prednisone has been researched along with Fracture, Pathologic in 37 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Disability after treatment due to pathological fracture was not seen." | 2.76 | Limited chemotherapy and shrinking field radiotherapy for Osteolymphoma (primary bone lymphoma): results from the trans-Tasman Radiation Oncology Group 99.04 and Australasian Leukaemia and Lymphoma Group LY02 prospective trial. ( Barton, M; Christie, D; Dear, K; Le, T; Porter, D; Pratt, G; Roos, D; Wirth, A, 2011) |
| "Prednisone was used as the corticosteroid during postremission therapy from 1987 to 1991, and dexamethasone was used from 1991 to 1995." | 1.31 | Bony morbidity in children treated for acute lymphoblastic leukemia. ( Dalton, VM; Gelber, RD; Sallan, SE; Silverman, LB; Strauss, AJ; Su, JT, 2001) |
| "We report a patient with severe chronic renal failure who developed spontaneous bone fractures." | 1.29 | Modulation of renal osteodystrophy by extrarenal production of calcitriol. ( Delmez, JA; Dusso, AS; Slatopolsky, E; Teitelbaum, SL, 1995) |
| "Therapies to prevent bone loss and treat established osteoporosis are uncommonly utilized in glucocorticoid-treated patients with end-stage pulmonary disease." | 1.29 | Osteoporosis in lung transplantation candidates with end-stage pulmonary disease. ( Addesso, V; Donovan, D; Jorgesen, B; McGregor, C; Papadopoulos, A; Schulman, L; Shane, E; Silverberg, SJ; Staron, RB, 1996) |
| "A 54 year old, postmenopause female with pulmonary fibrosis on steroid therapy is studied for lumbar and sacral pain." | 1.28 | [Spontaneous fracture of the sacrum in patient with pulmonary fibrosis and steroid treatment]. ( Alvarado, A; Guzmán, L; Maluje, V, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (45.95) | 18.7374 |
| 1990's | 5 (13.51) | 18.2507 |
| 2000's | 8 (21.62) | 29.6817 |
| 2010's | 7 (18.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ben Salah, H | 1 |
| Fourati, N | 1 |
| Elloumi, M | 1 |
| Boudawara, T | 1 |
| Frikha, M | 1 |
| Daoud, J | 1 |
| Ahmanna-Chakir, F | 1 |
| Becce, F | 1 |
| Aubry-Rozier, B | 1 |
| Newman, KA | 1 |
| Ahlman, MA | 1 |
| Hughes, M | 1 |
| Malayeri, AA | 1 |
| Pratt, D | 1 |
| Grayson, PC | 1 |
| Liu, B | 1 |
| Zhang, X | 1 |
| Zhang, W | 1 |
| Wang, JB | 1 |
| Zhang, FC | 1 |
| Christie, D | 1 |
| Dear, K | 1 |
| Le, T | 1 |
| Barton, M | 1 |
| Wirth, A | 1 |
| Porter, D | 1 |
| Roos, D | 1 |
| Pratt, G | 1 |
| Di Munno, O | 1 |
| Delle Sedie, A | 1 |
| Logothetis, CJ | 1 |
| Basch, E | 1 |
| Molina, A | 1 |
| Fizazi, K | 1 |
| North, SA | 1 |
| Chi, KN | 1 |
| Jones, RJ | 1 |
| Goodman, OB | 1 |
| Mainwaring, PN | 1 |
| Sternberg, CN | 1 |
| Efstathiou, E | 1 |
| Gagnon, DD | 1 |
| Rothman, M | 1 |
| Hao, Y | 1 |
| Liu, CS | 1 |
| Kheoh, TS | 1 |
| Haqq, CM | 1 |
| Scher, HI | 1 |
| de Bono, JS | 1 |
| Yen, D | 1 |
| Hedden, D | 1 |
| Oliveri, B | 1 |
| Di Gregorio, S | 1 |
| Parisi, MS | 1 |
| Solís, F | 1 |
| Mautalen, C | 1 |
| Toliusis, V | 1 |
| Pamerneckas, A | 1 |
| Petrulis, A | 1 |
| Tamulaitis, G | 1 |
| Pilipavicius, G | 1 |
| Pijadin, A | 1 |
| Tanaka, Y | 1 |
| Basi, S | 1 |
| Schulman, G | 1 |
| Fogo, AB | 1 |
| Papierska, L | 1 |
| Rabijewski, M | 1 |
| Scott, S | 1 |
| Alazraki, N | 1 |
| Manaster, B | 1 |
| Abbrederis, K | 1 |
| Gattringer, C | 1 |
| König, P | 1 |
| Gastl, G | 1 |
| Rubinow, A | 1 |
| Brandt, KD | 1 |
| Cohen, AS | 1 |
| Sack, B | 1 |
| Delmez, JA | 1 |
| Dusso, AS | 1 |
| Slatopolsky, E | 1 |
| Teitelbaum, SL | 1 |
