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prednisone and Glomerulonephritis, Lupus

prednisone has been researched along with Glomerulonephritis, Lupus in 212 studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Research Excerpts

ExcerptRelevanceReference
"Previous studies have compared mycophenolate mofetil and azathioprine as maintenance therapy for lupus nephritis (LN)."9.51Leflunomide versus azathioprine for maintenance therapy of lupus nephritis: a prospective, multicentre, randomised trial and long-term follow-up. ( Bao, C; Dai, L; Dai, M; Fu, Q; He, L; Li, Z; Lu, L; Sun, L; Wang, S; Wu, C; Xu, J; Zhu, X, 2022)
"A prospective, multi-center, randomized controlled study was conducted to evaluate the efficacy and safety of a 24-week course low-dose leflunomide combined with prednisone in the induction treatment of proliferative lupus nephritis in Chinese patients."9.30Leflunomide versus cyclophosphamide in the induction treatment of proliferative lupus nephritis in Chinese patients: a randomized trial. ( Chen, J; Chen, Q; Guan, T; Jiang, G; Li, D; Luo, P; Ni, Z; Qi, C; Sun, M; Sun, Z; Wan, J; Wang, L; Wang, S; Xing, C; Zha, Y; Zhang, M, 2019)
"Intravenous cyclophosphamide with prednisone is an effective treatment for lupus nephritis, but with significant toxicities."9.15Short-term outcomes of induction therapy with tacrolimus versus cyclophosphamide for active lupus nephritis: A multicenter randomized clinical trial. ( Chen, J; Chen, W; Fan, A; Fu, J; Fu, P; Kong, Y; Li, Z; Liao, Y; Liu, F; Liu, Q; Liu, Z; Lou, T; Rao, S; Tang, X; Yang, Z; Yu, X; Zhang, J, 2011)
"With extended follow-up, pulse cyclophosphamide continued to show superior efficacy over pulse methylprednisolone alone for treatment of lupus nephritis."9.09Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. ( Austin, HA; Balow, JE; Boumpas, DT; Collins, L; Crane, M; Danning, CL; Gourley, MF; Illei, GG; Klippel, JH; Kuroiwa, T; Steinberg, AD; Vaughan, EM; Yarboro, CH, 2001)
"To describe the clinical course of severe lupus nephritis and to identify the risk factors for progression to renal failure among patients treated with prednisone and short-term courses of low-dose oral cyclophosphamide."9.07Progression and remission of renal disease in the Lupus Nephritis Collaborative Study. Results of treatment with prednisone and short-term oral cyclophosphamide. ( Corwin, HL; Hunsicker, LG; Kasinath, BS; Lachin, J; Lan, SP; Levey, AS; Lewis, EJ; Neilson, EG, 1992)
"The existing guidelines for lupus nephritis (LN) recommend initial prednisone doses of 0."8.12Medium Versus High Initial Prednisone Dose for Remission Induction in Lupus Nephritis: A Propensity Score-Matched Analysis. ( Al-Sheikh, H; Gladman, DD; Su, J; Tselios, K; Urowitz, MB, 2022)
"Mycophenolic acid (MPA) is an effective oral immunosuppressive drug used to treat lupus nephritis (LN), which exhibits large pharmacokinetic variability."7.96Population pharmacokinetics of mycophenolic acid in Mexican patients with lupus nephritis. ( Abud-Mendoza, C; Martínez-Martínez, MU; Medellín-Garibay, SE; Milán-Segovia, RDC; Reséndiz-Galván, JE; Romano-Aguilar, M; Romano-Moreno, S, 2020)
"A combination of medium-dose prednisone, methylprednisolone pulses, cyclophosphamide and hydroxychloroquine is at least as effective in achieving remission of lupus nephritis as regimes containing high-dose prednisone and causes less toxicity."7.80Prednisone in lupus nephritis: how much is enough? ( Danza, A; Delgado, S; Garcia, M; Khamashta, M; Perales, I; Ruiz-Irastorza, G; Villar, I, 2014)
"To investigate the effects of Artemisinin on the expressions of GRalpha mRNA, GRbeta mRNA and P300/CBP protein in lupus nephritis mice."7.78[Effect of artemisinin on the expressions of GRalpha mRNA, GRbeta mRNA and P300/CBP protein in lupus nephritis mice]. ( An, P; Qiao, CL; Shi, XM; Sun, WS; Wang, Z; Wu, XL, 2012)
"To investigate the therapeutic effects and mechanisms of using artemisinin (Art) combined with glucocorticoid (GC) to treat lupus nephritis (LN) mice."7.77Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor α mRNA, glucocorticoid receptor β mRNA and P300/CBP protein in lupus nephritis mice. ( An, P; Qiao, CL; Shi, XM; Sun, WS; Wang, Z; Wu, XL; Zhang, WG, 2011)
"To evaluate the efficacy of pentoxifylline in the treatment of refractory nephrotic syndrome secondary to lupus nephritis."7.72Pentoxifylline in the treatment of refractory nephrotic syndrome secondary to lupus nephritis. ( Aviña-Zubieta, JA; Bustamante, R; Esquivel-Nava, G; Galindo-Rodríguez, G; Salazar-Exaire, D; Vadillo-Buenfil, M; Vela-Ojeda, J, 2003)
"It has been reported that outcomes are improved in patients with severe lupus nephritis treated with combined prednisone and intravenous cyclophosphamide, compared with those treated with prednisone alone."7.69The economic impact of treatment of severe lupus nephritis with prednisone and intravenous cyclophosphamide. ( Klippel, JH; McInnes, PM; Sanslone, WR; Schuttinga, J; Stark, SP, 1994)
") methylprednisolone (MP) pulses followed by low dose oral prednisone (PRED) was assessed in a group of patients with active lupus nephritis (LN)."7.69Long term efficacy of high-dose intravenous methylprednisolone pulses in active lupus nephritis. A 21-month prospective study. ( Bertoni, E; Bertoni, M; Brugnolo, F; Emmi, L; Romagnani, S; Salvadori, M, 1994)
"For patients with diffuse proliferative lupus nephritis, azathioprine or cyclosporine combined with corticosteroids demonstrated equal efficacy in the prevention of flares."6.72A randomized pilot trial comparing cyclosporine and azathioprine for maintenance therapy in diffuse lupus nephritis over four years. ( Alberighi, OD; Altieri, P; Doria, A; Ferraccioli, G; Ferrara, R; Greco, S; Manno, C; Moroni, G; Mosca, M; Ponticelli, C; Todesco, S, 2006)
"For the treatment of proliferative lupus nephritis, long-term cyclophosphamide (CY) regimens are efficacious, however, at the expense of substantial toxicity."6.71Maintenance therapies for proliferative lupus nephritis: mycophenolate mofetil, azathioprine and intravenous cyclophosphamide. ( Contreras, G; Metz, D; Nahar, N; Tozman, E, 2005)
"Previous studies have compared mycophenolate mofetil and azathioprine as maintenance therapy for lupus nephritis (LN)."5.51Leflunomide versus azathioprine for maintenance therapy of lupus nephritis: a prospective, multicentre, randomised trial and long-term follow-up. ( Bao, C; Dai, L; Dai, M; Fu, Q; He, L; Li, Z; Lu, L; Sun, L; Wang, S; Wu, C; Xu, J; Zhu, X, 2022)
"The BC followed international lupus nephritis guidelines, combining high-dose prednisone and either mycophenolate mofetil or cyclophosphamide, followed by maintenance therapy with low dose prednisone and immunosuppressive drugs."5.46Repeated pulses of methyl-prednisolone with reduced doses of prednisone improve the outcome of class III, IV and V lupus nephritis: An observational comparative study of the Lupus-Cruces and lupus-Bordeaux cohorts. ( Blanco, P; Couzi, L; Iza, A; Lazaro, E; Porta, S; Richez, C; Ruiz-Irastorza, G; Saenz, R; Saint-Pastou Terrier, C; Ugarte, A, 2017)
" The aim of this study was to investigate the efficacy and safety of bortezomib combined with glucocorticoids in refractory lupus patients."5.46The short-term efficacy of bortezomib combined with glucocorticoids for the treatment of refractory lupus nephritis. ( Hou, J; Hu, W; Huang, L; Huang, X; Liu, Z; Zhang, H; Zhou, M, 2017)
"Proteinuria was 2."5.38The dynamics of urinary N-acetyl-β-D-glucosaminidase (NAG), a marker of renal tubular dysfunction, in patients with lupus nephritis undergoing oral prednisone therapy. ( Bob, F; Bozdog, G; Cioca, D; Gadalean, F; Gluhovschi, C; Gluhovschi, G; Kaycsa, A; Marian, R; Petrica, L; Velciov, S; Vernic, C, 2012)
"The treatment of membranous lupus nephritis (MLN) is still controversial in the literature."5.37Prednisone monotherapy induced remission in a group of patients with membranous lupus nephritis. ( Alves de Brito, G; Bitencourt Dias, C; Dos Santos Silva, V; Gera Abrão, J; Malafronte, P; Pinheiro, CC; Titan, S; Toledo Barros, R; Woronik, V, 2011)
"Nine patients with diffuse proliferative lupus nephritis confirmed by renal biopsy received MMF/prednisone for six months when repeat biopsies were performed."5.32Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study. ( Ding, L; Liu, Y; Wang, H; Zhao, M; Zou, W, 2004)
"A prospective, multi-center, randomized controlled study was conducted to evaluate the efficacy and safety of a 24-week course low-dose leflunomide combined with prednisone in the induction treatment of proliferative lupus nephritis in Chinese patients."5.30Leflunomide versus cyclophosphamide in the induction treatment of proliferative lupus nephritis in Chinese patients: a randomized trial. ( Chen, J; Chen, Q; Guan, T; Jiang, G; Li, D; Luo, P; Ni, Z; Qi, C; Sun, M; Sun, Z; Wan, J; Wang, L; Wang, S; Xing, C; Zha, Y; Zhang, M, 2019)
"Intravenous cyclophosphamide with prednisone is an effective treatment for lupus nephritis, but with significant toxicities."5.15Short-term outcomes of induction therapy with tacrolimus versus cyclophosphamide for active lupus nephritis: A multicenter randomized clinical trial. ( Chen, J; Chen, W; Fan, A; Fu, J; Fu, P; Kong, Y; Li, Z; Liao, Y; Liu, F; Liu, Q; Liu, Z; Lou, T; Rao, S; Tang, X; Yang, Z; Yu, X; Zhang, J, 2011)
"A combination of prednisone and AZA is reasonably effective for the initial treatment of pure membranous lupus nephritis."5.11Treatment of pure membranous lupus nephropathy with prednisone and azathioprine: an open-label trial. ( Au, TC; Lau, CS; Mok, CC; Ng, WL; Wong, WS; Yim, CW; Ying, KY, 2004)
"For patients with proliferative lupus nephritis, short-term therapy with intravenous cyclophosphamide followed by maintenance therapy with mycophenolate mofetil or azathioprine appears to be more efficacious and safer than long-term therapy with intravenous cyclophosphamide."5.11Sequential therapies for proliferative lupus nephritis. ( Contreras, G; Leclercq, B; Lenz, O; O'Nan, P; Pardo, V; Roth, D; Tozman, E, 2004)
"With extended follow-up, pulse cyclophosphamide continued to show superior efficacy over pulse methylprednisolone alone for treatment of lupus nephritis."5.09Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. ( Austin, HA; Balow, JE; Boumpas, DT; Collins, L; Crane, M; Danning, CL; Gourley, MF; Illei, GG; Klippel, JH; Kuroiwa, T; Steinberg, AD; Vaughan, EM; Yarboro, CH, 2001)
"We carried out a randomized, controlled trial comparing a standard-therapy regimen of prednisone and cyclophosphamide (standard therapy) with a regimen of standard therapy plus plasmapheresis in 86 patients with severe lupus nephritis in 14 medical centers."5.07A controlled trial of plasmapheresis therapy in severe lupus nephritis. The Lupus Nephritis Collaborative Study Group. ( Hunsicker, LG; Lachin, JM; Lan, SP; Lewis, EJ; Rohde, RD, 1992)
"To describe the clinical course of severe lupus nephritis and to identify the risk factors for progression to renal failure among patients treated with prednisone and short-term courses of low-dose oral cyclophosphamide."5.07Progression and remission of renal disease in the Lupus Nephritis Collaborative Study. Results of treatment with prednisone and short-term oral cyclophosphamide. ( Corwin, HL; Hunsicker, LG; Kasinath, BS; Lachin, J; Lan, SP; Levey, AS; Lewis, EJ; Neilson, EG, 1992)
" The last drug was substituted with azathioprine in prevision of pregnancy."4.91Pregnancies in women receiving renal transplant for lupus nephritis: description of nine pregnancies and review of the literature. ( Campise, M; Giglio, E; Messa, P; Moroni, G; Trespidi, L, 2015)
"The Jieduquyuziyin prescription (JP), a traditional Chinese medicine (TCM) formula, has been used as an approved hospital prescription to improve the efficacy of prednisone (Pred) in systemic lupus erythematosus (SLE) and lupus nephritis (LN) treatment."4.12Jieduquyuziyin prescription promotes the efficacy of prednisone via upregulating Nrf2 in MRL/lpr kidneys. ( Du, L; Feng, Y; He, Z; Shi, X; Wang, C; Wen, C; Zhang, Y, 2022)
"The existing guidelines for lupus nephritis (LN) recommend initial prednisone doses of 0."4.12Medium Versus High Initial Prednisone Dose for Remission Induction in Lupus Nephritis: A Propensity Score-Matched Analysis. ( Al-Sheikh, H; Gladman, DD; Su, J; Tselios, K; Urowitz, MB, 2022)
"Combination therapy with mycophenolate mofetil, tacrolimus and steroids are effective in achieving complete remission in lupus nephritis (LN)."4.02Novel Effects of Combination Therapy Through Inhibition of Caspase-1/Gasdermin D Induced-Pyroptosis in Lupus Nephritis. ( Cao, H; He, Y; Jiang, S; Ke, Y; Liang, J; Lin, J; Liu, J; Sun, Y, 2021)
"Serious renal pathological changes, mass proteinuria, higher SLEDAI, higher prednisone dose, and a decline in CD4+ T cells could be risk factors for CM in patients with LN."3.96Cryptococcal meningitis in patients with lupus nephritis. ( Chen, J; Chen, P, 2020)
"Mycophenolic acid (MPA) is an effective oral immunosuppressive drug used to treat lupus nephritis (LN), which exhibits large pharmacokinetic variability."3.96Population pharmacokinetics of mycophenolic acid in Mexican patients with lupus nephritis. ( Abud-Mendoza, C; Martínez-Martínez, MU; Medellín-Garibay, SE; Milán-Segovia, RDC; Reséndiz-Galván, JE; Romano-Aguilar, M; Romano-Moreno, S, 2020)
"A recent clinical study showed that combination therapy consisting of mycophenolate mofetil, tacrolimus and steroids was shown to be more effective in achieving complete remission in patients with severe forms of lupus nephritis than conventional therapy consisting of intravenous cyclophosphamide and steroids."3.88Transcriptomic analysis uncovers novel synergistic mechanisms in combination therapy for lupus nephritis. ( Cai, M; Chuang, PY; Fu, J; He, JC; Lee, K; Liu, Z; Ma'ayan, A; Wang, Z; Wei, C; Zhang, M; Zhang, W; Zhou, M, 2018)
"A combination of medium-dose prednisone, methylprednisolone pulses, cyclophosphamide and hydroxychloroquine is at least as effective in achieving remission of lupus nephritis as regimes containing high-dose prednisone and causes less toxicity."3.80Prednisone in lupus nephritis: how much is enough? ( Danza, A; Delgado, S; Garcia, M; Khamashta, M; Perales, I; Ruiz-Irastorza, G; Villar, I, 2014)
"9 g 24-h proteinuria while still in remission of the protein-losing enteropathy, receiving 5 mg prednisone and 100 mg azathioprine daily."3.78Protein-losing enteropathy as initial manifestation of systemic lupus erythematosus. ( Braga, LL; Brandão, LA; Carneiro, FO; Rocha, FA; Sampaio, LR, 2012)
"To investigate the effects of Artemisinin on the expressions of GRalpha mRNA, GRbeta mRNA and P300/CBP protein in lupus nephritis mice."3.78[Effect of artemisinin on the expressions of GRalpha mRNA, GRbeta mRNA and P300/CBP protein in lupus nephritis mice]. ( An, P; Qiao, CL; Shi, XM; Sun, WS; Wang, Z; Wu, XL, 2012)
"To investigate the therapeutic effects and mechanisms of using artemisinin (Art) combined with glucocorticoid (GC) to treat lupus nephritis (LN) mice."3.77Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor α mRNA, glucocorticoid receptor β mRNA and P300/CBP protein in lupus nephritis mice. ( An, P; Qiao, CL; Shi, XM; Sun, WS; Wang, Z; Wu, XL; Zhang, WG, 2011)
"(1) Those patients with unstable status progestation, patients being newly diagnosed with SLE during pregnancy or patients irregularly using prednisone became active during pregnancy."3.73[Influential factors of systemic lupus erythematosus activity during pregnancy and its relationship with pregnancy outcome]. ( Tan, JP; Wang, YH; Wu, XX; Zhang, JP, 2006)
"To evaluate the efficacy of pentoxifylline in the treatment of refractory nephrotic syndrome secondary to lupus nephritis."3.72Pentoxifylline in the treatment of refractory nephrotic syndrome secondary to lupus nephritis. ( Aviña-Zubieta, JA; Bustamante, R; Esquivel-Nava, G; Galindo-Rodríguez, G; Salazar-Exaire, D; Vadillo-Buenfil, M; Vela-Ojeda, J, 2003)
"Seven lupus nephritis patients who failed to respond to at least prednisone and cyclophosphamide were studied."3.70Intravenous immunoglobulin treatment of lupus nephritis. ( Fabbrizzi, F; George, J; Langevitz, P; Levy, Y; Lukac, J; Poprac, P; Rauova, L; Rovensky, J; Sherer, Y; Shoenfeld, Y, 2000)
"It has been reported that outcomes are improved in patients with severe lupus nephritis treated with combined prednisone and intravenous cyclophosphamide, compared with those treated with prednisone alone."3.69The economic impact of treatment of severe lupus nephritis with prednisone and intravenous cyclophosphamide. ( Klippel, JH; McInnes, PM; Sanslone, WR; Schuttinga, J; Stark, SP, 1994)
") methylprednisolone (MP) pulses followed by low dose oral prednisone (PRED) was assessed in a group of patients with active lupus nephritis (LN)."3.69Long term efficacy of high-dose intravenous methylprednisolone pulses in active lupus nephritis. A 21-month prospective study. ( Bertoni, E; Bertoni, M; Brugnolo, F; Emmi, L; Romagnani, S; Salvadori, M, 1994)
"Twenty-two patients with histologically demonstrated diffuse proliferative lupus nephritis (DPLN) and glomerular thrombosis received a 14-day course of ancrod, followed in most by nitrogen mustard (mechlorethamine hydrochloride) 0."3.68Diffuse proliferative lupus nephritis: long-term observations in patients treated with ancrod. ( Hariharan, S; Kant, KS; Pollak, VE; Wadhwa, NK; Weiss, MA, 1990)
"Optimal treatment for pure membranous lupus nephritis (MLN) remains unknown."2.82Immunosuppressive treatment for pure membranous lupus nephropathy in a Hispanic population. ( Córdova-Sánchez, BM; Correa-Rotter, R; Mejía-Vilet, JM; Uribe-Uribe, NO, 2016)
"Treatment of lupus nephritis (LN) remains challenging."2.80Multitarget therapy for induction treatment of lupus nephritis: a randomized trial. ( Bao, H; Chen, J; Chen, N; Fu, P; Gu, Y; He, Y; Hu, W; Li, Y; Lin, H; Liu, F; Liu, Z; Miao, L; Ni, Z; Shi, W; Xing, C; Zeng, C; Zhang, H; Zhou, M, 2015)
"Prednisone alone was administered and dose-adjusted to control extrarenal manifestations."2.77Renal outcome in patients with lupus nephritis using a steroid-free regimen of monthly intravenous cyclophosphamide: a prospective observational study. ( Brinks, R; Chehab, G; Fischer-Betz, R; Sander, O; Schneider, M; Voiculescu, A; Vordenbäumen, S, 2012)
