prednisone has been researched along with Hyperglycemia, Postprandial in 74 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.
Excerpt | Relevance | Reference |
---|---|---|
"To assess metformin's prophylactic effectiveness of prednisone-induced hyperglycemia among hematological cancer patients." | 9.34 | Metformin's effectiveness in preventing prednisone-induced hyperglycemia in hematological cancers. ( Guantai, EM; Nyamu, DG; Ochola, LA; Weru, IW, 2020) |
"We determined retrospectively the frequency and risk of hyperglycemia in 421 children with leukemia who had received L-asparaginase and prednisone as part of their remission induction therapy." | 7.66 | Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone. ( Aur, RJ; Bowman, WP; Burghen, GA; Pui, CH, 1981) |
"L-Asparaginase was added to vincristine and prednisone for induction of first remission in 815 children with acute lymphocytic or acute undifferentiated leukemia." | 7.65 | L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia. ( Donaldson, MH; Hammond, D; Hittle, RE; Karon, M; Nesbit, ME; Ortega, JA; Weiner, J, 1977) |
"To assess metformin's prophylactic effectiveness of prednisone-induced hyperglycemia among hematological cancer patients." | 5.34 | Metformin's effectiveness in preventing prednisone-induced hyperglycemia in hematological cancers. ( Guantai, EM; Nyamu, DG; Ochola, LA; Weru, IW, 2020) |
"We have recently shown that adjunct prednisone shortens the time taken to reach clinical stability (time to clinical stability, TTCS) in patients with community-acquired pneumonia (CAP)." | 5.22 | Benefit of adjunct corticosteroids for community-acquired pneumonia in diabetic patients. ( Blum, CA; Christ-Crain, M; Mueller, B; Nigro, N; Popovic, M; Schuetz, P, 2016) |
" This study assessed whether treatment with the glucagon-like peptide receptor agonist (GLP-1 RA) exenatide (EXE) could prevent GC-induced glucose intolerance." | 5.15 | Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans. ( Diamant, M; Linssen, MM; Ouwens, DM; van Genugten, RE; van Raalte, DH, 2011) |
"Many adjuvant chemotherapy regimens used for breast cancer include prednisone, which has the potential to cause hyperglycemia." | 5.06 | Hyperglycemic complications associated with adjuvant chemotherapy of breast cancer. A cancer and leukemia group B (CALGB) study. ( Ellis, ME; Korzun, AH; Lesnick, GJ; Norton, L; Perloff, M; Rice, MA; Weiss, RB; Wood, WC, 1986) |
" After being treated for a presumed asthma exacerbation with prednisone, she experienced worsening dyspnea, night sweats, and unintentional weight loss." | 3.88 | A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report. ( Herzog, EL; Homer, R; Kelleher, DW; Ryu, C; Yaggi, M, 2018) |
"1007/s00125-016-4091-4 ) have conducted a subanalysis within a randomised controlled trial of prednisone therapy for community-acquired pneumonia." | 3.83 | Steroid-induced hyperglycaemia in hospitalised patients: does it matter? ( Cheung, NW, 2016) |
"We determined retrospectively the frequency and risk of hyperglycemia in 421 children with leukemia who had received L-asparaginase and prednisone as part of their remission induction therapy." | 3.66 | Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone. ( Aur, RJ; Bowman, WP; Burghen, GA; Pui, CH, 1981) |
"L-Asparaginase was added to vincristine and prednisone for induction of first remission in 815 children with acute lymphocytic or acute undifferentiated leukemia." | 3.65 | L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia. ( Donaldson, MH; Hammond, D; Hittle, RE; Karon, M; Nesbit, ME; Ortega, JA; Weiner, J, 1977) |
"Six regimens utilizing L-asparaginase in doses of 6,000 IU/M2, 2,000 IU/M2, and 500 IU/M2 in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 previously treated children with acute leukemia in relapse." | 3.65 | Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia. ( George, S; Haggard, ME; Humphrey, GB; Lowman, JT; Starling, KA; Sutow, WW; Vietti, TJ, 1976) |
" Here we characterise the safety of these agents in subpopulations and assess manageability of key adverse events (AEs)." | 3.30 | Safety Profile of Ipatasertib Plus Abiraterone vs Placebo Plus Abiraterone in Metastatic Castration-resistant Prostate Cancer. ( Bracarda, S; Chen, G; Chi, KN; de Bono, J; Garcia, J; Harris, A; Hinton, H; Massard, C; Matsubara, N; Olmos, D; Sandhu, S; Sane, R; Schenkel, F; Sternberg, CN; Sweeney, C, 2023) |