| Shane, E | 1 |
| Silverberg, SJ | 1 |
| Donovan, D | 1 |
| Papadopoulos, A | 1 |
| Staron, RB | 1 |
| Addesso, V | 1 |
| Jorgesen, B | 1 |
| McGregor, C | 1 |
| Schulman, L | 1 |
| Elstein, D | 1 |
| Abrahamov, A | 1 |
| Itzchaki, M | 1 |
| Zimran, A | 1 |
| Lespessailles, E | 1 |
| Poupon, S | 1 |
| Adriambelosoa, N | 1 |
| Pothuaud, L | 1 |
| Siroux, V | 1 |
| Bouillon, S | 1 |
| Benhamou, CL | 1 |
| Strauss, AJ | 1 |
| Su, JT | 1 |
| Dalton, VM | 1 |
| Gelber, RD | 1 |
| Sallan, SE | 1 |
| Silverman, LB | 1 |
| Lovschall, S | 1 |
| deCastro, LA | 1 |
| Kuhn, JP | 1 |
| Freeman, AI | 1 |
| Sinks, LF | 1 |
| Mindell, ER | 1 |
| Pinckney, L | 1 |
| Parker, BR | 1 |
| Maluje, V | 1 |
| Alvarado, A | 1 |
| Guzmán, L | 1 |
| Treadwell, EL | 1 |
| Cunningham, PR | 1 |
| Kowalski, HM | 1 |
| Weaver, MD | 1 |
| van Linthoudt, D | 1 |
| Ott, H | 1 |
| Lebovics, E | 1 |
| Schaffner, F | 1 |
| Klion, FM | 1 |
| Simon, C | 1 |
| Newman, AJ | 1 |
| Melhorn, DK | 1 |
| Duncan, H | 1 |
| Sterling, WA | 1 |
| Pierce, JC | 1 |
| Lee, HM | 1 |
| Hume, DM | 1 |
| Fine, RN | 1 |
| Korsch, BM | 1 |
| Brennan, LP | 1 |
| Edelbrock, HH | 1 |
| Stiles, QR | 1 |
| Riddell, HI | 1 |
| Weitzman, JJ | 1 |
| Mickelson, JC | 1 |
| Tucker, BL | 1 |
| Grushkin, CM | 1 |
| Rogge, CW | 1 |
| Taylor, RT | 1 |
| Huskisson, EC | 1 |
| Whitehouse, GH | 1 |
| Hart, FD | 1 |
| Beck, O | 1 |
| Möller, E | 1 |
| Brinkmann, W | 1 |
| Weber, O | 1 |
| Wildhirt, E | 1 |
| Nilius, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Non-randomised Trial of Chemotherapy and Radiotherapy for Osteolymphoma[NCT00141648] | 70 participants (Actual) | Interventional | 2000-09-30 | Completed | |||
| A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Docetaxel-Based Chemotherapy[NCT00638690] | Phase 3 | 1,195 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A prostate-specific antigen (PSA) response was defined as a >=50% decline from baseline. (NCT00638690)
Timeframe: Up to 12 months
| Intervention | Participants (Number) |
|---|---|
| Abiraterone Acetate | 232 |
| Placebo | 22 |
Overall survival is defined as the time interval from the date of randomization to the date of death from any cause. (NCT00638690)
Timeframe: Up to 60 months
| Intervention | Days (Median) |
|---|---|
| Abiraterone Acetate | 450.0 |
| Placebo | 332.0 |
Radiographic progression-free survival is based on imaging studies according to modified Response Evaluation Criteria in Solid Tumors (RECIST): baseline lymph node size must be >=2.0 cm to be considered a target lesion; progression on bone scans with >=2 new lesions not consistent with tumor flare, confirmed on a second scan >=6 weeks later that shows >=1 additional new lesion. (NCT00638690)
Timeframe: Up to 11 months
| Intervention | Days (Median) |
|---|---|
| Abiraterone Acetate | 171.0 |
| Placebo | 110.0 |
The time interval from the date of randomization to the date of the prostate-specific antigen (PSA) progression as defined in the protocol-specific Prostate Specific Antigen Working Group (PSAWG) criteria, namely, a PSA level of at least 5 ng/ml that has risen on at least 2 successive occasions, at least 2 weeks apart. (NCT00638690)
Timeframe: Up to 12 months
| Intervention | Days (Median) |
|---|---|
| Abiraterone Acetate | 309.0 |
| Placebo | 200.0 |
4 reviews available for prednisone and Fracture, Pathologic
| Article | Year |
|---|---|
[Prevention and treatment of glucocorticoid-induced osteoporosis in International and Italian scenarios].
