prednisone has been researched along with Muscle Weakness in 75 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventy-nine patients with cyclosporine- and prednisone-dependent myasthenia gravis (MG) after thymectomy received tacrolimus for a mean of 2." | 9.11 | Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis. ( Armengol, M; Azem, J; Buera, M; Cervera, C; Fort, JM; López-Cano, M; Ponseti, JM; Vilallonga, R, 2005) |
| "Thymectomy is a standard treatment of myasthenia gravis (MG)." | 6.72 | Experience with starting tacrolimus postoperatively after transsternal extended thymectomy in patients with myasthenia gravis. ( Armengol, M; Azem, J; Fort, JM; Gamez, J; López-Cano, M; Ponseti, JM; Vilallonga, R, 2006) |
| " The mean starting dosage of MTX in the study group was 15 mg/m(2)/week." | 6.71 | The effectiveness of treating juvenile dermatomyositis with methotrexate and aggressively tapered corticosteroids. ( Cameron, B; Campbell-Webster, N; Feldman, BM; Laxer, RM; Ota, S; Parker, S; Ramanan, AV; Schneider, R; Silverman, ED; Spiegel, L; Tran, D; Tyrrell, PN, 2005) |
| "Seventy-nine patients with cyclosporine- and prednisone-dependent myasthenia gravis (MG) after thymectomy received tacrolimus for a mean of 2." | 5.11 | Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis. ( Armengol, M; Azem, J; Buera, M; Cervera, C; Fort, JM; López-Cano, M; Ponseti, JM; Vilallonga, R, 2005) |
| " She had been taking prednisone 60-40 mg daily for 6 weeks for suspected giant cell arteritis, along with six other regular medications, and had recently finished a course of antibiotics." | 3.81 | No medicine is sometimes the best medicine. ( Wallis, KA, 2015) |
| " Three patients with long-standing polymyositis (PM) or dermatomyositis (DM) poorly responsive to prednisone combined with several immunosuppressants were given intravenous rituximab 1,000 mg on Days 0 and 14." | 3.73 | Rituximab as therapy for refractory polymyositis and dermatomyositis. ( Hausner-Sypek, DL; Noss, EH; Weinblatt, ME, 2006) |
| "Thymectomy is a standard treatment of myasthenia gravis (MG)." | 2.72 | Experience with starting tacrolimus postoperatively after transsternal extended thymectomy in patients with myasthenia gravis. ( Armengol, M; Azem, J; Fort, JM; Gamez, J; López-Cano, M; Ponseti, JM; Vilallonga, R, 2006) |
| " The mean starting dosage of MTX in the study group was 15 mg/m(2)/week." | 2.71 | The effectiveness of treating juvenile dermatomyositis with methotrexate and aggressively tapered corticosteroids. ( Cameron, B; Campbell-Webster, N; Feldman, BM; Laxer, RM; Ota, S; Parker, S; Ramanan, AV; Schneider, R; Silverman, ED; Spiegel, L; Tran, D; Tyrrell, PN, 2005) |
| "Brachial neuritis is uncommon in infants." | 2.58 | Infant brachial neuritis following a viral prodrome: a case in a 6-month old child and review of the literature. ( Langan, ST; Mrowczynski, OD; Rizk, EB, 2018) |
| "Waldenström's macroglobulinemia is a low-grade lymphoma that produces monoclonal IgM." | 2.41 | Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature. ( Alvarez-Ferreira, J; Canales, MA; Delgado, J; Garcia, B; Garcia-Grande, A; Hernandez-Navarro, F, 2002) |
| "Diagnosis of ocular myasthenia gravis was made in accordance with positive anti-acetylcholine receptor antibodies." | 1.91 | Diplopia in a patient presenting with "blurred vision": a case report. ( Harrison, A; Mudhar, O; Rampal, M; Yoo, J, 2023) |
| "A girl aged 14 years was admitted with stridor." | 1.62 | Stridor Due to Cranial Nerve X Palsy Progressing to Polyneuropathy in a Teenager With COVID-19. ( Chelius, D; Dean, A; Marri, K; Said, A, 2021) |