"Treatment with dapagliflozin was safe and there was no difference in risk of hypoglycaemia compared with placebo." | 2.87 | Dapagliflozin for prednisone-induced hyperglycaemia in acute exacerbation of chronic obstructive pulmonary disease. ( Brandjes, DPM; Gerards, MC; Gerdes, VEA; Hageman, IMG; Hoekstra, JBL; Kross, M; Patberg, KW; Potter van Loon, BJ; Snijders, D; Venema, GE; Vriesendorp, TM, 2018) |
"Glucocorticoids have powerful anti-inflammatory and immunomodulatory effects, but chronic use of these drugs can cause hyperglycemia, type 2 diabetes mellitus, hepatic steatosis, obesity, and other complications due to their metabolic actions." | 2.82 | The effect of metformin on glucose metabolism in patients receiving glucocorticoids. ( Fernandez, F; Landis, D; Nugent, K; Sutter, A, 2022) |
"Weight gain was also common, with a mean increase in body mass index of 1." | 2.74 | Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. ( Alexander, TH; Brookhouser, PE; Derebery, JM; Espeland, MA; Gantz, BJ; Gulya, AJ; Hammerschlag, PE; Hannley, M; Harris, JP; Hughes, GB; Moscicki, R; Nelson, RA; Niparko, JK; Rauch, SD; Telian, SA; Weisman, MH, 2009) |
" Long-term use of prednisone can give rise to multiple side effects and morbidity." | 2.68 | Late prednisone withdrawal in cyclosporine-treated kidney transplant patients: a randomized study. ( Hene, RJ; Hermans, J; Hollander, AA; van der Woude, FJ; van Es, LA, 1997) |
" More aggressive dosing initiation of NPH based on steroid dose may allow for earlier achievement of euglycemia without a difference in hypoglycemia." | 1.62 | Insulin NPH for steroid-induced hyperglycemia: Predictors for success. ( Dungan, K; Gaborcik, JW; Stone, AC, 2021) |
"Idiopathic Idiopathic membranous nephropathy (iMN) is an immune-complex mediated renal disease which is usually associated with the nephrotic syndrome (NS)." | 1.56 | Idiopathic Membranous Nephropathy and Treatment Related Complications. ( Dzemidzic, J; Haskovic, D; Muslimovic, A; Serdarevic, N; Uncanin, S, 2020) |
"We conclude that hyperglycemia is common during first-line NHL treatment with R-CHOP or DA-EPOCH-R, even in the absence of known diabetes and is associated with alterations of chemotherapy." | 1.48 | Hyperglycemia during first-line R-CHOP or dose adjusted R-EPOCH chemotherapy for non-Hodgkin lymphoma is prevalent and associated with chemotherapy alteration - a retrospective study. ( Dothard, A; Hurd, D; Isom, S; Kennedy, L; Lamar, ZS; Lesser, G; McClain, D; Robinson, M; Vaidya, R, 2018) |
"To investigate whether long-term use of low-dose P with or without AA leads to corticosteroid-associated adverse events (CA-AEs) in mCRPC patients." | 1.43 | Low Incidence of Corticosteroid-associated Adverse Events on Long-term Exposure to Low-dose Prednisone Given with Abiraterone Acetate to Patients with Metastatic Castration-resistant Prostate Cancer. ( Charnas, R; Chi, KN; de Bono, JS; De Porre, P; Fizazi, K; Gomella, LG; Londhe, A; McGowan, T; Miller, K; Montgomery, B; Pelhivanov, N; Rathkopf, DE; Ryan, CJ; Scher, HI; Shore, ND; Todd, MB, 2016) |
"When prednisone was administered as a once daily morning dose, glucose levels peaked in the afternoon, and would return to baseline by the next morning." | 1.39 | The high incidence of steroid-induced hyperglycaemia in hospital. ( Cheung, NW; Fong, AC, 2013) |
"To investigate whether children with acute lymphocytic leukemia (ALL) who have development of hyperglycemia during induction may have worse relapse-free (RFS) and overall survival (OS) rates." | 1.35 | Hyperglycemia during induction therapy is associated with poorer survival in children with acute lymphocytic leukemia. ( Haymond, MW; Margolin, JF; McKay, SV; Okcu, MF; Sonabend, RY; Yan, J, 2009) |
"Troglitazone (TGZ) treatment, beginning at 6 weeks of age, prevented the hyperglycemia, the hyperlipidemia, and the increase in 11beta-HSD-1." | 1.32 | Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone. ( Agarwal, AK; Duplomb, L; Lee, Y; Park, BH; Takaishi, K; Unger, RH; Wang, MY, 2004) |
