prednisone has been researched along with Lymphopenia in 38 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Lymphopenia: Reduction in the number of lymphocytes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A remission-induction regimen for childhood leukemia using cyclophosphamide, asparaginase, vincristine, and prednisone (CAVP) was compared to standard vincristine-prednisone (VP) induction." | 7.65 | Cyclophosphamide-asparaginase- vincristine-prednisone induction therapy in childhood acute lymphocytic and nonlymphocytic leukemia. ( Falletta, J; George, SL; Humphrey, GB; Komp, DM; Land, VJ; Lowman, J; Starling, KA, 1976) |
| " Thus, we studied absolute lymphocyte count (ALC) as a marker of poststandard chemotherapy (rituximab, cyclophosphamide, adriamycin, vincristine and prednisone (R-CHOP)) NHL relapse in patients with diffuse large B-cell lymphoma (DLBCL)." | 3.76 | Lymphopenia assessed during routine follow-up after immunochemotherapy (R-CHOP) is a risk factor for predicting relapse in patients with diffuse large B-cell lymphoma. ( Ansell, SM; Colgan, JP; Habermann, TM; Inwards, DJ; Johnston, PB; Markovic, SN; Micallef, IN; Nowakowski, GS; Porrata, LF; Rsitow, K; Thompson, CA; Witzig, TE, 2010) |
| "A 26-year-old woman, diagnosed with diffuse large B-cell lymphoma, was treated with CHOP (cyclophosphamide, hydroxydaunomycin, oncovin, prednisone), rituximab and radiotherapy." | 3.71 | Pure red cell aplasia due to parvovirus following treatment with CHOP and rituximab for B-cell lymphoma. ( Brien, W; Crump, M; Mollee, P; Patterson, B; Song, KW, 2002) |
| " Subsequent to cadaveric renal transplant and 8 years of immunosuppressive treatment with prednisone and azathioprine, the patient developed multiple life-threatening infections." | 3.67 | Hypogammaglobulinemia in a renal transplant recipient with antiglomerular basement membrane disease. ( Hasbargen, J; Rickman, W; Smolin, MR, 1988) |
| "A remission-induction regimen for childhood leukemia using cyclophosphamide, asparaginase, vincristine, and prednisone (CAVP) was compared to standard vincristine-prednisone (VP) induction." | 3.65 | Cyclophosphamide-asparaginase- vincristine-prednisone induction therapy in childhood acute lymphocytic and nonlymphocytic leukemia. ( Falletta, J; George, SL; Humphrey, GB; Komp, DM; Land, VJ; Lowman, J; Starling, KA, 1976) |
| "Lymphopenia is related to an increased risk of opportunistic infections." | 1.48 | Lymphopenia in atopic dermatitis patients treated with oral immunosuppressive drugs. ( Bakker, DS; Bruijnzeel-Koomen, CAFM; de Bruin-Weller, MS; Garritsen, FM; Leavis, HL; van den Broek, MPH; van der Schaft, J, 2018) |
| "Early relapse is a parameter that affects clinical outcomes in relapsed diffuse large B cell lymphoma (DLBCL)." | 1.38 | Lymphopenia following the completion of first-line therapy predicts early relapse in patients with diffuse large B cell lymphoma. ( Aoki, T; Imahashi, N; Kitamura, K; Nishiyama, T, 2012) |
| "We report on two brothers with hyperimmunoglobulinemia D (patient 1: serum immunoglobulin D [IgD] concentration initially 61 IU/ml, later on 340 IU/ml; patient 2: serum IgD concentration 144 IU/ml; normal <100 IU/ml, 97th centile) and periodic fever syndrome (HIDS)." | 1.35 | B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome. ( Ganschow, R; Sornsakrin, M; Wenner, K, 2009) |
