prednisone and Muscular Atrophy studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.

Research Excerpts

Excerpt	Relevance	Reference
"A controlled, prospective, double-blind, therapeutic trial of azathioprine was conducted in the initial therapy of polymyositis."	9.05	Azathioprine with prednisone for polymyositis. A controlled, clinical trial. ( Bunch, TW; Combs, JJ; Engel, AG; Ilstrup, DM; Worthington, JW, 1980)
"A controlled, prospective, double-blind, therapeutic trial of azathioprine was conducted in the initial therapy of polymyositis."	5.05	Azathioprine with prednisone for polymyositis. A controlled, clinical trial. ( Bunch, TW; Combs, JJ; Engel, AG; Ilstrup, DM; Worthington, JW, 1980)
" Chronic steroid use usually involves once-daily dosing, although weekly dosing in children has been suggested for its reduced side effects on behavior."	1.46	Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. ( Barefield, DY; Demonbreun, AR; Earley, JU; Hadhazy, M; McNally, EM; Quattrocelli, M; Vo, AH; Warner, JL, 2017)
"Mild limb weakness with severe muscle atrophy and diffuse muscle twitches were observed."	1.34	Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and Morvan's syndrome. ( Blesa, R; Dalmau, J; Díaz-Manera, J; Gallardo, E; Illa, I; Juárez, C; Martínez-Domeño, A; Martínez-Ramírez, S; Rojas-García, R, 2007)
" The progressive reduction of corticosteroid dosage led rapidly to a distinct improvement, but not to a remission, of symptoms."	1.28	Steroid myopathy: clinical and immunohistochemical study of a case. ( Camporeale, FS; Carandente, M; Cioffi, M; Gentile, A; Marolda, M; Orsini, AV; Palma, V, 1991)
"Two IgA-deficient children with inflammatory myopathy and intestinal malabsorption were evaluated."	1.26	Inflammatory myopathy, IgA deficiency, and intestinal malabsorption. ( Brooke, MH; Brown, WR; Carroll, JE; Isobe, Y; Kelts, KA; Silverman, A, 1976)

Research

Studies (31)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Muscle Imaging

Timeframe	Studies, this research(%)	All Research%
pre-1990	23 (74.19)	18.7374
1990's	5 (16.13)	18.2507
2000's	1 (3.23)	29.6817
2010's	2 (6.45)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Quattrocelli, M	1
Barefield, DY	1
Warner, JL	1
Vo, AH	1
Hadhazy, M	1
Earley, JU	1
Demonbreun, AR	1
McNally, EM	1
Jo, D	1
Pompa, T	1
Khalil, A	1
Kong, F	1
Wetz, R	1
Goldstein, M	1
DYK, T	1
STRAUSZ, I	1
JANIKOVSZKY, B	1
FOWLER, WM	1
PEARSON, CM	1
MORITZ, U	1
PRINEAS, JW	1
MASON, AS	1
HENSON, RA	1
Díaz-Manera, J	1
Rojas-García, R	1
Gallardo, E	1
Juárez, C	1
Martínez-Domeño, A	1
Martínez-Ramírez, S	1
Dalmau, J	1
Blesa, R	1
Illa, I	1
Bunch, TW	1
Worthington, JW	1
Combs, JJ	1
Ilstrup, DM	1
Engel, AG	1
Pasternak, JF	1
Fulling, K	1
Nelson, J	1
Prensky, AL	1
Serratrice, G	1
Gastaut, JL	1
Gastaut, JA	1
Tubiana, N	1
Carcassonne, Y	1
De Assis, JL	1
Marchiori, PE	1
Scaff, M	1
Touton, B	1
Lecerf, V	1
Crickx, B	1
Picard, C	1
Michaud, V	1
L'Anthoën-Arditi, MH	1
Belaïch, S	1
Rama-Maceiras, P	1
Pensado, A	1
Aymerich, H	1
Molins, N	1
Ferreira, TA	1
Vázquez-Fidalgo, A	1
Jerusalem, F	1
Puff, KH	1
Carroll, JE	1
Silverman, A	1
Isobe, Y	1
Brown, WR	1
Kelts, KA	1
Brooke, MH	1
Killeen, RN	1
Ayres, S	1
Mihan, R	1
Pinelli, P	1
Poloni, M	1
Nappi, G	1
Scelsi, R	1
Tamler, MS	1
Marolda, M	1
Palma, V	1
Camporeale, FS	1
Carandente, M	1
Cioffi, M	1
Orsini, AV	1
Gentile, A	1
Kelly, FJ	1
McGrath, JA	1
Goldspink, DF	1
Cullen, MJ	1
Lane, RJ	1
Fulthorpe, JJ	1
Hudgson, P	1
Dalakas, MC	1
Engel, WK	1
Horber, FF	1
Scheidegger, JR	1
Grünig, BE	1
Frey, FJ	1
Richier, JL	1
Guérin, D	1
Leblay, R	1
Pony, JC	1
Schneck, SA	1
de Fine Olivarius, AB	1
Thage, O	1
Fitch, CD	1
Lucy, DD	1
Bornhofen, JH	1
Dalrymple, GV	1
Fessel, WJ	1
Wieczorek, V	1
Jung, H	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Open Label Safety and Efficacy of Once Weekly Steroid in Patients With LGMD and Becker Muscular Dystrophy[NCT04054375]	Phase 2	20 participants (Actual)	Interventional	2019-07-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