"Class V lupus nephritis (LN) occurs in one-fifth of biopsy-proven cases of systemic lupus erythematosus."2.75Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis. ( Appel, GB; Ginzler, EM; Moutzouris, DA; Radhakrishnan, J; Siempos, II; Solomons, N, 2010)
"Patients with active lupus nephritis (renal biopsy class III, IV, or V) were recruited for the study (n = 370) and treated with mycophenolate mofetil (target dosage 3 gm/day) or intravenous cyclophosphamide (0."2.75Nonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial. ( Dooley, MA; Ginzler, EM; Gordon, C; Isenberg, D; Lisk, L; Wofsy, D, 2010)
"Median proteinuria was 5."2.74Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy. ( Austin, HA; Balow, JE; Braun, MJ; Illei, GG, 2009)
"Treatment of class V+IV lupus nephritis remains unsatisfactory despite the progress made in the treatment of diffuse proliferative lupus nephritis."2.73Successful treatment of class V+IV lupus nephritis with multitarget therapy. ( Bao, H; Hu, WX; Li, LS; Liu, ZH; Xie, HL; Zhang, HT, 2008)
"For patients with diffuse proliferative lupus nephritis, azathioprine or cyclosporine combined with corticosteroids demonstrated equal efficacy in the prevention of flares."2.72A randomized pilot trial comparing cyclosporine and azathioprine for maintenance therapy in diffuse lupus nephritis over four years. ( Alberighi, OD; Altieri, P; Doria, A; Ferraccioli, G; Ferrara, R; Greco, S; Manno, C; Moroni, G; Mosca, M; Ponticelli, C; Todesco, S, 2006)
"For the treatment of proliferative lupus nephritis, long-term cyclophosphamide (CY) regimens are efficacious, however, at the expense of substantial toxicity."2.71Maintenance therapies for proliferative lupus nephritis: mycophenolate mofetil, azathioprine and intravenous cyclophosphamide. ( Contreras, G; Metz, D; Nahar, N; Tozman, E, 2005)
"Eleven children with various forms of lupus nephritis were treated with oral MMF at a mean dose of 22 mg/kg/day (range 17-42) for a mean of 9."2.70Mycophenolate mofetil treatment of severe renal disease in pediatric onset systemic lupus erythematosus. ( Bartosh, S; Buratti, S; Reiff, A; Spencer, CH; Szer, IS, 2001)
"Forty-seven patients with lupus nephritis and abnormal serum creatinine or elevated 24-hr urine protein were enrolled."2.69Gallium-67 scintigraphy to predict response to therapy in active lupus nephritis. ( Lan, JL; Lin, WY; Wang, SJ, 1998)
" Prednisolone dosage was gradually tapered to 10 mg/d at 6 months, when cyclophosphamide was replaced by azathioprine (2 mg/kg/d p."2.69Treatment of membranous lupus nephritis with nephrotic syndrome by sequential immunosuppression. ( Chan, KW; Chan, TM; Hao, WK; Lai, KN; Li, FK; Lui, SL; Tang, S, 1999)
"Changes of activity index (AI) of lupus nephritis, urinary protein (UP), plasma albumin (PA), blood lipid (BL) of the patients before and after treatment were observed and compared."2.69[Clinical observation on nephrotic syndrome of lupus nephritis treated with integrated traditional Chinese and Western Medicine]. ( Wu, K; Wu, Q; Ye, R, 1998)
"005), despite a significant reduction in mean prednisone dosage (31 +/- 5 to 14 +/- 2 mg/day; p less than 0."2.66Intermittent intravenous cyclophosphamide therapy for lupus nephritis. ( Emery, HM; Kovalesky, A; Lehman, TJ; Magilavy, DB; McCurdy, DK; Sherry, DD; Wagner-Weiner, L, 1989)
"Lupus nephritis was present in two cases."2.49[Three cases of bullous lupus erythematosus]. ( Elomri, N; Elqatni, M; Ghafir, D; Jira, M; Mekouar, F; Sekkach, Y, 2013)
"The best therapeutic choice in lupus nephritis remains shrouded in a body of controversial literature."2.40Treatment of lupus nephritis: a meta-analysis of clinical trials. ( Bansal, VK; Beto, JA, 1997)
"Transformations from one pattern of lupus nephritis to another may occur, and there may also be prominent involvement of the tubulointerstitial compartment and vasculature."2.39The course and treatment of lupus nephritis. ( Appel, GB; Valeri, A, 1994)
" The corticosteroid dosage was gradually tapered."2.39Predominant tubulointerstitial lupus nephritis. ( Madias, NE; Singh, AK; Ucci, A, 1996)
"Prior to 1975 patients with systemic lupus erythematosus were generally not considered candidates for renal transplantation because of concern that immune complex deposition would rapidly destroy the allograft."2.38Renal transplantation for systemic lupus erythematosus and recurrent lupus nephritis. A single-center experience and a review of the literature. ( Cole, BR; Goss, JA; Hanto, DW; Jendrisak, MD; McCullough, CS; So, SK; Windus, DW, 1991)
" The LR treatment group received LR at the dosage of 1."1.91Lupus Recipe inhibits cGVHD-induced lupus nephritis in mice and promote renal LC3-associated autophagy. ( Fan, J; Guo, J; Huang, X; Liu, R; Peng, Y; Wu, H; Wu, M; Yang, X; Ye, H, 2023)
"028) and prednisone dosage during pregnancy ≥12."1.72Good pregnancy outcomes in lupus nephritis patients with complete renal remission. ( Chen, D; Chen, Y; Hu, W; Li, K; Liu, Z; Yang, L; Zhang, H, 2022)
"Renal biopsy revealed nodular glomerulosclerosis and FSGS."1.62Lupus podocytopathy superimposed on diabetic glomerulosclerosis: A case report. ( Liu, L; Murray, B; Tomaszewski, JE, 2021)
"An important goal in the management of systemic lupus erythematosus (SLE) is the prediction of relapses."1.56Anti-nucleosome antibodies increase the risk of renal relapse in a prospective cohort of patients with clinically inactive systemic lupus erythematosus. ( Alcaraz-Lopez, MF; Bonilla-Lara, D; Diaz-Rizo, V; Fajardo-Robledo, NS; Gamez-Nava, JI; Gonzalez-Lopez, L; Muñoz-Valle, JF; Perez-Guerrero, EE; Rodriguez-Jimenez, NA; Saldaña-Cruz, AM; Sanchez-Mosco, DI, 2020)
"Five hundred and two patients with systemic lupus erythematosus patients were included; 120 patients (23."1.56Predictors of renal damage in systemic lupus erythematous patients: data from a multiethnic, multinational Latin American lupus cohort (GLADEL). ( Alarcón, GS; Alvarellos, A; Amigo, MC; Barile-Fabris, LA; Berbotto, GA; Bonfa, E; Borba Neto, EF; Caeiro, F; Cardiel, MH; Catoggio, LJ; Cavalcanti, F; Chacón-Diaz, R; Da Silva, NA; de Oliveira E Silva Montandon, AC; Esteva-Spinetti, MH; Garcia de la Torre, I; García, MA; Guibert-Toledano, M; Harvey, GB; Massardo, L; Neira, OJ; Pons-Estel, BA; Pons-Estel, GJ; Portela-Hernández, M; Quintana, R; Reátegui-Sokolova, C; Reyes-Llerena, GA; Sacnun, MP; Sato, EI; Saurit, V; Segami, MI; Serrano-Morales, RM; Silveira, LH; Soriano, ER; Ugarte-Gil, MF; Vásquez, G; Wojdyla, D, 2020)
"Childhood-onset systemic lupus erythematosus (SLE) is a severe, lifelong, multisystem autoimmune disease."1.51Long-Term Clinical Outcomes in a Cohort of Adults With Childhood-Onset Systemic Lupus Erythematosus. ( Bijl, M; Bultink, IEM; de Leeuw, K; Dolhain, RJEM; Fritsch-Stork, R; Groot, N; Kamphuis, S; Shaikhani, D; Teng, YKO; Zirkzee, E, 2019)
"The BC followed international lupus nephritis guidelines, combining high-dose prednisone and either mycophenolate mofetil or cyclophosphamide, followed by maintenance therapy with low dose prednisone and immunosuppressive drugs."1.46Repeated pulses of methyl-prednisolone with reduced doses of prednisone improve the outcome of class III, IV and V lupus nephritis: An observational comparative study of the Lupus-Cruces and lupus-Bordeaux cohorts. ( Blanco, P; Couzi, L; Iza, A; Lazaro, E; Porta, S; Richez, C; Ruiz-Irastorza, G; Saenz, R; Saint-Pastou Terrier, C; Ugarte, A, 2017)
"Children with lupus nephritis have comparable or better cognitive function than their peers with other gCKDs, which is reassuring given the multiorgan and lifelong complications associated with lupus."1.46Cognitive Function in Children with Lupus Nephritis: A Cross-Sectional Comparison with Children with Other Glomerular Chronic Kidney Diseases. ( Furth, SL; Hooper, SR; Knight, A; Kogon, AJ; Matheson, MB; Warady, BA, 2017)
" The aim of this study was to investigate the efficacy and safety of bortezomib combined with glucocorticoids in refractory lupus patients."1.46The short-term efficacy of bortezomib combined with glucocorticoids for the treatment of refractory lupus nephritis. ( Hou, J; Hu, W; Huang, L; Huang, X; Liu, Z; Zhang, H; Zhou, M, 2017)
" An effective and safe alternative induction regimen is needed."1.46Efficacy and safety of rituximab in comparison with common induction therapies in pediatric active lupus nephritis. ( Babu, BG; Basu, B; Roy, B, 2017)
"Active lupus nephritis is a predictor for poor outcomes of pregnancies in SLE patients."1.43[Analysis of pregnancy outcomes in 66 patients with systemic lupus erythematosus]. ( Chen, JM; Song, XZ; Zhou, QG, 2016)
"The mean age at lupus nephritis presentation was 12."1.42Lupus nephritis in Croatian children: clinicopathologic findings and outcome. ( Batinić, D; Čorić, M; Jelušić, M; Milošević, D; Topalović-Grković, M; Turudić, D, 2015)
"Proteinuria was 2."1.38The dynamics of urinary N-acetyl-β-D-glucosaminidase (NAG), a marker of renal tubular dysfunction, in patients with lupus nephritis undergoing oral prednisone therapy. ( Bob, F; Bozdog, G; Cioca, D; Gadalean, F; Gluhovschi, C; Gluhovschi, G; Kaycsa, A; Marian, R; Petrica, L; Velciov, S; Vernic, C, 2012)
"Compared with pregnant women without lupus nephritis (n = 60), pregnancies with previous lupus nephritis (n = 35) were associated with a higher risk of maternal complications (88."1.38Impact of previous lupus nephritis on maternal and fetal outcomes during pregnancy. ( Arias-Flores, R; Cruz-Cruz, P; Cruz-Reyes, C; Jara, LJ; Romero, GT; Saavedra, MA; Vera-Lastra, O, 2012)
"01) and dosage of immunosuppressant."1.38APRIL, a proliferation-inducing ligand, as a potential marker of lupus nephritis. ( Avihingsanon, Y; Benjachat, T; Eiam-ong, S; Hirankarn, N; Kittikowit, W; Leelahavanichkul, A; Somparn, P; Tantivitayakul, P; Treamtrakanpon, W, 2012)
"The treatment of membranous lupus nephritis (MLN) is still controversial in the literature."1.37Prednisone monotherapy induced remission in a group of patients with membranous lupus nephritis. ( Alves de Brito, G; Bitencourt Dias, C; Dos Santos Silva, V; Gera Abrão, J; Malafronte, P; Pinheiro, CC; Titan, S; Toledo Barros, R; Woronik, V, 2011)
" Most adverse events were transient and did not require change in therapy."1.35The effectiveness and safety of mycophenolate mofetil in lupus nephritis. ( Ballou, S; Elyan, M, 2009)
"Maintenance therapy of severe pediatric systemic lupus erythematosus (SLE) usually consists of azathioprine and prednisone ."1.35Experience with mycophenolate mofetil as maintenance therapy in five pediatric patients with severe systemic lupus erythematosus. ( Amann, K; Benz, K; Dittrich, K; Dötsch, J; Ross, S, 2009)
"Patients with systemic lupus erythematosus (SLE) often produce autoantibodies against a large number of antigens."1.33Isaacs' syndrome (autoimmune neuromyotonia) in a patient with systemic lupus erythematosus. ( Taylor, PW, 2005)
"Pulmonary hemorrhage is a major life-threatening manifestation in children and adolescents with systemic lupus erythematosus, as well as in adults."1.32Treatment of pulmonary hemorrhage in childhood systemic lupus erythematosus with mycophenolate mofetil. ( Lindsley, CB; Samad, AS, 2003)
" Patients with carotid abnormalities were significantly older, had higher blood pressure and total serum cholesterol levels, and had taken a higher prednisone cumulative dosage than those without any lesions."1.32Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus. ( Corbanese, S; Doria, A; Favaretto, E; Gambari, PF; Ghirardello, A; Gilburd, B; Iaccarino, L; Patnaik, M; Pauletto, P; Peter, JB; Puato, M; Sherer, Y; Shoenfeld, Y; Todesco, S; Wu, R; Zampieri, S, 2003)
"In the immunosuppressive treatment of lupus nephritis the insertion of a consolidation phase with rituximab combined with cyclophosphamide achieves a therapeutically important and lasting deletion of the lymphocyte clone responsible for autoimmunity."1.32Remission of refractory lupus nephritis with a protocol including rituximab. ( Avanzi, GC; Bartoli, E; Fra, GP, 2003)
" CsA was given at a starting dosage of 5 mg x kg(-1) x d(-1) for 3 months, with a 1 mg x kg(-1) x d(-1) reduction every month and then maintained at a dosage of 2 mg x kg(-1) x d(-1)."1.32Cyclosporine A in treatment of membranous lupus nephropathy. ( Chen, H; Hu, W; Li, L; Li, S; Liu, Z; Shen, S; Yao, X, 2003)
"Nine patients with diffuse proliferative lupus nephritis confirmed by renal biopsy received MMF/prednisone for six months when repeat biopsies were performed."1.32Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study. ( Ding, L; Liu, Y; Wang, H; Zhao, M; Zou, W, 2004)
"Acquired ichthyosis is an uncommon disease, it is characterized by symmetric scaling of the skin, which ranges from minor roughness and dryness to the desquamation of large plaques."1.32Acquired ichthyosis associated with systemic lupus erythematosus. ( Guevara-Gutiérrez, E; Salazar-Páramo, M; Tlacuilo-Parra, JA, 2004)
"Azathioprine (AZA) was given as maintenance therapy in 117 patients (75%)."1.32Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis. ( Lau, CS; Lee, KW; Leung, CY; Mok, CC; Ng, WL; Tang, S; Wong, RW; Ying, KY, 2004)
" The initial dosage of MMF was 0."1.31Mycophenolate mofetil treatment for diffuse proliferative lupus nephritis: a multicenter clinical trial in China. ( Li, L; Lin, S; Wang, H, 2002)
"In the glomerulonephritides of systemic lupus erythematosus (SLE), the number of subendothelial deposits, when present, generally corresponds to the degree of light microscopic glomerular hypercellularity; only very rarely are no or few such deposits present in cases of focal (WHO class III) or diffuse (WHO class IV) proliferative lupus nephritis."1.31"Pauci-Immune" proliferative and necrotizing glomerulonephritis with thrombotic microangiopathy in patients with systemic lupus erythematosus and lupus-like syndrome. ( Charney, DA; Nadasdy, T; Nassar, G; Truong, L, 2000)
"To investigate the prognosis of lupus nephritis (LN) and its influencing factors in patients with lupus nephritis in China."1.30The prognosis of biopsy-proven lupus nephritis in chinese patients: long term follow-up of 86 cases. ( Li, L; Liu, Z; Shen, K; Tang, Z; Yu, Y, 1997)
"Mean proteinuria was 9 g/day with a mean duration of disease of 25 months (range 12-48)."1.30A pilot study of low-dose fludarabine in membranous nephropathy refractory to therapy. ( Austin, HA; Balow, JE; Boumpas, DT; Fleisher, TA; Kim, Y; Piscitelli, S; Pucino, F; Tassiulas, IO; Vaughan, E, 1999)
"Patients with lupus nephritis frequently exhibit increasing proteinuria, hypertension and deterioration of renal function due to either active lupus nephritis, chronic lupus nephritis and/or superimposed preeclampsia during pregnancy."1.29Evaluation of lupus nephritis during pregnancy by renal biopsy. ( Krane, NK; Meleg-Smith, S; Thakur, V; Wood, H, 1995)
"21 patients with severe active lupus nephritis (LN) were treated with intravenous cyclophosphamide monthly doses 0."1.29[Monthly intravenous cyclophosphamide in the treatment of lupus nephritis]. ( Czyz, W; Klinger, M; Rychlewska, B, 1994)
"The data show that patients with ESRD secondary to lupus nephritis can undergo renal transplantation with satisfactory outcome."1.29Renal transplantation in systemic lupus erythematosus: a single-center experience with sixty-four cases. ( Aswad, S; Bangsil, R; el-Shahawy, MA; Massry, SG; Mendez, R; Mendez, RG, 1995)
"We report a 49 years old woman with systemic lupus erythematosus and a WHO type IV nephropathy, treated with prednisone 1 mg/kg/day po and cyclophosphamide 1 g/month iv."1.29[Lupus erythematosus disseminatus and Pneumocystis carinii pneumonia]. ( Guzmán, L; Neira, O; Wainstein, E, 1993)
"End-stage renal disease (ESRD) is one of the most significant complications of systemic lupus erythematosus (SLE)."1.29Treatment of end-stage renal disease due to lupus nephritis: comparison of six patients treated with both peritoneal and hemodialysis. ( Krane, NK; Stock, GG, 1993)
"Among children with lupus nephritis, those with Class IV disease, hypertension, high creatinine levels, and low C3 complement levels at the time of diagnosis are at increased risk for ESRD."1.29Lupus nephritis in children: a longitudinal study of prognostic factors and therapy. ( Ahmad, H; Balachandra, S; Baqi, N; Moazami, S; Singh, A; Tejani, A, 1996)
"Most frequent are preeclampsia, premature labour, foetal maldevelopment and flare-ups of the underlying disease."1.28[Systemic lupus erythematosus and pregnancy. Clinical aspects, serology and management]. ( DuBois, A; Hillemanns, HG; Kerl, J; Quaas, L; Röther, E; Runge, HM, 1990)
"In 177 patients with lupus nephritis in the course of three decades three methods of immunotherapy were used the effect of which was evaluated retrospectively."1.28[Evaluation of long-term immunotherapy in patients with lupus nephritis]. ( Lukác, J; Rovenský, J; Zitnan, D, 1989)
" Twenty-five of 39 patients had normal complement levels within six months (Group 1), and immunosuppressive therapy was tapered but continuously readjusted to the lowest dosage that preserved normal CH50 and maintained clinical remission."1.28Effect of long-term normalization of serum complement levels on the course of lupus nephritis. ( Bank, N; Barland, P; Glicklich, D; Grayzel, AI; Laitman, RS; Sablay, LB, 1989)
"Six of 9 patients with ESRD and SLE died with active SLE and/or sepsis 1-28 months following the onset of dialysis."1.28Poor prognosis in end-stage lupus nephritis due to nonautologous vascular access site associated septicemia and lupus flares. ( Adler, SG; Cohen, AH; Louie, JS; Sires, RL, 1989)
"Treatment of lupus nephritis with high dose prednisone alone or in combination with immunosuppressants did not result in differences in patient survival or renal function preservation."1.28Systemic lupus erythematosus. III. Observations on clinical renal involvement and follow up of renal function: Dutch experience with 110 patients studied prospectively. ( Bronsveld, W; Nossent, JC; Swaak, AJ, 1989)
"We describe a patient who developed acute nonlymphocytic leukemia after receiving a total dose of 4 gm of cyclophosphamide over a 1-year period."1.27Acute nonlymphocytic leukemia following short-term, intermittent, intravenous cyclophosphamide treatment of lupus nephritis. ( Gibbons, RB; Westerman, E, 1988)
"Prednisone was discontinued in only one patient at any time during peritoneal dialysis."1.27Persistence of clinical and serologic activity in patients with systemic lupus erythematosus undergoing peritoneal dialysis. ( Korbet, SM; Lewis, EJ; Rodby, RA, 1987)