"Hyperglycemia has been linked to increased oxidative stress, leading to endothelial dysfunction, delayed cell replication, and enhanced apoptosis." | 1.32 | Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats. ( Abraham, NG; Goodman, AI; Ikehara, S; Inaba, M; Kaminski, PM; Morita, T; Quan, S; Wolin, MS; Yang, L, 2004) |
"We report a patient with systemic lupus erythematosus and severe insulin resistance due to insulin receptor antibodies." | 1.30 | Insulin receptor antibodies and insulin resistance. ( Magsino, CH; Spencer, J, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 38 (51.35) | 18.7374 |
1990's | 6 (8.11) | 18.2507 |
2000's | 8 (10.81) | 29.6817 |
2010's | 17 (22.97) | 24.3611 |
2020's | 5 (6.76) | 2.80 |
Authors | Studies |
---|---|
Landis, D | 1 |
Sutter, A | 1 |
Fernandez, F | 1 |
Nugent, K | 1 |
Matsubara, N | 1 |
de Bono, J | 1 |
Sweeney, C | 1 |
Chi, KN | 2 |
Olmos, D | 1 |
Sandhu, S | 1 |
Massard, C | 1 |
Garcia, J | 1 |
Chen, G | 1 |
Harris, A | 1 |
Schenkel, F | 1 |
Sane, R | 1 |
Hinton, H | 1 |
Bracarda, S | 1 |
Sternberg, CN | 1 |
Ochola, LA | 1 |
Nyamu, DG | 1 |
Guantai, EM | 1 |
Weru, IW | 1 |
Aisyi, M | 1 |
Andriastuti, M | 1 |
Kurniati, N | 1 |
Uncanin, S | 1 |
Dzemidzic, J | 1 |
Serdarevic, N | 1 |
Muslimovic, A | 1 |
Haskovic, D | 1 |
Stone, AC | 1 |
Dungan, K | 1 |
Gaborcik, JW | 1 |
Lamar, ZS | 1 |
Dothard, A | 1 |
Kennedy, L | 1 |
Isom, S | 1 |
Robinson, M | 1 |
Vaidya, R | 1 |
Hurd, D | 1 |
McClain, D | 1 |
Lesser, G | 1 |
Gerards, MC | 1 |
Venema, GE | 1 |
Patberg, KW | 1 |
Kross, M | 1 |
Potter van Loon, BJ | 1 |
Hageman, IMG | 1 |
Snijders, D | 1 |
Brandjes, DPM | 1 |
Hoekstra, JBL | 1 |
Vriesendorp, TM | 1 |
Gerdes, VEA | 1 |
Kelleher, DW | 1 |
Yaggi, M | 1 |
Homer, R | 1 |
Herzog, EL | 1 |
Ryu, C | 1 |
Abroug, F | 1 |
Ouanes-Besbes, L | 1 |
Fkih-Hassen, M | 1 |
Ouanes, I | 1 |
Ayed, S | 1 |
Dachraoui, F | 1 |
Brochard, L | 1 |
Elatrous, S | 1 |
Rowbottom, L | 1 |
Stinson, J | 1 |
McDonald, R | 1 |
Emmenegger, U | 1 |
Cheng, S | 1 |
Lowe, J | 1 |
Giotis, A | 1 |
Cheon, P | 1 |
Chow, R | 1 |
Pasetka, M | 1 |
Thavarajah, N | 1 |
Pulenzas, N | 1 |
Chow, E | 1 |
DeAngelis, C | 1 |
Fizazi, K | 1 |
de Bono, JS | 1 |
Gomella, LG | 1 |
Miller, K | 1 |
Rathkopf, DE | 1 |
Ryan, CJ | 1 |
Scher, HI | 1 |
Shore, ND | 1 |
De Porre, P | 1 |
Londhe, A | 1 |
McGowan, T | 1 |
Pelhivanov, N | 1 |
Charnas, R | 1 |
Todd, MB | 1 |
Montgomery, B | 1 |
Popovic, M | 1 |
Blum, CA | 1 |
Nigro, N | 1 |
Mueller, B | 1 |
Schuetz, P | 1 |
Christ-Crain, M | 1 |
Cheung, NW | 2 |
Wong, D | 1 |
Walsh, S | 1 |
Alhusayen, R | 1 |
Lowas, SR | 1 |
Marks, D | 1 |
Malempati, S | 1 |
Sonabend, RY | 1 |
McKay, SV | 1 |
Okcu, MF | 1 |
Yan, J | 1 |
Haymond, MW | 1 |
Margolin, JF | 1 |
Alexander, TH | 1 |
Weisman, MH | 1 |
Derebery, JM | 1 |
Espeland, MA | 1 |
Gantz, BJ | 1 |
Gulya, AJ | 1 |
Hammerschlag, PE | 1 |
Hannley, M | 1 |
Hughes, GB | 1 |
Moscicki, R | 1 |
Nelson, RA | 1 |
Niparko, JK | 1 |
Rauch, SD | 1 |
Telian, SA | 1 |
Brookhouser, PE | 1 |
Harris, JP | 1 |
Murray, SC | 1 |
Gasser, A | 1 |
Hess, RS | 1 |
Wallia, A | 1 |
Parikh, ND | 1 |
Molitch, ME | 1 |
Mahler, E | 1 |
Tian, L | 1 |
Huang, JJ | 1 |
Levitsky, J | 1 |
Brunello, A | 1 |
Kapoor, R | 1 |
Extermann, M | 1 |
Pidala, J | 1 |
Kim, J | 1 |
Kharfan-Dabaja, MA | 1 |
Nishihori, T | 1 |
Field, T | 1 |
Perkins, J | 1 |
Perez, L | 1 |
Fernandez, H | 1 |
Anasetti, C | 1 |
El-Darouti, MA | 1 |
Mashaly, HM | 1 |
El-Nabarawy, E | 1 |
El-Tawdy, AM | 1 |
Fawzy, MM | 1 |
Salem, DS | 1 |
El-Kaffas, KM | 1 |
El Sayed, DA | 1 |
van Raalte, DH | 1 |
van Genugten, RE | 1 |
Linssen, MM | 1 |
Ouwens, DM | 1 |
Diamant, M | 1 |
Udoetuk, JD | 1 |
Dai, Y | 1 |
Ying, GS | 1 |
Daniel, E | 1 |
Gangaputra, S | 1 |
Rosenbaum, JT | 1 |
Suhler, EB | 1 |
Thorne, JE | 1 |
Foster, CS | 1 |
Jabs, DA | 1 |
Levy-Clarke, GA | 1 |
Nussenblatt, RB | 1 |
Kempen, JH | 1 |
Fong, AC | 1 |
RIFKIND, D | 1 |
MARCHIORO, TL | 1 |
WADDELL, WR | 1 |
STARZL, TE | 1 |
BLEREAU, RP | 1 |
WEINGARTEN, CM | 1 |
Duplomb, L | 1 |
Lee, Y | 1 |
Wang, MY | 1 |
Park, BH | 1 |
Takaishi, K | 1 |
Agarwal, AK | 1 |
Unger, RH | 1 |
Quan, S | 1 |
Kaminski, PM | 1 |
Yang, L | 1 |
Morita, T | 1 |
Inaba, M | 1 |
Ikehara, S | 1 |
Goodman, AI | 1 |
Wolin, MS | 1 |
Abraham, NG | 1 |
Pestaner, JP | 1 |
Laselle, BT | 1 |
Boggio, LN | 1 |
Blum, MG | 1 |
Slansky, HH | 1 |
Kolbert, G | 1 |
Gartner, S | 1 |
Blaim, A | 1 |
Leśkiewicz, W | 1 |
Golczyk-Wojnar, A | 1 |