| "Lymphocytopenia has been reported in patients with connective tissue diseases, including dermatomyositis (DM)." | 1.32 | Peripheral blood lymphocyte subset counts in patients with dermatomyositis: clinical correlations and changes following therapy. ( Bachelez, H; de la Salmonière, P; Dubertret, L; Fouéré, S; Lebbe, C; Morel, P; Rabian, C; Viguier, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (50.00) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 4 (10.53) | 29.6817 |
| 2010's | 10 (26.32) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Lucijanic, M | 1 |
| Jaksic, O | 1 |
| Bakker, DS | 1 |
| Garritsen, FM | 1 |
| Leavis, HL | 1 |
| van der Schaft, J | 1 |
| Bruijnzeel-Koomen, CAFM | 1 |
| van den Broek, MPH | 1 |
| de Bruin-Weller, MS | 1 |
| Quintanilla-González, L | 1 |
| Torres-Villalobos, G | 1 |
| Hinojosa-Azaola, A | 1 |
| Michaelson, MD | 1 |
| Oudard, S | 1 |
| Ou, YC | 1 |
| Sengeløv, L | 1 |
| Saad, F | 1 |
| Houede, N | 1 |
| Ostler, P | 1 |
| Stenzl, A | 1 |
| Daugaard, G | 1 |
| Jones, R | 1 |
| Laestadius, F | 1 |
| Ullèn, A | 1 |
| Bahl, A | 1 |
| Castellano, D | 1 |
| Gschwend, J | 1 |
| Maurina, T | 1 |
| Chow Maneval, E | 1 |
| Wang, SL | 1 |
| Lechuga, MJ | 1 |
| Paolini, J | 1 |
| Chen, I | 1 |
| Ferreira, JC | 1 |
| Marques, HH | 1 |
| Ferriani, MP | 1 |
| Gormezano, NW | 1 |
| Terreri, MT | 1 |
| Pereira, RM | 1 |
| Magalhães, CS | 1 |
| Campos, LM | 1 |
| Bugni, V | 1 |
| Okuda, EM | 1 |
| Marini, R | 1 |
| Pileggi, GS | 1 |
| Barbosa, CM | 1 |
| Bonfá, E | 1 |
| Silva, CA | 1 |
| Sornsakrin, M | 1 |
| Wenner, K | 1 |
| Ganschow, R | 1 |
| Gluhovschi, C | 1 |
| Gluhovschi, G | 1 |
| Herman, D | 1 |
| Trandafirescu, V | 1 |
| Petrica, L | 1 |
| Velciov, S | 1 |
| Bozdog, G | 1 |
| Bob, F | 1 |
| Cioca, D | 1 |
| Porrata, LF | 1 |
| Rsitow, K | 1 |
| Inwards, DJ | 1 |
| Ansell, SM | 1 |
| Micallef, IN | 1 |
| Johnston, PB | 1 |
| Habermann, TM | 1 |
| Witzig, TE | 1 |
| Colgan, JP | 1 |
| Nowakowski, GS | 1 |
| Thompson, CA | 1 |
| Markovic, SN | 1 |
| Efthimiou, P | 1 |
| Pokharna, H | 1 |
| Kukar, M | 1 |
| Hennessey, K | 1 |
| Aoki, T | 1 |
| Nishiyama, T | 1 |
| Imahashi, N | 1 |
| Kitamura, K | 1 |
| Keel, SB | 1 |
| Phelps, S | 1 |
| Sabo, KM | 1 |
| O'Leary, MN | 1 |
| Kirn-Safran, CB | 1 |
| Abkowitz, JL | 1 |
| Hung, MH | 1 |
| Yu, YB | 1 |
| Huang, YC | 1 |
| Liu, HT | 1 |
| Hong, YC | 1 |
| Hsiao, LT | 1 |
| Liu, JH | 1 |
| Gau, JP | 1 |
| Chiou, TJ | 1 |
| Chen, PM | 1 |
| Tzeng, CH | 1 |
| Liu, CY | 1 |
| Song, KW | 1 |
| Mollee, P | 1 |
| Patterson, B | 1 |
| Brien, W | 1 |
| Crump, M | 1 |
| Viguier, M | 1 |
| Fouéré, S | 1 |
| de la Salmonière, P | 1 |
| Rabian, C | 1 |
| Lebbe, C | 1 |
| Dubertret, L | 1 |
| Morel, P | 1 |
| Bachelez, H | 1 |
| Kim, JG | 1 |
| Sohn, SK | 1 |
| Chae, YS | 1 |
| Cho, YY | 1 |
| Yang, DH | 1 |
| Lee, JJ | 1 |
| Kim, HJ | 1 |
| Shin, HJ | 1 |
| Chung, JS | 1 |
| Cho, GJ | 1 |
| Lee, WS | 1 |
| Joo, YD | 1 |
| Sohn, CH | 1 |
| Oh, SJ | 1 |
| Tabin, R | 1 |
| Guignard, JP | 1 |
| Gautier, E | 1 |
| Dubrit, M | 1 |
| Jeannet, M | 1 |
| Golaz, J | 1 |
| Moretta, L | 1 |
| Brahn, E | 1 |
| Helfgott, SM | 1 |
| Belli, JA | 1 |
| Anderson, RJ | 1 |
| Reinherz, EL | 1 |
| Schlossman, SF | 1 |
| Austen, KF | 1 |
| Trentham, DE | 1 |
| Fries, BC | 1 |
| Khaira, D | 1 |
