prednisone has been researched along with Emergencies in 59 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The groups treated continuously during the trial with either budesonide or nedocromil did not differ from the group given placebo in terms of lung function, control of asthma, or psychological status at the end of 4." | 9.14 | Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. ( Bender, B; Sternberg, AL; Strunk, RC; Szefler, SJ; Tonascia, J; Zeiger, RS, 2009) |
| "To compare nebulized dexamethasone with oral prednisone in the treatment of children with asthma." | 9.08 | Nebulized dexamethasone versus oral prednisone in the emergency treatment of asthmatic children. ( Decker, JM; Henretig, FM; Joffe, MD; Loiselle, JM; Scarfone, RJ; Wiley, JF, 1995) |
| "Although these preliminary results suggest that nebulized budesonide may be an effective adjunct to oral prednisone in the management of moderate to severe asthma exacerbations, a larger trial will be required before the widespread use of inhaled budesonide in acute asthma can be advocated." | 9.08 | Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma. ( Klassen, TP; Osmond, MH; Sung, L, 1998) |
| "These data demonstrate that oral prednisone, within 4 hours of its administration, reduced the need for hospitalization among a subset of children treated in the emergency department for acute asthma." | 9.07 | Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. ( Fuchs, SM; Nager, AL; Scarfone, RJ; Shane, SA, 1993) |
| "One hundred twenty-two patients treated in the emergency room for acute exacerbations of asthma were assigned in a randomized, double-blind fashion to receive at discharge either prednisone for eight days (the dose being tapered from 40 to 0 mg per day) or matching placebo." | 9.07 | Effect of a short course of prednisone in the prevention of early relapse after the emergency room treatment of acute asthma. ( Chapman, KR; Rebuck, AS; Verbeek, PR; White, JG, 1991) |
| "The effect of high orally administered doses of prednisone for 1 week early in the course of an acute exacerbation of asthma incompletely responsive to bronchodilators was examined in 41 patients randomly assigned to receive either prednisone or an identical appearing placebo." | 9.06 | Early intervention with short courses of prednisone to prevent progression of asthma in ambulatory patients incompletely responsive to bronchodilators. ( Harris, JB; Milavetz, G; Nassif, E; Smith, G; Stillerman, A; Weinberger, MM, 1987) |
| "The groups treated continuously during the trial with either budesonide or nedocromil did not differ from the group given placebo in terms of lung function, control of asthma, or psychological status at the end of 4." | 5.14 | Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. ( Bender, B; Sternberg, AL; Strunk, RC; Szefler, SJ; Tonascia, J; Zeiger, RS, 2009) |
| "To compare nebulized dexamethasone with oral prednisone in the treatment of children with asthma." | 5.08 | Nebulized dexamethasone versus oral prednisone in the emergency treatment of asthmatic children. ( Decker, JM; Henretig, FM; Joffe, MD; Loiselle, JM; Scarfone, RJ; Wiley, JF, 1995) |
| "Although these preliminary results suggest that nebulized budesonide may be an effective adjunct to oral prednisone in the management of moderate to severe asthma exacerbations, a larger trial will be required before the widespread use of inhaled budesonide in acute asthma can be advocated." | 5.08 | Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma. ( Klassen, TP; Osmond, MH; Sung, L, 1998) |