Dacou-Voutetakis, C | 1 |
Palis, J | 1 |
Haidas, S | 1 |
Zannos-Mariolea, L | 1 |
Georgiopoulou, P | 1 |
Matsaniotis, N | 1 |
Pui, CH | 1 |
Burghen, GA | 1 |
Bowman, WP | 1 |
Aur, RJ | 2 |
Sutherland, DE | 1 |
Goetz, FC | 1 |
Elick, BA | 1 |
Najarian, JS | 2 |
Davisson, NA | 1 |
Westervelt, FB | 1 |
Bolton, WK | 1 |
Hollander, AA | 1 |
Hene, RJ | 1 |
Hermans, J | 1 |
van Es, LA | 1 |
van der Woude, FJ | 1 |
Kailin, X | 1 |
Yushu, H | 1 |
Qingchao, W | 1 |
Yuanbo, L | 1 |
Walker, RE | 1 |
McCrindle, BW | 1 |
Coles, JG | 1 |
West, LJ | 1 |
Niewoehner, DE | 1 |
Erbland, ML | 1 |
Deupree, RH | 1 |
Collins, D | 1 |
Gross, NJ | 1 |
Light, RW | 1 |
Anderson, P | 1 |
Morgan, NA | 1 |
Magsino, CH | 1 |
Spencer, J | 1 |
Leventhal, B | 1 |
Soave, R | 1 |
Mouradian, J | 1 |
Cheigh, JS | 1 |
Ortega, JA | 1 |
Nesbit, ME | 1 |
Donaldson, MH | 1 |
Hittle, RE | 1 |
Weiner, J | 1 |
Karon, M | 1 |
Hammond, D | 1 |
Sutow, WW | 1 |
George, S | 1 |
Lowman, JT | 1 |
Starling, KA | 2 |
Humphrey, GB | 1 |
Haggard, ME | 1 |
Vietti, TJ | 1 |
Ridgway, D | 1 |
Neerhout, RC | 1 |
Bleyer, A | 1 |
Grimaldi, A | 1 |
Saint-Jean, O | 1 |
Bosquet, F | 1 |
Pennaforte, S | 1 |
Walker, ED | 1 |
Miyoshi, H | 1 |
Shulman, GI | 1 |
Peters, EJ | 1 |
Wolfe, MH | 1 |
Elahi, D | 1 |
Wolfe, RR | 1 |
Ellis, ME | 1 |
Weiss, RB | 1 |
Korzun, AH | 1 |
Rice, MA | 1 |
Norton, L | 1 |
Perloff, M | 1 |
Lesnick, GJ | 1 |
Wood, WC | 1 |
Curless, RG | 2 |
Flynn, J | 1 |
Bachynski, B | 1 |
Gregorios, JB | 1 |
Benke, P | 1 |
Cullen, R | 2 |
Bachynski, BN | 1 |
Flynn, JT | 1 |
Rodrigues, MM | 1 |
Rosenthal, S | 1 |
Vesely, DL | 1 |
Coleman, MJ | 1 |
Kohler, PO | 1 |
Jordan, RM | 1 |
Stanley, S | 1 |
Trygstad, O | 1 |
Foss, I | 1 |
Knappe, G | 1 |
Flemming, F | 1 |
Stobbe, H | 1 |
Wendt, F | 1 |
Anderson, RJ | 2 |
Schafer, LA | 2 |
Olin, DB | 2 |
Eickhoff, TC | 3 |
Lampe, EW | 1 |
Ruiz, JO | 1 |
Simmons, RL | 1 |
Daouk, AA | 1 |
Malek, GH | 1 |
Kauffman, HM | 1 |
Kisken, WA | 1 |
Falletta, JM | 1 |
Steuber, CP | 1 |
Hayes, JW | 1 |
Hill, LL | 1 |
Snowdon, JA | 1 |
Crowther, D | 1 |
Ryan, WG | 1 |
Schwartz, TB | 1 |
Nibbe, AF | 1 |
Ashworth, CJ | 1 |
Sacks, Y | 1 |
Williams, LF | 1 |
Byrne, JJ | 1 |
Corneo, G | 1 |
Cortellaro, M | 1 |
Maiolo, AT | 1 |
Pierce, LE | 1 |
O'Brien, JJ | 1 |
Limas, CJ | 1 |
Samad, A | 1 |
Seff, D | 1 |
Simone, JV | 1 |
Pratt, CB | 1 |
Lewis, GP | 1 |
Jick, H | 1 |
Slone, D | 1 |
Shapiro, S | 1 |
Onuma, T | 1 |
Rosner, F | 1 |
Levy, RN | 1 |
Cuttner, J | 1 |
Moon, JH | 1 |
Silver, RT | 1 |
Blom, J | 1 |
Falkson, G | 1 |
Burningham, R | 1 |
Glidewell, O | 1 |
Holland, JF | 1 |
Ulmer, WT | 1 |
Nicolas, R | 1 |
Toussaint, D | 1 |
Farnir, A | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Corticosteroid Treatment for Community-Acquired Pneumonia A Randomized, Double-blind Study- The STEP Trial[NCT00973154] | Phase 3 | 800 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
Metformin as an Adjunctive Therapy For Transient Hyperglycemia in Patients With Acute Lymphoblastic Leukemia During Induction Chemotherapy[NCT01486043] | 4 participants (Actual) | Interventional | 2011-12-31 | Terminated (stopped due to The research project was terminated due to lower than projected patient recruitment within the period of time allowed for the study.) | |||
Effect of Steroids on Post-tonsillectomy Morbidities[NCT02401529] | Phase 2 | 100 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
Prednisolone-induced Impairment of Glucose Metabolism and Beta-cell Dysfunction and the Protective Effects of Exenatide: a Single-center, Randomized, Double-blind, Placebo-controlled Crossover Study in Healthy Volunteers[NCT00744224] | 8 participants (Anticipated) | Interventional | 2009-02-28 | Completed | |||
"Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD - a Randomized, Double-blind, Non-inferiority Study (The RECUT-Trial)"[NCT02386735] | 470 participants (Anticipated) | Interventional | 2015-03-31 | Recruiting | |||
Effect of Prolonged (72 Hour) Glucagon Administration on Energy Expenditure in Healthy Obese Subjects[NCT03139305] | Phase 1 | 30 participants (Anticipated) | Interventional | 2017-10-24 | Active, not recruiting | ||
A Pilot Study to Determine Tolerability to Glucagon Infusion in Obese Subjects[NCT02817659] | Phase 1 | 20 participants (Actual) | Interventional | 2016-11-01 | Active, not recruiting | ||