| Pepe, MS | 1 |
| Torok-Storb, B | 1 |
| Ginsburg, C | 1 |
| Guillevin, L | 1 |
| Sauvaget, F | 1 |
| Lhote, F | 1 |
| Jarrousse, B | 1 |
| Komarover, H | 1 |
| Hachulla, E | 1 |
| Yu, DT | 1 |
| Clements, PJ | 1 |
| Paulus, HE | 1 |
| Peter, JB | 1 |
| Levy, J | 1 |
| Barnett, EV | 1 |
| Friedman, EA | 1 |
| Kosmidis, PA | 1 |
| Axelrod, AR | 1 |
| Palacas, C | 1 |
| Stahl, M | 1 |
| Hamilton, ME | 1 |
| Winfield, JB | 1 |
| Tanner, AR | 1 |
| Powell, LW | 1 |
| Fauci, AS | 2 |
| Komp, DM | 1 |
| George, SL | 1 |
| Falletta, J | 1 |
| Land, VJ | 1 |
| Starling, KA | 1 |
| Humphrey, GB | 1 |
| Lowman, J | 1 |
| Dale, DC | 1 |
| Bar, RS | 1 |
| Adlard, J | 1 |
| Thomas, FB | 1 |
| Belkov, SA | 1 |
| Andriukhin, VI | 1 |
| Korsakov, VB | 1 |
| Pugachev, VF | 1 |
| Riazantsev, EA | 1 |
| Smolin, MR | 1 |
| Rickman, W | 1 |
| Hasbargen, J | 1 |
| Gottlieb, JA | 1 |
| Resnick, J | 1 |
| Schanberger, JE | 1 |
| Coté, CJ | 1 |
| Meuwissen, HJ | 1 |
| Pickering, RJ | 1 |
| Green, AA | 1 |
| Gold, E | 1 |
| Videbaek, A | 1 |
| Evans, DI | 1 |
| Holzel, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Double-Blind, Phase 3 Study Of Sunitinib Plus Prednisone Versus Prednisone In Patients With Progressive Metastatic Castration-Resistant Prostate Cancer After Failure Of A Docetaxel-Based Chemotherapy Regimen[NCT00676650] | Phase 3 | 873 participants (Actual) | Interventional | 2008-07-31 | Terminated (stopped due to Study A6181120 was prematurely discontinued due to futility on 27 September 2010. No new or unexpected safety issues were identified.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
OS is the duration from randomization to death. For participants who were alive, overall survival was censored at the last contact. OS (in months) calculated as (date of death minus [-] date of randomization plus [+] 1) divided (/) 30.4. (NCT00676650)
Timeframe: Baseline up to 32 months
| Intervention | months (Median) |
|---|---|
| Sunitinib and Prednisone | 13.1 |
| Placebo and Prednisone | 11.8 |
OR defined as the percent (%) of participants with confirmed Complete Response (CR) (disappearance of all target lesions) or Partial Response (PR) (>=30% decrease in the sum of the longest dimensions of the target lesions taking as a reference the baseline sum longest dimensions) according to Response Evaluation Criteria in Solid Tumors (RECIST), relative to the full analysis population. Confirmed responses were those that persist on repeat imagining study >= 4 weeks after initial documentation of response. (NCT00676650)
Timeframe: Baseline, every 8 weeks up to 123 weeks
| Intervention | percentage of participants (Number) |
|---|---|
| Sunitinib and Prednisone | 6.1 |
| Placebo and Prednisone | 1.8 |
PFS is the period from randomization until disease progression or death on study. PFS is censored on the date of last tumor assessment documenting absence of progressive disease. PFS (weeks) calculated as (first event date - randomization date + 1)/7.02 (NCT00676650)
Timeframe: Baseline, every 8 weeks up to 123 weeks
| Intervention | weeks (Median) |
|---|---|
| Sunitinib and Prednisone | 24.1 |
| Placebo and Prednisone | 17.9 |
2 reviews available for prednisone and Lymphopenia
| Article | Year |
|---|---|
Corticosteroids in liver disease: possible mechanisms of action, pharmacology, and rational use.
