prednisone has been researched along with Hepatitis, Alcoholic in 18 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the impact of metadoxine (MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis (AH)." | 9.20 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. ( Abdo-Francis, JM; Cruz-Herrera, J; Higuera-de la Tijera, F; Pérez-Hernández, JL; Pérez-Torres, E; Salas-Gordillo, F; Serralde-Zúñiga, AE; Servín-Caamaño, AI, 2015) |
| "To determine the pharmacokinetic (PK) profile of manganese (Mn) after a 2-hour intravenous infusion of mangafodipir at 5 micromol/kg body weight and to correlate Mn concentrations with oxidative stress, early decrease in serum total bilirubin concentration, and prothrombin time (PT) in chronic alcoholic patients with acute alcoholic hepatitis." | 9.14 | Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis. ( Batteux, F; Debray, M; Hirt, D; Laurent, A; Pavlovic, S; Poupon, J; Richardet, JP; Sogni, P; Treluyer, JM; Urien, S; Weill, B, 2009) |
| "In this study, we assessed whether there were any survival advantages with a combination treatment of intravenous N-acetylcysteine (NAC) and prednisone over prednisone alone in those with severe alcoholic hepatitis [discriminant function (DF) ≥ 32]." | 7.96 | A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis. ( Alukal, J; Amjad, W; Doycheva, I; Maheshwari, A; Thuluvath, PJ; Yoo, H; Zhang, T, 2020) |
| "To evaluate the impact of metadoxine (MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis (AH)." | 5.20 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. ( Abdo-Francis, JM; Cruz-Herrera, J; Higuera-de la Tijera, F; Pérez-Hernández, JL; Pérez-Torres, E; Salas-Gordillo, F; Serralde-Zúñiga, AE; Servín-Caamaño, AI, 2015) |
| "To determine the pharmacokinetic (PK) profile of manganese (Mn) after a 2-hour intravenous infusion of mangafodipir at 5 micromol/kg body weight and to correlate Mn concentrations with oxidative stress, early decrease in serum total bilirubin concentration, and prothrombin time (PT) in chronic alcoholic patients with acute alcoholic hepatitis." | 5.14 | Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis. ( Batteux, F; Debray, M; Hirt, D; Laurent, A; Pavlovic, S; Poupon, J; Richardet, JP; Sogni, P; Treluyer, JM; Urien, S; Weill, B, 2009) |
| "In this study, we assessed whether there were any survival advantages with a combination treatment of intravenous N-acetylcysteine (NAC) and prednisone over prednisone alone in those with severe alcoholic hepatitis [discriminant function (DF) ≥ 32]." | 3.96 | A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis. ( Alukal, J; Amjad, W; Doycheva, I; Maheshwari, A; Thuluvath, PJ; Yoo, H; Zhang, T, 2020) |
| "Patients with alcoholic hepatitis had a very blunted response." | 1.30 | Tumor necrosis factor and alcoholic liver disease. ( Barve, S; Deaciuc, I; Hill, DB; McClain, CJ, 1998) |
| "Prednisone was administered for five days in falling dosis (1." | 1.26 | Influence of steroids on urea-cycle enzymes in chronic human liver disease. ( Gerok, W; Heimsoeth, H; Maier, KP; Talke, H, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Amjad, W | 1 |
| Alukal, J | 1 |
| Doycheva, I | 1 |
| Zhang, T | 1 |
| Maheshwari, A | 1 |
| Yoo, H | 1 |
| Thuluvath, PJ | 1 |
| Carey, W | 1 |
| Raff, E | 1 |
| Singal, AK | 1 |
| Higuera-de la Tijera, F | 1 |
| Servín-Caamaño, AI | 1 |
| Serralde-Zúñiga, AE | 1 |
| Cruz-Herrera, J | 1 |
| Pérez-Torres, E | 1 |
| Abdo-Francis, JM | 1 |
| Salas-Gordillo, F | 1 |
| Pérez-Hernández, JL | 1 |
| Hirt, D | 1 |
| Richardet, JP | 1 |
| Urien, S | 1 |
| Poupon, J | 1 |
| Sogni, P | 1 |
| Batteux, F | 1 |
| Laurent, A | 1 |
| Pavlovic, S | 1 |
| Debray, M | 1 |
| Treluyer, JM | 1 |
| Weill, B | 1 |
| Spahr, L | 1 |
| Rubbia-Brandt, L | 1 |
| Frossard, JL | 1 |
| Giostra, E | 1 |
| Rougemont, AL | 1 |
| Pugin, J | 1 |
| Fischer, M | 1 |
| Egger, H | 1 |
| Hadengue, A | 1 |
| Natali, G | 1 |
| Trotta, A | 1 |
| Colantonio, D | 1 |
| Cascone, F | 1 |
| Di Lauro, G | 1 |
| Ruggieri, M | 1 |
| Di Pietro, M | 1 |
| Korula, J | 1 |
| Larvol, L | 1 |
| Colardelle, P | 1 |
| Callard, P | 1 |
| Levecq, H | 1 |
| Morgado, MJ | 1 |
| Marques, A | 1 |
| Areias, E | 1 |
| Moura, MC | 1 |
| Achord, JL | 1 |
| Colli, A | 1 |
| Cocciolo, M | 1 |
| Mumoli, N | 1 |
| Zuccoli, E | 1 |
| McClain, CJ | 1 |
| Barve, S | 2 |
| Deaciuc, I | 1 |
| Hill, DB | 1 |
| Maier, KP | 1 |
| Talke, H | 1 |
| Heimsoeth, H | 1 |
| Gerok, W | 1 |
| Magnenat, P | 1 |
| Carey, WD | 1 |
| Asnis, DS | 1 |
| Mollura, JL | 1 |
| Juhl, E | 1 |
| Christensen, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Omega-5 Fatty Acid Supplement on Markers of Inflammation and Oxidative Stress in Patients With Severe Alcoholic Hepatitis Treated With Prednisone[NCT03732586] | 40 participants (Actual) | Interventional | 2018-09-30 | Completed | |||
| Impact of Metadoxine in the Oxidative Stress and Early Mortality in Patients With Severe Alcoholic Hepatitis[NCT02161653] | Phase 4 | 135 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for prednisone and Hepatitis, Alcoholic
| Article | Year |
|---|---|
Optimal management of alcoholic hepatitis.
