe, JD, 1993) |
| "Intravenous methylprednisolone followed by oral prednisone speeds the recovery of visual loss due to optic neuritis and results in slightly better vision at six months." | 5.07 | A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group. ( Anderson, MM; Beck, RW; Buckley, EG; Cleary, PA; Corbett, JJ; Kaufman, DI; Keltner, JL; Kupersmith, MJ; Miller, NR; Shults, WT, 1992) |
| "The visual benefit from treating acute optic neuritis with intravenous followed by oral corticosteroids is short term, limited to an accelerated rate of recovery." | 2.67 | Optic neuritis treatment trial. One-year follow-up results. ( Beck, RW; Cleary, PA, 1993) |
| "Optic neuritis is an inflammatory disease of the optic nerve." | 2.52 | Corticosteroids for treating optic neuritis. ( Beck, R; Gal, RL; Vedula, SS, 2015) |
| "Optic neuritis is an inflammatory disease of the optic nerve." | 2.48 | Corticosteroids for treating optic neuritis. ( Beck, R; Gal, RL; Vedula, SS, 2012) |
| "Monosymptomatic optic neuritis has important implications for the development of multiple sclerosis." | 2.41 | Inflammatory optic neuropathies. ( Eggenberger, ER, 2001) |
| "Among these optic neuritis is a rare presentation with only a handful of cases reported in the literature thus far." | 1.48 | Recurrent optic neuritis as the only manifestation of chronic hepatitis B virus flare: a case report. ( Asif, A; Campbell, N; Curras-Martin, D; Haroon, A; Hossain, MA, 2018) |
| "Acute isolated optic neuritis is often the first manifestation of multiple sclerosis (MS)." | 1.35 | [Management of isolated optic neuritis in France: survey of neurologists and ophthalmologists]. ( Atkins, EJ; Biousse, V; Calvetti, O; Drews-Botsch, CD; Newman, NJ; Vignal-Clermont, C, 2008) |
| " Adverse events observed after treatment with chloroquine or prednisone (chloroquine maculopathy,cataract, glaucoma) are related to dosage and duration of the treatment." | 1.34 | [Ocular changes and general condition in lupus erythematosus (SLE)--own observation]. ( Brydak-Godowska, J, 2007) |
| "Optic neuritis is a common feature of this demyelinating disease, and a paucity of data regarding this entity exists in the ophthalmologic literature." | 1.33 | Ophthalmologic manifestations in pediatric patients with acute disseminated encephalomyelitis. ( Guthrie, DS; Kodsi, SR; Kotlus, BS; Slavin, ML, 2005) |
| " Many of these adverse side effects can be greatly reduced or prevented with close monitoring of patients." | 1.31 | Ocular toxicity of systemic medications: a case series. ( To, TQ; Townsend, JC, 2000) |
| " The regimen of glucocorticoid therapy was oral prednisone, starting with 160 mg daily followed by reducing the dosage by 20 mg every three days until 40 mg per day was attained and then tapering the dosage at 70 mg every other day until stoppage of the drug." | 1.30 | [Treatment of acute optic neuritis with high dose of prednisone]. ( Ai, F; Hu, T; Jiang, R; Liu, Q; Zhang, M, 1998) |
| "The diagnosis of optic neuritis is based on clinical signs and symptoms." | 1.29 | [Neuro-ophthalmology--new challenges]. ( Stankiewicz, A, 1995) |
| "Neuroretinitis is a distinct clinical entity consisting of moderate to severe visual loss, optic nerve head edema, macular exudate in a stellate pattern, and variable vitreous inflammation." | 1.29 | Toxoplasmosis neuroretinitis. ( Fish, RH; Hoskins, JC; Kline, LB, 1993) |
| "Neuroretinitis is a clinical condition usually seen in young healthy adults that is characterized by rapid profound unilateral loss of vision." | 1.28 | Neuroretinitis: an unusual presentation of ocular toxoplasmosis. ( Moreno, RJ; Waller, S; Weisman, J, 1992) |
| "Sinus disease is an infrequent, but treatable, cause of optic neuritis." | 1.27 | Optic neuritis secondary to sinus disease. ( Kivlin, JD; Sanborn, GE; Stevens, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (21.43) | 18.7374 |
| 1990's | 48 (38.10) | 18.2507 |
| 2000's | 28 (22.22) | 29.6817 |
| 2010's | 17 (13.49) | 24.3611 |
| 2020's | 6 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| De Lott, LB | 1 |
| Lin, CC | 1 |
| Burke, JF | 1 |
| Wallace, B | 1 |
| Saukkonen, D | 1 |
| Waljee, AK | 1 |
| Kerber, KA | 1 |
| Solli, E | 1 |
| Doshi, H | 1 |
| Elze, T | 1 |
| Pasquale, LR | 1 |
| Branco, J | 1 |
| Wall, M | 2 |
| Kupersmith, M | 1 |
| Ssemmanda, S | 1 |
| Musubire, AK | 1 |
| Navarro-Perea, C | 1 |
| Garcia-Gonzalez, J | 1 |
| Perez-Blazquez, E | 1 |
| Beck, RW | 15 |
| Cleary, PA | 10 |
| Backlund, JC | 3 |
| Zhou, S | 1 |
| Jones-Lopez, EC | 1 |
| Soneji, DJ | 1 |
| Azevedo, CJ | 1 |
| Patel, VR | 1 |
| Paviolo, JP | 1 |
| Tkachuk, VA | 1 |
| Shankar Iyer, R | 1 |
| Padmanaban, S | 1 |
| Ramachandran, M | 1 |
| Ramanathan, S | 1 |
| Mohammad, S | 1 |
| Tantsis, E | 1 |
| Nguyen, TK | 1 |
| Merheb, V | 1 |
| Fung, VSC | 1 |
| White, OB | 1 |
| Broadley, S | 1 |
| Lechner-Scott, J | 1 |
| Vucic, S | 1 |