Topics: Adult; Aged; Algorithms; Bone Density; Bone Density Conservation Agents; Diphosphonates; Female; Fra | 2011 |
[Corticosteroid therapy for nephrotic syndrome].
Topics: Drug Resistance; Drug Therapy, Combination; Femur Head Necrosis; Fractures, Spontaneous; Humans; Imm | 2004 |
[Glucocorticoid-induced osteoporosis].
Topics: Alendronate; Bone Density; Bone Density Conservation Agents; Calcium; Diphosphonates; Female; Fractu | 2007 |
Osteoporosis in rheumatoid arthritis and corticosteroid induced osteoporosis.
Topics: Animals; Arthritis, Juvenile; Arthritis, Rheumatoid; Bone Regeneration; Cervical Vertebrae; Child, P | 1972 |
2 trials available for prednisone and Fracture, Pathologic
| Article | Year |
|---|---|
Limited chemotherapy and shrinking field radiotherapy for Osteolymphoma (primary bone lymphoma): results from the trans-Tasman Radiation Oncology Group 99.04 and Australasian Leukaemia and Lymphoma Group LY02 prospective trial.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antin | 2011 |
Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised tri
Topics: Abiraterone Acetate; Adult; Aged; Aged, 80 and over; Androgen Antagonists; Androstadienes; Bone Neop | 2012 |
31 other studies available for prednisone and Fracture, Pathologic
| Article | Year |
|---|---|
[Localized primary bone lymphoma: about four cases].
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; | 2014 |
Osseous Sarcoidosis Revealed by a Pathologic Fracture and Successfully Treated With Methotrexate and Prednisone.
Topics: Adult; Antirheumatic Agents; Bone Diseases; Finger Injuries; Finger Phalanges; Fractures, Spontaneou | 2016 |
Diagnosis of Giant Cell Arteritis in an Asymptomatic Patient.
Topics: Aftercare; Aged; Antineoplastic Combined Chemotherapy Protocols; Aorta; Asymptomatic Diseases; Cyclo | 2016 |
Solitary osseous sarcoidosis: a rare reason for pathologic fracture.
Topics: Biopsy; Bone Diseases; Diagnosis, Differential; Female; Finger Phalanges; Fractures, Spontaneous; Gl | 2012 |
Multiple vertebral compression fractures in a patient treated with corticosteroids for cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents; Casts, Surgical; Cystic Fibrosis; Fatal Outcome; Fractures, Sp | 2002 |
Is ultrasound of bone relevant for corticosteroid-treated patients? A comparative study with bone densitometry measured by DEXA.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Bone and Bones; Bone Density; Calcaneus; Dose-Respo | 2003 |
[Primary non-Hodgkin's lymphoma of bone].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Regeneration; Cyclophosphamide; | 2004 |
Multiple complications in multiple myeloma.
Topics: Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Female; Fractures, Spontaneous; Hip Fr | 2005 |
Failure of bone scanning to detect fractures in a woman on chronic steroid therapy.
Topics: Adult; Diphosphonates; Female; Fractures, Spontaneous; Hip Fractures; Humans; Immunosuppressive Agen | 1984 |
[Long-term osteoporosis with multiple fractures as the early monosymptomatic stage of multiple myeloma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Fractures, Spontaneous; Hum | 1984 |
Iatrogenic morbidity accompanying suppression of temporal arteritis by adrenal corticosteroids.
Topics: Adrenal Cortex Hormones; Aged; Drug Administration Schedule; Female; Fractures, Spontaneous; Giant C | 1984 |
Modulation of renal osteodystrophy by extrarenal production of calcitriol.