| "These data demonstrate that oral prednisone, within 4 hours of its administration, reduced the need for hospitalization among a subset of children treated in the emergency department for acute asthma." | 5.07 | Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma. ( Fuchs, SM; Nager, AL; Scarfone, RJ; Shane, SA, 1993) |
| "One hundred twenty-two patients treated in the emergency room for acute exacerbations of asthma were assigned in a randomized, double-blind fashion to receive at discharge either prednisone for eight days (the dose being tapered from 40 to 0 mg per day) or matching placebo." | 5.07 | Effect of a short course of prednisone in the prevention of early relapse after the emergency room treatment of acute asthma. ( Chapman, KR; Rebuck, AS; Verbeek, PR; White, JG, 1991) |
| "The effect of high orally administered doses of prednisone for 1 week early in the course of an acute exacerbation of asthma incompletely responsive to bronchodilators was examined in 41 patients randomly assigned to receive either prednisone or an identical appearing placebo." | 5.06 | Early intervention with short courses of prednisone to prevent progression of asthma in ambulatory patients incompletely responsive to bronchodilators. ( Harris, JB; Milavetz, G; Nassif, E; Smith, G; Stillerman, A; Weinberger, MM, 1987) |
| " Vitamin D or dihydrotachysterol (DHT) do not correct hypocalcemia immediately, since their effects may be delayed up to 15-25 days." | 4.75 | [Hypo and hypercalcemia as an emergency]. ( Dambacher, MA; Guncaga, J; Haas, HG, 1975) |
| "A 36-year-old patient presented with a severe hand ischemia after intraarterial injection of four dissolved tablets of Methylphenidate each 10 mg (Ritalin into the right radial artery." | 3.72 | [Acute ischemia after intraarterial drug injection]. ( Aschwanden, M; Jäger, KA; Kliem, M; Stürchler, M; Thalhammer, C, 2004) |
| "To study the natural history of corticosteroid-dependent asthma, we evaluated 40 randomly selected adult patients with severe asthma who were refractory to management with inhaled corticosteroids and bronchodilators and who required long-term prednisone therapy (mean duration, 6." | 3.67 | Natural history of asthma in patients requiring long-term systemic corticosteroids. ( Dykewicz, MS; Greenberger, PA; Halwig, JM; Patterson, R, 1986) |
| "Severe acute ulcerative colitis unresponsive to medical management is characterized by multiple associated risk factors including anemia, hypoproteinemia, and high steroid requirements when urgent surgery is required." | 2.67 | Management of fulminant ulcerative colitis by primary restorative proctocolectomy. ( Harms, BA; Myers, GA; Rosenfeld, DJ; Starling, JR, 1994) |
| "Periodic fevers are acquired or inherited disorders of innate immunity, which were first described in the 1940s." | 2.49 | A taste of periodic fever syndromes. ( Chiang, VW; Hazen, MM; Koyfman, A; Lovallo, E, 2013) |
| " The addition of methotrexate to a tapered dosage of prednisone 10 mg daily was unsuccessful, and she remains on prednisone 20 mg daily for disease control." | 1.46 | Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report. ( Gulati, M; Herzog, EL; Homer, R; Pan, H; Ryu, C, 2017) |
| "Oculomotor nerve palsy is a rare finding in children and, when reported, is most frequently either congenital or acquired from postnatal trauma, infection, aneurysm, or migraine." | 1.38 | Interpeduncular fossa lipoma: a novel cause of oculomotor nerve palsy in childhood. ( Bogie, A; Crittenden-Byers, C; Malone, JR, 2012) |