| Henderson, APD | 1 |
| Barnett, MH | 1 |
| Reddel, SW | 1 |
| Brilot, F | 1 |
| Dale, RC | 1 |
| Morrow, SA | 1 |
| Fraser, JA | 1 |
| Day, C | 1 |
| Bowman, D | 1 |
| Rosehart, H | 1 |
| Kremenchutzky, M | 1 |
| Nicolle, M | 1 |
| Curras-Martin, D | 1 |
| Campbell, N | 1 |
| Haroon, A | 1 |
| Hossain, MA | 1 |
| Asif, A | 1 |
| Liu, H | 1 |
| Zhou, H | 1 |
| Wang, J | 1 |
| Sun, M | 1 |
| Teng, D | 1 |
| Song, H | 1 |
| Xu, Q | 1 |
| Wei, S | 1 |
| Taylor, MR | 1 |
| Gaco, D | 1 |
| Grahn, BH | 1 |
| Starrack, G | 1 |
| Bauer, B | 1 |
| Moss, HE | 2 |
| Gao, W | 1 |
| Balcer, LJ | 2 |
| Joslin, CE | 1 |
| Gal, RL | 6 |
| Vedula, SS | 2 |
| Beck, R | 2 |
| Bicer, T | 1 |
| Kosker, M | 1 |
| Celikay, O | 1 |
| Gurdal, C | 1 |
| Volpe, NJ | 1 |
| Prasad, S | 1 |
| Lee, EB | 1 |
| Glisson, CC | 1 |
| Galetta, SL | 2 |
| Purvin, V | 1 |
| Kawasaki, A | 1 |
| Clark, D | 1 |
| Kebede, W | 1 |
| Eggenberger, E | 2 |
| Bamrolia, N | 1 |
| Yadava, U | 1 |
| Anand, A | 1 |
| Chaudhuri, Z | 1 |
| Querques, G | 1 |
| Bux, AV | 1 |
| Forte, R | 1 |
| Francesco, P | 1 |
| Cristiana, I | 1 |
| Noci, ND | 1 |
| Buzzacco, DM | 1 |
| Lubow, M | 1 |
| Davidorf, FH | 1 |
| Cebulla, CM | 1 |
| Morotti, A | 1 |
| Liberini, P | 1 |
| Padovani, A | 1 |
| Tornerup, NR | 1 |
| Carstensen, H | 1 |
| Fledelius, HC | 1 |
| Benz, MS | 1 |
| Glaser, JS | 2 |
| Davis, JL | 2 |
| Trobe, JD | 5 |
| Moke, PS | 3 |
| Xing, D | 1 |
| Bhatti, MT | 1 |
| Brodsky, MC | 1 |
| Buckley, EG | 2 |
| Chrousos, GA | 2 |
| Corbett, J | 2 |
| Goodwin, JA | 1 |
| Katz, B | 2 |
| Kaufman, DI | 4 |
| Keltner, JL | 2 |
| Kupersmith, MJ | 5 |
| Miller, NR | 3 |
| Nazarian, S | 1 |
| Orengo-Nania, S | 1 |
| Savino, PJ | 3 |
| Shults, WT | 2 |
| Smith, CH | 1 |
| PAEZ ALLENDE, F | 1 |
| AUDOUEINEIX, E | 2 |
| STELLA, H | 1 |
| CALDERON, R | 1 |
| Pless, ML | 1 |
| Malik, SI | 1 |
| Nakamoto, BK | 1 |
| Dorotheo, EU | 1 |
| Biousse, V | 2 |
| Tang, RA | 1 |
| Schiffman, JS | 1 |
| Newman, NJ | 2 |
| Monteiro, ML | 1 |
| Borges, WI | 1 |
| do Val Ferreira Ramos, C | 1 |
| Lucato, LT | 1 |
| Leite, CC | 1 |
| Garcia-Porrua, C | 1 |
| Santamarina, R | 1 |
| Armesto, V | 1 |
| Gonzalez-Gay, MA | 1 |
| Kotlus, BS | 1 |
| Slavin, ML | 1 |
| Guthrie, DS | 1 |
| Kodsi, SR | 1 |
| Brydak-Godowska, J | 1 |
| Pérez-Díaz, H | 1 |
| Casado, JL | 1 |
| Uclés-Sánchez, A | 1 |
| Saiz, A | 1 |
| Krämer, M | 1 |
| Baumgärtel, MW | 1 |
| Neuen-Jacob, E | 1 |
| Berlit, P | 1 |
| Calvetti, O | 1 |
| Vignal-Clermont, C | 1 |
| Drews-Botsch, CD | 1 |
| Atkins, EJ | 1 |
| Gressel, MG | 1 |
| Tomsak, RL | 1 |
| Sanborn, GE | 1 |
| Kivlin, JD | 1 |
| Stevens, M | 1 |
| Hallermann, W | 1 |
| Haller, P | 1 |
| Krüger, C | 1 |
| Schiemann, M | 1 |
| Patzold, U | 1 |
| Alaev, BA | 1 |
| Stankiewicz, A | 1 |
| Corbett, JJ | 2 |
| Abbas, A | 1 |
| Styra, R | 1 |
| Olek, MJ | 1 |
| Khan, OA | 1 |
| Wilson, WB | 1 |
| Paty, DW | 1 |
| Brown, CH | 1 |
| Silberberg, DH | 1 |
| Goodin, DS | 2 |
| DeBroff, BM | 1 |
| Donahue, SP | 1 |
| Lossos, A | 1 |
| Eliashiv, S | 1 |
| Ben-Chetrit, E | 1 |
| Reches, A | 1 |
| Fish, RH | 1 |
| Hoskins, JC | 1 |
| Kline, LB | 1 |
| Shetty, T | 1 |
| Goodkin, DE | 1 |
| Rudick, RA | 1 |
| Kinkel, R | 1 |
| Ransohoff, RM | 1 |
| Kattah, JC | 1 |
| Anderson, MM | 2 |
| Kenny, DJ | 1 |
| Backlund, JY | 1 |
| Gilbert, PR | 1 |
| Schneider, T | 1 |
| Ray, CL | 1 |
| Dreizin, IJ | 1 |
| Bourque, LB | 1 |
| Miskala, PH | 1 |
| Chang, TS | 1 |
| Aylward, GW | 1 |
| Mieler, WF | 1 |
| Oliver, GL | 1 |
| Maberley, AL | 1 |
| Gass, JD | 1 |
| Bernardczyk-Meller, J | 1 |
| Załecki, K | 1 |
| Kortvelesy, S | 1 |
| Stan, C | 1 |
| Săceleanu, AM | 1 |
| Erneston, AG | 1 |
| To, TQ | 1 |
| Townsend, JC | 1 |
| Hauser, SL | 1 |
| Oksenberg, JR | 1 |
| Lincoln, R | 1 |
| Garovoy, J | 1 |
| Cole, SR | 1 |
| Kip, KE | 2 |
| Long, DT | 2 |
| Eggenberger, ER | 2 |
| Whitaker, JN | 1 |
| Leiba, H | 1 |
| Schatz, NJ | 1 |
| Siatkowski, RM | 1 |
| Kiefer, G | 1 |
| Rieckmann, P | 1 |
| Liu, Q | 1 |
| Zhang, M | 1 |
| Ai, F | 1 |
| Jiang, R | 1 |
| Hu, T | 1 |
| Arruga Ginebreda, J | 1 |
| Blair, RC | 1 |
| Katz, BJ | 1 |
| Labalette, P | 1 |
| Bermond, D | 1 |
| Dedes, V | 1 |
| Savage, C | 1 |
| Perry, HD | 1 |
| Mallen, FJ | 1 |
| Grodin, RW | 1 |
| Cossari, AJ | 1 |
| Slagsvold, JE | 1 |
| Kazarian, EL | 1 |
| Gager, WE | 1 |
| Moreno, RJ | 1 |
| Weisman, J | 1 |
| Waller, S | 1 |
| Wilhelm, H | 1 |
| Schiefer, U | 1 |
| Wiethölter, H | 1 |
| Menzi, J | 1 |
| Körner, F | 1 |
| Colucciello, M | 1 |
| Brucker, AJ | 1 |
| Goyal, A | 1 |
| Achiron, A | 1 |
| Djaldetti, R | 1 |
| Ziv, I | 1 |
| Scholl, GB | 1 |
| Song, HS | 1 |
| Wray, SH | 2 |
| Lessell, S | 1 |
| Frohman, LP | 2 |
| Cook, SD | 1 |
| Bielory, L | 1 |
| Abd Elrazak, M | 1 |
| Bar, S | 1 |
| Segal, M | 1 |
| Shapira, R | 1 |
| Savir, H | 1 |
| Farris, BK | 1 |
| Pickard, DJ | 1 |
| Müller, J | 1 |
| Todt, H | 1 |