Topics: Adrenal Cortex Hormones; Chronic Disease; Hepatitis; Humans; Immunity, Cellular; Liver Diseases; Liv | 1979 |
Glucocorticoids in haematology.
Topics: Adult; Agranulocytosis; Anemia, Hemolytic, Autoimmune; Antibodies; Blood Cell Count; Blood Cells; Ch | 1969 |
2 trials available for prednisone and Lymphopenia
| Article | Year |
|---|---|
Randomized, placebo-controlled, phase III trial of sunitinib plus prednisone versus prednisone alone in progressive, metastatic, castration-resistant prostate cancer.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Di | 2014 |
Alemtuzumab plus CHOP as front-line chemotherapy for patients with peripheral T-cell lymphomas: a phase II study.
Topics: Adult; Aged; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neo | 2007 |
34 other studies available for prednisone and Lymphopenia
| Article | Year |
|---|---|
Progressive multifocal leukoencephalopathy during rituximab maintenance after rituximab and bendamustine treatment for relapsed follicular lymphoma.
Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; | 2020 |
Lymphopenia in atopic dermatitis patients treated with oral immunosuppressive drugs.
Topics: Administration, Oral; Adult; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dermatitis, Ato | 2018 |
Risk factors for development of early infectious and noninfectious complications in systemic lupus erythematosus patients undergoing major surgery.
Topics: Adolescent; Adult; Aged; Anemia; Aspirin; Child; Elective Surgical Procedures; Female; Humans; Logis | 2018 |
Herpes zoster infection in childhood-onset systemic lupus erythematosus patients: a large multicenter study.
Topics: Acyclovir; Adolescent; Adult; Age of Onset; Antiviral Agents; Brazil; Child; Child, Preschool; Cyclo | 2016 |
B cell cytopenia in two brothers with hyper-IgD and periodic fever syndrome.
Topics: Agammaglobulinemia; Azathioprine; B-Lymphocytes; Child; Fever; Glucocorticoids; Heterozygote; Humans | 2009 |
Treatment of systemic lupus erythematosus in two patients with extreme B-cell lymphopenia: importance of immunomonitoring and avoidance of B-cell targeted therapy.
Topics: Adult; B-Lymphocytes; Blood Pressure; Creatinine; Cyclophosphamide; Fatal Outcome; Female; Humans; I | 2010 |
Lymphopenia assessed during routine follow-up after immunochemotherapy (R-CHOP) is a risk factor for predicting relapse in patients with diffuse large B-cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Anti | 2010 |
PCP chemoprophylaxis is essential for lymphopenic dermatomyositis patients treated with immunomodulators.
Topics: Chemoprevention; Dermatomyositis; Humans; Inflammation Mediators; Lymphopenia; Male; Middle Aged; Op | 2011 |
Lymphopenia following the completion of first-line therapy predicts early relapse in patients with diffuse large B cell lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antin | 2012 |
Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis.
Topics: Agranulocytosis; Alleles; Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Chromosome Deletion | 2012 |
Patients with diffuse large B cell lymphoma in partial response or stable disease after first-line R-CHOP: the prognostic value of the absolute lymphocyte count and impact of autologous stem cell transplantation.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antineoplastic Combined Chemoth | 2012 |
Pure red cell aplasia due to parvovirus following treatment with CHOP and rituximab for B-cell lymphoma.
Topics: Acute Disease; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic | 2002 |
Peripheral blood lymphocyte subset counts in patients with dermatomyositis: clinical correlations and changes following therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; | 2003 |
Corticoresistant nephrotic syndrome associated with T-cell deficiency in two sisters.
Topics: Child; Child, Preschool; Consanguinity; Female; Glomerulosclerosis, Focal Segmental; Humans; Immunol | 1983 |
Total lymphoid irradiation therapy in refractory rheumatoid arthritis. Fifteen- to forty-month followup.
Topics: Adult; Aged; Anemia, Aplastic; Arthritis, Rheumatoid; Blood Transfusion; Bone Marrow; Drug Resistanc | 1984 |
Declining lymphocyte counts following cytomegalovirus (CMV) infection are associated with fatal CMV disease in bone marrow transplant patients.