| "Myalgia is fairly common in the prodromal phase of the viral illness which self-resolves." | 1.62 | COVID-19 IgG-related autoimmune inflammatory necrotizing myositis. ( Ayesha, B; Koyoda, S; Veyseh, M, 2021) |
| "Myasthenia gravis is an autoimmune disease of the neuromuscular junction, commonly affecting the ocular muscles." | 1.43 | Cigarette Smoking and Activities of Daily Living in Ocular Myasthenia Gravis. ( Feuer, WJ; Gratton, SM; Herro, AM; Lam, BL, 2016) |
| "Sarcoidosis is a multi-system disease characterized by the presence of non-caseating epithelioid granulomas in affected tissues, including skeletal muscle." | 1.43 | Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent. ( Eutsler, E; Ferguson, C; Kitcharoensakkul, M; Orandi, AB; White, AJ, 2016) |
| "Idiopathic inflammatory myositis is a challenging group of heterogenous disorders." | 1.39 | Inflammatory myopathies--a review of newly diagnosed patients (2004-2008) in the Counties Manukau region. ( Gow, PJ; Gupta, R, 2013) |
| "Calcinosis is a severe manifestation that can be debilitating." | 1.38 | Refractory calcinosis in a patient with dermatomyositis: response to intravenous immune globulin. ( Shahani, L, 2012) |
| "The sporadic inclusion body myositis weakness composite index, which correlated with grip strength (correlation coefficient: 0." | 1.37 | Long-term observational study of sporadic inclusion body myositis. ( Allenbach, Y; Benveniste, O; Brady, S; Dubourg, O; Eymard, B; Freebody, J; Guiguet, M; Herson, S; Hilton-Jones, D; Leite, MI; Maisonobe, T; Squier, W; Stojkovic, T, 2011) |
| "In this case, adult-onset nemaline myopathy was probably the primary disease process." | 1.35 | Adult nemaline myopathy with trabecular muscle fibers. ( de Armond, SJ; Irodenko, VS; Layzer, RB; Lee, HS, 2009) |
| "Prednisone was started during the ambulant phase at age 3." | 1.35 | Prednisone 10 days on/10 days off in patients with Duchenne muscular dystrophy. ( de Groot, IJ; Overweg-Plandsoen, WC; Straathof, CS; van den Burg, GJ; van der Kooi, AJ; Verschuuren, JJ, 2009) |
| "Mild limb weakness with severe muscle atrophy and diffuse muscle twitches were observed." | 1.34 | Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and Morvan's syndrome. ( Blesa, R; Dalmau, J; Díaz-Manera, J; Gallardo, E; Illa, I; Juárez, C; Martínez-Domeño, A; Martínez-Ramírez, S; Rojas-García, R, 2007) |
| "Neurosarcoidosis is a rare manifestation of sarcoidosis." | 1.33 | Cauda equina and conus medullaris syndrome in sarcoidosis. ( Hayat, GR; Kaiboriboon, K; Olsen, TJ, 2005) |
| " She had received several bouts of steroids and had been in clinical remission for 12 weeks under a dosage of 40 mg/d prednisone." | 1.33 | [Recurrent aseptic osteonecrosis in Crohn's disease - extraintestinal manifestation or steroid related complication?]. ( Dienes, HP; Kruis, W; Lanyi, B, 2005) |
| "Their usage in Duchenne muscular dystrophy may prolong ambulation and upper limb function with similar potency." | 1.33 | Corticosteroid treatment and functional improvement in Duchenne muscular dystrophy: long-term effect. ( Balaban, B; Carry, T; Clayton, GH; Matthews, DJ, 2005) |
| " A high daily dosage of prednisone relative to body weight was found to be neither a predictor of exacerbation nor a predictor of early improvement in bivariate correlation analysis." | 1.33 | Clinical predictors of steroid-induced exacerbation in myasthenia gravis. ( Bae, JS; Go, SM; Kim, BJ, 2006) |