Research

Studies (212)

TimeframeStudies, this research(%)All Research%
pre-199025 (11.79)18.7374
1990's60 (28.30)18.2507
2000's51 (24.06)29.6817
2010's58 (27.36)24.3611
2020's18 (8.49)2.80

Authors

AuthorsStudies
Chen, Y1
Li, K1
Zhang, H4
Liu, Z14
Chen, D1
Yang, L1
Hu, W5
Liu, L1
Murray, B1
Tomaszewski, JE1
Cao, H1
Liang, J1
Liu, J2
He, Y4
Ke, Y1
Sun, Y1
Jiang, S1
Lin, J1
Fu, Q1
Wu, C1
Dai, M1
Wang, S2
Xu, J1
Dai, L1
Li, Z2
He, L1
Zhu, X1
Sun, L2
Lu, L1
Bao, C1
Du, L1
Feng, Y1
Wang, C2
Shi, X1
Wen, C1
He, Z1
Zhang, Y1
Usiskin, IM1
Kyttaris, VC2
Liu, R1
Huang, X2
Ye, H1
Wu, H1
Guo, J1
Peng, Y1
Wu, M1
Fan, J1
Yang, X3
Chang, JC1
Varghese, SA1
Behrens, EM1
Gmuca, S1
Kennedy, JS1
Liebling, EJ1
Lerman, MA1
Mehta, JJ1
Rutstein, BH1
Sherry, DD2
Stingl, CJ1
Weaver, LK1
Weiss, PF1
Burnham, JM1
Shi, Y1
Yao, W1
Li, G1
Liu, H1
Ding, P1
Xu, H2
Chen, J6
Chen, P1
Arpali, E1
Akyollu, B1
Yelken, B1
Tekin, S1
Turkmen, A1
Kocak, B1
Prasad, N1
Kurian, J1
Agarwal, V1
Bhadauria, D1
Behera, M1
Yacha, M1
Kushwaha, R1
Agrawal, V1
Jain, M1
Gupta, A1
Romano-Aguilar, M1
Reséndiz-Galván, JE1
Medellín-Garibay, SE1
Milán-Segovia, RDC1
Martínez-Martínez, MU1
Abud-Mendoza, C1
Romano-Moreno, S1
Rodriguez-Jimenez, NA1
Perez-Guerrero, EE1
Gamez-Nava, JI1
Sanchez-Mosco, DI1
Saldaña-Cruz, AM1
Alcaraz-Lopez, MF1
Fajardo-Robledo, NS1
Muñoz-Valle, JF1
Bonilla-Lara, D1
Diaz-Rizo, V1
Gonzalez-Lopez, L1
Fayed, A1
El Menyawi, MM1
Ghanema, M1
Shaker, O1
Elgohary, R1
Reátegui-Sokolova, C1
Ugarte-Gil, MF1
Harvey, GB1
Wojdyla, D1
Pons-Estel, GJ1
Quintana, R1
Serrano-Morales, RM1
Sacnun, MP1
Catoggio, LJ1
Soriano, ER1
García, MA1
Saurit, V1
Alvarellos, A1
Caeiro, F1
Berbotto, GA1
Sato, EI1
Borba Neto, EF1
Bonfa, E3
de Oliveira E Silva Montandon, AC1
Da Silva, NA1
Cavalcanti, F1
Vásquez, G1
Guibert-Toledano, M1
Reyes-Llerena, GA1
Massardo, L1
Neira, OJ1
Cardiel, MH1
Barile-Fabris, LA1
Amigo, MC1
Silveira, LH1
Portela-Hernández, M1
Garcia de la Torre, I1
Segami, MI1
Chacón-Diaz, R1
Esteva-Spinetti, MH1
Alarcón, GS1
Pons-Estel, BA1
Tselios, K1
Gladman, DD1
Al-Sheikh, H1
Su, J1
Urowitz, MB1
Zen, M1
Fuzzi, E1
Loredo Martinez, M1
Depascale, R1
Fredi, M1
Gatto, M1
Larosa, M1
Saccon, F1
Iaccarino, L2
Doria, A5
Chavatza, K1
Kostopoulou, M1
Nikolopoulos, D1
Gioti, O1
Togia, K1
Andreoli, L1
Aringer, M1
Boletis, J1
Houssiau, FA1
Jayne, D2
Mosca, M2
Svenungsson, E1
Tincani, A1
Bertsias, G1
Fanouriakis, A1
Boumpas, DT3
Bomback, AS1
Ruiz-Irastorza, G2
Ugarte, A1
Saint-Pastou Terrier, C1
Lazaro, E1
Iza, A1
Couzi, L1
Saenz, R1
Richez, C1
Porta, S1
Blanco, P1
Knight, A1
Kogon, AJ1
Matheson, MB1
Warady, BA1
Furth, SL1
Hooper, SR1
Zhou, M4
Xing, C3
Lin, H2
Ni, Z3
Fu, P3
Liu, F3
Chen, N2
Zeng, C2
Fu, J2
Wang, Z3
Lee, K1
Wei, C1
Zhang, M2
Cai, M1
Zhang, W1
Chuang, PY1
Ma'ayan, A1
He, JC1
Chen, WL1
Liu, YD1
Li, XL1
Feng, SX1
Zhou, XY1
Ma, WX1
Li, Y2
Ye, DS1
Chen, X1
Chen, SL1
Karasawa, K1
Uchida, K1
Takabe, T1
Moriyama, T1
Nitta, K1
Groot, N1
Shaikhani, D1
Teng, YKO1
de Leeuw, K1
Bijl, M2
Dolhain, RJEM1
Zirkzee, E1
Fritsch-Stork, R1
Bultink, IEM1
Kamphuis, S1
Castro, M1
Ugolini-Lopes, M1
Borba, EF2
Seguro, LPC1
Qi, C1
Zha, Y1
Luo, P1
Wang, L1
Sun, Z1
Wan, J1
Jiang, G1
Sun, M1
Chen, Q1
Li, D1
Guan, T1
Fangtham, M1
Petri, M5
Danza, A1
Perales, I1
Villar, I1
Garcia, M1
Delgado, S1
Khamashta, M1
Jira, M1
Elqatni, M1
Sekkach, Y1
Elomri, N1
Mekouar, F1
Ghafir, D1
Tian, SY2
Feldman, BM2
Beyene, J2
Brown, PE2
Uleryk, EM2
Silverman, ED2
Watson, P1
Brennan, A1
Birch, H1
Fang, H1
Miao, L1
Gu, Y1
Shi, W1
Bao, H3
Arends, S1
Berden, JH2
Grootscholten, C1
Derksen, RH2
Berger, SP1
de Sévaux, RG1
Voskuyl, AE2
Batinić, D1
Milošević, D1
Čorić, M1
Topalović-Grković, M1
Jelušić, M1
Turudić, D1
Cotton, D1
Mahmoud, GA1
Zayed, HS1
Ghoniem, SA1
Hu, WX2
Chen, YH1
Liu, ZZ1
Wang, SF1
Zhang, HT2
Liu, ZH2
Campise, M1
Giglio, E1
Trespidi, L1
Messa, P1
Moroni, G5
Warren, CC1
Gendy, MG1
Kim, JE1
Mejía-Vilet, JM1
Córdova-Sánchez, BM1
Uribe-Uribe, NO1
Correa-Rotter, R1
Staveri, C1
Karokis, D1
Liossis, SC1
Tsang-A-Sjoe, MW1
Bultink, IE1
Heslinga, M1
Song, XZ1
Chen, JM1
Zhou, QG1
Huang, L1
Hou, J1
Al-Khazraji, A1
Takher, J1
Alkhawam, H1
Fabbri, M1
Basu, B1
Roy, B1
Babu, BG1
Ataia, I1
Casaulta, C1
von Vigier, RO1
Pfammatter, JP1
Brekenfeld, C1
Sauvain, MJ1
Steinlin, M1
Cohen, RA1
Bayliss, G1
Crispin, JC1
Kane-Wanger, GF1
Van Beek, CA1
Avalos, I1
Yu, CY1
Tsokos, GC1
Stillman, IE1
Xie, HL1
Li, LS1
Ahmadzadeh, A2
Derakhshan, A1
Austin, HA3
Illei, GG2
Braun, MJ1
Balow, JE3
Elyan, M1
Ballou, S1
Yu, F1
Tan, Y1
Liu, G1
Wang, SX1
Zou, WZ1
Zhao, MH1
Radhakrishnan, J2
Moutzouris, DA1
Ginzler, EM5
Solomons, N3
Siempos, II1
Appel, GB5
Isenberg, D2
Contreras, G3
Dooley, MA3
Sánchez-Guerrero, J1
Wofsy, D2
Yu, X4
Dittrich, K1
Ross, S1
Benz, K1
Amann, K1
Dötsch, J1
Gordon, C1
Lisk, L2
Gluhovschi, C2
Gluhovschi, G2
Herman, D1
Trandafirescu, V1
Petrica, L2
Velciov, S2
Bozdog, G2
Bob, F2
Cioca, D2
Patel, SB1
Korbet, SM3
Lewis, EJ8
Chen, W4
Tang, X1
Liu, Q1
Liao, Y1
Yang, Z1
Zhang, J2
Lou, T1
Kong, Y1
Fan, A1
Rao, S1
Kendouci-Tani, MS1
Talet, HB1
Sekkal, A1
Heras, M1
Saiz, A1
Fernández-Reyes, MJ1
Sánchez, R1
Zurita, P1
Urrego, C1
Wu, XL2
Zhang, WG1
Shi, XM2
An, P2
Sun, WS2
Qiao, CL2
Kaycsa, A1
Marian, R1
Gadalean, F1
Vernic, C1
Bitencourt Dias, C1
Pinheiro, CC1
Malafronte, P1
Titan, S1
Alves de Brito, G1
Gera Abrão, J1
Dos Santos Silva, V1
Toledo Barros, R1
Woronik, V1
Carneiro, FO1
Sampaio, LR1
Brandão, LA1
Braga, LL1
Rocha, FA1
Paliga, A1
Shahbazi, N1
Gonsalves, C1
Bormanis, J1
Padmore, R1
Pinto Valdivia, M1
Samson, M1
Audia, S1
Leguy, V1
Berthier, S1
Janikashvili, N1
Martin, L1
Bonnotte, B1
Lorcerie, B1
Saavedra, MA1
Cruz-Reyes, C1
Vera-Lastra, O1
Romero, GT1
Cruz-Cruz, P1
Arias-Flores, R1
Jara, LJ1
Wax, S1
Rajeswaran, A1
Copt, S1
Hillson, J1
Ramos, E1
Singer, NG1
Rubio-Rivas, M1
Gómez-Junyent, J1
Simonetti, A1
Mitjavila, F1
Capdevila, O1
Pujol, R1
Rivera, F2
Fulladosa, X1
Poveda, R1
Frutos, MA1
García-Frías, P1
Ara, J1
Illescas, L1
López-Rubio, E1
Mérida, E1
Carreño, A2
Ballarín, J1
Fernández-Juárez, G1
Baltar, J1
Ramos, C1
Pons, S1
Oliet, A1
Vigil, A1
Praga, M1
Segarra, A1
Redondo-Pachón, MD1
Enríquez, R2
Sirvent, AE1
Andrada, E1
Millán, I1
Amorós, F2
Sundel, R1
Fischer-Betz, R1
Chehab, G1
Sander, O1
Vordenbäumen, S1
Voiculescu, A1
Brinks, R1
Schneider, M1
Treamtrakanpon, W1
Tantivitayakul, P1
Benjachat, T1
Somparn, P1
Kittikowit, W1
Eiam-ong, S1
Leelahavanichkul, A1
Hirankarn, N1
Avihingsanon, Y1
Ayodele, OE1
Okpechi, IG1
Swanepoel, CR1
Li, L3
Wang, H3
Lin, S1
Lavina, AM1
Agarwal, A1
Hunyor, A1
Gass, JD1
Samad, AS1
Lindsley, CB1
POLLAK, VE3
KARK, RM2
PIRANI, CL2
WILSON, RM1
MAHER, JF1
SCHREINER, GE1
SMITH, FG1
LITMAN, N1
LATTA, H1
Shoenfeld, Y2
Wu, R1
Gambari, PF1
Puato, M1
Ghirardello, A1
Gilburd, B1
Corbanese, S1
Patnaik, M1
Zampieri, S1
Peter, JB1
Favaretto, E1
Sherer, Y2
Todesco, S2
Pauletto, P1
Fra, GP1
Avanzi, GC1
Bartoli, E1
Utiger, RD1
Galindo-Rodríguez, G1
Bustamante, R1
Esquivel-Nava, G1
Salazar-Exaire, D1
Vela-Ojeda, J1
Vadillo-Buenfil, M1
Aviña-Zubieta, JA1
Shen, S1
Li, S1
Yao, X1
Chen, H1
Mok, CC2
Ying, KY2
Lau, CS2
Yim, CW1
Ng, WL2
Wong, WS1
Au, TC1
Lehman, TJ2
Edelheit, BS1
Onel, KB1
Ding, L1
Zhao, M1
Zou, W1
Liu, Y3
Pardo, V1
Leclercq, B1
Lenz, O1
Tozman, E2
O'Nan, P1
Roth, D1
Zappitelli, M1
Duffy, C1
Bernard, C1
Scuccimarri, R1
Watanabe Duffy, K1
Kagan, R1
Gupta, IR1
Liang, L2
Zhan, Z2
Ye, Y2
Tlacuilo-Parra, JA1
Guevara-Gutiérrez, E1
Salazar-Páramo, M1
Farhey, Y1
Hess, E1
Tang, S2
Leung, CY1
Lee, KW1
Wong, RW1
Taylor, PW1
Nahar, N1
Metz, D1
Hauser, AC1
Hauser, L1
Pabinger-Fasching, I1
Quehenberger, P1
Derfler, K1
Hörl, WH1
Aranow, C1
Kim, MY1
Buyon, J1
Merrill, JT1
Gilkeson, GS1
Wallace, DJ3
Weisman, MH1
Zheng, WC1
Hu, SJ1
Fang, Q1
Ozkan, HA1
Ozkalemkas, F1
Ali, R1
Ozkocaman, V1
Ozcelik, T1
Sánchez de la Nieta, MD1
de la Torre, M1
Kasitanon, N1
Fine, DM1
Haas, M1
Magder, LS1
Mittal, BV1
Pendse, S1
Rennke, HG1
Singh, AK3
Burchardi, C1
Schlöndorff, D1
Wang, YH1
Wu, XX1
Tan, JP1
Zhang, JP1
Chan, TM2
Cavallasca, JA1
Laborde, HA1
Ruda-Vega, H1
Nasswetter, GG1
Zar, T1
Samson, W1
Palmisano, J1
Alberighi, OD1
Ferraccioli, G1
Manno, C1
Altieri, P1
Ferrara, R1
Greco, S1
Ponticelli, C4
de Groot, K1
Schwartz, MM3
Krane, NK2
Thakur, V1
Wood, H1
Meleg-Smith, S1
Remuzzi, G1
Gotti, E1
Klinger, M1
Rychlewska, B1
Czyz, W1
el-Shahawy, MA1
Aswad, S1
Mendez, RG1
Bangsil, R1
Mendez, R1
Massry, SG1
Oberle, GP1
Helmchen, U1
Stahl, RA1
van den Wall Bake, AW1
de Glas-Vos, JW1
Hagen, EC1
Valeri, A2
Estes, D1
D'Agati, V1
Kopelman, R1
Pernis, A1
Flis, R1
Pirani, C1
Piccoli, A1
Vesco, P1
Vaccaro, E1
Marson, P1
De Silvestro, G1
Ossi, E1
Gambari, P1
Ye, RG1
Ren, GH1