A Prospective Randomized, Placebo (Saline)-Controlled, Balanced, 3-treatment Regimen Crossover Study Comparing the Effects of Prolonged (13 h) Hyperglucagonemia With Those of Acute (3 hr) Hyperglucagonemia on Energy Expenditure and Endogenous Glucose Prot[NCT02237053] | Phase 1 | 6 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
(NCT01486043)
Timeframe: At 1 month
Intervention | percent of hemoglobin (Mean) |
---|---|
Metformin and Insulin Therapy | 4.8 |
(NCT01486043)
Timeframe: During the 30 days of induction chemotherapy (plus or minus 2 weeks)
Intervention | days (Mean) |
---|---|
Metformin and Insulin Therapy | 7.5 |
(NCT01486043)
Timeframe: At 1 month
Intervention | uM (Mean) |
---|---|
Metformin and Insulin Therapy | 190 |
adequacy of meals (inadequate, adequate) (NCT02401529)
Timeframe: 3 days
Intervention | participants (Number) | |
---|---|---|
inadequate | adequate | |
IV Dexamethasone and Oral Prednisolone | 16 | 34 |
Placebo | 27 | 23 |
average frequency of meals (1 meal, 2 meals, if more specify) (NCT02401529)
Timeframe: average number of meals consumed per day for the 1st three days post-surgery
Intervention | participants (Number) | ||
---|---|---|---|
1 meal | 2 meals | 3 meals | |
IV Dexamethasone and Oral Prednisolone | 2 | 20 | 28 |
Placebo | 1 | 34 | 15 |
Postoperative nausea duration (no nausea,1 day, 2 days, 3 days, 4 days, if more specify) (NCT02401529)
Timeframe: 7 days
Intervention | participants (Number) | |||
---|---|---|---|---|
no nausea | one day | two days | three days | |
IV Dexamethasone and Oral Prednisolone | 33 | 3 | 14 | 0 |
Placebo | 21 | 8 | 15 | 6 |
4 selections (1 day, 2 days, 3 days, if more specify) (NCT02401529)
Timeframe: number of days at which pain was experienced within the the 1st sevn days post -surgery
Intervention | participants (Number) | ||
---|---|---|---|
one day | two days | three days | |
IV Dexamethasone and Oral Prednisolone | 36 | 11 | 3 |
Placebo | 23 | 19 | 8 |
5 grades (pain free, low disability and low intensity, low disability and high intensity, high disability and moderate intensity, high disability and severly limiting) (NCT02401529)
Timeframe: The severest pain grade felt within a week
Intervention | participants (Number) | ||
---|---|---|---|
Low disability and low intensity | high disability and moderate intensity | high disability and high intensity | |
IV Dexamethasone and Oral Prednisolone | 37 | 13 | 0 |
Placebo | 26 | 21 | 3 |
Postoperative nausea occurence (yes, no) (NCT02401529)
Timeframe: 7 days
Intervention | participants (Number) | |
---|---|---|
yes | no | |
IV Dexamethasone and Oral Prednisolone | 17 | 33 |
Placebo | 29 | 21 |
Postoperative vomiting occurrence (yes, no) (NCT02401529)
Timeframe: 7 days
Intervention | participants (Number) | |
---|---|---|
yes | no | |
IV Dexamethasone and Oral Prednisolone | 25 | 25 |
Placebo | 36 | 14 |
feeding onset (1st day i. surgery day, 2nd day, 3rd day) (NCT02401529)
Timeframe: Onset of 1st post-operative oral intake recorded within the 1st 3days post-surgery
Intervention | participants (Number) | |
---|---|---|
surgery day | 1st day after surgery | |
IV Dexamethasone and Oral Prednisolone | 46 | 4 |
Placebo | 37 | 13 |
Postoperative nausea onset (no nausea, immediate, 1st day, 2nd day, 3rd day, 4th day, 5th day, 6th day, 7th day) (NCT02401529)
Timeframe: onset of 1st ocurence of nausea attack within the 1st week post-surgery
Intervention | participants (Number) | |||
---|---|---|---|---|
no nausea | immediately | 1st day | immediately and 1st day | |
IV Dexamethasone and Oral Prednisolone | 33 | 10 | 4 | 3 |
Placebo | 21 | 8 | 11 | 10 |
Postoperative vomiting number of attacks (no vomiting,1, 2, 3, if more specify) (NCT02401529)
Timeframe: total number of post-operative vomiting episodes which were experienced within the 1st week post-surgery
Intervention | participants (Number) | ||||
---|---|---|---|---|---|
no vomiting | once | twice | three times | more than 3 times | |
IV Dexamethasone and Oral Prednisolone | 25 | 13 | 7 | 4 | 1 |
Placebo | 14 | 9 | 19 | 8 | 0 |
1 review available for prednisone and Hyperglycemia, Postprandial
Article | Year |
---|---|
The effect of metformin on glucose metabolism in patients receiving glucocorticoids.