| "Idiopathic thrombocytopenic purpura is an autoimmune disorder characterized by a low platelet count." | 1.35 | [Anesthetic management in a pregnant woman suffering from idiopathic thrombocytopenic purpura]. ( Borras, R; Cambray, C; Jamart, V; Mailan, J; Raynard Ortiz, M, 2009) |
| "A relapse was defined as an unscheduled revisit to the ED within 14 days of initial treatment." | 1.28 | Treatment of decompensated chronic obstructive pulmonary disease in the emergency department--correlation between clinical features and prognosis. ( Chick, TW; Gorby, MS; Halperin, AK; Murata, GH, 1991) |
| "A 9-year-old boy with systemic onset juvenile rheumatoid arthritis (JRA) presented with fever and chest pain and rapidly developed pericarditis and cardiac tamponade." | 1.27 | Cardiac tamponade in systemic juvenile rheumatoid arthritis requiring emergency pericardiectomy. ( Alukal, MK; Costello, PB; Green, FA, 1984) |
| "Acute vesicular or weeping dermatoses are best treated with cool, wet compresses and topical lotions, whereas dry, scaly skin conditions should be treated with hydrating measures and topical ointments." | 1.27 | Dermatologic emergencies. ( Rapini, RP, 1986) |
| "In conclusion, in patients with hyperleukocytosis the complications of blast cell lysis and leukostasis were manageable with acceptable morbidity and minimal mortality in a group of patients treated with vigorous hydration, allopurinol, and alkalinization of the urine before beginning chemotherapy." | 1.27 | The effect of initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia. ( Bleyer, WA; Finklestein, JZ; Gaynon, PS; Hammond, GD; Maurer, HS; Reaman, GH; Sather, HN; Steinherz, PG, 1988) |
| "Patients with previous anaphylactoid reactions to radiographic contrast media (RCM) are at increased risk for subsequent reactions on repeat exposure." | 1.27 | Emergency administration of radiocontrast media in high-risk patients. ( Greenberger, PA; Halwig, JM; Patterson, R; Wallemark, CB, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (32.20) | 18.7374 |
| 1990's | 16 (27.12) | 18.2507 |
| 2000's | 9 (15.25) | 29.6817 |
| 2010's | 15 (25.42) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lazovic, B | 1 |
| Zlatkovic-Svenda, M | 1 |
| Jasarovic, D | 1 |
| Stevanovic, D | 1 |
| Zanelli, M | 1 |
| Zizzo, M | 1 |
| Mengoli, MC | 1 |
| Valli, R | 1 |
| Martino, G | 1 |
| Fenocchio, D | 1 |
| De Marco, L | 1 |
| Ascani, S | 1 |
| Mouton, C | 1 |
| Leroux, L | 1 |
| Bonnet, G | 1 |
| Seguy, B | 1 |
| Lafargue, A | 1 |
| Baulier, G | 1 |
| Castet, S | 1 |
| Fiore, M | 1 |
| Mithoowani, S | 1 |
| Arnold, DM | 1 |
| Koyfman, A | 1 |
| Lovallo, E | 1 |
| Hazen, MM | 1 |
| Chiang, VW | 1 |
| Arias Palomero, A | 1 |
| Infantes Molina, EJ | 1 |
| López Arroquia, E | 1 |
| Riveira Villalobos, L | 1 |
| López Mondéjar, E | 1 |
| González del Valle, F | 1 |
| Ryu, C | 1 |
| Herzog, EL | 1 |
| Pan, H | 1 |
| Homer, R | 1 |
| Gulati, M | 1 |
| Strunk, RC | 1 |
| Sternberg, AL | 1 |
| Szefler, SJ | 1 |
| Zeiger, RS | 1 |
| Bender, B | 1 |
| Tonascia, J | 1 |
| Raynard Ortiz, M | 1 |
| Jamart, V | 1 |
| Cambray, C | 1 |
| Borras, R | 1 |
| Mailan, J | 1 |
| Chen, CY | 1 |
| Wu, CC | 1 |
| Hsiao, CW | 1 |
| Chen, CW | 1 |
| Jin, JS | 1 |
| Jao, SW | 1 |
| Shah, UK | 1 |
| Nicholas, B | 1 |
| Hurd, J | 1 |
| Nesargi, S | 1 |
| Corao-Uribe, D | 1 |
| Santos Nores, J | 1 |
| Bravo López, JJ | 1 |
| Borrajo Prol, MP | 1 |