Topics: Adult; Arthritis, Juvenile; Biopsy; Bone and Bones; Calcitriol; Chronic Kidney Disease-Mineral and B | 1995 |
Osteoporosis in lung transplantation candidates with end-stage pulmonary disease.
Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Bone Density; Cystic Fibrosis; Female; Fractures, S | 1996 |
Commentary: low-dose high-frequency enzyme replacement therapy prevents fractures without complete suppression of painful bone crises in patients with severe juvenile onset type I Gaucher disease.
Topics: Adolescent; Adult; Age Factors; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Ste | 1998 |
Glucocorticoid-induced osteoporosis: is the bone density decrease the only explanation?
Topics: Bone Density; Case-Control Studies; Female; Fractures, Spontaneous; Glucocorticoids; Humans; Middle | 2000 |
Bony morbidity in children treated for acute lymphoblastic leukemia.
Topics: Adolescent; Analysis of Variance; Antineoplastic Agents, Hormonal; Boston; Child; Child, Preschool; | 2001 |
[Azathioprine in the treatment of temporal arteritis and polymyalgia rheumatica].
Topics: Aged; Azathioprine; Back Pain; Drug Evaluation; Drug Therapy, Combination; Female; Fractures, Sponta | 1977 |
Complete remodeling of the vertebrae in a child successfully treated for acute lymphocytic leukemia (ALL).
Topics: Bone Regeneration; Child; Cyclophosphamide; Daunorubicin; Fractures, Spontaneous; Humans; Leukemia, | 1977 |
Myelosclerosis and myelofibrosis in treated histiocytosis-X.
Topics: Fractures, Spontaneous; Histiocytosis, Langerhans-Cell; Humans; Infant; Male; Prednisone; Primary My | 1977 |
[Spontaneous fracture of the sacrum in patient with pulmonary fibrosis and steroid treatment].
Topics: Chloroquine; Female; Fractures, Spontaneous; Humans; Middle Aged; Naproxen; Osteoporosis, Postmenopa | 1991 |
Thoracolumbar compression fractures presenting with an acute ileus.
Topics: Aged; Female; Fractures, Spontaneous; Humans; Intestinal Obstruction; Lumbar Vertebrae; Lupus Erythe | 1990 |
Supraacetabular and femoral head stress fracture during fluoride treatment.
Topics: Acetabulum; Aged; Female; Femoral Neck Fractures; Fractures, Spontaneous; Humans; Osteoporosis; Pred | 1987 |
Autoimmune chronic active hepatitis in postmenopausal women.
Topics: Aged; Antibodies, Antinuclear; Ascites; Autoimmune Diseases; Azathioprine; Diabetes Mellitus; Drug T | 1985 |
Vertebral compression in childhood leukemia.
Topics: Age Factors; Child; Female; Fractures, Spontaneous; Humans; Leukemia, Lymphoid; Male; Mercaptopurine | 1973 |
Rehabilitation of retransplant patients.
Topics: Azathioprine; Bone Diseases; Creatinine; Fractures, Spontaneous; Graft Rejection; Humans; Hypertensi | 1972 |
Renal transplantation in young children.
Topics: Age Factors; Azathioprine; Bone Diseases; Cadaver; Cataract; Child; Child, Preschool; Epiphyses, Sli | 1973 |
Necrosis of the femoral head occurring in association with corticosteroid medication.
Topics: Adult; Anemia, Aplastic; Female; Femur Head Necrosis; Fractures, Spontaneous; Humans; Lupus Erythema | 1972 |
Spontaneous fractures of pelvis in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Fractures, Spontaneous; Humans; Hydrocortisone; Injectio | 1971 |
[Problems of long-term prednisone therapy in existing senile osteoporosis].
Topics: Aged; Asthma; Female; Fractures, Spontaneous; Humans; Middle Aged; Osteomalacia; Osteoporosis; Predn | 1967 |
[Side-effects of glucocorticoids in liver therapy].
Topics: Acute Disease; Chronic Disease; Diabetes Mellitus; Fractures, Spontaneous; Glucocorticoids; Hepatiti | 1969 |
[Bone changes due to prednisone addiction].
Topics: Diagnosis, Differential; Female; Fractures, Spontaneous; Gastric Juice; Humans; Kidney Function Test | 1965 |