Page last updated: 2024-11-07

prednisone and Hyperaldosteronism

prednisone has been researched along with Hyperaldosteronism in 11 studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Hyperaldosteronism: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.

Research Excerpts

ExcerptRelevanceReference
" This trial evaluated the efficacy and safety of AA in combination with prednisone to reduce the symptoms of secondary hyperaldosteronism that can occur with AA monotherapy."5.14Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer. ( Anand, A; Bubley, GJ; Danila, DC; de Bono, JS; Denmeade, SR; Fleisher, M; Haqq, C; Kheoh, T; Koscuiszka, M; Larson, SM; Molina, A; Morris, MJ; Ryan, CJ; Scher, HI; Schwartz, LH; Smith, MR; Taplin, ME, 2010)
" A 64-year-old woman with diffuse histiocytic lymphoma developed persistent hypokalemia following a course of Cytoxan (cyclophosphamide), Adriamycin (doxorubicin), vincristine, and prednisone (CHOP)-Bleo."3.67Potassium-wasting nephropathy secondary to chemotherapy simulating Bartter's syndrome. ( Floyd, M; Lieber, IH; McGuffin, WL; Stoneburner, SD, 1984)
"Dexamethasone-suppressible hyperaldosteronism should be considered in hypertensive infants who have normal genitalia and low PRA."1.27Low-renin hypertension in young infants. ( Field, ML; Roy, S; Stapleton, FB, 1985)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19907 (63.64)18.7374
1990's2 (18.18)18.2507
2000's0 (0.00)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Battistel, M1
Ceolotto, G1
Barbiero, G1
Rossitto, G1
Rossi, GP1
Danila, DC1
Morris, MJ1
de Bono, JS1
Ryan, CJ1
Denmeade, SR1
Smith, MR1
Taplin, ME1
Bubley, GJ1
Kheoh, T1
Haqq, C1
Molina, A1
Anand, A1
Koscuiszka, M1
Larson, SM1
Schwartz, LH1
Fleisher, M1
Scher, HI1
BEAULIEU, EE2
FUNEL, P2
LEMONNIER, F2
VESIN, P2
STEINBECK, AW1
Lieber, IH1
Stoneburner, SD1
Floyd, M1
McGuffin, WL1
Ganguly, A1
Grim, CE1
Weinberger, MH1
Cugini, P1
Battisti, P1
Di Palma, L1
Cavallini, M1
Pozzilli, P1
Scibilia, G1
Letizia, C1
Cassisi, A1
Cioli, AR1
Marino, B1
Norrdin, RW1
Histand, MB1
Sheahan, HJ1
Carpenter, TR1
Field, ML1
Roy, S1
Stapleton, FB1
Salti, IS1
Stiefel, M1
Ruse, JL1
Laidlaw, JC1
Miniconi, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase I/II Study of Alisertib in Combination With Abiraterone and Prednisone for Patients With Castration-Resistant Prostate Cancer After Progression on Abiraterone[NCT01848067]Phase 1/Phase 29 participants (Actual)Interventional2013-08-14Completed
Phase II Randomized Study of Abiraterone Acetate Plus ADT Versus APALUTAMIDE Versus Abiraterone and APALUTAMIDE in Patients With Advanced Prostate Cancer With Non-castrate Testosterone Levels[NCT02867020]Phase 2128 participants (Actual)Interventional2017-10-11Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With a PSA Value Equal to or Greater Than 25%

Compared between the two patient subsets using the nonparametric Mann-Whitney test. A comparison of CTC counts between baseline and at progression for those who have progressed will be carried out using either a paired t test or the nonparameteric Wilcoxon matched pairs test. (NCT01848067)
Timeframe: Baseline up to 3 months

InterventionParticipants (Count of Participants)
Treatment (Alisertib, Abiraterone Acetate, Prednisone)3

Phase I: Frequency of Dose Limiting Toxicities of Alisertib, Graded According to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) v4.1

Summarized with descriptive statistics. (NCT01848067)
Timeframe: Up to 21 days

InterventionParticipants (Count of Participants)
Treatment (Alisertib, Abiraterone Acetate, Prednisone)2

Reviews

1 review available for prednisone and Hyperaldosteronism

ArticleYear
THE ADRENAL CORTEX AND REPRODUCTIVE FUNCTIONS.
    Modern trends in human reproductive physiology, 1963, Volume: 15

    Topics: Addison Disease; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormon

1963

Trials

1 trial available for prednisone and Hyperaldosteronism

ArticleYear
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-20, Volume: 28, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Androstenes; Androstenols; Antineoplastic Combined Chemotherapy Prot

2010
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-20, Volume: 28, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Androstenes; Androstenols; Antineoplastic Combined Chemotherapy Prot

2010
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-20, Volume: 28, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Androstenes; Androstenols; Antineoplastic Combined Chemotherapy Prot

2010
Phase II multicenter study of abiraterone acetate plus prednisone therapy in patients with docetaxel-treated castration-resistant prostate cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-20, Volume: 28, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Androstenes; Androstenols; Antineoplastic Combined Chemotherapy Prot

2010

Other Studies

9 other studies available for prednisone and Hyperaldosteronism

ArticleYear
Adrenal venous sampling in dye-allergic primary aldosteronism patients: prevalence, pitfalls and a possible solution.
    Journal of hypertension, 2018, Volume: 36, Issue:9

    Topics: Adrenal Glands; Adult; Aged; Carbon Dioxide; Chlorpheniramine; Contrast Media; Drug Hypersensitivity

2018
[Reduction of hyperaldosteronism during ascitic cirrhosis under the effect of delta-cortisone].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1956, Oct-22, Volume: 32, Issue:62

    Topics: Aldosterone; Ascites; Cortisone; Humans; Hyperaldosteronism; Liver Cirrhosis; Prednisone

1956
[Reduction of hyperaldosteronism during ascitic cirrhosis under the effect of delta-cortisone].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1956, Oct-22, Volume: 32, Issue:62

    Topics: Aldosterone; Ascites; Cortisone; Humans; Hyperaldosteronism; Liver Cirrhosis; Prednisone

1956
[Reduction of hyperaldosteronism during ascitic cirrhosis under the effect of delta-cortisone].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1956, Oct-22, Volume: 32, Issue:62

    Topics: Aldosterone; Ascites; Cortisone; Humans; Hyperaldosteronism; Liver Cirrhosis; Prednisone

1956
[Reduction of hyperaldosteronism during ascitic cirrhosis under the effect of delta-cortisone].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1956, Oct-22, Volume: 32, Issue:62

    Topics: Aldosterone; Ascites; Cortisone; Humans; Hyperaldosteronism; Liver Cirrhosis; Prednisone

1956
Potassium-wasting nephropathy secondary to chemotherapy simulating Bartter's syndrome.
    Cancer, 1984, Sep-01, Volume: 54, Issue:5

    Topics: Aldosterone; Antineoplastic Combined Chemotherapy Protocols; Bartter Syndrome; Bleomycin; Cyclophosp

1984
Anomalous postural aldosterone response in glucocorticoid-suppressible hyperaldosteronism.
    The New England journal of medicine, 1981, Oct-22, Volume: 305, Issue:17

    Topics: Adrenocorticotropic Hormone; Aldosterone; Depression, Chemical; Dexamethasone; Glucocorticoids; Huma

1981
Secondary aldosteronism documented by plasma renin and aldosterone circadian rhythm in subjects with kidney or heart transplantation.
    Renal failure, 1992, Volume: 14, Issue:1

    Topics: Adult; Aldosterone; Circadian Rhythm; Cyclosporine; Female; Heart Transplantation; Humans; Hydrocort

1992
Effects of corticosteroids on mechanical strength of intervertebral joints and vertebrae in dogs.
    Clinical orthopaedics and related research, 1990, Issue:259

    Topics: Animals; Biomechanical Phenomena; Calcium; Dogs; Hyperaldosteronism; Hypothyroidism; Joints; Prednis

1990
Low-renin hypertension in young infants.
    American journal of diseases of children (1960), 1985, Volume: 139, Issue:8

    Topics: Dexamethasone; Female; Humans; Hyperaldosteronism; Hypertension; Infant; Male; Prednisone; Renin

1985
Non-tumorous "primary" aldosteronism. I. Type relieved by glucocorticoid (glucocorticoid-remediable aldosteronism).
    Canadian Medical Association journal, 1969, Jul-12, Volume: 101, Issue:1

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenalectomy; Adult; Aldosterone; Androgens

1969
[Secondary hyperaldosteronism of ascitogenic cirrhosis. Therapeutic results].
    Semaine therapeutique, 1963, Volume: 39, Issue:5

    Topics: Humans; Hyperaldosteronism; Liver Cirrhosis; Prednisone; Spironolactone

1963