Li, HQ1
McInnes, PM1
Schuttinga, J1
Sanslone, WR1
Stark, SP1
Klippel, JH2
Wainstein, E1
Neira, O1
Guzmán, L1
Stock, GG1
Bertoni, M1
Brugnolo, F1
Bertoni, E1
Salvadori, M1
Romagnani, S1
Emmi, L1
Santos, RD1
Vinagre, CG1
Pileggi, FJ1
Cossermelli, W1
Maranhão, RC1
Fagundus, DM1
Leroy, EC1
Gandhi, R1
Hussein, MM1
Mooij, JM1
Roujouleh, H1
Ucci, A1
Madias, NE1
Baqi, N1
Moazami, S1
Singh, A1
Ahmad, H1
Balachandra, S1
Tejani, A1
Bansal, VK1
Beto, JA1
Cockwell, P1
Asherson, RA1
Schatten, S1
Hughes, GR1
Ware, AE1
Mongey, AB1
Matuszkiewicz-Rowińska, J2
Ostrowski, K1
Shen, K1
Yu, Y1
Tang, Z1
Ye, R2
Xie, C1
Diouf, B1
Toure, AO1
Ka, MM1
Pouye, A1
Diop, TM1
Lin, WY1
Lan, JL1
Wang, SJ1
Jiang, Y1
Huong, DL1
Papo, T1
Beaufils, H1
Wechsler, B1
Blétry, O1
Baumelou, A1
Godeau, P1
Piette, JC1
Tassiulas, IO1
Fleisher, TA1
Vaughan, E1
Piscitelli, S1
Kim, Y1
Pucino, F1
Li, FK1
Hao, WK1
Chan, KW1
Lui, SL1
Lai, KN1
Levy, Y1
George, J1
Rovensky, J2
Lukac, J2
Rauova, L1
Poprac, P1
Langevitz, P1
Fabbrizzi, F1
Charney, DA1
Nassar, G1
Truong, L1
Nadasdy, T1
Belmont, HM1
Emre, S1
Bilge, I1
Sirin, A1
Kilicaslan, I1
Nayir, A1
Oktem, F1
Uysal, V1
Wu, Q1
Wu, K1
Crane, M1
Collins, L1
Gourley, MF2
Yarboro, CH1
Vaughan, EM1
Kuroiwa, T1
Danning, CL1
Steinberg, AD3
Buratti, S1
Szer, IS2
Spencer, CH1
Bartosh, S1
Reiff, A1
Tam, LS1
Li, EK1
Szeto, CC1
Wong, SM1
Leung, CB1
Lai, FM1
Wong, KC1
Lui, SF1
Yin, P1
Ter Meulen, CG1
Pieters, GF1
Huysmans, FT1
Lachin, JM3
Lan, SP4
Balletta, M1
Sabella, D1
Magri, P1
Sepe, V1
Stanziale, P1
Di Luccio, R1
Colucci, G1
Fuiano, G1
Banfi, G3
Muir, J1
Scott, DE1
Robinson, JA1
Zhuang, GK1
Yuan, ZZ1
Zhang, ZL1
Qing, WZ1
Jin, Y1
Euler, HH1
Schroeder, JO1
Sesso, R1
Klag, M1
Lauzurica, R1
Bonet, J1
Vaquero, M1
Torguet, P1
Serra, A1
Borrás, M1
Caralps, A1
Hunsicker, LG2
Rohde, RD1
Levey, AS1
Corwin, HL1
Kasinath, BS1
Lachin, J1
Neilson, EG1
Ballati, G1
Tucciarone, L1
Diamanti, A1
Frangella, E1
Chiaramida, N1
Steinberg, SC1
Goss, JA1
Cole, BR1
Jendrisak, MD1
McCullough, CS1
So, SK1
Windus, DW1
Hanto, DW1
Tovar, JV1
Cabezuelo, JB1
Gonzalez, C1
Pohl, MA1
Berl, T1
Hahn, BH1
Hariharan, S1
Kant, KS1
Weiss, MA1
Wadhwa, NK1
Escobar, A1
Del Brutto, OH1
Clough, JD1
Runge, HM1
Röther, E1
Kerl, J1
DuBois, A1
Quaas, L1
Hillemanns, HG1
Bernstein, J1
Hill, GS1
Holley, K1
Phillips, EA1
Wagner-Weiner, L1
McCurdy, DK1
Emery, HM1
Magilavy, DB1
Kovalesky, A1
Pozsonyi, T1
Jakab, L1
Síró, I1
Potyondi, J1
Zitnan, D1
Laitman, RS1
Glicklich, D1
Sablay, LB1
Grayzel, AI1
Barland, P1
Bank, N1
Ostrov, BE1
Min, W1
Eichenfield, AH1
Goldsmith, DP1
Kaplan, B1
Athreya, BH1
Sires, RL1
Adler, SG1
Louie, JS1
Cohen, AH1
Nossent, JC1
Bronsveld, W1
Swaak, AJ1
Gibbons, RB1
Westerman, E1
Stone, J1
Smurra, G1
Quaranta, G1
Angiello, G1
Zucchelli, P1
Cagnoli, L1
Pasquali, S1
Walker, RJ1
Bailey, RR1
Swainson, CP1
Lynn, KL1
Rodby, RA1
Dillard, MG1
Kawala, K1
Strober, S1
Farinas, MC1
Field, EH1
Solovera, JJ1
Kiberd, BA1
Myers, BD1
Hoppe, RT1
Garin, EH1
Sleasman, JW1
Richard, GA1
Iravani, AA1
Fennell, RS1

Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Multicenter Trial Comparing Leflunomide and Azathioprine as Remission-Maintaining Treatment for Proliferative Lupus Glomerulonephritis.[NCT01172002]200 participants (Anticipated)Interventional2010-03-31Recruiting
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)[NCT00327860]1,100 participants (Actual)Observational2003-10-31Active, not recruiting
Effectiveness of Mycophenolate Mofetil Combined With Tacrolimus for Steroid Tapering in Systemic Lupus Erythematosus: A Prospective, Random Control, Open-label, Single Center Clinical Trial[NCT05916781]Phase 4220 participants (Anticipated)Interventional2023-07-01Recruiting
Personalised Pharmacological Approach to the Tapering of Corticosteroid Doses in Systemic Lupus Patients Treated With Prednisone[NCT03187743]72 participants (Actual)Interventional2018-04-17Completed
Efficacy of Lower Dose Prednisolone in the Induction of Remission of Lupus Nephritis[NCT04146220]Phase 432 participants (Actual)Interventional2018-07-16Completed
An Multi-site, Open, Prospective Study to Assess the Efficacy and Safety of Multi-target Therapy in the Treatment of Class Ⅲ,Ⅳ,Ⅴ,Ⅲ+Ⅴand Ⅳ+Ⅴ Lupus Nephritis[NCT00876616]362 participants (Actual)Interventional2009-04-30Completed
An Open, Prospective Study to Assess the Efficacy and Safety of FK506 Combined MMF in the Treatment of Class III,IV,V + IV or V + III Lupus Nephritis[NCT00298506]120 participants (Actual)Interventional2005-09-30Completed
A Prospective, Randomized, Active Controlled, Parallel Group, Multi-center Trial to Assess the Efficacy and Safety of Mycophenolate Mofetil (MMF) in Inducing Response and Maintaining Remission in Subjects With Lupus Nephritis.[NCT00377637]Phase 3370 participants (Actual)Interventional2005-07-31Completed
[NCT00615173]Phase 381 participants (Actual)Interventional2006-07-31Completed
A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Atacicept in Subjects With Lupus Nephritis in Combination With Mycophenolate Mofetil Therapy.[NCT00573157]Phase 2/Phase 36 participants (Actual)Interventional2007-12-31Terminated (stopped due to The study was terminated due to unanticipated safety issues)
Insulin Resistance and Atherosclerosis in a Sample of Women With Systemic Lupus Erythematosus[NCT00544102]50 participants (Actual)Observational2007-10-11Completed
Treatment of Periodontal Disease in Systemic Lupus Erytematosus: A Pilot Randomized Controlled Clinical Trial[NCT04046172]200 participants (Anticipated)Interventional2021-11-01Not yet recruiting
A Randomized, Multicenter Study to Assess the Efficacy on Diseases Activity of Enteric-coated Mycophenolate Sodium Versus Continuation of Azathioprine in Patients With Systemic Lupus Erythematosus on Azathioprine Maintenance Therapy.[NCT00504244]Phase 312 participants (Actual)Interventional2007-07-31Terminated (stopped due to Insufficient recruitment)
Five-Year Single-Blind, Phase III Effectiveness Randomised Actively Controlled Clinical Trial in New Onset Juvenile Systemic Lupus Erythematosus Nephritis: Oral Cyclophosphamide Versus High Dose Intravenous Cyclophosphamide Versus Intermediate Dose Intrav[NCT00336414]Phase 30 participants (Actual)Interventional2006-06-30Withdrawn (stopped due to the study is withdrawn due to low and unexpected enrollment rate)
CYCLONES - CYClophosphamide LOw Dose and No Extra Steroid[NCT03492255]49 participants (Actual)Interventional2018-04-12Terminated (stopped due to Significative difference between percentage of renal response (primary outcome) between the two study arms.)
Cyclophosphamide and Hydroxychloroquine for the Treatment of Severe Thrombocytopenia in Systemic Lupus Erythematosus[NCT02444728]Phase 350 participants (Actual)Interventional2015-07-31Terminated (stopped due to Because of insufficient enrollement)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Maintenance Phase: Events Contributing to the Primary Endpoint: Number of Deaths

Treatment Failure was adjudicated by a clinical endpoints committee (CEC) and was defined as the time to the earliest occurrence of any one of the following: death, end stage renal disease, sustained doubling of serum creatinine, renal flare, or a requirement for rescue therapy for exacerbation or deterioration of Lupus nephritis (LN). (NCT00377637)
Timeframe: From the start of the Maintenance Phase to Month 36

InterventionDeaths (Number)
Mycophenolate Mofetil (MMF)0
Azathioprine (AZA)1

Maintenance Phase: Events Contributing to the Primary Endpoint: Number of Participants With End-stage Renal Disease (ESRD)

Time to treatment failure, adjudicated by the Clinical Endpoints Committee (CEC), was defined as any 1 the following: death, ESRD, sustained doubling of serum creatinine, renal flare (proteinuric or nephritic), or requirement for rescue therapy to treat deterioration or exacerbation of Lupus nephritis. ESRD is defined as progression to chronic hemodialysis or renal transplant. (NCT00377637)
Timeframe: From the start of the Maintenance Phase to Month 36

Interventionparticipants (Number)
Mycophenolate Mofetil (MMF)0
Azathioprine (AZA)3

Maintenance Phase: Events Contributing to the Primary Endpoint: Number of Participants With Sustained Doubling of Serum Creatinine

Sustained doubling of serum creatinine concentration is defined as the first serum creatinine value that is twice the mean of the lowest 2 values from screening to end of induction, as confirmed by a second serum creatinine value obtained at least 4 weeks after the initial doubling. (NCT00377637)
Timeframe: From the start of the Maintenance Phase to Month 36