| Sauermann, W | 1 |
| Burde, RM | 1 |
| Warren, FA | 1 |
| Klingele, TG | 1 |
| Mitnick, H | 1 |
| Holte, H | 1 |
| Saeter, G | 1 |
| Dahl, IM | 1 |
| Abrahamsen, AF | 1 |
| Miller, DH | 1 |
| Kay, R | 1 |
| Schon, F | 1 |
| McDonald, WI | 1 |
| Haas, LF | 1 |
| Hughes, RA | 1 |
| Erkkilä, H | 1 |
| Raitta, C | 1 |
| Iivanainen, M | 1 |
| Taskinen, E | 1 |
| Unnérus, HA | 1 |
| Gummerus, M | 1 |
| Henkind, P | 1 |
| Charles, NC | 1 |
| Pearson, J | 1 |
| Landy, PJ | 1 |
| Ohlrich, GD | 1 |
| Jampol, LM | 1 |
| Woodfin, W | 1 |
| McLean, EB | 1 |
| Harrington, DO | 1 |
| Nauman, J | 1 |
| Kronschnabel, EF | 1 |
| Hackett, ER | 1 |
| Martinez, RD | 1 |
| Larson, PF | 1 |
| Paddison, RM | 1 |
| Berg, EF | 1 |
| Coyle, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Recovery of Demyelinating Optic Neuritis After Treatment With Equivalent High Doses of Oral vs. Intravenous Corticosteroids: a Randomized Single Blinded Clinical Trial[NCT01524250] | Phase 2/Phase 3 | 51 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| [NCT00000147] | 0 participants | Interventional | 1988-07-31 | Active, not recruiting | |||
| [NCT00000146] | Phase 3 | 0 participants | Interventional | 1988-07-31 | Active, not recruiting | ||
| Dalfampridine After Optic Neuritis to Improve Visual Function in Multiple Sclerosis[NCT01337986] | Phase 2/Phase 3 | 53 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Observational Prospective Multicentered Study Evaluating Initial Clinical Presentation of Inflammatory Optic Neuritis (ON) Associated or Not With Autoantibodies Anti- Myelin-oligodendrocyte-glycoprotein (MOG-Ab)[NCT03345537] | 103 participants (Actual) | Observational | 2018-02-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Intent to treat analysis of treatment effect in primary endpoint EDTRS 5% Contrast Sensitivity. Change in the number of letters able to read while on Dalfampridine and Placebo relative to their baseline scores. (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | letters (Mean) |
|---|---|
| Dalfampridine | 3 |
| Placebo | 2.5 |
Dalfampridine will change color vision Total Error Scores from baseline on the Farnsworth Munsell 100 Hue Sort Test. Farnsworth Munsell 100 Hue Test requires placing 100 color palettes in the correct order based upon color hue. Scores are determined by the frequency and severity of any displacement in the correct order. One error equates to one misplaced hue, by one step or position. An error score greater than 500 indicates virtually no color discrimination. An error score of 0 indicates no errors in ordering the hues. A Total Error Score of 0 to 128 could be seen in a normal population. (NCT01337986)
Timeframe: Visit 1 (Week 0 - baseline), Visit 2 (Week 3 - postintervention 1) and Visit 3 (Week 8 - post intervention 2)
| Intervention | FM100 Total Error Score (Mean) |
|---|---|
| Dalfampridine | -13.0 |
| Placebo | -10.6 |
Dalfampridine treatment will result in change in quality of life. The National Eye Institute Visual Function Questionnaire consists of 25 questions characterizing visual function at home and in the community. Score ranges from 100 (best) to 0 (worst). (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | NEI VFQ percentage (Median) |
|---|---|
| Dalfampridine | 0 |
| Placebo | 0 |
Intent to treat analysis of treatment effect in primary endpoint EDTRS 5% Contrast Sensitivity. Improvement from baseline scores. (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | 5% Contrast LogMAR Score (Mean) |
|---|---|
| Dalfampridine | 0.06 |
| Placebo | 0.05 |
Difference in Pelli- Robson Score at Visits 2 and 3 Relative to Visit 1 on Dalfampridine vs Placebo. Pelli-Robson is scored based upon the numbers read on the chart converted to LogMAR units. The scale is 0.00 (worst) to 2.35 (best). (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | units on a scale (Mean) |
|---|---|
| Dalfampridine | 0.07 |
| Placebo | 0.06 |
Per Protocol Analysis to assess difference in number of letters on the EDTRS 5% Contrast Sensitivity (LogMAR) Chart scores at visits 2 and 3 Relative to Visit 1 (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | letters (Mean) |
|---|---|
| Group B: Dalfampridine | 2 |
| Group B: Placebo | 2 |
| Group A: Placebo | 4 |
| Group A: Dalfampridine | 3 |
Per Protocol Analysis to assess differences in EDTRS 5% Contrast Sensitivity (LogMAR) Scores at visits 2 and 3 Relative to Visit 1 on patients taking Dalfampridine vs Placebo. (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | LogMAR Score (Mean) |
|---|---|
| Group B: Dalfampridine | -0.04 |
| Group B: Placebo | -0.06 |
| Group A: Placebo | -0.08 |
| Group A: Dalfampridine | -0.06 |
(NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | Percentages of eyes that improved (Number) |
|---|---|
| Dalfampridine | 9.7 |
| Placebo | 11.1 |
| Both | 11.1 |
| None | 68.1 |