Topics: Anti-Inflammatory Agents; Blood Glucose; Diabetes Mellitus, Type 2; Fatty Acids; Glucocorticoids; Hu | 2022 |
11 trials available for prednisone and Hyperglycemia, Postprandial
Article | Year |
---|---|
Safety Profile of Ipatasertib Plus Abiraterone vs Placebo Plus Abiraterone in Metastatic Castration-resistant Prostate Cancer.
Topics: Abiraterone Acetate; Antineoplastic Combined Chemotherapy Protocols; Exanthema; Humans; Hyperglycemi | 2023 |
Metformin's effectiveness in preventing prednisone-induced hyperglycemia in hematological cancers.
Topics: Adult; Aged; Blood Glucose; Fasting; Female; Hematologic Neoplasms; Humans; Hyperglycemia; Hypoglyce | 2020 |
Dapagliflozin for prednisone-induced hyperglycaemia in acute exacerbation of chronic obstructive pulmonary disease.
Topics: Aged; Benzhydryl Compounds; Combined Modality Therapy; Diabetes Mellitus, Type 2; Double-Blind Metho | 2018 |
Prednisone in COPD exacerbation requiring ventilatory support: an open-label randomised evaluation.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Disease Progression; Female; Humans; Hyperglyc | 2014 |
Benefit of adjunct corticosteroids for community-acquired pneumonia in diabetic patients.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Community-Acquired Infections; Diabetes Mellitus; | 2016 |
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease.
Topics: Adrenal Cortex Hormones; Adult; Aged; Autoimmune Diseases; Double-Blind Method; Ear, Inner; Female; | 2009 |
Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans.
Topics: Adolescent; Adult; Blood Glucose; C-Peptide; Cross-Over Studies; Exenatide; Glucagon-Like Peptide 1; | 2011 |
Abnormal glucose tolerance in children with acute leukemia. Effect of induction chemotherapy including L-asparaginase.
Topics: Adolescent; Asparaginase; Blood Glucose; Child; Child, Preschool; Drug Therapy, Combination; Female; | 1983 |
Late prednisone withdrawal in cyclosporine-treated kidney transplant patients: a randomized study.
Topics: Adult; Aged; Cyclosporine; Drug Therapy, Combination; Female; Graft Rejection; Humans; Hypercholeste | 1997 |
Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group.
Topics: Administration, Oral; Aged; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combina | 1999 |
Hyperglycemic complications associated with adjuvant chemotherapy of breast cancer. A cancer and leukemia group B (CALGB) study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Clinical Trials as Topi | 1986 |
62 other studies available for prednisone and Hyperglycemia, Postprandial
Article | Year |
---|---|
The Effect of Combination of Steroid and L-Asparaginase on Hyperglycemia in Children with Acute Lymphoblastic Leukemia (ALL).
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; D | 2019 |
Idiopathic Membranous Nephropathy and Treatment Related Complications.
Topics: Anti-Inflammatory Agents; Anticoagulants; Antineoplastic Agents, Alkylating; Chlorambucil; Drug Ther | 2020 |
Insulin NPH for steroid-induced hyperglycemia: Predictors for success.
Topics: Adult; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin, Isophane; Prednisone; Retrospective Stud | 2021 |
Hyperglycemia during first-line R-CHOP or dose adjusted R-EPOCH chemotherapy for non-Hodgkin lymphoma is prevalent and associated with chemotherapy alteration - a retrospective study.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Blood | 2018 |
A rare presentation of pulmonary sarcoidosis as a solitary lung mass: a case report.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Bronchoscopy; Diabetes Mellitus, Type 2; Diagnosis, Differe | 2018 |
Retrospective review of the incidence of monitoring blood glucose levels in patients receiving corticosteroids with systemic anticancer therapy.
Topics: Aged; Antineoplastic Agents; Blood Glucose; Comorbidity; Dexamethasone; Diabetes Complications; Diab | 2015 |
Low Incidence of Corticosteroid-associated Adverse Events on Long-term Exposure to Low-dose Prednisone Given with Abiraterone Acetate to Patients with Metastatic Castration-resistant Prostate Cancer.
Topics: Abiraterone Acetate; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; | 2016 |
Steroid-induced hyperglycaemia in hospitalised patients: does it matter?
Topics: Community-Acquired Infections; Diabetes Mellitus; Glucocorticoids; Hospitalization; Humans; Hypergly | 2016 |
Low-dose systemic corticosteroid treatment for recalcitrant hidradenitis suppurativa.
Topics: Adalimumab; Adult; Aged; Anti-Bacterial Agents; Drug Therapy, Combination; Female; Hidradenitis Supp | 2016 |
Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Body Mass Index; Child; Ch | 2009 |
Hyperglycemia during induction therapy is associated with poorer survival in children with acute lymphocytic leukemia.