Topics: Algorithms; Drug Therapy, Combination; Evidence-Based Medicine; Glucocorticoids; Hepatitis, Alcoholi | 2014 |
[Acute alcoholic hepatitis complicated by cardiac arrhythmia. Alcohol, hepatitis, hypomagnesemia, torsades de pointes, corticotherapy].
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Drug Therapy, Combination; Female; Hepatitis, Alcohol | 1994 |
Review of alcoholic hepatitis, and its treatment.
Topics: Alcoholism; Anabolic Agents; Colchicine; Enteral Nutrition; Ethanol; Female; Food, Formulated; Gluca | 1993 |
3 trials available for prednisone and Hepatitis, Alcoholic
| Article | Year |
|---|---|
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Anesthetics, Local; Antineoplastic Combined Chemotherapy Pro | 2009 |
Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Apoptosis; Biop | 2002 |
12 other studies available for prednisone and Hepatitis, Alcoholic
| Article | Year |
|---|---|
A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis.
Topics: Acetylcysteine; Adult; Anti-Inflammatory Agents; Drug Monitoring; Drug Therapy, Combination; Female; | 2020 |
Know When to Hold 'em, Know When to Treat 'em, Know When to Cut 'em: Why Severe Alcoholic Hepatitis Is Becoming a Surgical Disease.
Topics: Acetylcysteine; Hepatitis, Alcoholic; Humans; Prednisone; Retrospective Studies | 2020 |
[Leukemoid reaction in a case of severe acute alcoholic hepatitis].
Topics: Adult; Female; Hepatitis, Alcoholic; Hepatomegaly; Humans; Leukemoid Reaction; Liver; Prednisone; Sp | 1982 |
Tuberculous peritonitis complicating corticosteroid therapy for acute alcoholic hepatitis.
Topics: Acute Disease; Adult; Female; Glucocorticoids; Hepatitis, Alcoholic; Humans; Peritonitis, Tuberculou | 1995 |
[Acute alcoholic hepatitis and leukemoid reaction].
Topics: Blood Cell Count; Female; Hematologic Tests; Hepatitis, Alcoholic; Hepatomegaly; Humans; Leukemoid R | 1993 |
Kaposi's sarcoma in severe alcoholic hepatitis.
Topics: Female; Glucocorticoids; Hepatitis, Alcoholic; Humans; Liver Neoplasms; Middle Aged; Prednisone; Sar | 1997 |
Tumor necrosis factor and alcoholic liver disease.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; | 1998 |
Influence of steroids on urea-cycle enzymes in chronic human liver disease.
Topics: Arginase; Argininosuccinate Synthase; Hepatitis; Hepatitis, Alcoholic; Humans; Ligases; Liver; Ornit | 1978 |
[Immunosuppressive drugs in the treatment of liver diseases (author's transl)].
Topics: Aspartate Aminotransferases; Azathioprine; Chronic Disease; Hepatitis; Hepatitis, Alcoholic; Humans; | 1979 |
Steroids in alcoholic hepatitis: another salvo of data.
Topics: Acute Disease; Hepatitis, Alcoholic; Humans; Prednisone | 1992 |
Acute febrile alcoholic hepatitis treated with corticosteroids.
Topics: Acute Disease; Fever; Hepatitis, Alcoholic; Humans; Male; Middle Aged; Prednisone | 1992 |
Anti-inflammatory and immunosuppressive treatment of alcoholic liver disease.
Topics: Colchicine; Female; Hepatitis, Alcoholic; Humans; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoho | 1985 |