Interventionparticipants (Number)
Mycophenolate Mofetil1
Azathioprine5

Maintenance Phase: Participants With Major Extra-renal Flare

A major extra-renal flare is defined as a British Isles Lupus Assessment Group (BILAG) Score category A in one extrarenal organ or three organs with concurrent category B scores. BILAG indices provide a scoring system for the assessment of lupus disease activity in terms of the need for steroid treatment in 8 organs/systems. Eighty-six items were scored resulting in a classification of A (severe activity), B (moderate activity), C (mild activity), D (no current activity) and E (no activity ever observed) for each organ system. (NCT00377637)
Timeframe: From the start of the Maintenance Phase to Month 36

Interventionparticipants (Number)
Mycophenolate Mofetil7
Azathioprine6

Induction Phase: Change From Baseline in Short-Form Health Survey (SF-36) Domain and Component Scores

The SF-36 is a 36 item quality of life questionnaire. The short-form version has eleven questions that permit the participant to rate how they feel that particular day. The SF-36 consists of eight scaled scores and two component scores, which are the weighted sums of the questions in their section. Each scale is directly transformed into a 0-100 score with the higher scores indicating better quality of life. (NCT00377637)
Timeframe: Baseline and 24 weeks

,
InterventionScores on a scale (Mean)
Physical Component Summary [n=139, 137]Mental Component Summary [n=139, 137]Bodily Pain Score [n=141, 137]General Health Score [n=139, 137]Mental Health Score [n=141, 137]Physical functioning Score [n=141, 137]Role-Emotional Score [n=141, 137]Role-Physical Score [n=141, 137]Social Function Score [n=141, 137]Vitality Score [n=141, 137]
Intravenous Cyclophosphamide6.45.716.811.59.89.318.434.018.211.6
Mycophenolate Mofetil5.26.713.49.19.311.623.428.617.714.2

Induction Phase: Change From Baseline to Week 24 in 24-hour Urine Protein

24-hour urine protein was measured at Baseline and Week 24. (NCT00377637)
Timeframe: Baseline, Week 24

,
Interventionmg/day (Mean)
Baseline [n=180, 180]Week 24 [n= 150, 144]Change from Baseline to Week 24 [n= 146, 142]
Intravenous Cyclophosphamide4451.41831.6-2513.7
Mycophenolate Mofetil4208.91599.0-2510.6

Induction Phase: Change From Baseline to Week 24 in Serum Albumin

(NCT00377637)
Timeframe: Baseline, Week 24

,
Interventiong/L (Mean)
Baseline [n=184, 185]Week 24 [n=155, 151]Change from Baseline to Week 24 [n=154, 151]
Intravenous Cyclophosphamide28.638.39.0
Mycophenolate Mofetil30.538.47.5

Induction Phase: Change From Baseline to Week 24 in Serum Creatinine

(NCT00377637)
Timeframe: Baseline, Week 24

,
Interventionµmol/L (Mean)
Baseline [n= 184, 185]Week 24 [n= 155, 151]Change from Baseline to Week 24 [n= 154, 151]
Intravenous Cyclophosphamide92.783.5-5.1
Mycophenolate Mofetil108.677.6-18.9

Induction Phase: Change in Renal British Isles Lupus Assessment Group (BILAG) Score

"BILAG indices provide a scoring system for the assessment of lupus disease activity in terms of the need for steroid treatment in 8 organs/systems. Eighty-six items were scored resulting in a classification of A (severe activity), B (moderate activity), C (mild activity), D (no current activity) and E (no activity ever observed) for each organ system. The BILAG individual system summaries were calculated by a program supplied by ADS-Limathon (Sheffield, UK).~The score at baseline was compared to the score at the 24 week endpoint for each treatment group, reported here for the renal system." (NCT00377637)
Timeframe: Baseline, 24 weeks

,
InterventionPercentage of participants (Number)
Shift from Baseline=A to 24 Week Endpoint=AShift from Baseline=A to 24 Week Endpoint=BShift from Baseline=A to 24 Week Endpoint=CShift from Baseline=A to 24 Week Endpoint=DShift from Baseline=B to 24 Week Endpoint=AShift from Baseline=B to 24 Week Endpoint=BShift from Baseline=B to 24 Week Endpoint=CShift from Baseline=B to 24 Week Endpoint=DShift from Baseline=C to 24 Week Endpoint=AShift from Baseline=C to 24 Week Endpoint=BShift from Baseline=C to 24 Week Endpoint=CShift from Baseline=C to 24 Week Endpoint=DShift from Baseline=D to 24 Week Endpoint=AShift from Baseline=D to 24 Week Endpoint=BShift from Baseline=D to 24 Week Endpoint=CShift from Baseline=D to 24 Week Endpoint=D
Intravenous Cyclophosphamide27.134.824.99.40.01.11.70.00.00.60.00.00.00.00.60.0
Mycophenolate Mofetil17.139.233.15.50.01.72.21.10.00.00.00.00.00.00.00.0

Induction Phase: Number of Participants Achieving Complete Remission

Number of participants achieving complete remission as defined by return to normal serum creatinine, proteinuria ≤500 mg/24 hours and an inactive urinary sediment (absence of red blood cells, white blood cells or cellular or granular casts) after 24 weeks. (NCT00377637)
Timeframe: 24 weeks

,
Interventionparticipants (Number)
Complete Remission - YesComplete Remission - No
Intravenous Cyclophosphamide15170
Mycophenolate Mofetil16169

Induction Phase: Number of Patients Showing Treatment Response

Treatment response was adjudicated by a blinded clinical endpoints committee (CEC) and defined as: a) Decrease in proteinuria, defined as a decrease in the urine protein to creatinine ratio (UPCr) to <3 in subjects with baseline proteinuria ≥3 UPCr or a decrease in the UPCr by ≥50% in subjects with proteinuria <3 UPCr at Baseline, and b) Stabilization of serum creatinine or improvement. UPCr were derived from the 24 hour urine collection. Patients who did not show a treatment response at Week 24 or who withdrew earlier than Week 24 were considered non-responders. (NCT00377637)
Timeframe: 24 weeks

,
Interventionparticipants (Number)
ResponderNon-responder
Intravenous Cyclophosphamide9887
Mycophenolate Mofetil10481

Maintenance Phase: Events Contributing to the Primary Endpoint: Kaplan-Meier Estimates of Percentage of Participants Not Receiving Rescue Therapy

The primary efficacy parameter was the time to treatment failure, adjudicated by the Clinical Endpoints Committee (CEC), defined as any of the following: death, end stage renal disease, sustained doubling of serum creatinine, renal flare, or requirement for rescue therapy to treat deterioration or exacerbation of Lupus nephritis. Kaplan-Meier survival curves were estimated from the observed time to rescue treatment for each patient. The data presented are the percentage of participants who were rescue treatment free at each time interval as estimated by Kaplan-Meier. (NCT00377637)
Timeframe: From the start of the Maintenance Phase to Month 36

,
InterventionPercentage of participants (Number)
Start of Maintenance Phase to Month 3Month 3 to Month 6Month 6 to Month 9Month 9 to Month 12Month 12 to Month 15Month 15 to Month 18Month 18 to Month 21Month 21 to Month 24Month 24 to Month 27Month 27 to Month 30Month 30 to Month 33Month 33 to Month 36
Azathioprine99.195.193.091.988.487.183.183.181.780.378.875.9
Mycophenolate Mofetil10098.297.294.294.294.293.191.990.890.890.890.8

Maintenance Phase: Events Contributing to the Primary Endpoint: Kaplan-Meier Estimates of Percentage of Participants Renal Flare Free, by Time Interval

A proteinuric flare is defined as a doubling of the urine protein:creatinine ratio, and proteinuria ≥1 g/24 h in patients with urine protein ≤0.5 g/24 h at the end of the induction phase, or proteinuria ≥2 g/24 h if urine protein was >0.5 g/24 h at the end of the induction phase. A nephritic flare is defined as a 25% increase in serum creatinine accompanied by 1 or more of the following: (a) simultaneous doubling of the proteinuria reaching a minimum of 2 g/24 h (b) new/increased hematuria or (c) the appearance of cellular casts. All flares were adjudicated by a clinical endpoints committee. (NCT00377637)
Timeframe: From the start of the Maintenance Phase to Month 36

,
InterventionPercentage of participants (Number)
Start of Maintenance Phase to Month 3Month 3 to Month 6Month 6 to Month 9Month 9 to Month 12Month 12 to Month 15Month 15 to Month 18Month 18 to Month 21Month 21 to Month 24Month 24 to Month 27Month 27 to Month 30Month 30 to Month 33Month 33 to Month 36
Azathioprine97.290.387.285.082.879.278.075.574.274.272.970.1
Mycophenolate Mofetil98.294.690.887.887.886.886.886.886.886.885.685.6

Maintenance Phase: Kaplan-Meier Estimates of Percentage of Participants Treatment Failure Free, by Time Interval

Treatment Failure was adjudicated by a clinical endpoints committee and was defined as the time to the earliest occurrence of any one of the following: death, end stage renal disease, sustained doubling of serum creatinine, renal flare, or a requirement for rescue therapy for exacerbation or deterioration of Lupus nephritis. Kaplan-Meier survival curves were estimated from the observed time to treatment failure for each patient. The data presented are the percentage of participants who were treatment-failure free at each time interval as estimated by Kaplan-Meier. (NCT00377637)
Timeframe: From the start of the Maintenance Phase to Month 36

,
InterventionPercentage of participants (Number)
Start of Maintenance Phase to Month 3Month 3 to Month 6Month 6 to Month 9Month 9 to Month 12Month 12 to Month 15Month 15 to Month 18Month 18 to Month 21Month 21 to Month 24Month 24 to Month 27Month 27 to Month 30Month 30 to Month 33Month 33 to Month 36
Azathioprine97.289.386.283.077.574.170.768.367.165.963.458.6
Mycophenolate Mofetil98.293.789.986.086.084.984.983.982.882.881.781.7

Reviews

16 reviews available for prednisone and Glomerulonephritis, Lupus

ArticleYear
Recent Advances in Treatment Strategies for Lupus Nephritis.
    Contributions to nephrology, 2018, Volume: 195

    Topics: Antihypertensive Agents; Antirheumatic Agents; Cyclophosphamide; Drug Therapy, Combination; Glucocor

2018
2013 update: Hopkins lupus cohort.
    Current rheumatology reports, 2013, Volume: 15, Issue:9

    Topics: Antirheumatic Agents; Cardiovascular Diseases; Cognition Disorders; Cohort Studies; Creatinine; Gluc

2013
[Three cases of bullous lupus erythematosus].
    Annales de dermatologie et de venereologie, 2013, Volume: 140, Issue:12

    Topics: Adult; Arthralgia; Autoantibodies; Blister; Collagen; Diagnosis, Differential; Disease Progression;

2013
Immunosuppressive therapies for the induction treatment of proliferative lupus nephritis: a systematic review and network metaanalysis.
    The Journal of rheumatology, 2014, Volume: 41, Issue:10

    Topics: Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Lupus Nephritis; Mycophenolic Acid

2014
Pregnancies in women receiving renal transplant for lupus nephritis: description of nine pregnancies and review of the literature.
    Lupus, 2015, Volume: 24, Issue:11

    Topics: Abortion, Spontaneous; Adult; Anti-Inflammatory Agents; Antibodies, Antinuclear; Antihypertensive Ag

2015
Immunosuppressive Therapies for the Maintenance Treatment of Proliferative Lupus Nephritis: A Systematic Review and Network Metaanalysis.
    The Journal of rheumatology, 2015, Volume: 42, Issue:8

    Topics: Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Lupus Nephritis; Mycophenolic Acid

2015
[Lupus nephritis].
    Der Internist, 1995, Volume: 36, Issue:3

    Topics: Antibodies, Antinuclear; Biopsy; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administra

1995
The course and treatment of lupus nephritis.
    Annual review of medicine, 1994, Volume: 45

    Topics: Azathioprine; Cyclophosphamide; Drug Combinations; Humans; Lupus Nephritis; Prednisone; Prognosis; W

1994
Predominant tubulointerstitial lupus nephritis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1996, Volume: 27, Issue:2

    Topics: Acute Kidney Injury; Glucocorticoids; Humans; Kidney Glomerulus; Kidney Tubules; Lupus Nephritis; Ma

1996
Treatment of lupus nephritis: a meta-analysis of clinical trials.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1997, Volume: 29, Issue:2

    Topics: Adult; Azathioprine; Child; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunosuppr

1997
[Lupus nephropathy--therapeutic options 1996].
    Polskie Archiwum Medycyny Wewnetrznej, 1997, Volume: 97, Issue:1

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Cyclophosphamide; Female; Humans; Immunosuppressi

1997
Initial management of proliferative lupus nephritis: to cytotoxic or not to cytotoxic?
    Current rheumatology reports, 1999, Volume: 1, Issue:2

    Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Azathioprine; Clinical Trials as Topic; Cyclophospha

1999
Renal transplantation for systemic lupus erythematosus and recurrent lupus nephritis. A single-center experience and a review of the literature.
    Transplantation, 1991, Volume: 52, Issue:5

    Topics: Adult; Animals; Antibodies, Antinuclear; Antilymphocyte Serum; Azathioprine; Complement System Prote

1991
[Systemic lupus erythematosus and pregnancy].
    Orvosi hetilap, 1989, Jul-02, Volume: 130, Issue:27

    Topics: Adult; Breast Feeding; Female; Glomerulonephritis; Humans; Infant, Newborn; Lupus Erythematosus, Sys

1989
[Lupus nephropathy. II. Treatment].
    Polskie Archiwum Medycyny Wewnetrznej, 1989, Volume: 81, Issue:5

    Topics: Azathioprine; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Humans; Immunotherapy; L

1989
Long-term prognosis of diffuse lupus nephritis.
    Clinical nephrology, 1987, Volume: 28, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Creatinine; Female; Follow-Up Studies; Humans; Infusions, I

1987

Trials

48 trials available for prednisone and Glomerulonephritis, Lupus

ArticleYear
Leflunomide versus azathioprine for maintenance therapy of lupus nephritis: a prospective, multicentre, randomised trial and long-term follow-up.
    Annals of the rheumatic diseases, 2022, Volume: 81, Issue:11

    Topics: Adult; Azathioprine; Creatinine; Cyclophosphamide; Drug Therapy, Combination; Follow-Up Studies; Hum

2022
Effectiveness of renoprotective approaches for persistent proteinuria in lupus nephritis: more than just immunosuppression.
    Lupus, 2018, Volume: 27, Issue:14

    Topics: Adult; Azathioprine; Blood Pressure; Brazil; Drug Therapy, Combination; Female; Humans; Immunosuppre

2018
Leflunomide versus cyclophosphamide in the induction treatment of proliferative lupus nephritis in Chinese patients: a randomized trial.
    Clinical rheumatology, 2019, Volume: 38, Issue:3

    Topics: Adult; Antibodies, Antinuclear; China; Complement C3; Cyclophosphamide; DNA; Drug Therapy, Combinati

2019
Multitarget therapy for induction treatment of lupus nephritis: a randomized trial.
    Annals of internal medicine, 2015, Jan-06, Volume: 162, Issue:1

    Topics: Adolescent; Adult; Aged; Biopsy; Cyclophosphamide; Drug Therapy, Combination; Female; Glucocorticoid

2015
Immunosuppressive treatment for pure membranous lupus nephropathy in a Hispanic population.
    Clinical rheumatology, 2016, Volume: 35, Issue:9

    Topics: Adolescent; Adult; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female; Glomerulonephr

2016
Successful treatment of class V+IV lupus nephritis with multitarget therapy.
    Journal of the American Society of Nephrology : JASN, 2008, Volume: 19, Issue:10

    Topics: Adult; Drug Therapy, Combination; Enzyme Inhibitors; Female; Glucocorticoids; Humans; Immunosuppress

2008
Randomized, controlled trial of prednisone, cyclophosphamide, and cyclosporine in lupus membranous nephropathy.
    Journal of the American Society of Nephrology : JASN, 2009, Volume: 20, Issue:4

    Topics: Adolescent; Adult; Age of Onset; Cyclophosphamide; Cyclosporine; Female; Hematocrit; Humans; Immunos

2009
Mycophenolate mofetil and intravenous cyclophosphamide are similar as induction therapy for class V lupus nephritis.
    Kidney international, 2010, Volume: 77, Issue:2

    Topics: Adolescent; Adult; Creatinine; Cyclophosphamide; Female; Glucocorticoids; Humans; Immunosuppressive

2010
Influence of race/ethnicity on response to lupus nephritis treatment: the ALMS study.
    Rheumatology (Oxford, England), 2010, Volume: 49, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combin

2010
Nonrenal disease activity following mycophenolate mofetil or intravenous cyclophosphamide as induction treatment for lupus nephritis: findings in a multicenter, prospective, randomized, open-label, parallel-group clinical trial.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Complement System Proteins;