| Iglesias Forneiro, A | 1 |
| Heras, M | 1 |
| Saiz, A | 1 |
| Fernández-Reyes, MJ | 1 |
| Sánchez, R | 1 |
| Zurita, P | 1 |
| Urrego, C | 1 |
| Roda-Safont, A | 1 |
| Simeón-Aznar, CP | 1 |
| Fonollosa-Plà, V | 1 |
| Segarra-Medrano, A | 1 |
| Vilardell-Tarrés, M | 1 |
| Marzano, AV | 1 |
| Tosi, D | 1 |
| Cusini, M | 1 |
| Nunzi, E | 1 |
| Massone, C | 1 |
| Crosti, C | 1 |
| Malone, JR | 1 |
| Bogie, A | 1 |
| Crittenden-Byers, C | 1 |
| Rapp, M | 2 |
| Berg, C | 1 |
| Knoepfle, G | 1 |
| Müller, AM | 2 |
| Bartmann, P | 1 |
| Rivera Irigoín, R | 1 |
| Nicolau Ramis, J | 1 |
| Terrasa Sagrista, F | 1 |
| Masmiquel Comas, L | 1 |
| Scarfone, RJ | 3 |
| Friedlaender, E | 1 |
| Thalhammer, C | 1 |
| Aschwanden, M | 1 |
| Kliem, M | 1 |
| Stürchler, M | 1 |
| Jäger, KA | 1 |
| Schulthess, G | 1 |
| Kolyvanos Naumann, U | 1 |
| Käser, L | 1 |
| Vetter, W | 1 |
| Wondergem, MJ | 1 |
| Overbeeke, M | 1 |
| Som, N | 1 |
| Chamuleau, ME | 1 |
| Jonkhoff, AR | 1 |
| Zweegman, S | 1 |
| Vachani, C | 1 |
| Parry, EH | 1 |
| Alukal, MK | 1 |
| Costello, PB | 1 |
| Green, FA | 1 |
| Richter, K | 1 |
| Loiselle, JM | 1 |
| Wiley, JF | 1 |
| Decker, JM | 1 |
| Henretig, FM | 1 |
| Joffe, MD | 1 |
| Massaro, AF | 1 |
| Gaston, B | 1 |
| Kita, D | 1 |
| Fanta, C | 1 |
| Stamler, JS | 1 |
| Drazen, JM | 1 |
| Harms, BA | 1 |
| Myers, GA | 1 |
| Rosenfeld, DJ | 1 |
| Starling, JR | 1 |
| Perry, RF | 1 |
| Allison, EJ | 1 |
| Evans, JM | 1 |
| Vukov, LF | 1 |
| Hunder, GG | 1 |
| Roizin, H | 1 |
| Ballin, A | 1 |
| Hadani, M | 1 |
| Barzilay, Z | 1 |
| Fuchs, SM | 1 |
| Nager, AL | 1 |
| Shane, SA | 1 |
| Win, N | 1 |
| Peterkin, MA | 1 |
| Watson, WH | 1 |
| Kelso, TM | 1 |
| Abou-Shala, N | 1 |
| Heilker, GM | 1 |
| Arheart, KL | 1 |
| Portner, TS | 1 |
| Self, TH | 1 |
| Weinberger, M | 1 |
| Sung, L | 1 |
| Osmond, MH | 1 |
| Klassen, TP | 1 |
| D'Urzo, AD | 1 |
| Bone, RC | 1 |
| Hiller, C | 1 |
| Hoagland, HC | 1 |
| Perry, MC | 1 |
| Haas, HG | 1 |
| Dambacher, MA | 1 |
| Guncaga, J | 1 |
| Buckingham, JM | 1 |
| Remine, WH | 1 |
| Franz, A | 1 |
| Roth, U | 1 |
| Schneider, I | 1 |
| Manresa, JM | 1 |
| Contreras, E | 1 |
| Caballol, R | 1 |
| Sirvent, JJ | 1 |
| Fitzgerald, JM | 1 |
| Hargreave, FE | 1 |
| Wong, S | 1 |
| Dykewicz, MS | 3 |
| Patterson, R | 5 |
| Murata, GH | 1 |
| Gorby, MS | 1 |
| Chick, TW | 1 |
| Halperin, AK | 1 |
| Chapman, KR | 1 |
| Verbeek, PR | 1 |
| White, JG | 1 |
| Rebuck, AS | 1 |
| Boxer, MB | 1 |
| Greenberger, PA | 3 |
| Rapini, RP | 1 |
| Maurer, HS | 1 |
| Steinherz, PG | 1 |
| Gaynon, PS | 1 |
| Finklestein, JZ | 1 |
| Sather, HN | 1 |
| Reaman, GH | 1 |
| Bleyer, WA | 1 |
| Hammond, GD | 1 |
| Wiggins, CA | 1 |
| Harris, JB | 1 |
| Weinberger, MM | 1 |
| Nassif, E | 1 |
| Smith, G | 1 |
| Milavetz, G | 1 |
| Stillerman, A | 1 |
| Phillips, SL | 1 |
| Frank, E | 1 |
| Halwig, JM | 2 |
| Wallemark, CB | 1 |
| Werner, SC | 1 |
| Oldfather, T | 1 |
| Bizot, W | 1 |
| Kinnaird, D | 1 |
| Polk, HC | 1 |
| Strem, EL | 1 |
| Austrian, S | 1 |
| Sand, RE | 1 |
| Vaccarella, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Budesonide Inhalation Suspension for Acute Asthma in Children[NCT00393367] | Phase 4 | 179 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| Single Dose Dexamethasone is as Effective as Two Doses in Mild to Moderate Pediatric Asthma Exacerbations in the Emergency Department[NCT02192827] | Phase 3 | 318 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513458] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2020-09-30 | Withdrawn (stopped due to [The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.) | ||