Percentage of eyes that improved by one-line (5 letters) on the 5% contrast sensitivity chart (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | Percent of Eyes (Number) |
|---|---|
| Dalfampridine | 11.1 |
| Placebo | 15.3 |
| Both | 37.5 |
| Neither | 36.1 |
Visual evoked potential 60min P100 latency on dalfampridine vs. placebo. (NCT01337986)
Timeframe: Visit 1 (Week 0), Visit 2 (Week 3) and Visit 3 (Week 8)
| Intervention | milliseconds (Mean) |
|---|---|
| Dalfampridine | 121.6 |
| Placebo | 120.2 |
"The Visual Field Index (VFI) is a global index that assigns a number between 1% to 100% based on an aggregate percentage of visual function, with 100% being a perfect age-adjusted visual field.~Probability of falling in the best quartile for visual field (VFI) measures (Q1), relative to the three next quartiles for worse VFIs (Q2-4), while on Dalfampridine vs Placebo. Due to the clustered observations at different times in a cross-over design, the visual field data is not suited to a normal theory model and should not be expressed as a continuous variable. Thus, a categorical model that uses a multinomial distribution for measurement of 4 categories was selected for proper statistical modeling, with results expressed as odds ratios." (NCT01337986)
Timeframe: Visit 1 (Week 0 - baseline), Visit 2 (Week 3 - post intervention 1) and Visit 3 (Week 8 - post intervention 2)
| Intervention | Visual Field Index % of normal vision (Mean) | ||
|---|---|---|---|
| Baseline (Visit 1) | Post Intervention 1 (Visit 2) | Post Intervention 2 (Visit 3) | |
| Dalfampridine Then Placebo | 77.53 | 78.50 | 79.71 |
| Placebo Then Dalfampridine | 85.38 | 86.65 | 86.00 |
10 reviews available for prednisone and Optic Neuritis
| Article | Year |
|---|---|
Corticosteroids for treating optic neuritis.
Topics: Acute Disease; Administration, Oral; Anti-Inflammatory Agents; Contrast Sensitivity; Dexamethasone; | 2015 |
Corticosteroids for treating optic neuritis.
Topics: Acute Disease; Administration, Oral; Anti-Inflammatory Agents; Contrast Sensitivity; Dexamethasone; | 2012 |
Treatment of acute demyelinating optic neuritis.
Topics: Acute Disease; Clinical Trials as Topic; Demyelinating Diseases; Humans; Infusions, Intravenous; Int | 2002 |
Progressive outer retinal necrosis presenting with isolated optic neuropathy.
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Infection | 2004 |
Recent advances in the management of optic neuritis.
Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents; Drug Administration Schedule; | 1997 |
[Behçet's disease with a fatal evolution].
Topics: Acute Disease; Adult; Behcet Syndrome; Cyclophosphamide; Cyclosporine; Drug Therapy, Combination; Fa | 1997 |
Practice parameter: the role of corticosteroids in the management of acute monosymptomatic optic neuritis. Report of the Quality Standards Subcommittee of the American Academy of Neurology.
Topics: Academies and Institutes; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Humans; Methylprednisol | 2000 |
[Optic neuritis. First manifestation of multiple sclerosis? Current diagnostic and therapeutic strategies].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Child; Diagnosis, Differential; Female; Fluorescein Ang | 2001 |
Inflammatory optic neuropathies.
Topics: Anti-Inflammatory Agents; Contraindications; Diagnostic Techniques, Ophthalmological; Humans; Magnet | 2001 |
[Ocular changes in Graves-Basedov disease].
Topics: Autoimmune Diseases; Eye Diseases; Eye Manifestations; Female; Graves Disease; Humans; Long-Acting T | 1972 |
22 trials available for prednisone and Optic Neuritis
| Article | Year |
|---|---|
The Course of Visual Recovery after Optic Neuritis: Experience of the Optic Neuritis Treatment Trial.
Topics: Administration, Oral; Adult; Aged; Cohort Studies; Female; Follow-Up Studies; Glucocorticoids; Human | 2020 |
Effect of Treating Acute Optic Neuritis With Bioequivalent Oral vs Intravenous Corticosteroids: A Randomized Clinical Trial.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adrenal Cortex Hormones; Adult; Ev | 2018 |
Association of race/ethnicity with visual outcomes following acute optic neuritis: an analysis of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Black or African American; Contrast Sensitiv | 2014 |
The optic neuritis treatment trial: a definitive answer and profound impact with unexpected results.
Topics: Administration, Oral; Glucocorticoids; Humans; Injections, Intravenous; Methylprednisolone; Multiple | 2008 |
Treatment of acute optic neuritis: a summary of findings from the optic neuritis treatment trial.
Topics: Acute Disease; Administration, Oral; Adult; Female; Glucocorticoids; Humans; Injections, Intravenous | 2008 |
High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial.
Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents; Brain; Cohort Studies; Female; Humans; M | 2003 |
Experience of the optic neuritis treatment trial.