| "Proximal muscle weakness was presented by all and only two patients complained of myalgia." | 1.31 | Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases. ( Greboge, P; Iwamoto, FM; Prevedello, DM; Scola, RH; Werneck, LC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (6.67) | 18.2507 |
| 2000's | 36 (48.00) | 29.6817 |
| 2010's | 30 (40.00) | 24.3611 |
| 2020's | 4 (5.33) | 2.80 |
| Authors | Studies |
|---|---|
| Dean, A | 1 |
| Said, A | 1 |
| Marri, K | 1 |
| Chelius, D | 1 |
| Wang, S | 1 |
| Yang, H | 1 |
| Guo, R | 1 |
| Wang, L | 1 |
| Zhang, Y | 2 |
| Lv, J | 1 |
| Zhao, X | 1 |
| Zhang, J | 1 |
| Fang, H | 1 |
| Zhang, Q | 1 |
| Yang, J | 1 |
| Cui, X | 1 |
| Gao, P | 1 |
| Chang, T | 1 |
| Gao, F | 1 |
| Harrison, A | 1 |
| Mudhar, O | 1 |
| Yoo, J | 1 |
| Rampal, M | 1 |
| de Meel, RHP | 1 |
| Tannemaat, MR | 1 |
| Verschuuren, JJGM | 1 |
| Veyseh, M | 1 |
| Koyoda, S | 1 |
| Ayesha, B | 1 |
| Mrowczynski, OD | 1 |
| Langan, ST | 1 |
| Rizk, EB | 1 |
| Koroscil, MT | 1 |
| Rohan, CA | 1 |
| Morris, MJ | 1 |
| Scott, JN | 1 |
| Tidwell, WJ | 1 |
| Callen, JP | 1 |
| Thapa, K | 1 |
| Romo, ML | 1 |
| Carpio, A | 1 |
| Leslie, D | 1 |
| Andrews, H | 1 |
| Hauser, WA | 1 |
| Kelvin, EA | 1 |
| Gupta, R | 1 |
| Gow, PJ | 1 |
| Borrego-Utiel, FJ | 1 |
| Pérez-del Barrio, Mdel P | 1 |
| Polaina-Rusillo, M | 1 |
| Borrego-Hinojosa, J | 1 |
| Chen, AY | 1 |
| Stevens, WW | 1 |
| Sporn, PH | 1 |
| Kararizou, E | 1 |
| Anagnostou, E | 1 |
| Kapaki, E | 1 |
| Davaki, P | 1 |
| Wallis, KA | 1 |
| Gratton, SM | 1 |
| Herro, AM | 1 |
| Feuer, WJ | 1 |
| Lam, BL | 1 |
| Bravenboer, B | 1 |
| Debels, L | 1 |
| Orandi, AB | 1 |
| Eutsler, E | 1 |
| Ferguson, C | 1 |
| White, AJ | 1 |
| Kitcharoensakkul, M | 1 |
| Kuye, IO | 1 |
| Smith, GP | 1 |
| Wakamoto, H | 1 |
| Chisaka, A | 1 |
| Inoue, N | 1 |
| Nakano, N | 1 |
| Kostera-Pruszczyk, A | 1 |
| Ryniewicz, B | 1 |
| Rowinska-Marcinska, K | 1 |
| Dutkiewicz, M | 1 |
| Kamińska, A | 1 |
| Sarkhy, A | 1 |
| Persad, R | 1 |
| Tarnopolsky, M | 1 |
| Cros, D | 1 |
| Gonzalez, RG | 1 |
| Mark, EJ | 1 |
| Irodenko, VS | 1 |
| Lee, HS | 1 |
| de Armond, SJ | 1 |
| Layzer, RB | 1 |
| Rogo, T | 1 |
| Kamat, R | 1 |
| Arabshahi, B | 1 |
| Lateef, T | 1 |
| Straathof, CS | 1 |
| Overweg-Plandsoen, WC | 1 |
| van den Burg, GJ | 1 |
| van der Kooi, AJ | 1 |
| Verschuuren, JJ | 1 |
| de Groot, IJ | 1 |
| Rigamonti, A | 2 |
| Lauria, G | 2 |
| Balgera, R | 1 |
| Agostoni, E | 2 |
| Cucurachi, L | 1 |
| Cattaneo, L | 1 |
| Gemignani, F | 1 |
| Pavesi, G | 1 |
| Rath, JJ | 1 |
| Ronday, HK | 1 |
| Wirtz, PW | 1 |
| Garcin, B | 1 |
| Lenglet, T | 1 |
| Dubourg, O | 2 |
| Mesnage, V | 1 |
| Levy, R | 1 |
| Marie, I | 1 |
| Lahaxe, L | 1 |
| Vera, P | 1 |
| Edet-Samson, A | 1 |
| Tang, Y | 1 |
| Wang, X | 1 |
| Ding, Y | 1 |
| Li, C | 1 |
| Jia, J | 1 |
| Nguyen, H | 2 |
| Le, C | 1 |
| Piamarta, F | 1 |
| Fiumani, A | 1 |
| Suga, H | 1 |
| Asano, Y | 1 |
| Tamaki, Z | 1 |
| Yamamoto, M | 1 |
| Sugaya, M | 1 |
| Shimizu, J | 1 |
| Sato, S | 1 |
| Benveniste, O | 1 |
| Guiguet, M | 1 |
| Freebody, J | 1 |
| Squier, W | 1 |
| Maisonobe, T | 1 |
| Stojkovic, T | 1 |
| Leite, MI | 1 |
| Allenbach, Y | 1 |
| Herson, S | 1 |
| Brady, S | 1 |
| Eymard, B | 1 |
| Hilton-Jones, D | 1 |
| Scheer, BV | 1 |
| Valero-Burgos, E | 1 |
| Costa, R | 1 |
| Nielsen, AA | 1 |
| Smith, BE | 1 |
| Engel, AG | 1 |
| Bosch, EP | 1 |
| Vallet, AE | 1 |
| Didelot, A | 1 |
| Guebre-Egziabher, F | 1 |
| Bernard, M | 1 |
| Mauguière, F | 1 |
| Shahani, L | 1 |
| Alaama, T | 1 |
| Basharat, P | 1 |
| Nicolle, MW | 1 |
| Schlienger, M | 1 |
| Ferroir, JP | 1 |
| Huguet, F | 1 |
| Deluen, F | 1 |
