Page last updated: 2024-11-07
prednisone and Gulf War Syndrome
prednisone has been researched along with Gulf War Syndrome in 1 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "The prednisone-associated improvement in physical HRQOL supports the GWI inflammation hypothesis." | 9.69 | Gulf war illness inflammation reduction trial: A phase 2 randomized controlled trial of low-dose prednisone chronotherapy, effects on health-related quality of life. ( Bach, RR; Rudquist, RR, 2023) |
| "The prednisone-associated improvement in physical HRQOL supports the GWI inflammation hypothesis." | 5.69 | Gulf war illness inflammation reduction trial: A phase 2 randomized controlled trial of low-dose prednisone chronotherapy, effects on health-related quality of life. ( Bach, RR; Rudquist, RR, 2023) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Bach, RR | 1 |
| Rudquist, RR | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| Gulf War Illness Inflammation Reduction Trial[NCT02506192] | Phase 2 | 83 participants (Actual) | Interventional | 2015-07-31 | Completed |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Change From Baseline of Veterans RAND 36-Item Health Survey Mental Component Summary Score (MCS) Scores at 8 and 16 Weeks
"SF-36V MCS is a measure of HRQOL with respect to mental functioning. The SF-36V is a modification of the well-established Medical Outcomes Study Short Form Health Survey (SF-36). It surveys eight concepts of health: physical functioning, role limitations because of physical problems, bodily pain, general health perceptions, energy/vitality, social functioning, role limitations due to emotional problems and mental health. From these concepts, two summary component scores are derived: a Physical Component Summary (PCS) and a Mental Component Summary (MCS).~To calculate MCS, scales are standardized with a scoring algorithm or by the scoring software. Scores are standardized and range from 0 to 100, with a US population mean of 50 points and a SD of 10 points. The PCS and the MCS have been demonstrated to have excellent psychometric properties. SF-36V MCS is a measure of HRQOL with respect to mental functioning and symptoms. Higher scores indicate better health status," (NCT02506192)
Timeframe: 0, 8, and 16 weeks
| Intervention | units on a scale (Mean) |
|---|
| baseline | 8 weeks | 16 weeks |
|---|
| Modified-Release Prednisone | 40.8 | 42.4 | 40.1 |
,| Placebo | 40.4 | 43.1 | 42.7 |
Change From Baseline of Veterans RAND 36-Item Health Survey Physical Component Summary Score (PCS) Scores at 8 and 16 Weeks
"The SF-36V is a modification of the well-established Medical Outcomes Study Short Form Health Survey (SF-36). It surveys eight concepts of health: physical functioning, role limitations because of physical problems, bodily pain, general health perceptions, energy/vitality, social functioning, role limitations due to emotional problems and mental health. From these concepts, two summary component scores are derived: a Physical Component Summary (PCS) and a Mental Component Summary (MCS).~To calculate PCS, scales are standardized with a scoring algorithm or by the scoring software. Scores are standardized and range from 0 to 100, with a US population mean of 50 points and a SD of 10 points. The PCS and the MCS have been demonstrated to have excellent psychometric properties. SF-36V PCS is a measure of HRQOL with respect to physical functioning and symptoms. Higher scores indicate better health status," (NCT02506192)
Timeframe: 0, 8, and 16 weeks
| Intervention | units on a scale (Mean) |
|---|
| baseline | 8 weeks | 16 weeks |
|---|
| Modified-Release Prednisone | 40.8 | 43.5 | 40.8 |
,| Placebo | 41.5 | 43.4 | 41.4 |
Trials
1 trial available for prednisone and Gulf War Syndrome