Topics: Adult; Bone Marrow Transplantation; Cytomegalovirus Infections; Dexamethasone; Female; Graft vs Host | 1993 |
[Systemic diseases treated by corticoids, plasma exchange and cyclophosphamide: infectious complications and lymphopenia].
Topics: Adult; Aged; Bacterial Infections; Cyclophosphamide; Female; Humans; Lymphopenia; Male; Middle Aged; | 1993 |
Arthritis and primary antiphospholipid syndrome.
Topics: Antibodies, Antinuclear; Antiphospholipid Syndrome; Arthritis; Humans; Lupus Erythematosus, Systemic | 1997 |
Human lymphocyte subpopulations. Effect of corticosteroids.
Topics: B-Lymphocytes; Female; Glucocorticoids; Humans; Hydrocortisone; Lymphocyte Count; Lymphocyte Subsets | 1974 |
Corticosteroids in immunosuppression: partial fulfillment of a promise.
Topics: Antibody Formation; Azathioprine; Cell Membrane; Cyclophosphamide; Glucocorticoids; Graft Rejection; | 1975 |
Angioimmunoblastic lymphadenopathy: a T-cell deficiency.
Topics: B-Lymphocytes; Cell Migration Inhibition; Humans; Immunity, Cellular; In Vitro Techniques; Lymphatic | 1978 |
Tgamma cells in systemic lupus erythematosus. Variation with disease activity.
Topics: B-Lymphocytes; Fluorescent Antibody Technique; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G | 1979 |
Corticosteroids and circulating lymphocytes.
Topics: Administration, Oral; Animals; Cell Movement; Chromium Radioisotopes; Glucocorticoids; Guinea Pigs; | 1975 |
Cyclophosphamide-asparaginase- vincristine-prednisone induction therapy in childhood acute lymphocytic and nonlymphocytic leukemia.
Topics: Asparaginase; Child; Cyclophosphamide; Drug Therapy, Combination; Humans; Leukemia; Leukemia, Lympho | 1976 |
Alternate-day prednisone therapy and human lymphocyte subpopulations.
Topics: Adolescent; Adult; Aged; Chromium Radioisotopes; Collagen Diseases; Female; Humans; Hypersensitivity | 1975 |
Lymphopenic infectious mononucleosis.
Topics: Acute Kidney Injury; Adolescent; Adrenal Cortex Hormones; Anti-Bacterial Agents; Bicarbonates; Digit | 1975 |
[Plasmapheresis in the treatment of cytostatic disease in patients with lymphogranulomatosis].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; | 1991 |
Hypogammaglobulinemia in a renal transplant recipient with antiglomerular basement membrane disease.
Topics: Adult; Agammaglobulinemia; Anti-Glomerular Basement Membrane Disease; Azathioprine; Basement Membran | 1988 |
Combination chemotherapy: rationale for schedule selection and use of agents with independent toxicities in phase I and II clinical trials.
Topics: Acute Disease; Adult; Agranulocytosis; BCG Vaccine; Bleomycin; Cytarabine; Doxorubicin; Drug Combina | 1973 |
Varicella reactivation in nephrotic syndrome treated with cyclophosphamide and adrenal corticosteroids.
Topics: Antibodies, Viral; Antibody Formation; Chickenpox; Child, Preschool; Cyclophosphamide; Female; Fluor | 1973 |
Effects on the neonate of prednisone and azathioprine administered to the mother during pregnancy.
Topics: Azathioprine; Cytomegalovirus; Female; Glomerulonephritis; Humans; Immunoglobulin A; Immunoglobulin | 1974 |
The prognostic value of bone marrow lymphocytes in acute lymphocytic leukemia of childhood.
Topics: Adolescent; Age Factors; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Cell Count; Child; | 1974 |
Infections associated with immunologic deficiency diseases.
Topics: Acute Kidney Injury; Adult; Agammaglobulinemia; Anti-Bacterial Agents; Antibody Formation; Aspergill | 1974 |
Immune deficiency state in a girl with eczema and low serum IgM. Possible female variant of Wiskott-Aldrich syndrome.
Topics: Antibodies; Child; Child, Preschool; Eczema; Female; Herpes Simplex; Humans; Immunoglobulin M; Immun | 1970 |