| Pène, F | 1 |
| Marseguerra, R | 1 |
| Touboul, E | 1 |
| Fernández-Serna, M | 1 |
| Arboleya, L | 1 |
| Alonso, S | 1 |
| Queiro, R | 1 |
| Alperi, M | 1 |
| Lagalla, G | 1 |
| Logullo, F | 1 |
| Di Bella, P | 1 |
| Provinciali, L | 1 |
| Ceravolo, MG | 1 |
| Greenberg, SA | 1 |
| Restrepo, S | 1 |
| Voermans, NC | 1 |
| Vaneker, M | 1 |
| Hengstman, GJ | 1 |
| ter Laak, HJ | 1 |
| Zimmerman, C | 1 |
| Schelhaas, HJ | 1 |
| Zwarts, MJ | 1 |
| Ben Ghorbel, I | 1 |
| Ibnelhadj, Z | 1 |
| Zouari, M | 1 |
| Nagi, S | 1 |
| Khanfir, M | 1 |
| Hentati, F | 1 |
| Houman, MH | 1 |
| Kaiboriboon, K | 1 |
| Olsen, TJ | 1 |
| Hayat, GR | 1 |
| Ponseti, JM | 2 |
| Azem, J | 2 |
| Fort, JM | 2 |
| López-Cano, M | 2 |
| Vilallonga, R | 2 |
| Buera, M | 1 |
| Cervera, C | 1 |
| Armengol, M | 2 |
| Wipff, J | 1 |
| Allanore, Y | 1 |
| Cormier, C | 1 |
| Redondo, A | 1 |
| Kahan, A | 1 |
| Lanyi, B | 1 |
| Dienes, HP | 1 |
| Kruis, W | 1 |
| Goodall, J | 1 |
| Usatine, RP | 1 |
| Balaban, B | 1 |
| Matthews, DJ | 1 |
| Clayton, GH | 1 |
| Carry, T | 1 |
| Gómez-Choco, MJ | 1 |
| Valls-Solé, J | 1 |
| Grau, JM | 1 |
| Graus, F | 1 |
| Ramanan, AV | 1 |
| Campbell-Webster, N | 1 |
| Ota, S | 1 |
| Parker, S | 1 |
| Tran, D | 1 |
| Tyrrell, PN | 1 |
| Cameron, B | 1 |
| Spiegel, L | 1 |
| Schneider, R | 1 |
| Laxer, RM | 1 |
| Silverman, ED | 1 |
| Feldman, BM | 1 |
| Sivakumar, K | 1 |
| Fife, TD | 1 |
| Ríos, G | 1 |
| van Alfen, N | 1 |
| van Engelen, BG | 1 |
| Bergler-Czop, B | 1 |
| Brzezińska-Wcisło, L | 1 |
| Lis, A | 1 |
| Krauze, E | 1 |
| Marszał, E | 1 |
| Jamroz, E | 1 |
| Klimek, B | 1 |
| Kajor, M | 1 |
| Noss, EH | 1 |
| Hausner-Sypek, DL | 1 |
| Weinblatt, ME | 1 |
| Gamez, J | 1 |
| Bae, JS | 1 |
| Go, SM | 1 |
| Kim, BJ | 1 |
| Díaz-Manera, J | 1 |
| Rojas-García, R | 1 |
| Gallardo, E | 1 |
| Juárez, C | 1 |
| Martínez-Domeño, A | 1 |
| Martínez-Ramírez, S | 1 |
| Dalmau, J | 1 |
| Blesa, R | 1 |
| Illa, I | 1 |
| Bhagavati, S | 1 |
| Maccabee, PJ | 1 |
| Chari, G | 1 |
| Jhamb, R | 1 |
| Gupta, N | 1 |
| Garg, S | 1 |
| Kumar, S | 1 |
| Gulati, S | 1 |
| Mishra, D | 1 |
| Beniwal, P | 1 |
| Magro, CM | 1 |
| Schaefer, JT | 1 |
| Waldman, J | 1 |
| Knight, D | 1 |
| Seilstad, K | 1 |
| Hearne, D | 1 |
| Sinno, DD | 1 |
| Darras, BT | 1 |
| Yamout, BI | 1 |
| Rebeiz, JG | 1 |
| Mikati, MA | 1 |
| Meretoja, P | 1 |
| Möttönen, T | 1 |
| Halonen, JP | 1 |
| Koski, K | 1 |
| Kalimo, H | 1 |
| Khan, AR | 1 |
| Bertorini, TE | 1 |
| Horner, LH | 1 |
| Brubaker, PH | 1 |
| Brozena, SC | 1 |
| Morley, DL | 1 |
| Walter, JD | 1 |
| Berry, MJ | 1 |
| Rose, MR | 1 |
| Levin, KH | 1 |
| Griggs, RC | 1 |
| Lacomis, D | 1 |
| Giuliani, MJ | 1 |
| Wasko, MC | 1 |
| Oddis, CV | 1 |
| Scola, RH | 1 |
| Werneck, LC | 1 |
| Prevedello, DM | 1 |
| Greboge, P | 1 |
| Iwamoto, FM | 1 |
| Delgado, J | 1 |
| Canales, MA | 1 |
| Garcia, B | 1 |
| Alvarez-Ferreira, J | 1 |
| Garcia-Grande, A | 1 |
| Hernandez-Navarro, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/IIa Gene Transfer Clinical Trial for Duchenne Muscular Dystrophy Using rAAVrh74.MCK.GALGT2[NCT03333590] | Phase 1/Phase 2 | 2 participants (Actual) | Interventional | 2017-11-06 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Percentage of fibers expressing GALGT2 in each biopsy sample. (NCT03333590)
Timeframe: Day 90 (Cohort 2) and Day 120 (Cohort 1)
| Intervention | Percentage of Positive Fibers (Number) |
|---|---|
| Cohort 1 (Minimal Efficacious Dose) | 1.95 |
| Cohort 2 | 1.72 |
(NCT03333590)
Timeframe: Day 90 (Cohort 2) and Day 120 (Cohort 1)