2010
The prognosis of severe lupus nephritis based on the Modification of Diet in Renal Disease (MDRD) study estimated glomerular filtration rate.
    Lupus, 2011, Volume: 20, Issue:3

    Topics: Adult; Anti-Inflammatory Agents; Creatinine; Cyclophosphamide; Diet; Female; Glomerular Filtration R

2011
Short-term outcomes of induction therapy with tacrolimus versus cyclophosphamide for active lupus nephritis: A multicenter randomized clinical trial.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2011, Volume: 57, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; China; Creatinine; Cyclophosphamide; Drug Therapy, Combination; Fem

2011
Atacicept in combination with MMF and corticosteroids in lupus nephritis: results of a prematurely terminated trial.
    Arthritis research & therapy, 2012, Feb-07, Volume: 14, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Dose-Response Relationship, Drug; Double-Blind Method; D

2012
Efficacy of mycophenolate mofetil in adolescent patients with lupus nephritis: evidence from a two-phase, prospective randomized trial.
    Lupus, 2012, Volume: 21, Issue:13

    Topics: Administration, Oral; Adolescent; Age Factors; Asia; Azathioprine; Biomarkers; Creatinine; Cyclophos

2012
Renal outcome in patients with lupus nephritis using a steroid-free regimen of monthly intravenous cyclophosphamide: a prospective observational study.
    The Journal of rheumatology, 2012, Volume: 39, Issue:11

    Topics: Administration, Intravenous; Adrenal Cortex Hormones; Adult; Creatinine; Cyclophosphamide; Dose-Resp

2012
Treatment of pure membranous lupus nephropathy with prednisone and azathioprine: an open-label trial.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2004, Volume: 43, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; Asian People; Azathioprine; Female; Humans; Immunosuppressive Agent

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Mar-04, Volume: 350, Issue:10

    Topics: Adult; Amenorrhea; Azathioprine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combi

2004
Maintenance therapies for proliferative lupus nephritis: mycophenolate mofetil, azathioprine and intravenous cyclophosphamide.
    Lupus, 2005, Volume: 14 Suppl 1

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Cell Proliferation; Cyclophosphamide; Disease-Free Su

2005
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis.
    The New England journal of medicine, 2005, Nov-24, Volume: 353, Issue:21

    Topics: Administration, Oral; Adult; Cross-Over Studies; Cyclophosphamide; Drug Therapy, Combination; Female

2005
[Intervention of liuwei dihuang pill on lupus nephropathy treated with cylophosphamide and glucocorticoids].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2005, Volume: 25, Issue:11

    Topics: Adolescent; Adult; Cyclophosphamide; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Human

2005
A randomized pilot trial comparing cyclosporine and azathioprine for maintenance therapy in diffuse lupus nephritis over four years.
    Clinical journal of the American Society of Nephrology : CJASN, 2006, Volume: 1, Issue:5

    Topics: Administration, Oral; Adult; Azathioprine; Complement C3; Complement C4; Creatinine; Cyclophosphamid

2006
The prognosis and pathogenesis of severe lupus glomerulonephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:4

    Topics: Administration, Oral; Adult; Biopsy; Cyclophosphamide; Disease Progression; Drug Therapy, Combinatio

2008
Intravenous pulse cyclophosphamide treatment of severe lupus nephritis: a prospective five-year study.
    Clinical nephrology, 1994, Volume: 42, Issue:2

    Topics: Adult; Biopsy; Cyclophosphamide; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Ki

1994
Therapy of lupus nephritis. A two-year prospective study.
    Annales de medecine interne, 1994, Volume: 145, Issue:5

    Topics: Adolescent; Adult; Aged; Azathioprine; Combined Modality Therapy; Drug Therapy, Combination; Humans;

1994
[Therapy of integrated traditional Chinese medicine and Western medicine on 74 lupus nephritis].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1994, Volume: 14, Issue:6

    Topics: Adolescent; Adult; Child; Cyclophosphamide; Drug Therapy, Combination; Drugs, Chinese Herbal; Female

1994
Early and intensive treatment of lupus nephritis with pulse cyclophosphamide.
    The Journal of the Association of Physicians of India, 1993, Volume: 41, Issue:2

    Topics: Cyclophosphamide; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Lupus Nephri

1993
Gallium-67 scintigraphy to predict response to therapy in active lupus nephritis.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998, Volume: 39, Issue:12

    Topics: Adult; Aged; Creatinine; Cyclophosphamide; Female; Follow-Up Studies; Gallium Radioisotopes; Humans;

1998
Treatment of membranous lupus nephritis with nephrotic syndrome by sequential immunosuppression.
    Lupus, 1999, Volume: 8, Issue:7

    Topics: Adult; Alopecia; Anti-Inflammatory Agents; Azathioprine; Cohort Studies; Cyclophosphamide; Drug Ther

1999
[Clinical observation on nephrotic syndrome of lupus nephritis treated with integrated traditional Chinese and Western Medicine].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1998, Volume: 18, Issue:12

    Topics: Adolescent; Adult; Child; Cyclophosphamide; Drug Therapy, Combination; Drugs, Chinese Herbal; Female

1998
Combination therapy with pulse cyclophosphamide plus pulse methylprednisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis.
    Annals of internal medicine, 2001, Aug-21, Volume: 135, Issue:4

    Topics: Adult; Anti-Inflammatory Agents; Creatinine; Cyclophosphamide; Drug Administration Schedule; Drug Th

2001
Mycophenolate mofetil treatment of severe renal disease in pediatric onset systemic lupus erythematosus.
    The Journal of rheumatology, 2001, Volume: 28, Issue:9

    Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Drug Administration Schedule; Drug Therap

2001
Treatment of membranous lupus nephritis with prednisone, azathioprine and cyclosporin A.
    Lupus, 2001, Volume: 10, Issue:11

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Cyclosporine; Drug Therapy, Combination; Humans; Immu

2001
Plasmapheresis therapy is ineffective in SLE. Lupus Nephritis Collaborative Study Group.
    Journal of clinical apheresis, 1992, Volume: 7, Issue:3

    Topics: Adult; Cyclophosphamide; Female; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Middl

1992
Termination of a clinical trial with no treatment group difference: the Lupus Nephritis Collaborative Study.
    Controlled clinical trials, 1992, Volume: 13, Issue:1

    Topics: Combined Modality Therapy; Cyclophosphamide; Data Interpretation, Statistical; Follow-Up Studies; Hu

1992
Ciclosporin plus steroids versus steroids alone in the treatment of lupus nephritis.
    Contributions to nephrology, 1992, Volume: 99

    Topics: Creatinine; Cyclosporine; Drug Therapy, Combination; Humans; Lupus Nephritis; Prednisone; Proteinuri

1992
Treatment of diffuse proliferative lupus nephritis.
    Contributions to nephrology, 1992, Volume: 99

    Topics: Adult; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Injections, Intravenous;

1992
Approach to lupus nephritis based upon randomized trials.
    Contributions to nephrology, 1992, Volume: 99

    Topics: Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Lupus Nephritis; Male; Me

1992
Plasmapheresis for lupus nephritis.
    The New England journal of medicine, 1992, Oct-01, Volume: 327, Issue:14

    Topics: Combined Modality Therapy; Cyclophosphamide; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis;

1992
Plasmapheresis for lupus nephritis. Lupus Plasmapheresis Study Group.
    The New England journal of medicine, 1992, Oct-01, Volume: 327, Issue:14

    Topics: Combined Modality Therapy; Cyclophosphamide; Humans; Lupus Nephritis; Plasmapheresis; Prednisone

1992
Plasmapheresis for lupus nephritis.
    The New England journal of medicine, 1992, Oct-01, Volume: 327, Issue:14

    Topics: Combined Modality Therapy; Cyclophosphamide; Humans; Lupus Nephritis; Plasmapheresis; Prednisone; Re

1992
Plasmapheresis for lupus nephritis.
    The New England journal of medicine, 1992, Oct-01, Volume: 327, Issue:14

    Topics: Combined Modality Therapy; Cyclophosphamide; Humans; Lupus Nephritis; Plasmapheresis; Prednisone

1992
A controlled trial of plasmapheresis therapy in severe lupus nephritis. The Lupus Nephritis Collaborative Study Group.
    The New England journal of medicine, 1992, May-21, Volume: 326, Issue:21

    Topics: Adult; Autoantibodies; Combined Modality Therapy; Creatinine; Cryoglobulins; Cyclophosphamide; DNA;

1992
Progression and remission of renal disease in the Lupus Nephritis Collaborative Study. Results of treatment with prednisone and short-term oral cyclophosphamide.
    Annals of internal medicine, 1992, Jan-15, Volume: 116, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Combined Modality Therapy; Creatinine

1992
[The efficacy of cyclophosphamide bolus therapy in a girl with SLE with a nephritic onset].
    Minerva pediatrica, 1991, Volume: 43, Issue:9

    Topics: Biopsy; Child; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Kidney;

1991
Long-term preservation of renal function in patients with lupus nephritis receiving treatment that includes cyclophosphamide versus those treated with prednisone only.
    Arthritis and rheumatism, 1991, Volume: 34, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Azathioprine; Cyclophosphamide; Dose-Response Relationship,

1991
Plasmapheresis does not increase the risk for infection in immunosuppressed patients with severe lupus nephritis. The Lupus Nephritis Collaborative Study Group.
    Annals of internal medicine, 1991, Jun-01, Volume: 114, Issue:11

    Topics: Adult; Cause of Death; Combined Modality Therapy; Cyclophosphamide; Disease Susceptibility; Female;

1991
Predictive value of renal pathology in diffuse proliferative lupus glomerulonephritis. Lupus Nephritis Collaborative Study Group.
    Kidney international, 1989, Volume: 36, Issue:5

    Topics: Adult; Biopsy; Cyclophosphamide; Female; Humans; Kidney; Kidney Failure, Chronic; Lupus Nephritis; M

1989
Intermittent intravenous cyclophosphamide therapy for lupus nephritis.
    The Journal of pediatrics, 1989, Volume: 114, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infusions, Intravenous; Lupus

1989

Other Studies

148 other studies available for prednisone and Glomerulonephritis, Lupus

ArticleYear
Good pregnancy outcomes in lupus nephritis patients with complete renal remission.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2022, 09-22, Volume: 37, Issue:10

    Topics: Adult; Female; Humans; Lupus Nephritis; Prednisone; Pregnancy; Pregnancy Complications; Pregnancy Ou

2022
Lupus podocytopathy superimposed on diabetic glomerulosclerosis: A case report.
    Medicine, 2021, Sep-17, Volume: 100, Issue:37

    Topics: Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Glucocorticoids; Humans; Insulin Infusion

2021
Novel Effects of Combination Therapy Through Inhibition of Caspase-1/Gasdermin D Induced-Pyroptosis in Lupus Nephritis.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Adolescent; Adult; Aged; Animals; Calcineurin Inhibitors; Caspase 1; Caspase Inhibitors; Cells, Cult

2021
Jieduquyuziyin prescription promotes the efficacy of prednisone via upregulating Nrf2 in MRL/lpr kidneys.
    Journal of ethnopharmacology, 2022, Nov-15, Volume: 298

    Topics: Animals; Drugs, Chinese Herbal; Female; Kidney; Lupus Nephritis; Mice; Mice, Inbred MRL lpr; Prednis

2022
Estimating glucocorticoid-related morbidity in lupus nephritis using the glucocorticoid toxicity index.
    Lupus, 2023, Volume: 32, Issue:4

    Topics: Adult; Cohort Studies; Glucocorticoids; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephrit

2023
Lupus Recipe inhibits cGVHD-induced lupus nephritis in mice and promote renal LC3-associated autophagy.
    Immunity, inflammation and disease, 2023, Volume: 11, Issue:3

    Topics: Animals; Autophagy; Bronchiolitis Obliterans Syndrome; Kidney; Lupus Erythematosus, Systemic; Lupus

2023
Improving Outcomes of Pediatric Lupus Care Delivery With Provider Goal-Setting Activities and Multidisciplinary Care Models.
    Arthritis care & research, 2023, Volume: 75, Issue:11

    Topics: Adolescent; Child; Delivery of Health Care; Goals; Humans; Lupus Erythematosus, Systemic; Lupus Neph

2023
The new complement inhibitor CRIg/FH ameliorates lupus nephritis in lupus-prone MRL/lpr mice.
    BMC nephrology, 2019, 11-21, Volume: 20, Issue:1

    Topics: Animals; Blood Urea Nitrogen; Complement Activation; Complement Inactivating Agents; Creatinine; Fem

2019
Cryptococcal meningitis in patients with lupus nephritis.
    Clinical rheumatology, 2020, Volume: 39, Issue:2

    Topics: Adult; Case-Control Studies; CD4 Lymphocyte Count; Female; Fever; Glucocorticoids; Headache; Humans;

2020
Case report: A kidney transplant patient with mild COVID-19.
    Transplant infectious disease : an official journal of the Transplantation Society, 2020, Volume: 22, Issue:4

    Topics: Adult; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Cough; COVID-19; COVID-19 Drug Tre

2020
Long-term outcomes of lupus nephritis treated with regimens based on cyclophosphamide and mycophenolate mofetil.
    Lupus, 2020, Volume: 29, Issue:8

    Topics: Adult; Azathioprine; Cyclophosphamide; Disease-Free Survival; Drug Administration Schedule; Drug The

2020
Population pharmacokinetics of mycophenolic acid in Mexican patients with lupus nephritis.
    Lupus, 2020, Volume: 29, Issue:9

    Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Linear Model

2020
Anti-nucleosome antibodies increase the risk of renal relapse in a prospective cohort of patients with clinically inactive systemic lupus erythematosus.
    Scientific reports, 2020, 07-29, Volume: 10, Issue:1

    Topics: Administration, Oral; Adult; Antibodies, Antinuclear; Asymptomatic Diseases; DNA; Female; Humans; Im

2020
Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study.
    Reumatismo, 2020, Nov-19, Volume: 72, Issue:3

    Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Biomarkers; Case-Control Studies; Complement

2020
Predictors of renal damage in systemic lupus erythematous patients: data from a multiethnic, multinational Latin American lupus cohort (GLADEL).
    RMD open, 2020, Volume: 6, Issue:3

    Topics: Cohort Studies; Humans; Latin America; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Prednis

2020
Medium Versus High Initial Prednisone Dose for Remission Induction in Lupus Nephritis: A Propensity Score-Matched Analysis.
    Arthritis care & research, 2022, Volume: 74, Issue:9

    Topics: Cyclophosphamide; Glucocorticoids; Humans; Immunosuppressive Agents; Lupus Nephritis; Prednisone; Pr

2022
Immunosuppressive therapy withdrawal after remission achievement in patients with lupus nephritis.
    Rheumatology (Oxford, England), 2022, 02-02, Volume: 61, Issue:2

    Topics: Adult; Biopsy; Creatinine; Female; Humans; Immunosuppressive Agents; Kidney; Logistic Models; Lupus

2022
Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients.
    Annals of the rheumatic diseases, 2021, Volume: 80, Issue:9

    Topics: Angiotensin-Converting Enzyme Inhibitors; Antirheumatic Agents; Aspirin; Drug Tapering; Europe; Fema

2021
A Pregnant Woman with Lupus and Nephrotic-Range Proteinuria.
    Clinical journal of the American Society of Nephrology : CJASN, 2017, 09-07, Volume: 12, Issue:9

    Topics: Biopsy; Drug Administration Schedule; Female; Glucocorticoids; Humans; Lupus Nephritis; Prednisone;

2017
Repeated pulses of methyl-prednisolone with reduced doses of prednisone improve the outcome of class III, IV and V lupus nephritis: An observational comparative study of the Lupus-Cruces and lupus-Bordeaux cohorts.
    Autoimmunity reviews, 2017, Volume: 16, Issue:8

    Topics: Adult; Anti-Inflammatory Agents; Cyclophosphamide; Drug Therapy, Combination; Female; Glucocorticoid

2017
Cognitive Function in Children with Lupus Nephritis: A Cross-Sectional Comparison with Children with Other Glomerular Chronic Kidney Diseases.
    The Journal of pediatrics, 2017, Volume: 189

    Topics: Adolescent; Child; Child, Preschool; Cognition; Cohort Studies; Cross-Sectional Studies; Female; Glo

2017
Multitarget Therapy for Maintenance Treatment of Lupus Nephritis.
    Journal of the American Society of Nephrology : JASN, 2017, Volume: 28, Issue:12

    Topics: Adolescent; Adult; Aged; Azathioprine; China; Cyclophosphamide; Drug Therapy, Combination; Female; H

2017
Transcriptomic analysis uncovers novel synergistic mechanisms in combination therapy for lupus nephritis.
    Kidney international, 2018, Volume: 93, Issue:2

    Topics: Animals; Cytoskeleton; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Ge

2018
[Pregnancy outcome in a woman with premature ovarian insufficiency complicated by systemic lupus erythematosus during pregnancy: a case report].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2017, Dec-20, Volume: 37, Issue:12