MRI of leg muscles to measure changes in muscle fat percentage. The data point was collected by taking fat percentage at 6 months minus fat percentage at baseline with the following equation: (([final fat percentage - initial fat percentage]/initial fat percentage) * 100%)). All participants were included, both ambulatory and nonambulatory, with all genetic subtypes included. Five participants didn't have an MRI scan at 6 months and therefore were not included. Muscles imaged were analyzed for muscle fat changes from baseline to 6 months. Data is limited in interpretation due to various muscle groups in both ambulatory and non-ambulatory patients. (NCT04054375)
Timeframe: Baseline, 6 months

10 Meter Run Timed

Intervention	percent of change from baseline (Mean)
Weekly Steroid	-14

time in seconds to walk/run 10 meters , less time to run indicates greater motor function (NCT04054375)
Timeframe: Baseline, Month 6

6 Minute Walk Test

Intervention	seconds (Mean)
	Baseline	6 months
Steroid Treatment	7.32	6.67

number of meters walked in 6 minute period. Higher values indicate more motor function. (NCT04054375)
Timeframe: Baseline, Month 6

Bone Density

Intervention	meters (Mean)
	Baseline	6 months
Steroid Group	386	410

"whole dexa body scan to assess bone density with Z scores (more negative z score indicates increased risk for fractures).~Z-score of 0 represents the population mean, and is the average bone density. Positive scores indicate greater bone density and negative scores indicate decreased bone density, which could be clinically correlated with osteoporosis." (NCT04054375)
Timeframe: Baseline, 6 months

Brooke Scale Score

Intervention	z-score (Mean)
	baseline	6 months
Weekly Steroid	-1.64	-1.65

upper extremity assessment, scoring between 1- 6, lower score indicates more upper extremity function (NCT04054375)
Timeframe: Baseline, Month 6

Creatine Kinase

Intervention	scores on a scale (Mean)
	baseline	6 months
Weekly Steroid	3	3

units/L, 0-unlimited, higher scores indicate worse outcome (NCT04054375)
Timeframe: Baseline and 6 months (Final Visit)

Fasting Glucose

Intervention	U/L (Mean)
	Baseline	End
Weekly Steroid	1574	1047

mg/dL, 0-unlimited, higher score indicates worse outcome (NCT04054375)
Timeframe: Baseline and 6 months (Final Visit)

Fasting Lipid Profile

Intervention	mg/dL (Mean)
	Baseline	End
Weekly Steroid	93	102

cholesterol levels - mg/dL, higher levels indicate worse outcomes (NCT04054375)
Timeframe: Baseline and 6 months (Final Visit)

Functional Assessments - NSAD Change

Intervention	mg/dL (Mean)
	Baseline	End
Weekly Steroid	182	185

"Northstar Assessment for Dysferlinopathy~- score out of 58, range from 0 to 58, higher score indicates greater functional ability." (NCT04054375)
Timeframe: Baseline, Month 6

Functional Assessments - Upper Limb Strength

Intervention	score on a scale (Mean)
	baseline	6 months
Weekly Steroid	18.4	18.6

"Grip strength of the total force (Newtons) in both hands.~Participants attempted 3 trials in the right hand that was then averaged to create a right-hand average force score.~Then, the participants attempted 3 trials in the left hand that was then averaged to create a left-hand average force score.~The right-hand average force score was added to the left-hand average force score to create a total grip strength score." (NCT04054375)
Timeframe: Baseline and 6 months

HbgA1c

Intervention	Force (Newtons) (Mean)
	Baseline	6 months
Weekly Steroid	39	41

% , 0-100, higher score indicates worse outcome (NCT04054375)
Timeframe: Baseline and 6 months (Final Visit)

Lean Mass %

Intervention	% A1c (Mean)
	Baseline	End
Weekly Steroid	5.2	5.3

whole body dexa scans to assess lean mass % (0- 100 %). Increase lean mass % is the desired outcome. (NCT04054375)
Timeframe: Baseline, 6 months