| Intervention | ng/mg total protein (Number) |
|---|---|
| Cohort 1 (Minimal Efficacious Dose) | 12 |
| Cohort 2 | 14.6 |
(NCT03333590)
Timeframe: 2 years
| Intervention | events (Number) |
|---|---|
| Cohort 1 (Minimal Efficacious Dose) | 0 |
| Cohort 2 | 0 |
(NCT03333590)
Timeframe: Day 90 (Cohort 2) and Day 120 (Cohort 1) and Day 180 for both cohorts
| Intervention | meters (Number) | |
|---|---|---|
| Day 90 (Cohort 2) /Day 120 (Cohort 1) | Day 180 | |
| Cohort 1 (Minimal Efficacious Dose) | 320 | 324 |
| Cohort 2 (Minimal Efficacious Dose) | 405 | 416 |
The NSAA provides a score between 0 and 34 where higher numbers represent greater muscle function. (NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1) and both Cohorts at Day 180, Months 12, 18 and 24
| Intervention | score on a scale (Number) | ||||
|---|---|---|---|---|---|
| Day 90/Day 120 | Day 180 | Month 12 | Month 18 | Month 24 | |
| Cohort 1 (Minimal Efficacious Dose) | 16 | 14 | 10 | 6 | 2 |
| Cohort 2 | 21 | 23 | 23 | 23 | 23 |
(NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1) and both Cohorts at Day 180, Months 12, 18 and 24
| Intervention | kg (Number) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 90/Day 120-Right Knee Extension | Day 90/Day 120-Right Knee Flexion | Day 90/Day 120- Left Knee Extension | Day 90/Day 120-Left Knee Flexion | Day 180-Right Knee Extension | Day 180-Right Knee Flexion | Day 180-Left Knee Extension | Day 180-Left Knee Flexion | Month 12-Right Knee Extension | Month 12-Right Knee Flexion | Month 12-Left Knee Extension | Month 12-Left Knee Flexion | Month 18-Right Knee Extension | Month 18-Right Knee Flexion | Month 18-Left Knee Extension | Month 18-Left Knee Flexion | Month 24-Right Knee Extension | Month 24-Right Knee Flexion | Month 24-Left Knee Extension | Month 24-Left Knee Flexion | |
| Cohort 1 (Minimal Efficacious Dose) | 7.42 | 6.06 | 8.78 | 6.12 | 7.13 | 6.1 | 8.66 | 6.69 | 7.49 | 5.67 | 7.5 | 5.32 | 4.55 | 6.11 | 4.96 | 6.26 | 5.06 | 4.41 | 6.93 | 4.17 |
| Cohort 2 | 7.04 | 8.12 | 5.9 | 8.4 | 9.73 | 4.24 | 8.19 | 5.25 | 9.85 | 5.85 | 8.02 | 5.12 | 7.67 | 6.89 | 7.34 | 6.08 | 9.81 | 5.04 | 5.21 | 4.87 |
(NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1); both Cohorts at Day 180, Months 12, 18 and Cohort 2 at Month 24
| Intervention | seconds (Number) | |||
|---|---|---|---|---|
| Day 90/Day 120 | Day 180 | Month 12 | Month 18 | |
| Cohort 1 (Minimal Efficacious Dose) | 98.2 | 110.9 | 144.5 | 167.8 |
(NCT03333590)
Timeframe: Days 90 (Cohort 2), 120 (Cohort 1); both Cohorts at Day 180, Months 12, 18 and Cohort 2 at Month 24
| Intervention | seconds (Number) | ||||
|---|---|---|---|---|---|
| Day 90/Day 120 | Day 180 | Month 12 | Month 18 | Month 24 | |
| Cohort 2 | 56.1 | 44.9 | 44.7 | 65.6 | 48.4 |
6 reviews available for prednisone and Muscle Weakness
| Article | Year |
|---|---|
Infant brachial neuritis following a viral prodrome: a case in a 6-month old child and review of the literature.
Topics: Anti-Inflammatory Agents; Brachial Plexus Neuritis; Female; Humans; Infant; Muscle Weakness; Paresis | 2018 |
Muscle restricted vasculitis causing dropped head syndrome: a case report and review of the literature.
Topics: Cyclophosphamide; Electromyography; Head Movements; Humans; Magnetic Resonance Imaging; Male; Middle | 2012 |
[Dropped Head Syndrome after whiplash injury in a patient treated for a Hodgkin's lymphoma by mantle field radiotherapy].
Topics: Accidents, Traffic; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cervical Plexus; Cerv | 2013 |
Dropped head syndrome in a patient with scleromyositis.