Topics: Adolescent; Adult; Follow-Up Studies; Glucocorticoids; Humans; Methylprednisolone; Middle Aged; Mult | 2004 |
The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Female; Follow-Up Studies; Humans; Injection | 1994 |
The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Female; Follow-Up Studies; Humans; Injection | 1994 |
The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Female; Follow-Up Studies; Humans; Injection | 1994 |
The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Female; Follow-Up Studies; Humans; Injection | 1994 |
[Glucocorticoid treatment of acute optic neuritis and multiple sclerosis risk].
Topics: Acute Disease; Administration, Oral; Adult; Humans; Injections, Intravenous; Magnetic Resonance Imag | 1994 |
The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adult; Drug Therapy, Combination; Female; Follow-Up Studies; Hu | 1993 |
Corticosteroids and optic neuritis.
Topics: Administration, Oral; Humans; Magnetic Resonance Imaging; Methylprednisolone; Optic Neuritis; Placeb | 1993 |
Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Affective Disorders, Psychotic; Female; Huma | 1993 |
Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Affective Disorders, Psychotic; Female; Huma | 1993 |
Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Affective Disorders, Psychotic; Female; Huma | 1993 |
Side effects of glucocorticoid treatment. Experience of the Optic Neuritis Treatment Trial.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Affective Disorders, Psychotic; Female; Huma | 1993 |
Fellow eye abnormalities in acute unilateral optic neuritis. Experience of the optic neuritis treatment trial.
Topics: Acute Disease; Adolescent; Adult; Brain Diseases; Color Vision Defects; Contrast Sensitivity; Demyel | 1993 |
Fellow eye abnormalities in acute unilateral optic neuritis. Experience of the optic neuritis treatment trial.
Topics: Acute Disease; Adolescent; Adult; Brain Diseases; Color Vision Defects; Contrast Sensitivity; Demyel | 1993 |
Fellow eye abnormalities in acute unilateral optic neuritis. Experience of the optic neuritis treatment trial.
Topics: Acute Disease; Adolescent; Adult; Brain Diseases; Color Vision Defects; Contrast Sensitivity; Demyel | 1993 |
Fellow eye abnormalities in acute unilateral optic neuritis. Experience of the optic neuritis treatment trial.
Topics: Acute Disease; Adolescent; Adult; Brain Diseases; Color Vision Defects; Contrast Sensitivity; Demyel | 1993 |
Design, methods, and conduct of the Optic Neuritis Treatment Trial.
Topics: Adolescent; Adult; Female; Humans; Male; Methylprednisolone; Middle Aged; Optic Nerve; Optic Neuriti | 1993 |
Design, methods, and conduct of the Optic Neuritis Treatment Trial.
Topics: Adolescent; Adult; Female; Humans; Male; Methylprednisolone; Middle Aged; Optic Nerve; Optic Neuriti | 1993 |
Design, methods, and conduct of the Optic Neuritis Treatment Trial.
Topics: Adolescent; Adult; Female; Humans; Male; Methylprednisolone; Middle Aged; Optic Nerve; Optic Neuriti | 1993 |
Design, methods, and conduct of the Optic Neuritis Treatment Trial.
Topics: Adolescent; Adult; Female; Humans; Male; Methylprednisolone; Middle Aged; Optic Nerve; Optic Neuriti | 1993 |
Optic neuritis treatment trial. One-year follow-up results.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Drug Therapy, Combination; Female; Follow-Up | 1993 |
Optic neuritis treatment trial. One-year follow-up results.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Drug Therapy, Combination; Female; Follow-Up | 1993 |
Optic neuritis treatment trial. One-year follow-up results.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Drug Therapy, Combination; Female; Follow-Up | 1993 |
Optic neuritis treatment trial. One-year follow-up results.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Drug Therapy, Combination; Female; Follow-Up | 1993 |
The Optic Neuritis Treatment Trial. Putting the results in perspective. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Drug Therapy, Combination; Female; Humans; In | 1995 |
The Optic Neuritis Treatment Trial. Putting the results in perspective. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Drug Therapy, Combination; Female; Humans; In | 1995 |
The Optic Neuritis Treatment Trial. Putting the results in perspective. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Drug Therapy, Combination; Female; Humans; In | 1995 |
The Optic Neuritis Treatment Trial. Putting the results in perspective. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Drug Therapy, Combination; Female; Humans; In | 1995 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
Visual symptoms after optic neuritis. Results from the Optic Neuritis Treatment Trial.
Topics: Adult; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Methylprednisolone Hemisuccinate; O | 1997 |
The 5-year risk of MS after optic neuritis. Experience of the optic neuritis treatment trial.
Topics: Adult; Anti-Inflammatory Agents; Cohort Studies; Disability Evaluation; Disease Progression; Female; | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group.
Topics: Administration, Oral; Adolescent; Adult; Cohort Studies; Color Perception; Contrast Sensitivity; Fem | 1997 |
The SKILL Card test in optic neuritis: experience of the Optic Neuritis Treatment Trial. Smith-Kettlewell Institute Low Luminance. Optic Neuritis Study Group.
Topics: Adolescent; Adult; Contrast Sensitivity; Female; Glucocorticoids; Health Status Indicators; Humans; | 2001 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. The Optic Neuritis Study Group.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Color Perception; Female; Follow-Up Studies; | 1992 |
Corticosteroid treatment of acute optic neuritis.
Topics: Acute Disease; Administration, Oral; Humans; Injections, Intravenous; Methylprednisolone; Optic Neur | 1992 |
94 other studies available for prednisone and Optic Neuritis
| Article | Year |
|---|---|
Predictors of Glucocorticoid Use for Acute Optic Neuritis in the United States, 2005-2019.
Topics: Adolescent; Adult; Female; Glucocorticoids; Humans; Longitudinal Studies; Male; Middle Aged; Optic N | 2023 |
Archetypal analysis of visual fields in optic neuritis reveals functional biomarkers associated with outcome and treatment response.
Topics: Biomarkers; Disease Progression; Humans; Methylprednisolone; Optic Neuritis; Prednisone; Retrospecti | 2022 |
Different clinical phenotypes of AQP4-IgG positive NMOSD in two first degree relatives.
Topics: Adult; Autoimmune Diseases; Azathioprine; Female; Gadolinium; HIV Infections; Humans; Immunoglobulin | 2023 |
Case report: Bilateral uveitis and papillitis secondary to treatment with pembrolizumab.
Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Drug Combinations; D | 2019 |
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis and Myelitis in COVID-19.
Topics: Adult; Autoantibodies; Betacoronavirus; Coronavirus Infections; COVID-19; Glucocorticoids; Humans; M | 2020 |
[Isolated area postrema syndrome with anti-MOG antibodies, a rare association].
Topics: Antibody Specificity; Area Postrema; Autoantibodies; Autoantigens; Demyelinating Autoimmune Diseases | 2020 |
Unilateral optic disc swelling associated with idiopathic hypertrophic pachymeningitis: a rare cause for a rare clinical finding.
Topics: Adult; Anti-Inflammatory Agents; Female; Headache Disorders; Humans; Hypertrophy; Magnetic Resonance | 2017 |
Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination.
Topics: Adolescent; Adult; Aged; Autoantibodies; Brain; Child; Child, Preschool; Cohort Studies; Demyelinati | 2018 |
Recurrent optic neuritis as the only manifestation of chronic hepatitis B virus flare: a case report.
Topics: Antiviral Agents; Glucocorticoids; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Optic N | 2018 |
The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis.
Topics: Adult; Age of Onset; Aged; Anti-Inflammatory Agents; Aquaporin 4; Autoantibodies; Female; Humans; Ma | 2019 |
Symptomatic sinus bradycardia after a treatment course of high-dose oral prednisone.
Topics: Administration, Oral; Arrhythmia, Sinus; Bradycardia; Female; Humans; Middle Aged; Multiple Sclerosi | 2013 |
Diagnostic ophthalmology.
Topics: Animals; Anti-Inflammatory Agents; Blindness; Dog Diseases; Dogs; Male; Optic Neuritis; Prednisone | 2013 |
A case of retrobulbar optic neuritis caused by duloxetine.
Topics: Adult; Anti-Inflammatory Agents; Antidepressive Agents; Depressive Disorder, Major; Duloxetine Hydro | 2016 |
Clinical reasoning: a 42-year-old man with sequential monocular visual loss.
Topics: Adult; Blindness; Diagnosis, Differential; Drug Therapy, Combination; Humans; Male; Methylprednisolo | 2008 |
Optic perineuritis secondary to Wegener's granulomatosis.
Topics: Aged; Female; Glucocorticoids; Granulomatosis with Polyangiitis; Humans; Magnetic Resonance Imaging; | 2009 |
Optic neuritis.
Topics: Administration, Oral; Anti-Inflammatory Agents; Frontal Lobe; Humans; Magnetic Resonance Imaging; Mu | 2010 |
Bilateral retrobulbar neuritis in an adolescent boy with lymphoma.
Topics: Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; | 2011 |
[Multiple evanescent white dot syndrome and multiple sclerosis].
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Brain; Chorioretinitis; Diplopia; Drug Therap | 2011 |
Atypical cat scratch disease with vitritis, serous macular detachment, neuroretinitis, and retrobulbar optic neuritis.
Topics: Adult; Anti-Bacterial Agents; Antibodies, Bacterial; Bartonella henselae; Cat-Scratch Disease; Doxyc | 2013 |
Bilateral optic perineuritis as the presenting feature of giant cell arteritis.
Topics: Aged; Anti-Inflammatory Agents; Facial Dermatoses; Giant Cell Arteritis; Humans; Jaw Diseases; Magne | 2013 |
Bilateral optic neuritis in a 9-year-old girl.
Topics: Child; Female; Glucocorticoids; Humans; Magnetic Resonance Imaging; Optic Nerve; Optic Neuritis; Pre | 2003 |
Progressive outer retinal necrosis in immunocompetent patients treated initially for optic neuropathy with systemic corticosteroids.
Topics: Acyclovir; Aged; Antiviral Agents; Aqueous Humor; Blindness; DNA, Viral; Drug Therapy, Combination; | 2003 |
[Acute retrobulbar optic neuritis; rapid recovery with tetracycline & prednisone therapy].
Topics: Disease; Eye; Humans; Neuritis; Optic Nerve; Optic Nerve Diseases; Optic Neuritis; Prednisone; Tetra | 1958 |
[Mumps causing retrobulbar optic neuritis & corticotherapy].
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Disease; Humans; Mumps; Neuritis; Optic Nerve; O | 1958 |
[delta-Cortisone therapy of 11 cases of acute retro-bulbar optic neuritis; discussion of their viral origin].
Topics: Disease; Eye; Neuritis; Optic Nerve; Optic Nerve Diseases; Optic Neuritis; Prednisone | 1959 |
[Treatment by delta-cortisone of II cases of acute retrobulbar optic neuritis. Discussion of their viral origin].
Topics: Neuritis; Optic Nerve; Optic Nerve Diseases; Optic Neuritis; Prednisone | 1959 |
[Treatment of optic neuritis and papilledema with prednisone, gonadotrophin and ACTH].
Topics: Adrenocorticotropic Hormone; Gonadotropins; Neuritis; Optic Nerve; Optic Nerve Diseases; Optic Neuri | 1959 |
BEHCET'S DISEASE WITH NEUROLOGICAL INVOLVEMENT.
Topics: Behcet Syndrome; Cerebrospinal Fluid; Cortisone; Drug Therapy; Electrocardiography; Electroencephalo | 1964 |
Relapsing-remitting, corticosteroid-sensitive, varicella zoster virus optic neuritis.
Topics: Adolescent; Anti-Inflammatory Agents; Chronic Disease; Glucocorticoids; Herpesvirus 3, Human; Humans | 2003 |
Bilateral optic neuritis in wegener granulomatosis.
Topics: Adult; Cyclophosphamide; Drug Therapy, Combination; Glucocorticoids; Granulomatosis with Polyangiiti | 2005 |
Magnetic resonance imaging in optic neuritis due to giant cell arteritis.
Topics: Administration, Oral; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dru | 2005 |
Ophthalmologic manifestations in pediatric patients with acute disseminated encephalomyelitis.
Topics: Administration, Oral; Child; Child, Preschool; Encephalomyelitis, Acute Disseminated; Female; Follow | 2005 |
[Ocular changes and general condition in lupus erythematosus (SLE)--own observation].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Female; Humans | 2007 |
[Chronic relapsing inflammatory optic neuropathy (CRION) without detection of IgG-NMO antibodies].