Muscle Strength Test

Intervention	percentage (Mean)
	baseline	6 months
Weekly Steroid	37.5	38.1

Manual motor testing of the right knee flexion muscle group. (NCT04054375)
Timeframe: baseline, 6 months

Respiratory Changes

Intervention	Units on scale (Mean)
	Baseline	6 months
Weekly Steroid	3	3

Force Vital Capacity (% of predicted value), decrease in FVC indicates declining respiratory function. (NCT04054375)
Timeframe: Baseline, 6 months

Vignos Scale Score

Intervention	% Expected (Mean)
	Baseline	End
Weekly Steroid	80	79

Lower extremity assessment, score from 1-10, lower score indicates more function. (NCT04054375)
Timeframe: Baseline, Month 6

Article	Year
Rheumatoid myositis leading to acute lower extremity compartment syndrome: a case-based review. Clinical rheumatology, 2015, Volume: 34, Issue:10 Topics: Arthritis, Rheumatoid; Biopsy; Blood Sedimentation; Compartment Syndromes; Creatine Kinase; Edema; F	2015
[Dermatomyositis in childhood with recurrence in adulthood: 2 cases]. Annales de dermatologie et de venereologie, 1993, Volume: 120, Issue:11 Topics: Adult; Age Factors; Alopecia Areata; Atrophy; Child; Child, Preschool; Dermatomyositis; Female; Huma	1993
[Treatment of myopathies and spinal muscular atrophies (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, Jan-24, Volume: 67, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Azathioprine; Collagen Diseases; Dermatomyositis; Glycogen Storage Di	1978
[Polymyositis]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1 Topics: Antineoplastic Agents; Child; Dermatomyositis; Enzymes; Humans; Immunosuppression Therapy; Methotrex	1976

