prednisone has been researched along with Glioblastoma in 5 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is no benefit to the treatment of high-grade astrocytomas in children with eight-drugs-in-1-day chemotherapy compared with CCNU, vincristine, and prednisone." | 9.08 | Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. ( Bertolone, SJ; Boyett, JM; Cherlow, JM; Finlay, JL; Geyer, JR; McGuire, P; Milstein, JM; Tefft, M; Wisoff, JH; Yates, AJ, 1995) |
| "There is no benefit to the treatment of high-grade astrocytomas in children with eight-drugs-in-1-day chemotherapy compared with CCNU, vincristine, and prednisone." | 5.08 | Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. ( Bertolone, SJ; Boyett, JM; Cherlow, JM; Finlay, JL; Geyer, JR; McGuire, P; Milstein, JM; Tefft, M; Wisoff, JH; Yates, AJ, 1995) |
| " The primary objective was to investigate the steroid dosage required to control brain oedema on the last day of RT in each arm." | 2.90 | Angiotensin II receptor blockers, steroids and radiotherapy in glioblastoma-a randomised multicentre trial (ASTER trial). An ANOCEF study. ( Carpentier, AF; Charissoux, M; Chinot, O; Cuzzubbo, S; Ducray, F; Hoang-Xuan, K; Le Rhun, E; Levy-Piedbois, C; Mandonnet, E; Portal, JJ; Psimaras, D; Quillien, V; Ricard, D; Sejalon, F; Thomas, L; Tibi, A; Ursu, R; Vicaut, E, 2019) |
| "Temozolomide (TMZ) is a cytotoxic agent of the imidazotetrazine class, chemically related to dacarbazine." | 1.35 | Tuberculosis in a patient on temozolomide: a case report. ( de Barros e Silva, MJ; de Paiva, TF; Fanelli, MF; Gimenes, DL; Rinck, JA, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ursu, R | 1 |
| Thomas, L | 1 |
| Psimaras, D | 1 |
| Chinot, O | 1 |
| Le Rhun, E | 1 |
| Ricard, D | 1 |
| Charissoux, M | 1 |
| Cuzzubbo, S | 1 |
| Sejalon, F | 1 |
| Quillien, V | 1 |
| Hoang-Xuan, K | 1 |
| Ducray, F | 1 |
| Portal, JJ | 1 |
| Tibi, A | 1 |
| Mandonnet, E | 1 |
| Levy-Piedbois, C | 1 |
| Vicaut, E | 1 |
| Carpentier, AF | 1 |
| de Paiva, TF | 1 |
| de Barros e Silva, MJ | 1 |
| Rinck, JA | 1 |
| Fanelli, MF | 1 |
| Gimenes, DL | 1 |
| Finlay, JL | 1 |
| Boyett, JM | 1 |
| Yates, AJ | 1 |
| Wisoff, JH | 1 |
| Milstein, JM | 1 |
| Geyer, JR | 1 |
| Bertolone, SJ | 1 |
| McGuire, P | 1 |
| Cherlow, JM | 1 |
| Tefft, M | 1 |
| Sposto, R | 1 |
| Ertel, IJ | 1 |
| Jenkin, RD | 1 |
| Boesel, CP | 1 |
| Venes, JL | 1 |
| Ortega, JA | 1 |
| Evans, AE | 1 |
| Wara, W | 1 |
| Hammond, D | 1 |
| Levin, VA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma- A Randomized Multicenter Trial[NCT01805453] | Phase 3 | 80 participants (Actual) | Interventional | 2013-03-29 | Completed | ||
| A Phase I Trial of Lenalidomide and Radiotherapy in Children With Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas[NCT01222754] | Phase 1 | 29 participants (Actual) | Interventional | 2010-11-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for prednisone and Glioblastoma
| Article | Year |
|---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
3 trials available for prednisone and Glioblastoma
| Article | Year |
|---|---|
Angiotensin II receptor blockers, steroids and radiotherapy in glioblastoma-a randomised multicentre trial (ASTER trial). An ANOCEF study.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Anti-Inflammatory Agents; Brain Neoplasms; Chemoradio | 2019 |
Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Che | 1995 |
The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi | 1989 |
1 other study available for prednisone and Glioblastoma
| Article | Year |
|---|---|
Tuberculosis in a patient on temozolomide: a case report.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibiotics, Antitubercular; Ant | 2009 |