Topics: Adult; Chronic Disease; Diagnosis, Differential; Fluorescent Antibody Technique, Indirect; Humans; I | 2007 |
[Myalgia in Neuro-Behçet's disease. Medication side effects or expression of underlying disease].
Topics: Adult; Azathioprine; Behcet Syndrome; Biopsy; Brain Diseases; Cyclosporine; Dose-Response Relationsh | 2008 |
[Management of isolated optic neuritis in France: survey of neurologists and ophthalmologists].
Topics: Anti-Inflammatory Agents; Data Collection; Drug Utilization; France; Humans; Immunologic Factors; In | 2008 |
Recurrent bilateral optic neuropathy in mixed connective tissue disease.
Topics: Adult; Cyclophosphamide; Female; Humans; Mixed Connective Tissue Disease; Optic Atrophy; Optic Neuri | 1983 |
Optic neuritis secondary to sinus disease.
Topics: Child, Preschool; Female; Humans; Male; Middle Aged; Optic Neuritis; Prednisone; Sinusitis; Visual A | 1984 |
[Progress of optic neuritis with and without corticosteroid treatment. Findings in a long-term investigation with static perimetry].
Topics: Adult; Female; Humans; Male; Optic Neuritis; Prednisone; Visual Field Tests | 1983 |
[Clinical picture of transitional forms between multiple and diffuse sclerosis].
Topics: Adolescent; Arachnoiditis; Diagnostic Errors; Female; Humans; Multiple Sclerosis; Optic Chiasm; Opti | 1981 |
[Neuro-ophthalmology--new challenges].
Topics: Administration, Oral; Counseling; Humans; Methylprednisolone; Multiple Sclerosis; Optic Nerve Diseas | 1995 |
What have the optic neuritis treatment trial and the longitudinal optic neuritis study shown us?
Topics: Administration, Oral; Clinical Trials as Topic; Cohort Studies; Follow-Up Studies; Humans; Injection | 1994 |
Optic neuritis treatment trial.
Topics: Acute Disease; Adolescent; Adult; Female; Humans; Male; Methylprednisolone; Middle Aged; Multicenter | 1994 |
Valproate prophylaxis against steroid induced psychosis.
Topics: Adult; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans | 1994 |
Corticosteroids, optic neuritis, and multiple sclerosis.
Topics: Humans; Methylprednisolone; Multiple Sclerosis; Optic Neuritis; Prednisone | 1994 |
How much should we editorialize?
Topics: Acute Disease; Administration, Oral; Humans; Injections, Intravenous; Methylprednisolone; Optic Neur | 1994 |
Corticosteroids and optic neuritis.
Topics: Acute Disease; Anti-Inflammatory Agents; Bias; Humans; Methylprednisolone; Multiple Sclerosis; Optic | 1993 |
Treatment of optic neuritis.
Topics: Clinical Trials as Topic; Humans; Methylprednisolone; Optic Neuritis; Prednisone | 1993 |
High-dose corticosteroid regimen retards development of multiple sclerosis in optic neuritis treatment trial.
Topics: Acute Disease; Administration, Oral; Drug Administration Schedule; Humans; Incidence; Injections, In | 1994 |
Bilateral optic neuropathy as the initial manifestation of systemic sarcoidosis.
Topics: Administration, Oral; Adult; Female; Humans; Lung Diseases; Optic Neuritis; Prednisone; Sarcoidosis; | 1993 |
Optic neuritis associated with familial Mediterranean fever.
Topics: Adult; Colchicine; Familial Mediterranean Fever; Female; Humans; Male; Optic Neuritis; Prednisone | 1993 |
Toxoplasmosis neuroretinitis.
Topics: Adult; Anti-Bacterial Agents; Child; Female; Humans; Male; Optic Neuritis; Prednisone; Recurrence; R | 1993 |
Corticosteroids and optic neuritis.
Topics: Administration, Oral; Adolescent; Adrenocorticotropic Hormone; Child; Female; Humans; Male; Methylpr | 1993 |
Recovery from severe visual loss in optic neuritis.
Topics: Administration, Oral; Humans; Injections, Intravenous; Methylprednisolone; Optic Neuritis; Prednison | 1993 |
Recovery from severe visual loss in optic neuritis.
Topics: Administration, Oral; Humans; Injections, Intravenous; Methylprednisolone; Optic Neuritis; Prednison | 1993 |
Recovery from severe visual loss in optic neuritis.
Topics: Administration, Oral; Humans; Injections, Intravenous; Methylprednisolone; Optic Neuritis; Prednison | 1993 |
Recovery from severe visual loss in optic neuritis.
Topics: Administration, Oral; Humans; Injections, Intravenous; Methylprednisolone; Optic Neuritis; Prednison | 1993 |
Corticosteroids and optic neuritis.
Topics: Administration, Oral; Humans; Methylprednisolone; Optic Neuritis; Prednisone; Recurrence; T-Lymphocy | 1993 |
Rapid growth of an intracranial aneurysm causing apparent retrobulbar optic neuritis.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Brain; Carotid Artery, Internal; Cerebral Angiograph | 1995 |
Bilateral optic neuropathy associated with influenza vaccination.
Topics: Female; Glucocorticoids; Humans; Influenza A virus; Influenza B virus; Influenza Vaccines; Influenza | 1996 |
Idiopathic retinal vasculitis, aneurysms, and neuro-retinitis. Retinal Vasculitis Study.
Topics: Adult; Aneurysm; Anti-Inflammatory Agents; Child; Female; Fluorescein Angiography; Fundus Oculi; Hum | 1995 |
[Bilateral neuropathy of the optic nerve as a complication of mumps].
Topics: Child; Female; Humans; Mumps; Optic Nerve Diseases; Optic Neuritis; Prednisone; Visual Acuity; Visua | 1996 |
Multiple sclerosis, the great masquerader: an atypical ocular presentation.
Topics: Administration, Oral; Adult; Brain; Chronic Disease; Female; Follow-Up Studies; Glucocorticoids; Hum | 1997 |
Ocular toxicity of systemic medications: a case series.
Topics: Adult; Aged; Amiodarone; Cataract; Corneal Diseases; Eye Diseases; Female; Glaucoma; Humans; Isoniaz | 2000 |
Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group.
Topics: Administration, Oral; Adult; Alleles; Brain; Drug Therapy, Combination; Female; Haplotypes; HLA-DR2 | 2000 |
Postpartum optic neuritis: etiologic and pathophysiologic considerations.