| Ideal Steroids for Asthma Treatment in the PICU (iSTAT PICU): A Prospective, Comparative, Single-arm Study Assessing Dexamethasone Versus Methylprednisolone in Severe Status Asthmaticus Admitted to the Pediatric Intensive Care Unit[NCT03900624] | Phase 4 | 92 participants (Actual) | Interventional | 2019-04-21 | Completed | ||
| Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation[NCT03513471] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2019-08-09 | Withdrawn (stopped due to The risk of inhaled allergen challenge and anakinra treatment outweigh benefits to participants with allergic asthma due to the COVID-19 pandemic.) | ||
| Initiating Inhaled Corticosteroid Therapy at Discharge From the Pediatric Emergency Department to Prevent Asthma Relapse: A Randomized Control Trial[NCT03369847] | Phase 4 | 43 participants (Actual) | Interventional | 2017-09-10 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mean of heart rate in beats per minute before treatment minus mean of heart rate 2 hours after treatment with either budesonide/albuterol or saline/albuterol (NCT00393367)
Timeframe: From the initial heart rate to heart rate 2 hours after intervention with budesonide/albuterol or saline/albuterol comparator
| Intervention | Beats per minute (Mean) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | 12 |
| Placebo (Normal Saline) | 13 |
The scale used is the Asthma Score published by Qureshi et al. The Asthma Score ranges from a low of 5 to maximum of 15 points. One to 3 points are given for each of 5 categories: age-based respiratory rate, oxygen saturation, wheeze, retractions, and dyspnea. For category detalails, please see the Qureshi reference. Scores of 5-7 are considered mild, 8-11 moderate, and 12-15 severe. Asthma Scores are recorded prior to any intervention and at 2 hours after budesonide inhalation suspension/albuterol intervention or saline placebo/albuterol comparator. (NCT00393367)
Timeframe: Initial asthma score minus score 2 hours after budesonide/albuterol intervention or saline placebo/albuterol comparator
| Intervention | Units on a scale (Mean) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | -2.9 |
| Placebo (Normal Saline) | -3.0 |
Mean respiratory rate in breaths per minute before treatment minus respiratory rate 2 hours after treatment with either budesonide/albuterol or saline/albuterol comparator. (NCT00393367)
Timeframe: Initial rate, minus rate taken 2 hours after budesonide/albuterol intervention or saline/albuterol comparator
| Intervention | Breaths per minute (Mean) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | -6 |
| Placebo (Normal Saline) | -6 |
The scale used is the Asthma Score published by Qureshi et al. The Asthma Score ranges from a low of 5 to maximum of 15 points. One to 3 points are given for each of 5 categories: age-based respiratory rate, oxygen saturation, wheeze, retractions, and dyspnea. For category detalails, please see the Qureshi reference. Scores of 5-7 are considered mild, 8-11 moderate, and 12-15 severe. Asthma Scores are recorded prior to any intervention and at 2 hours after budesonide inhalation suspension/albuterol intervention or saline placebo/albuterol comparator. (NCT00393367)
Timeframe: Initial asthma score minus score 2 hours after budesonide/albuterol intervention or saline placebo/albuterol comparator