Topics: Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Aged; Muscle Weakness; Myositis; Neck | 2013 |
Primary respiratory failure in inclusion body myositis.
Topics: Anti-Inflammatory Agents; Biopsy; Electromyography; Female; Humans; Middle Aged; Muscle Weakness; My | 2004 |
Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow; Brain; Cladribine; Combin | 2002 |
5 trials available for prednisone and Muscle Weakness
| Article | Year |
|---|---|
The effect of albendazole treatment on non-seizure outcomes in patients with symptomatic neurocysticercosis.
Topics: Administration, Oral; Albendazole; Animals; Anthelmintics; Double-Blind Method; Drug Administration | 2018 |
Influence of early high-dose steroid treatment on Bell's palsy evolution.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Bell Palsy; Dose-Response Rela | 2002 |
Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Ataxia; Autoantibodies; Cyclos | 2005 |
The effectiveness of treating juvenile dermatomyositis with methotrexate and aggressively tapered corticosteroids.
Topics: Dermatomyositis; Disability Evaluation; Dose-Response Relationship, Drug; Drug Administration Schedu | 2005 |
Experience with starting tacrolimus postoperatively after transsternal extended thymectomy in patients with myasthenia gravis.
Topics: Adolescent; Adult; Aged; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Middle Age | 2006 |
64 other studies available for prednisone and Muscle Weakness
| Article | Year |
|---|---|
Stridor Due to Cranial Nerve X Palsy Progressing to Polyneuropathy in a Teenager With COVID-19.
Topics: Acute Disease; Adolescent; Combined Modality Therapy; COVID-19; Deglutition Disorders; Diagnosis, Di | 2021 |
Antibodies to Full-Length Agrin Protein in Chinese Patients With Myasthenia Gravis.
Topics: Age of Onset; Aged; Agrin; Autoantibodies; Autoantigens; China; Cholinesterase Inhibitors; Female; G | 2021 |
Diplopia in a patient presenting with "blurred vision": a case report.
Topics: Diplopia; Female; Humans; Muscle Weakness; Myasthenia Gravis; Prednisone; Pyridostigmine Bromide; Vi | 2023 |
Heterogeneity and shifts in distribution of muscle weakness in myasthenia gravis.
Topics: Adult; Age of Onset; Aged; Blepharoptosis; Cholinesterase Inhibitors; Cohort Studies; Deglutition Di | 2019 |
COVID-19 IgG-related autoimmune inflammatory necrotizing myositis.
Topics: Antibodies, Viral; Autoimmune Diseases; COVID-19; Diagnosis, Differential; Female; Humans; Immunoglo | 2021 |
Wong-Type Dermatomyositis Complicated by Interstitial Lung Disease.
Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Biopsy; Dermatomyositis; Diagnosis, Different | 2018 |
Koebner Phenomenon in Juvenile Dermatomyositis.
Topics: Adolescent; Anti-Inflammatory Agents; Antirheumatic Agents; Biopsy; Creatine Kinase; Dermatologic Ag | 2018 |
Inflammatory myopathies--a review of newly diagnosed patients (2004-2008) in the Counties Manukau region.
Topics: Adult; Aged; Antibodies, Antinuclear; Biopsy; Blood Sedimentation; C-Reactive Protein; Creatine Kina | 2013 |
Painful gynaecomastia secondary to cyclosporine A and tacrolimus in a patient with focal segmental glomerulosclerosis.
Topics: Antihypertensive Agents; Cyclophosphamide; Cyclosporine; Drug Substitution; Drug Therapy, Combinatio | 2013 |
The hidden culprit.
Topics: Aged, 80 and over; Anti-Inflammatory Agents; Antibodies, Antineutrophil Cytoplasmic; Cyclophosphamid | 2013 |
Bilateral diaphragm weakness after chemotherapy for lymphoma.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Diaphragm; Doxorubicin; | 2014 |
Chronic inflammatory demyelinating polyneuropathy associated with neurosyphilis.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Biopsy; Cognitive Dysfunction; Electromyography; Ex | 2015 |
No medicine is sometimes the best medicine.
Topics: Aged; Anti-Bacterial Agents; Cough; Fatigue; Female; Giant Cell Arteritis; Hospitalization; Humans; | 2015 |
Cigarette Smoking and Activities of Daily Living in Ocular Myasthenia Gravis.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Autoantibodies; Cholinesterase Inhibitor | 2016 |
A patient with muscle weakness.
Topics: Adult; Anti-Inflammatory Agents; Dermatomyositis; Female; Humans; Muscle Weakness; Prednisone | 2016 |
Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent.
Topics: Adalimumab; Adolescent; Antirheumatic Agents; Diagnosis, Differential; Female; Granuloma; Humans; Hy | 2016 |
The Use of Rituximab in the Management of Refractory Dermatomyositis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Dermatomyositis; Drug-Related Side Effects and Advers | 2017 |
Childhood multifocal acquired demyelinating sensory and motor neuropathy.