Topics: Adult; Brain; Female; Glucocorticoids; Humans; Magnetic Resonance Imaging; Methylprednisolone; Multi | 2000 |
[Treatment of acute optic neuritis with high dose of prednisone].
Topics: Acute Disease; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Evoked Potentials, Visual; | 1998 |
[What have we learned from the multicenter study on optic neuritis corticosteroid treatment?].
Topics: Clinical Trials as Topic; Glucocorticoids; Humans; Methylprednisolone; Multicenter Studies as Topic; | 2001 |
Cat-scratch disease neuroretinitis diagnosed by a polymerase chain reaction approach.
Topics: Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents; Axilla; Bartonella henselae; Cat-Scratc | 2001 |
The 5-year risk of MS after optic neuritis: experience of the optic neuritis treatment trial. 1997.
Topics: Female; History, 20th Century; Humans; Male; Methylprednisolone; Multiple Sclerosis; Optic Neuritis; | 2001 |
Reversible blindness in optic neuritis associated with influenza vaccination.
Topics: Blindness; Fluorescein Angiography; Humans; Influenza Vaccines; Male; Middle Aged; Optic Neuritis; P | 1979 |
Pulfrich pendulum phenomenon in patients with a history of acute optic neuritis.
Topics: Acute Disease; Adolescent; Adult; Female; Humans; Illusions; Male; Middle Aged; Optic Neuritis; Opti | 1978 |
Optic neuritis complicating measles, mumps, and rubella vaccination.
Topics: Adult; Child; Female; Humans; Male; Measles Vaccine; Mumps Vaccine; Ophthalmoscopy; Optic Disk; Opti | 1978 |
Neuroretinitis: an unusual presentation of ocular toxoplasmosis.
Topics: Adult; Anti-Bacterial Agents; Antibodies, Protozoan; Enzyme-Linked Immunosorbent Assay; Fluorescein | 1992 |
[Bilateral optic neuropathy with papilledema].
Topics: Adult; Diagnosis, Differential; Female; Fluorescein Angiography; Follow-Up Studies; Humans; Male; Mi | 1992 |
[Systemic corticosteroid therapy in non-arteritic anterior ischemic optic neuropathy].
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Intracranial Arterio | 1992 |
Corticosteroids in the treatment of optic neuritis.
Topics: Humans; Multiple Sclerosis; Optic Neuritis; Prednisone; Recurrence | 1992 |
Corticosteroids in the treatment of optic neuritis.
Topics: Humans; Optic Neuritis; Prednisone; Recurrence | 1992 |
Uhthoff's symptom in optic neuritis: relationship to magnetic resonance imaging and development of multiple sclerosis.
Topics: Acute Disease; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Brain; Child; Evoked Potentials | 1991 |
Dysgammaglobulinemia in steroid-dependent optic neuritis: response to gammaglobulin treatment.
Topics: Adolescent; Dysgammaglobulinemia; Encephalomyelitis; Growth Disorders; Humans; IgG Deficiency; Immun | 1991 |
Brucella optic neuritis.
Topics: Adolescent; Brucellosis; Female; Humans; Optic Neuritis; Prednisone; Saudi Arabia; Streptomycin; Tet | 1991 |
Neuroretinitis associated with cat scratch disease.
Topics: Cat-Scratch Disease; Child; Fundus Oculi; Humans; Male; Optic Neuritis; Prednisone | 1990 |
Bilateral postinfectious optic neuritis and intravenous steroid therapy in children.
Topics: Adolescent; Child; Child, Preschool; Female; Gastrointestinal Diseases; Humans; Magnetic Resonance I | 1990 |
[Multiple sclerosis with early manifestation in children].
Topics: Adolescent; Child; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Male; Multiple Sclero | 1990 |
Autoimmune optic neuropathy: evaluation and treatment.
Topics: Adult; Antibodies, Antinuclear; Autoimmune Diseases; Collagen Diseases; Dose-Response Relationship, | 1988 |
Progressive loss of vision in patients with high-grade non-Hodgkin's lymphoma.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Combined | 1987 |
Optic neuritis following chickenpox in adults.
Topics: Acyclovir; Adult; Chickenpox; Dexamethasone; Female; Humans; Male; Myelitis, Transverse; Optic Neuri | 1986 |
Optic neuritis during lactation.
Topics: Adult; Evoked Potentials, Visual; Female; Humans; Lactation; Optic Neuritis; Prednisone; Pregnancy; | 1985 |
Histopathology of ischemic optic neuropathy.
Topics: Aged; Arteries; Blindness; Ciliary Body; Female; Giant Cell Arteritis; Humans; Ischemia; Nerve Degen | 1970 |
Optic neuritis and its relationship to disseminated sclerosis.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Australia; Child; Child, Preschool; Dex | 1970 |
Optic nerve sarcoidosis. Report of a case.
Topics: Adult; Diagnosis, Differential; Female; Granuloma; Humans; Ophthalmoscopy; Optic Atrophy; Optic Nerv | 1972 |
The treatment of optic neuritis.
Topics: Adrenocorticotropic Hormone; Humans; Injections, Intramuscular; Injections, Intravenous; Optic Neuri | 1972 |
Analysis of some unusual and difficult visual field defects.
Topics: Adolescent; Adult; Child; Craniopharyngioma; Diagnosis, Differential; Female; Fluorescein Angiograph | 1972 |
Orbital apex syndrome due to sinus infection.
Topics: Abscess; Anti-Bacterial Agents; Blepharoptosis; Blindness; Cellulitis; Conjunctiva; Cornea; Diagnosi | 1974 |
Optic neuritis in systemic lupus erythematosus.
Topics: Adult; Child; Diagnostic Errors; Eye Manifestations; Female; Humans; Lupus Erythematosus, Systemic; | 1974 |
Retrobulbar neuritis. A case report of presumed solvent toxicity.
Topics: Adolescent; Butanones; Formaldehyde; Humans; Male; Methanol; Optic Neuritis; Poisoning; Prednisone; | 1971 |
Chiasmatic arachnoiditis. A case report and review.
Topics: Adolescent; Arachnoiditis; Cerebral Ventriculography; Craniotomy; Eye Diseases; Facial Paralysis; Fe | 1969 |