    Topics: Aspirin; Cesarean Section; Embryo Transfer; Female; Fertilization in Vitro; Humans; Lupus Erythemato

2017
Long-Term Clinical Outcomes in a Cohort of Adults With Childhood-Onset Systemic Lupus Erythematosus.
    Arthritis & rheumatology (Hoboken, N.J.), 2019, Volume: 71, Issue:2

    Topics: Adolescent; Adult; Age of Onset; Aged; Antibodies, Antiphospholipid; Antirheumatic Agents; Child; Ch

2019
Prednisone in lupus nephritis: how much is enough?
    Autoimmunity reviews, 2014, Volume: 13, Issue:2

    Topics: Adult; Cyclophosphamide; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Hydroxychloroqu

2014
An integrated extrapolation of long-term outcomes in systemic lupus erythematosus: analysis and simulation of the Hopkins lupus cohort.
    Rheumatology (Oxford, England), 2015, Volume: 54, Issue:4

    Topics: Adult; Anemia; Black or African American; Cohort Studies; Cost-Benefit Analysis; Female; Health Care

2015
Induction therapy with short-term high-dose intravenous cyclophosphamide followed by mycophenolate mofetil in proliferative lupus nephritis.
    The Netherlands journal of medicine, 2014, Volume: 72, Issue:9

    Topics: Administration, Intravenous; Adult; Anti-Inflammatory Agents; Azathioprine; Cyclophosphamide; Drug T

2014
Lupus nephritis in Croatian children: clinicopathologic findings and outcome.
    Lupus, 2015, Volume: 24, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Croatia; Female; Humans; Kidney; Lupus Nephritis; Male; Prednis

2015
Celebrating the ACP centennial: from the Annals archive.
    Annals of internal medicine, 2015, Jan-06, Volume: 162, Issue:1

    Topics: Azathioprine; Cyclophosphamide; Female; Glomerulonephritis; Glucocorticoids; Humans; Immunosuppressi

2015
Renal outcomes among Egyptian lupus nephritis patients: a retrospective analysis of 135 cases from a single centre.
    Lupus, 2015, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Egypt; Female; Humans; Immunosuppressive Agents; Lupus Nephritis; Male; Prednison

2015
Glucocorticoid with or without additional immunosuppressant therapy for patients with lupus podocytopathy: a retrospective single-center study.
    Lupus, 2015, Volume: 24, Issue:10

    Topics: Adolescent; Adult; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female; Follow-Up Stud

2015
Unilateral Perivascular Infiltrates in Lupus Retinopathy.
    JAMA ophthalmology, 2015, Volume: 133, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Autoantigens; Drug Therapy, Combin

2015
New onset of lupus nephritis in two patients with SLE shortly after initiation of treatment with belimumab.
    Seminars in arthritis and rheumatism, 2017, Volume: 46, Issue:6

    Topics: Adult; Antibodies, Monoclonal, Humanized; Azathioprine; Disease Progression; Drug Therapy, Combinati

2017
Both prolonged remission and Lupus Low Disease Activity State are associated with reduced damage accrual in systemic lupus erythematosus.
    Rheumatology (Oxford, England), 2017, Volume: 56, Issue:1

    Topics: Adult; Arthritis; Cataract; Cohort Studies; Diabetes Mellitus; Disease Progression; Female; Glucocor

2017
[Analysis of pregnancy outcomes in 66 patients with systemic lupus erythematosus].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016, Dec-20, Volume: 36, Issue:12

    Topics: Birth Weight; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Lupus Nephritis; Predn

2016
The short-term efficacy of bortezomib combined with glucocorticoids for the treatment of refractory lupus nephritis.
    Lupus, 2017, Volume: 26, Issue:9

    Topics: Administration, Intravenous; Adult; Antineoplastic Agents; Autoantibodies; Bortezomib; Drug Therapy,

2017
Primary Tuberculous Pyomyositis of the Calf Muscles.
    The American journal of the medical sciences, 2017, Volume: 353, Issue:2

    Topics: Adult; Female; Fever; Humans; Immunocompromised Host; Lupus Erythematosus, Systemic; Lupus Nephritis

2017
Efficacy and safety of rituximab in comparison with common induction therapies in pediatric active lupus nephritis.
    Pediatric nephrology (Berlin, Germany), 2017, Volume: 32, Issue:6

    Topics: Child; Child, Preschool; Clinical Protocols; Cyclophosphamide; Disease-Free Survival; Female; Follow

2017
[Vasculitis as a reason of chronic headache].
    Praxis, 2008, Mar-19, Volume: 97, Issue:6

    Topics: Adolescent; Anemia, Hemolytic, Autoimmune; Chorea; Cyclophosphamide; Diagnosis, Differential; Drug T

2008
T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis.
    Clinical immunology (Orlando, Fla.), 2008, Volume: 128, Issue:1

    Topics: Anti-Inflammatory Agents; Complement C4; Cryoglobulins; Female; Fluorescent Antibody Technique; Huma

2008
A clinicopathological study of lupus nephritis in children.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2008, Volume: 19, Issue:5

    Topics: Adolescent; Biopsy; Child; Cyclophosphamide; Disease Progression; Female; Humans; Iran; Kidney; Kidn

2008
The effectiveness and safety of mycophenolate mofetil in lupus nephritis.
    Clinical rheumatology, 2009, Volume: 28, Issue:7

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Drug Therapy, Combination; F

2009
Clinicopathological characteristics and outcomes of patients with crescentic lupus nephritis.
    Kidney international, 2009, Volume: 76, Issue:3

    Topics: Adolescent; Adult; Antibodies, Antineutrophil Cytoplasmic; Asian People; China; Female; Glucocortico

2009
Experience with mycophenolate mofetil as maintenance therapy in five pediatric patients with severe systemic lupus erythematosus.
    Klinische Padiatrie, 2009, Volume: 221, Issue:7

    Topics: Adolescent; Azathioprine; Child; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy

2009
Treatment of systemic lupus erythematosus in two patients with extreme B-cell lymphopenia: importance of immunomonitoring and avoidance of B-cell targeted therapy.
    Immunopharmacology and immunotoxicology, 2010, Volume: 32, Issue:4

    Topics: Adult; B-Lymphocytes; Blood Pressure; Creatinine; Cyclophosphamide; Fatal Outcome; Female; Humans; I

2010
Clinical research in systemic lupus erythematosus: immediate relevance to clinical practice.
    International journal of rheumatic diseases, 2011, Volume: 14, Issue:1

    Topics: Adult; Atherosclerosis; Biomedical Research; Female; Humans; Lupus Erythematosus, Systemic; Lupus Ne

2011
[Intestinal halo sign in systemic lupus erythematosus].
    Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:11

    Topics: Adult; Anti-Inflammatory Agents; Diagnosis, Differential; Female; Humans; Hydronephrosis; Intestinal

2011
[Cyclophosphamide-induced lupus flare in diffuse proliferative lupus nephropathy].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2011, Volume: 31, Issue:2

    Topics: Acute Disease; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema;

2011
Effect of artemisinin combined with glucocorticoid on the expressions of glucocorticoid receptor α mRNA, glucocorticoid receptor β mRNA and P300/CBP protein in lupus nephritis mice.
    Chinese journal of integrative medicine, 2011, Volume: 17, Issue:4

    Topics: Animals; Artemisinins; Base Sequence; Disease Models, Animal; DNA Primers; Electrophoresis, Agar Gel

2011
The dynamics of urinary N-acetyl-β-D-glucosaminidase (NAG), a marker of renal tubular dysfunction, in patients with lupus nephritis undergoing oral prednisone therapy.
    Immunopharmacology and immunotoxicology, 2012, Volume: 34, Issue:1

    Topics: Acetylglucosaminidase; Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents; Biomarkers

2012
Prednisone monotherapy induced remission in a group of patients with membranous lupus nephritis.
    Clinical nephrology, 2011, Volume: 76, Issue:1

    Topics: Adult; Azathioprine; Creatinine; Cyclophosphamide; Drug Therapy, Combination; Female; Glomerulonephr

2011
Protein-losing enteropathy as initial manifestation of systemic lupus erythematosus.
    Lupus, 2012, Volume: 21, Issue:4

    Topics: Adolescent; Antibodies, Antinuclear; Azathioprine; Biomarkers; Complement C3; Diarrhea; Drug Therapy

2012
Trilineage myelodysplasia and hemophagocytosis associated with systemic lupus erythematosus.
    American journal of hematology, 2012, Volume: 87, Issue:5

    Topics: Acute Kidney Injury; Adult; Blood Component Transfusion; Bone Marrow; Cell Lineage; Combined Modalit

2012
[Lupus, Graves' disease, and vasculitis: a case report].
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2012, Volume: 59, Issue:3

    Topics: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Autoantibodies; Cushing Syndrome; Dipyro

2012
Haemolytic-uraemic syndrome during severe lupus nephritis: efficacy of plasma exchange.
    Internal medicine journal, 2012, Volume: 42, Issue:1

    Topics: Acute Kidney Injury; Adult; Biopsy; Combined Modality Therapy; Cyclophosphamide; Drug Therapy, Combi

2012
Impact of previous lupus nephritis on maternal and fetal outcomes during pregnancy.
    Clinical rheumatology, 2012, Volume: 31, Issue:5

    Topics: Adult; Antimalarials; Azathioprine; Comorbidity; Drug Therapy, Combination; Female; Fetal Diseases;

2012
[Proliferative mesangial lupus nephritis: description of a cohort of 27 patients].
    Medicina clinica, 2012, Oct-06, Volume: 139, Issue:8

    Topics: Adolescent; Adult; Anti-Inflammatory Agents; Disease Progression; Drug Administration Schedule; Drug

2012
Mycophenolate as induction therapy in lupus nephritis with renal function impairment.
    American journal of nephrology, 2012, Volume: 35, Issue:5

    Topics: Adult; Antibiotics, Antineoplastic; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Ag

2012
Minimal-change nephropathy in systemic lupus erythematosus.
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2012, May-14, Volume: 32, Issue:3

    Topics: Anti-Inflammatory Agents; Diagnosis, Differential; Edema; Female; Humans; Hypertension, Renal; Immun

2012
[Effect of artemisinin on the expressions of GRalpha mRNA, GRbeta mRNA and P300/CBP protein in lupus nephritis mice].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2012, Volume: 35, Issue:4

    Topics: Animals; Artemisia annua; Artemisinins; Disease Models, Animal; Female; Leukocytes, Mononuclear; Lup

2012
APRIL, a proliferation-inducing ligand, as a potential marker of lupus nephritis.
    Arthritis research & therapy, 2012, Nov-21, Volume: 14, Issue:6

    Topics: Adult; B-Cell Activating Factor; Biomarkers; Cyclophosphamide; Drug Therapy, Combination; Enzyme-Lin

2012
Long-term renal outcome and complications in South Africans with proliferative lupus nephritis.
    International urology and nephrology, 2013, Volume: 45, Issue:5

    Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Blood Pressure; Creatinine; Cyclophosphamide; Disease

2013
Mycophenolate mofetil treatment for diffuse proliferative lupus nephritis: a multicenter clinical trial in China.
    Zhonghua nei ke za zhi, 2002, Volume: 41, Issue:7

    Topics: Cyclophosphamide; Humans; Immunosuppressive Agents; Kidney; Lupus Nephritis; Prednisone

2002
Lupus choroidopathy and choroidal effusions.
    Retina (Philadelphia, Pa.), 2002, Volume: 22, Issue:5

    Topics: Adult; Antirheumatic Agents; Azathioprine; Choroid Diseases; Ciliary Body; Drug Therapy, Combination

2002
Treatment of pulmonary hemorrhage in childhood systemic lupus erythematosus with mycophenolate mofetil.
    Southern medical journal, 2003, Volume: 96, Issue:7

    Topics: Adolescent; Combined Modality Therapy; Disease Progression; Drug Therapy, Combination; Hemorrhage; H

2003
Corticosteroid therapy in lupus nephritis. Importance of adequate dosage.
    Bulletin on the rheumatic diseases, 1961, Volume: 11

    Topics: Adrenal Cortex Hormones; Glomerulonephritis; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis;

1961
Effect of large doses of prednisone on the renal lesions and life span of patients with lupus glomerulonephritis.
    The Journal of laboratory and clinical medicine, 1961, Volume: 57

    Topics: Glomerulonephritis; Humans; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Prednisone

1961
Lupus nephritis. Clinical and histologic survey.
    Archives of internal medicine, 1963, Volume: 111

    Topics: Adrenocorticotropic Hormone; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Mechlorethamine

1963
LUPUS GLOMERULONEPHRITIS. THE EFFECT OF LARGE DOSES OF CORTICOSTEROIDS ON RENAL FUNCTION AND RENAL LESIONS IN TWO CHILDREN.
    American journal of diseases of children (1960), 1965, Volume: 110

    Topics: Adolescent; Adrenal Cortex Hormones; Cortisone; Drug Therapy; Glomerulonephritis; Guanethidine; Hydr

1965
Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:11

    Topics: Adult; Age Factors; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cross-Sectional St

2003
Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:11

    Topics: Adult; Age Factors; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cross-Sectional St

2003
Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:11

    Topics: Adult; Age Factors; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cross-Sectional St

2003
Risk factors for subclinical atherosclerosis in a prospective cohort of patients with systemic lupus erythematosus.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:11

    Topics: Adult; Age Factors; Anti-Inflammatory Agents; Arteriosclerosis; Carotid Arteries; Cross-Sectional St

2003
Remission of refractory lupus nephritis with a protocol including rituximab.
    Lupus, 2003, Volume: 12, Issue:10

    Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Cyclop

2003
Questions & answers. My doctor told me I might develop Cushing's syndrome because of the prednisone I take for kidney disease caused by lupus. What symptoms should I expect?
    Health news (Waltham, Mass.), 2003, Volume: 9, Issue:11

    Topics: Cushing Syndrome; Glucocorticoids; Humans; Lupus Nephritis; Prednisone

2003
Pentoxifylline in the treatment of refractory nephrotic syndrome secondary to lupus nephritis.
    The Journal of rheumatology, 2003, Volume: 30, Issue:11

    Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Cyclophosphamide; Dose-Response Relationship,

2003
Cyclosporine A in treatment of membranous lupus nephropathy.
    Chinese medical journal, 2003, Volume: 116, Issue:12

    Topics: Adolescent; Adult; Cyclosporine; Female; Glomerulonephritis, Membranous; Humans; Lupus Nephritis; Ma

2003
Combined intravenous methotrexate and cyclophosphamide for refractory childhood lupus nephritis.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:3

    Topics: Blood Proteins; Chronic Disease; Complement C3; Creatinine; Cyclophosphamide; Drug Therapy, Combinat

2004
Mycophenolate mofetil combined with prednisone for diffuse proliferative lupus nephritis: a histopathological study.
    Lupus, 2004, Volume: 13, Issue:2

    Topics: Actins; Adolescent; Adult; Chronic Disease; Collagen; Drug Therapy, Combination; Female; Fibronectin

2004
Clinicopathological study of the WHO classification in childhood lupus nephritis.
    Pediatric nephrology (Berlin, Germany), 2004, Volume: 19, Issue:5

    Topics: Adolescent; Alkylating Agents; Anti-Inflammatory Agents; Antimetabolites; Azathioprine; Biopsy; Bloo

2004
Clinical predictors of recovery and complications in the management of recent-onset renal failure in lupus nephritis: a Chinese experience.
    The Journal of rheumatology, 2004, Volume: 31, Issue:4

    Topics: Adult; China; Cohort Studies; Cyclophosphamide; Female; Forecasting; Glucocorticoids; Humans; Immuno

2004
Acquired ichthyosis associated with systemic lupus erythematosus.
    Lupus, 2004, Volume: 13, Issue:4

    Topics: Administration, Oral; Adult; Cyclophosphamide; Female; Humans; Ichthyosis; Immunosuppressive Agents;

2004
Sequential therapies for proliferative lupus nephritis.
    The New England journal of medicine, 2004, Jun-10, Volume: 350, Issue:24

    Topics: Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Lupus Nephritis; Mycophenolic Acid

2004
Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:8

    Topics: Adult; Azathioprine; Biopsy; Complement C3; Creatinine; Cyclophosphamide; Female; Humans; Kidney; Ki

2004
Isaacs' syndrome (autoimmune neuromyotonia) in a patient with systemic lupus erythematosus.
    The Journal of rheumatology, 2005, Volume: 32, Issue:4

    Topics: Amines; Anticonvulsants; Autoantibodies; Azathioprine; Clonazepam; Cyclohexanecarboxylic Acids; Drug

2005
The course of anticardiolipin antibody levels under immunoadsorption therapy.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 46, Issue:3

    Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Antibodies, Anticardiolipin; Antibodies, Antinucle

2005
Propylthiouracil-induced lupus-like syndrome: successful management with oral corticosteroids.
    Thyroid : official journal of the American Thyroid Association, 2005, Volume: 15, Issue:10