Topics: Antineoplastic Agents; Asparaginase; Blood Glucose; Child; Child, Preschool; Daunorubicin; Dexametha | 2009 |
Transient hyperglycaemia in a prediabetic dog treated with prednisone and cyclosporin A.
Topics: Animals; Cyclosporine; Dog Diseases; Dogs; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resi | 2009 |
Posttransplant hyperglycemia is associated with increased risk of liver allograft rejection.
Topics: Adult; Aged; Blood Glucose; Female; Graft Rejection; Humans; Hyperglycemia; Immunosuppressive Agents | 2010 |
Hyperglycemia during chemotherapy for hematologic and solid tumors is correlated with increased toxicity.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chem | 2011 |
Dysglycemia following glucocorticoid therapy for acute graft-versus-host disease adversely affects transplantation outcomes.
Topics: Acute Disease; Adult; Aged; Blood Glucose; Cohort Studies; Diabetes Complications; Drug Monitoring; | 2011 |
Comparative study of the effect of a daily steroid regimen versus a weekly oral pulse steroid regimen on morphological changes, blood sugar, bone mineral density and suprarenal gland activity.
Topics: Administration, Oral; Adrenal Glands; Adult; Aged; Blood Glucose; Bone Density; Cushing Syndrome; Di | 2012 |
Risk of corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye diseases.
Topics: Cohort Studies; Female; Follow-Up Studies; Glucocorticoids; Humans; Hyperglycemia; Hypoglycemic Agen | 2012 |
The high incidence of steroid-induced hyperglycaemia in hospital.
Topics: Australia; Blood Glucose; Dexamethasone; Hospitalization; Humans; Hydrocortisone; Hyperglycemia; Inc | 2013 |
INFECTIOUS DISEASES ASSOCIATED WITH RENAL HOMOTRANSPLANTATION.
Topics: Adolescent; Agammaglobulinemia; Agranulocytosis; Azathioprine; Bacteriophage Typing; Child; Diagnosi | 1964 |
DIABETIC ACIDOSIS SECONDARY TO STEROID THERAPY.
Topics: Diabetes Mellitus; Diabetic Ketoacidosis; Drug Therapy; Humans; Hyperglycemia; Lung Diseases; Predni | 1964 |
Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Animals, Genetically Modified; Blotting, Weste | 2004 |
Heme oxygenase-1 prevents superoxide anion-associated endothelial cell sloughing in diabetic rats.
Topics: Animals; Anions; Antineoplastic Combined Chemotherapy Protocols; Aorta; Apoptosis; Bilirubin; Blotti | 2004 |
Fatal mix-up between prednisone and primidone.
Topics: Anticonvulsants; Child; Fatal Outcome; Glucocorticoids; Humans; Hyperglycemia; Male; Medication Erro | 2004 |
Presentation and management of a stage Ia lung cancer patient with a paraneoplastic factor VIII inhibitor.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Autoimmune Dis | 2006 |
Exophathalmos induced by steroids.
Topics: Adult; Aged; Cataract; Exophthalmos; Female; Humans; Hydrocortisone; Hyperglycemia; Intraocular Pres | 1967 |
[Diminishing of glucose tolerance in children with simple obesity].
Topics: Adolescent; Child; Glucose Tolerance Test; Humans; Hyperglycemia; Obesity; Prednisone | 1967 |
Risk factors for hyperglycemia in children with leukemia receiving L-asparaginase and prednisone.
Topics: Adolescent; Adult; Age Factors; Asparaginase; Child; Child, Preschool; Diabetes Mellitus; Down Syndr | 1981 |
Experience with 49 segmental pancreas transplants in 45 diabetic patients.
Topics: Adult; Antilymphocyte Serum; Cyclosporins; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic R | 1982 |
Comparison of alternate day steroids and daily steroids in renal transplant recipients.
Topics: Blood Glucose; Blood Pressure; Body Weight; Creatinine; Graft Rejection; Humans; Hyperglycemia; Hype | 1980 |
Hyperinsulinemia accompanying hyperglycemia in Chinese patients with aplastic anemia.
Topics: Adolescent; Adult; Aged; Anabolic Agents; Anemia, Aplastic; Blood Glucose; Female; Glucagon; Glucoco | 1997 |
Clinical outcomes associated with conversion to tacrolimus-based immunosuppression in pediatric cardiac transplantation.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Cyclosporine; Drug Therapy, Combination; Female; | 1998 |
Insulin receptor antibodies and insulin resistance.
Topics: Acanthosis Nigricans; Adult; Anti-Inflammatory Agents; Autoantibodies; Blood Glucose; Female; Humans | 1999 |
Renal dysfunction and hyperglycemia in a renal transplant recipient.
Topics: Adult; Biopsy; Creatinine; Drug Therapy, Combination; Furosemide; Hematuria; Humans; Hyperglycemia; | 1999 |
L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia.
Topics: Adolescent; Asparaginase; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Hyperg | 1977 |
Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.
Topics: Acute Disease; Adolescent; Asparaginase; Child; Child, Preschool; Daunorubicin; Drug Evaluation; Dru | 1976 |
Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child, Preschool; Erwinia; | 1989 |
[Cure of diabetes by corticotherapy in Horton's disease].
Topics: Aged; Female; Giant Cell Arteritis; Humans; Hyperglycemia; Prednisone | 1985 |
Hyperglycemia. A complication of chemotherapy in children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Humans; Hyperglycemia; Leukemia | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Hormonal control of substrate cycling in humans.