Topics: Adolescent; Anti-Inflammatory Agents; Child; Electromyography; Female; Foot; Hereditary Sensory and | 2008 |
Lambert-Eaton myasthenic syndrome in childhood.
Topics: Autoantibodies; Azathioprine; Calcium Channels, P-Type; Child; Humans; Immunosuppressive Agents; Lam | 2009 |
Muscle weakness in a girl with autoimmune hepatitis and Graves' disease.
Topics: Autoantibodies; Comorbidity; Diagnosis, Differential; Electromyography; Female; Graves Disease; Hepa | 2009 |
Case records of the Massachusetts General Hospital. Case 6-2009. A 37-year-old woman with vertigo, facial weakness, and a generalized seizure.
Topics: Adult; Amenorrhea; Anti-Inflammatory Agents; Biopsy; Brain; Brain Diseases; Diagnosis, Differential; | 2009 |
Adult nemaline myopathy with trabecular muscle fibers.
Topics: Biopsy; Disease Progression; Humans; Immunosuppressive Agents; Inclusion Bodies; Male; Middle Aged; | 2009 |
An adolescent with fever, weakness, and pain.
Topics: Adolescent; Anti-Bacterial Agents; Diagnosis, Differential; Fever; Glucocorticoids; Humans; Male; Mu | 2009 |
Prednisone 10 days on/10 days off in patients with Duchenne muscular dystrophy.
Topics: Adolescent; Age Factors; Age of Onset; Akathisia, Drug-Induced; Anti-Inflammatory Agents; Child; Chi | 2009 |
Subacute inflammatory polyradiculopathy associated with Sjögren's syndrome.
Topics: Aged; Disease Progression; Electrodiagnosis; Female; Humans; Immunosuppressive Agents; Magnetic Reso | 2009 |
Late onset generalized myasthenia gravis presenting with facial weakness and bulbar signs without extraocular muscle involvement.
Topics: Action Potentials; Aged; Anti-Inflammatory Agents; Cholinesterase Inhibitors; Deglutition Disorders; | 2009 |
Acute transverse myelitis in psoriatic arthritis.
Topics: Administration, Oral; Arthritis, Psoriatic; Female; Humans; Injections, Intravenous; Leg; Magnetic R | 2010 |
Dropped head syndrome as a presenting sign of scleromyositis.
Topics: Female; Glucocorticoids; Humans; Middle Aged; Muscle Weakness; Neck Muscles; Polymyositis; Prednison | 2010 |
Follow-up of muscular sarcoidosis using fluorodeoxyglucose positron emission tomography.
Topics: Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Fluorodeoxyglucose F18; Humans; Infliximab; | 2010 |
Longitudinal lesion of the spinal cord in a patient with Vogt-Koyanagi-Harada disease.
Topics: Adolescent; Anti-Inflammatory Agents; Atrophy; Cyclophosphamide; Cyclosporine; Dysuria; Female; Huma | 2010 |
Cervical myelopathy from spinal sarcoidosis as the unexpected initial presentation for systemic sarcoidosis.
Topics: Adult; Cervical Vertebrae; Clonidine; Contrast Media; Gadolinium DTPA; Glucocorticoids; Humans; Hype | 2010 |
Thymoma-associated myasthenia gravis without acetylcholine receptor antibodies.
Topics: Action Potentials; Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Electric Stimulation; Evo | 2011 |
A case of systemic sclerosis with sarcoidosis.
Topics: Anti-Inflammatory Agents; Female; Hand Dermatoses; Humans; Lung Diseases, Interstitial; Middle Aged; | 2011 |
Long-term observational study of sporadic inclusion body myositis.
Topics: Aged; Azathioprine; Cohort Studies; Disability Evaluation; Female; Humans; Immunoglobulins, Intraven | 2011 |
Myasthenia gravis and endurance exercise.
Topics: Athletes; Cholinesterase Inhibitors; Deglutition Disorders; Fatigue; Glucocorticoids; Humans; Male; | 2012 |
Initial neuro-ophthalmological manifestations in Churg-Strauss syndrome.
Topics: Aged; Anti-Inflammatory Agents; Blindness; Churg-Strauss Syndrome; Cyclophosphamide; Diplopia; Drug | 2010 |
Refractory calcinosis in a patient with dermatomyositis: response to intravenous immune globulin.
Topics: Adult; Anti-Inflammatory Agents; Calcinosis; Dermatomyositis; Female; Humans; Immunoglobulins, Intra | 2012 |
Unusual case of recurrent falls: myasthenia gravis in an elderly patient.
Topics: Accidental Falls; Aged, 80 and over; Antibodies; Blepharoptosis; Cholinesterase Inhibitors; Dysarthr | 2012 |
Acquired rippling muscle disease with myasthenia gravis.
Topics: Adult; Alopecia Areata; Antineoplastic Agents; Electromyography; Humans; Male; Muscle Contraction; M | 2004 |
New treatment alternatives for Duchenne and Becker muscular dystrophy.
Topics: Administration, Oral; Adrenergic beta-Agonists; Albuterol; Child; Child, Preschool; Clinical Trials | 2004 |
[Behçet's disease associated with peripheral neuropathy].