    Topics: Female; Goiter, Nodular; Humans; Lupus Nephritis; Middle Aged; Prednisone; Propylthiouracil

2005
[Lupus nephritis, mycophenolate, and cytomegalovirus infection].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2006, Volume: 26, Issue:1

    Topics: Adult; Antibodies, Viral; Cyclophosphamide; Cyclosporine; Cytomegalovirus; Cytomegalovirus Infection

2006
Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis.
    Lupus, 2006, Volume: 15, Issue:6

    Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal

2006
Hematuria in a patient with class IV lupus nephritis.
    Kidney international, 2006, Volume: 70, Issue:6

    Topics: Antihypertensive Agents; Biopsy; Cyclophosphamide; El Salvador; Female; Follow-Up Studies; Glomerula

2006
Induction therapy for active lupus nephritis: mycophenolate mofetil versus cyclophosphamide.
    Nature clinical practice. Nephrology, 2006, Volume: 2, Issue:6

    Topics: Administration, Oral; Adult; Cross-Over Studies; Cyclophosphamide; Drug Therapy, Combination; Female

2006
[Influential factors of systemic lupus erythematosus activity during pregnancy and its relationship with pregnancy outcome].
    Zhonghua fu chan ke za zhi, 2006, Volume: 41, Issue:9

    Topics: Abortion, Spontaneous; Adult; Female; Fetal Death; Fetal Growth Retardation; Gestational Age; Humans

2006
Histologic deterioration and more flares: the case against azathioprine plus methylprednisolone in the treatment of proliferative lupus nephritis.
    Arthritis and rheumatism, 2007, Volume: 56, Issue:3

    Topics: Anti-Inflammatory Agents; Azathioprine; Biopsy; Creatinine; Cyclophosphamide; Dose-Response Relation

2007
Maternal and fetal outcomes of 72 pregnancies in Argentine patients with systemic lupus erythematosus (SLE).
    Clinical rheumatology, 2008, Volume: 27, Issue:1

    Topics: Adult; Antiphospholipid Syndrome; Argentina; Comorbidity; Female; Humans; Infant, Low Birth Weight;

2008
Reversible posterior leukoencephalopathy syndrome (RPLS) in a patient with systemic lupus erythematosus (SLE) and lupus nephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:8

    Topics: Adult; Brain; Cerebrovascular Disorders; Comorbidity; Female; Humans; Hydrocortisone; Kidney Disease

2007
[Interdisciplinary consensus to management of lupus nephritis in Germany].
    Zeitschrift fur Rheumatologie, 2007, Volume: 66, Issue:8

    Topics: Anti-Inflammatory Agents; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunos

2007
Evaluation of lupus nephritis during pregnancy by renal biopsy.
    American journal of nephrology, 1995, Volume: 15, Issue:3

    Topics: Adult; Biopsy; Cyclophosphamide; Female; Follow-Up Studies; Humans; Kidney; Kidney Failure, Chronic;

1995
Clinical problem solving. The girl with the curl.
    The New England journal of medicine, 1995, Oct-05, Volume: 333, Issue:14

    Topics: Acyclovir; Antitubercular Agents; Cyclosporine; Female; Fever; Herpesvirus 4, Human; Humans; Immunos

1995
[Monthly intravenous cyclophosphamide in the treatment of lupus nephritis].
    Polskie Archiwum Medycyny Wewnetrznej, 1994, Volume: 92 Spec No

    Topics: Adolescent; Adult; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Infusions, Intrav

1994
Renal transplantation in systemic lupus erythematosus: a single-center experience with sixty-four cases.
    American journal of nephrology, 1995, Volume: 15, Issue:2

    Topics: Adult; Azathioprine; Cadaver; Cyclosporine; Female; Graft Survival; Humans; Immunosuppression Therap

1995
Therapy of proliferative lupus glomerulonephritis: a prospective trial in The Netherlands.
    The Netherlands journal of medicine, 1994, Volume: 45, Issue:6

    Topics: Azathioprine; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Humans; Lupus N

1994
The economic impact of treatment of severe lupus nephritis with prednisone and intravenous cyclophosphamide.
    Arthritis and rheumatism, 1994, Volume: 37, Issue:7

    Topics: Adult; Costs and Cost Analysis; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Injecti

1994
[Lupus erythematosus disseminatus and Pneumocystis carinii pneumonia].
    Revista medica de Chile, 1993, Volume: 121, Issue:12

    Topics: Bronchoalveolar Lavage Fluid; Cyclophosphamide; Female; Humans; Lung; Lupus Erythematosus, Systemic;

1993
Treatment of end-stage renal disease due to lupus nephritis: comparison of six patients treated with both peritoneal and hemodialysis.
    Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, 1993, Volume: 9

    Topics: Adolescent; Adult; Age of Onset; Female; Humans; Kidney Failure, Chronic; Lupus Erythematosus, Syste

1993
Long term efficacy of high-dose intravenous methylprednisolone pulses in active lupus nephritis. A 21-month prospective study.
    Scandinavian journal of rheumatology, 1994, Volume: 23, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Complement C3; Complement C4; Creatinine; Dose-Respon

1994
Lipoprotein(a) levels in systemic lupus erythematosus.
    The Journal of rheumatology, 1994, Volume: 21, Issue:2

    Topics: Adult; Antibodies, Anticardiolipin; Female; Humans; Lipoprotein(a); Lupus Erythematosus, Systemic; L

1994
Lupus and its management.
    Journal of the South Carolina Medical Association (1975), 1993, Volume: 89, Issue:11

    Topics: Adolescent; Antibiotics, Antineoplastic; Autoantibodies; Azathioprine; Cyclophosphamide; Dose-Respon

1993
Cyclosporine in the treatment of lupus nephritis including two patients treated during pregnancy.
    Clinical nephrology, 1993, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Cyclosporine; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Lupus

1993
[Lupus nephritis in male adults, an analysis of the clinical and pathological features].
    Zhonghua nei ke za zhi, 1995, Volume: 34, Issue:12

    Topics: Adolescent; Adult; Age Factors; Aged; Female; Glucocorticoids; Humans; Kidney; Lupus Nephritis; Male

1995
Lupus nephritis in children: a longitudinal study of prognostic factors and therapy.
    Journal of the American Society of Nephrology : JASN, 1996, Volume: 7, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Cyclophosphamide; Disease Progression; Drug Therapy, Combinatio

1996
Systemic lupus erythematosus [clinical inference].
    BMJ (Clinical research ed.), 1997, Jan-25, Volume: 314, Issue:7076

    Topics: Adult; Antiphospholipid Syndrome; Azathioprine; Cyclophosphamide; Female; Humans; Lupus Erythematosu

1997
Methotrexate in systemic lupus erythematosus.
    The Journal of rheumatology, 1997, Volume: 24, Issue:3

    Topics: Adult; Female; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Methotrexate; Prednisone

1997
Lupus and cerebrovascular accidents.
    Lupus, 1997, Volume: 6, Issue:5

    Topics: Adult; Antibodies, Anticardiolipin; Anticoagulants; Antiphospholipid Syndrome; Autoimmune Diseases;

1997
The prognosis of biopsy-proven lupus nephritis in chinese patients: long term follow-up of 86 cases.
    Chinese medical journal, 1997, Volume: 110, Issue:7

    Topics: Adult; Biopsy, Needle; Cyclophosphamide; Drugs, Chinese Herbal; Female; Follow-Up Studies; Humans; I

1997
[Attention should be paid to the research on lupus glomerulonephritis].
    Zhonghua nei ke za zhi, 1997, Volume: 36, Issue:2

    Topics: Anti-Inflammatory Agents; Antibodies, Antinuclear; Cyclophosphamide; Humans; Immunosuppressive Agent

1997
[Management of lupus nephritis in Senegal].
    Dakar medical, 1997, Volume: 42, Issue:2

    Topics: Amenorrhea; Anti-Inflammatory Agents; Autoimmune Diseases; Cyclophosphamide; Female; Femur Head Necr

1997
[Factors analysis of pregnancy success in chronic glomerulus diseases].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1997, Volume: 22, Issue:1

    Topics: Adult; Anti-Inflammatory Agents; Female; Glomerulonephritis; Humans; Lupus Nephritis; Nephrotic Synd

1997
Renal involvement in systemic lupus erythematosus. A study of 180 patients from a single center.
    Medicine, 1999, Volume: 78, Issue:3

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Anti-Inflammatory Agents; Biopsy; Cause of Death; Chil

1999
A pilot study of low-dose fludarabine in membranous nephropathy refractory to therapy.
    Clinical nephrology, 1999, Volume: 52, Issue:2

    Topics: Adult; Alkylating Agents; Anti-Inflammatory Agents; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-P

1999
Intravenous immunoglobulin treatment of lupus nephritis.
    Seminars in arthritis and rheumatism, 2000, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Biomarkers; Cyclophosphamide; Drug Resistance; Female; Humans; Immunoglobulins, I

2000
"Pauci-Immune" proliferative and necrotizing glomerulonephritis with thrombotic microangiopathy in patients with systemic lupus erythematosus and lupus-like syndrome.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2000, Volume: 35, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Anticardiolipin; Antibodies, Antineutrophil Cytop

2000
Lupus nephritis and the anti-phospholipid antibody syndrome in pregnancy.
    Kidney international, 2000, Volume: 58, Issue:5

    Topics: Abortion, Induced; Adult; Antiphospholipid Syndrome; Cyclophosphamide; Female; Glucocorticoids; Huma

2000
Lupus nephritis in children: prognostic significance of clinicopathological findings.
    Nephron, 2001, Volume: 87, Issue:2

    Topics: Adolescent; Anemia; Blood Pressure; Child; Child, Preschool; Creatinine; Cyclophosphamide; Female; H

2001
[Appraisal of renal failure reversing therapies in lupus nephritis].
    Zhonghua nei ke za zhi, 2001, Volume: 40, Issue:2

    Topics: Administration, Oral; Cohort Studies; Cyclophosphamide; Cyclosporine; Dexamethasone; Female; Follow-

2001
Flaccid paresis due to distal renal tubular acidosis preceding systemic lupus erythematosus.
    The Netherlands journal of medicine, 2002, Volume: 60, Issue:1

    Topics: Acidosis, Renal Tubular; Adult; Female; Follow-Up Studies; Humans; Kidney Function Tests; Lupus Eryt

2002
[Treatment of lupus erythematosus with integrated traditional Chinese medicine and Western medicine].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1992, Volume: 12, Issue:4

    Topics: Drugs, Chinese Herbal; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Prednisone; Tripteryg

1992
Recurrence of membranous lupus glomerulonephritis two months after a renal cadaver transplant.
    Transplantation proceedings, 1992, Volume: 24, Issue:1

    Topics: Adult; Azathioprine; Cyclosporine; Humans; Immunosuppression Therapy; Kidney Transplantation; Lupus

1992
A critique of the NIH lupus nephritis survey.
    Arthritis and rheumatism, 1992, Volume: 35, Issue:5

    Topics: Cyclophosphamide; Health Surveys; Humans; Injections, Intravenous; Kidney; Lupus Nephritis; National

1992
Can ciclosporin A be used without steroids in systemic lupus erythematosus?
    Nephron, 1991, Volume: 57, Issue:3

    Topics: Adult; Cyclosporins; Drug Therapy, Combination; Female; Humans; Lupus Erythematosus, Systemic; Lupus

1991
Lupus nephritis: therapeutic decisions.
    Hospital practice (Office ed.), 1990, Mar-30, Volume: 25, Issue:3A

    Topics: Adult; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Kidney Glomerulus;

1990
Diffuse proliferative lupus nephritis: long-term observations in patients treated with ancrod.
    Clinical nephrology, 1990, Volume: 34, Issue:2

    Topics: Adult; Ancrod; Blood Pressure; Creatinine; Drug Therapy, Combination; Female; Follow-Up Studies; Hum

1990
Multiple brain abscesses from isolated cerebral mucormycosis.
    Journal of neurology, neurosurgery, and psychiatry, 1990, Volume: 53, Issue:5

    Topics: Adult; Brain Abscess; Cyclophosphamide; Female; Frontal Lobe; Humans; Lupus Erythematosus, Systemic;

1990
Treatment protocols of the lupus nephritis collaborative study of plasmapheresis in severe lupus nephritis. The Lupus Nephritis Collaborative Study Group.
    Progress in clinical and biological research, 1990, Volume: 337

    Topics: Clinical Protocols; Combined Modality Therapy; Cyclophosphamide; Drug Therapy, Combination; Humans;

1990
[Systemic lupus erythematosus and pregnancy. Clinical aspects, serology and management].
    Geburtshilfe und Frauenheilkunde, 1990, Volume: 50, Issue:7

    Topics: Antibodies, Antinuclear; Azathioprine; Female; Fetal Death; Humans; Infant, Newborn; Lupus Erythemat

1990
[Evaluation of long-term immunotherapy in patients with lupus nephritis].
    Vnitrni lekarstvi, 1989, Volume: 35, Issue:2

    Topics: Cyclophosphamide; Drug Therapy, Combination; Humans; Immunotherapy; Levamisole; Lupus Nephritis; Pre

1989
Effect of long-term normalization of serum complement levels on the course of lupus nephritis.
    The American journal of medicine, 1989, Volume: 87, Issue:2

    Topics: Azathioprine; Complement System Proteins; Drug Administration Schedule; Female; Follow-Up Studies; H

1989
Hypertension in children with systemic lupus erythematosus.
    Seminars in arthritis and rheumatism, 1989, Volume: 19, Issue:2

    Topics: Adolescent; Antihypertensive Agents; Child; Female; Glomerulonephritis, Membranoproliferative; Human

1989
Poor prognosis in end-stage lupus nephritis due to nonautologous vascular access site associated septicemia and lupus flares.
    American journal of nephrology, 1989, Volume: 9, Issue:4

    Topics: Adult; Bacterial Infections; Cyclophosphamide; Female; Humans; Kidney Failure, Chronic; Lupus Erythe

1989
Systemic lupus erythematosus. III. Observations on clinical renal involvement and follow up of renal function: Dutch experience with 110 patients studied prospectively.
    Annals of the rheumatic diseases, 1989, Volume: 48, Issue:10

    Topics: Adult; Female; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Lupus Nephritis; Mal

1989
Acute nonlymphocytic leukemia following short-term, intermittent, intravenous cyclophosphamide treatment of lupus nephritis.
    Arthritis and rheumatism, 1988, Volume: 31, Issue:12

    Topics: Aged; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Inj

1988
The wolf inside.
    Delaware medical journal, 1988, Volume: 60, Issue:11

    Topics: Adult; Female; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Pericarditis; Prednisone

1988
[Corticosteroids administered in bolus in lupus nephropathy].
    Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna, 1986, Volume: 1, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Infusion

1986
Discontinuation of therapy in diffuse proliferative lupus nephritis.
    The American journal of medicine, 1988, Volume: 85, Issue:2

    Topics: Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Follow-Up Studies; Humans; Lupus Nephriti

1988
Lupus nephritis: a 13-year experience.
    The New Zealand medical journal, 1986, Nov-26, Volume: 99, Issue:814

    Topics: Adolescent; Adult; Azathioprine; Biopsy; Child; Female; Follow-Up Studies; Humans; Kidney; Lupus Nep

1986
Persistence of clinical and serologic activity in patients with systemic lupus erythematosus undergoing peritoneal dialysis.
    The American journal of medicine, 1987, Volume: 83, Issue:4

    Topics: Adult; Antibodies, Antinuclear; Complement C3; Complement C4; Female; Humans; Kidney Failure, Chroni

1987
Systemic lupus erythematosus--the nephrologist's viewpoint.
    Transplantation proceedings, 1987, Volume: 19, Issue:2 Suppl 2

    Topics: Azathioprine; Cyclophosphamide; Female; Humans; Lupus Nephritis; Male; Mechlorethamine; Prednisone;

1987
Histologic features that correlate with the prognosis of patients with lupus nephritis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 10, Issue:3

    Topics: Biopsy; Humans; Kidney Glomerulus; Lupus Nephritis; Prednisone; Prognosis

1987
Lupus nephritis after total lymphoid irradiation: persistent improvement and reduction of steroid therapy.
    Annals of internal medicine, 1987, Volume: 107, Issue:5

    Topics: Complement C3; Follow-Up Studies; Humans; Lupus Nephritis; Lymphoid Tissue; Prednisone; Proteinuria;

1987
The diagnosis and management of systemic lupus erythematosus in childhood.
    Pediatric annals, 1986, Volume: 15, Issue:9

    Topics: Child; Cyclophosphamide; Humans; Lupus Erythematosus, Systemic; Lupus Nephritis; Prednisone; Salicyl

1986
Pulsed methylprednisolone therapy compared to high dose prednisone in systemic lupus erythematosus nephritis.
    European journal of pediatrics, 1986, Volume: 145, Issue:5

    Topics: Adolescent; Adult; Blood Pressure; Child; Complement C3; Complement C4; Creatinine; Drug Administrat

1986