Topics: Adult; Blood Glucose; Epinephrine; Fatty Acids; Glucagon; Glucose; Humans; Hyperglycemia; Insulin; P | 1988 |
Fatal metabolic acidosis, hyperglycemia, and coma after steroid therapy for Kearns-Sayre syndrome.
Topics: Acidosis; Child; Coma; Death; Humans; Hyperglycemia; Kearns-Sayre Syndrome; Male; Ophthalmoplegia; P | 1986 |
Hyperglycemic acidotic coma and death in Kearns-Sayre syndrome.
Topics: Acidosis; Administration, Oral; Child; Child, Preschool; Coma; Electrocardiography; Humans; Hypergly | 1986 |
Hyperalimentation as cause of markedly worsened metabolic control in a patient with autoantibodies to the insulin receptor.
Topics: Acanthosis Nigricans; Adult; Autoantibodies; Blood Glucose; Cyclophosphamide; Female; Humans; Hyperg | 1985 |
The lipid-mobilizing effect of some pituitary gland preparations. IV. Subdivision of a human growth hormone preparation into a somatotrophic and an adipokinetic-hyperglycaemic agent.
Topics: Adipose Tissue; Animals; beta-Lipotropin; Biological Assay; Blood Glucose; Chromatography, Gel; Drug | 1968 |
[Pancreatic islet cell adenoma with the triad diarrhea, hypokalemia and hyperglycemia].
Topics: Adenoma, Islet Cell; Adult; Diarrhea; Female; Humans; Hyperglycemia; Hypokalemia; Prednisone; Radiog | 1966 |
Infectious risk factors in the immunosuppressed host.
Topics: Adolescent; Adult; Agammaglobulinemia; Age Factors; Antilymphocyte Serum; Azathioprine; Child; Femal | 1973 |
Septicemia in renal transplant recipients.
Topics: Escherichia coli Infections; Graft Rejection; Humans; Hyperglycemia; Kidney Failure, Chronic; Kidney | 1973 |
Infectious complications in renal transplant recipients.
Topics: Acute Kidney Injury; Antilymphocyte Serum; Central Nervous System Diseases; Hepatitis; Humans; Hyper | 1973 |
Hyperglycemic nonketotic coma after renal transplantation.
Topics: Blood Urea Nitrogen; Creatinine; Dehydration; Diabetic Coma; Diagnosis, Differential; Humans; Hyperg | 1974 |
Hyperosmolar non-ketotic coma in a kidney transplant recipient.
Topics: Adult; Coma; Dehydration; Graft Rejection; Humans; Hyperglycemia; Hypotonic Solutions; Immunosuppres | 1972 |
Nonketotic hyperglycemia due to prednisone (NSC-10023) following ketotic hyperglycemia due to L-asparaginase (NSC-109229) plus prednisone.
Topics: Adolescent; Asparaginase; Diabetic Ketoacidosis; Humans; Hyperglycemia; Leukemia; Leukopenia; Male; | 1972 |
Hyperglycaemic non-ketotic coma.
Topics: Diabetic Coma; Granulomatosis with Polyangiitis; Humans; Hyperglycemia; Insulin, Isophane; Male; Mid | 1973 |
L-asparaginase and human malignant disease.
Topics: Animals; Antineoplastic Agents; Asparaginase; Blood Coagulation; Central Nervous System; Drug Hypers | 1971 |
Serum immunoreactive insulin levels during glucose tolerance and intensive islet stimulation. Effect of prednisone.
Topics: Adolescent; Adult; Body Weight; Diabetes Mellitus; Female; Glucose Tolerance Test; Humans; Hyperglyc | 1971 |
Hyperosmolar hyperglycemic non-ketotic coma: its importance in surgical problems.
Topics: Aged; Burns; Coma; Dehydration; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosis, Differential; F | 1968 |
Aplastic anemia: some clinical and laboratory aspects and an evaluation of the androgen-glucocorticoid treatment.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Bilirubin; Bone Marrow Examination; Bone Marrow Transplan | 1971 |
Hyperglycemic coma associated with corticosteroid therapy.
Topics: Aged; Anemia, Hemolytic, Autoimmune; Coma; Female; Humans; Hyperglycemia; Prednisone | 1969 |
Hyperglycemic nonketotic coma as complication of steroid therapy.
Topics: Adult; Diabetic Coma; Female; Humans; Hyperglycemia; Polycystic Ovary Syndrome; Prednisone | 1971 |
Successful remission induction in children with acute lymphocytic leukemia at high risk for treatment failure.
Topics: Amylases; Asparaginase; Blood Coagulation Disorders; Child; Child, Preschool; Daunorubicin; Female; | 1971 |
The role of genetic factors and serum protein binding in determining drug response as revealed by comprehensive drug surveillance.
Topics: ABO Blood-Group System; Blood Proteins; Computers; Contraceptives, Oral; Female; Genetics, Medical; | 1971 |
Treatment of adult leukemia with L-asparaginase (NSC-109229).
Topics: Adolescent; Adult; Aged; Allopurinol; Anaphylaxis; Asparaginase; Blood Coagulation Disorders; Cytara | 1971 |
[Long-term treatment of chronic obstructive bronchitis with corticosteroids].
Topics: Adrenal Cortex Hormones; Adult; Aged; Bronchitis; Follow-Up Studies; Humans; Hyperglycemia; Middle A | 1966 |
[Study of the retinal vascularization of subjects treated with cortisone].
Topics: Adolescent; Adult; Aged; Aneurysm; Blood Glucose; Female; Humans; Hyperglycemia; Male; Middle Aged; | 1966 |