Article	Year
Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. The Journal of clinical investigation, 2017, Jun-01, Volume: 127, Issue:6 Topics: Animals; Annexin A6; Cells, Cultured; Drug Administration Schedule; Drug Evaluation, Preclinical; Ge	2017
[A case of acute systemic lupus erythematosus with extensive muscle atrophy; necessity of differentiation from dermatomyositis; positive effect of therapy with prednisone and nivaquine]. Polskie Archiwum Medycyny Wewnetrznej, 1958, Volume: 28, Issue:3 Topics: Cell Differentiation; Chloroquine; Dermatomyositis; Humans; Lupus Erythematosus, Systemic; Muscular	1958
[Corticosteroid myopathy]. Orvosi hetilap, 1960, Jul-03, Volume: 101 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Muscular Atrophy; Muscular Diseases; Prednison	1960
DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF SERUM ENZYMES. II. NEUROLOGIC DISEASES OTHER THAN MUSCULAR DYSTROPHY. Archives of physical medicine and rehabilitation, 1964, Volume: 45 Topics: Adenosine Triphosphatases; Alanine Transaminase; Arthritis; Arthritis, Rheumatoid; Aspartate Aminotr	1964
STUDIES ON MOTOR NERVE CONDUCTION IN RHEUMATOID ARTHRITIS. Acta rheumatologica Scandinavica, 1964, Volume: 10 Topics: Arthritis; Arthritis, Rheumatoid; Electric Stimulation; Electromyography; Electrophysiology; Humans;	1964
MYOPATHY IN METABOLIC BONE DISEASE. British medical journal, 1965, Apr-17, Volume: 1, Issue:5441 Topics: Acidosis; Acidosis, Renal Tubular; Adenoma; Celiac Disease; Diagnosis, Differential; Dihydrotachyste	1965
Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and Morvan's syndrome. Nature clinical practice. Neurology, 2007, Volume: 3, Issue:7 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Autoantibo	2007
An infant with chronic, relapsing polyneuropathy responsive to steroids. Developmental medicine and child neurology, 1982, Volume: 24, Issue:4 Topics: Child, Preschool; Chronic Disease; Female; Follow-Up Studies; Genes, Dominant; Humans; Infant; Infan	1982
[Cortico-responsive deficiency of girdle muscles in nocturnal paroxysmal hemoglobinuria]. La Nouvelle presse medicale, 1981, Oct-24, Volume: 10, Issue:38 Topics: Hemoglobinuria, Paroxysmal; Humans; Male; Middle Aged; Muscular Atrophy; Prednisone	1981
Atrophy of the tongue with persistent articulation disorder in myasthenia gravis: report of 10 patients. Auris, nasus, larynx, 1994, Volume: 21, Issue:4 Topics: Adult; Age of Onset; Articulation Disorders; Deglutition Disorders; Female; Humans; Immunosuppressiv	1994
[Prolonged neuromuscular block after a single dose of vecuronium in a patient with undiagnosed polyneuropathy and steroid myopathy]. Revista espanola de anestesiologia y reanimacion, 1999, Volume: 46, Issue:1 Topics: Anesthesia Recovery Period; Cyclosporine; Humans; Immunosuppressive Agents; Kidney Failure, Chronic;	1999
Inflammatory myopathy, IgA deficiency, and intestinal malabsorption. The Journal of pediatrics, 1976, Volume: 89, Issue:2 Topics: Autoantibodies; Child, Preschool; Dysgammaglobulinemia; Female; Humans; Immunoglobulin A; Immunologi	1976
Polymyositis: response to vitamin E. Southern medical journal, 1976, Volume: 69, Issue:10 Topics: Aged; Aspartate Aminotransferases; Creatine Kinase; Dose-Response Relationship, Drug; Electromyograp	1976
A case of late onset lipid storage myopathy. Electromyographic, histochemical and ultrastructural findings. European neurology, 1975, Volume: 13, Issue:3 Topics: Age Factors; Aged; Female; Humans; Lipid Metabolism; Lipidoses; Muscles; Muscular Atrophy; Muscular	1975
Liver transplant rehabilitation. American journal of physical medicine & rehabilitation, 1992, Volume: 71, Issue:4 Topics: Electromyography; Humans; Muscular Atrophy; Prednisone	1992
Steroid myopathy: clinical and immunohistochemical study of a case. Italian journal of neurological sciences, 1991, Volume: 12, Issue:4 Topics: Adult; Creatine; Electromyography; Female; Foot Diseases; Humans; Muscle Hypotonia; Muscular Atrophy	1991
A morphological/biochemical study on the actions of corticosteroids on rat skeletal muscle. Muscle & nerve, 1986, Volume: 9, Issue:1 Topics: Adrenal Cortex Hormones; Animals; Cortisone; Dexamethasone; Male; Microscopy, Electron; Muscle Prote	1986
Inclusion body myositis: a case with associated collagen vascular disease responding to treatment. Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:3 Topics: Azathioprine; Cell Nucleus; Dermatomyositis; Drug Therapy, Combination; Humans; Inclusion Bodies; Ma	1985
Prednisone-responsive limb-girdle syndrome: a special disorder? Neuropediatrics, 1987, Volume: 18, Issue:2 Topics: Biopsy; Child; Follow-Up Studies; Humans; Male; Motor Skills; Muscles; Muscular Atrophy; Neuromuscul	1987
Thigh muscle mass and function in patients treated with glucocorticoids. European journal of clinical investigation, 1985, Volume: 15, Issue:6 Topics: Adult; Exercise Therapy; Female; Humans; Kidney Transplantation; Male; Middle Aged; Muscle Contracti	1985
[Therapeutic effect of alpha-tocopher- yl-quinone on muscular disorders of hyperthyroidism and of prolonged treatment by corticoids and antimitotics]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1969, Apr-26, Volume: 45, Issue:20 Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents; Asthenia; Busulfan; Chlorambucil; Cobal	1969
Neurology and neuropathology of immunosuppressive therapy and acquired immunological deficiency. Research publications - Association for Research in Nervous and Mental Disease, 1971, Volume: 49 Topics: Adolescent; Adult; Agammaglobulinemia; Aspergillus; Azathioprine; Brain; Brain Diseases; Candida; Ce	1971
[Myasthenia gravis. Some clinical aspects]. Ugeskrift for laeger, 1971, Dec-24, Volume: 133, Issue:51 Topics: Adolescent; Adult; Aged; Autopsy; Child; Diagnosis, Differential; Electromyography; Eye Manifestatio	1971
Creatine metabolism in skeletal muscle. II. creatine kinetics in man. Neurology, 1968, Volume: 18, Issue:1 Pt 1 Topics: Adult; Carbon Isotopes; Child; Child, Preschool; Creatine; Creatinine; Female; Humans; Kinetics; Mal	1968
Myopathy of hypothyroidism. Annals of the rheumatic diseases, 1968, Volume: 27, Issue:6 Topics: Adult; Aged; Antibodies; Female; Humans; Hypothyroidism; Male; Middle Aged; Muscular Atrophy; Muscul	1968
[On the clinical picture of the neuralgic amyotrophy (Syndrom of Parsonage and Turner)]. Der Nervenarzt, 1965, Volume: 36, Issue:7 Topics: Adult; Blood Sedimentation; Cerebrospinal Fluid; Electromyography; Female; Humans; Male; Muscular At	1965

prednisone and Muscular Atrophy