Topics: Anti-Inflammatory Agents; Anticonvulsants; Behcet Syndrome; Carbamazepine; Cyclophosphamide; Diarrhe | 2005 |
Cauda equina and conus medullaris syndrome in sarcoidosis.
Topics: Anti-Inflammatory Agents; Central Nervous System Diseases; Electrodiagnosis; Electromyography; Femal | 2005 |
[Ossification of the common posterior longitudinal ligament of the spine and spinal cord compression in a patient from Senegal].
Topics: Anti-Inflammatory Agents; Back Pain; Erectile Dysfunction; Humans; Longitudinal Ligaments; Magnetic | 2005 |
[Recurrent aseptic osteonecrosis in Crohn's disease - extraintestinal manifestation or steroid related complication?].
Topics: Anti-Inflammatory Agents; Arthroplasty, Replacement, Hip; Biopsy; Bone and Bones; Bone Density; Croh | 2005 |
Skin rash and muscle weakness.
Topics: Dermatomyositis; Exanthema; Female; Glucocorticoids; Humans; Middle Aged; Muscle Weakness; Prednison | 2005 |
Corticosteroid treatment and functional improvement in Duchenne muscular dystrophy: long-term effect.
Topics: Adolescent; Anti-Inflammatory Agents; Body Height; Body Weight; Disease Progression; Dose-Response R | 2005 |
Episodic hyperhidrosis as the only clinical manifestation of neuromyotonia.
Topics: Aged; Anti-Inflammatory Agents; Cyclophosphamide; Electromyography; Humans; Hyperhidrosis; Isaacs Sy | 2005 |
Autoimmune hearing loss in chronic inflammatory demyelinating polyneuropathy.
Topics: Adult; Anti-Inflammatory Agents; Autoantibodies; Cochlea; Female; Hair Cells, Auditory; Hearing Loss | 2005 |
Retrospective review of the clinical manifestations and outcomes in Puerto Ricans with idiopathic inflammatory myopathies.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antibodies, Antinuclear; Arthritis, Rheumatoid; Biopsy; | 2005 |
The clinical spectrum of neuralgic amyotrophy in 246 cases.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age of Onset; Aged; Brachial Plexus; Brachial Plexus Neu | 2006 |
[Juvenile dermatomyositis in 12 years old girl].
Topics: Antibodies, Antinuclear; Child; Dermatomyositis; Erythema; Female; Glucocorticoids; Humans; Muscle W | 2005 |
Rituximab as therapy for refractory polymyositis and dermatomyositis.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD19; Azathioprine; B-Lymp | 2006 |
Clinical predictors of steroid-induced exacerbation in myasthenia gravis.
Topics: Adult; Age Factors; Anti-Inflammatory Agents; Brain Stem; Disability Evaluation; Female; Humans; Mal | 2006 |
Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and Morvan's syndrome.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Autoantibo | 2007 |
Is cerebral involvement an occasional feature of muscle-specific kinase antibody-positive syndrome?
Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Brain; Cho | 2007 |
Diffuse lymphomatous infiltration of kidney presenting as renal tubular acidosis and hypokalemic paralysis: case report.
Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Adult; Antigens, CD19; Antigens, CD20; Antineoplasti | 2007 |
Terbinafine-induced dermatomyositis: a case report and literature review of drug-induced dermatomyositis.
Topics: Antifungal Agents; Blotting, Western; Complement Membrane Attack Complex; Dermatomyositis; Endotheli | 2008 |
Motor variant of chronic inflammatory demyelinating polyneuropathy in a child.
Topics: Anti-Inflammatory Agents; Biopsy; Child, Preschool; Electrodiagnosis; Electroencephalography; Electr | 2008 |
[Skeletal muscle weakness in a young woman].
Topics: Adult; Diagnosis, Differential; Drug Administration Schedule; Female; Humans; Muscle Weakness; Muscl | 1994 |
Tongue involvement in a patient with granulomatous myositis.
Topics: Anti-Inflammatory Agents; Deglutition Disorders; Female; Follow-Up Studies; Granuloma; Humans; Middl | 1997 |
Exercise-induced ventilatory abnormalities in orthotopic heart transplant patients.
Topics: Adult; Blood Pressure; Carbon Dioxide; Case-Control Studies; Exercise Test; Exercise Tolerance; Fati | 1997 |
The dropped head plus syndrome: quantitation of response to corticosteroids.
Topics: Adrenal Cortex Hormones; Adult; Azathioprine; Body Mass Index; Drug Therapy, Combination; Head Movem | 1999 |
Giant cell arteritis presenting with proximal weakness and skeletal muscle vasculitis.
Topics: Aged; Drug Therapy, Combination; Female; Giant Cell Arteritis; Humans; Methotrexate; Muscle Weakness | 1999 |
Symptomatic muscle involvement in neurosarcoidosis: a clinicopathological study of 5 cases.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Biopsy; Central Nervous System Diseases; Female; Humans | 2001 |