| Intervention | Units on a scale (Median) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | -3 |
| Placebo (Normal Saline) | -3 |
The number of patients requiring hospital admission 4 hours after budesonide/albuterol intervention or saline/albuterol comparator. All hospitalization decisions are made at the discretion of the attending physician. (NCT00393367)
Timeframe: within 4 hours after the budesonide/albuterol intervention or saline/albuterol placebo
| Intervention | Participants (Number) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | 56 |
| Placebo (Saline) | 55 |
Of the patients who presented in the severe asthma category (Asthma Severity score of 12-15), those who moved to the mild category (Asthma Severity score 5-7) 2 hours after the budesonide/albuterol intervention or saline/albuterol comparator. (NCT00393367)
Timeframe: From the initial score to 2 hours after intervention with budesonide/albuterol or saline/albuterol comparator
| Intervention | Participants (Number) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | 8 |
| Placebo (Normal Saline) | 10 |
Of the patients who presented in the severe asthma category (Asthma Severity score of 12-15), those who moved to the moderate category (Asthma Severity score 8-11) 2 hours after the budesonide/albuterol intervention or saline/albuterol comparator. (NCT00393367)
Timeframe: From the initial score to 2 hours after intervention with budesonide/albuterol or saline/albuterol comparator
| Intervention | Participants (Number) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | 22 |
| Placebo (Normal Saline) | 11 |
Of the patients who presented in the severe asthma category (Asthma Severity score of 12-15), those who remained in this category 2 hours after the budesonide/albuterol intervention or saline/albuterol comparator. (NCT00393367)
Timeframe: From the initial score to 2 hours after intervention with budesonide/albuterol or saline/albuterol comparator
| Intervention | Participants (Number) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | 4 |
| Placebo (Normal Saline) | 4 |
Mean oxygen saturation (non-invasive pulse-oximetry, % hemoglobin saturation) 2 hours after treatment with either budesonide/albuterol or saline/albuterol comparator minus mean oxygen saturation before treatment. (NCT00393367)
Timeframe: 2 hours after treatment with either budesonide/albuterol or saline/albuterol comparator
| Intervention | Percent Hemoglobin Saturation (Mean) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | 1.0 |
| Placebo (Normal Saline) | 1.0 |
Participants admitted to the hospital within 5 days of the ED visit (NCT00393367)
Timeframe: within 5 days of ED visit
| Intervention | Participants (Number) |
|---|---|
| Budesonide Inhalation Suspension (BIS) | 2 |
| Placebo (Normal Saline) | 2 |
(NCT00393367)
Timeframe: within 30 days of the ED visit
| Intervention | Participants (Number) | |||||
|---|---|---|---|---|---|---|
| Rhinorrhea | Headache | Diarrhea | Sore throat | Cough | Hyperglycemia | |
| Budesonide Inhalation Suspension (BIS) | 6 | 5 | 3 | 4 | 2 | 2 |
| Placebo (Normal Saline) | 11 | 9 | 7 | 3 | 3 | 0 |
Serious Adverse Events (NCT00393367)
Timeframe: 0-5 days
| Intervention | participants (Number) | |
|---|---|---|
| Return within 5 days with hosptial admission | Increased level of care | |
| Budesonide Inhalation Suspension (BIS) | 2 | 1 |
| Placebo (Saline) | 2 | 0 |
The investigators will determine if each patient had any unscheduled visits to the emergency room, urgent care or primary care physician. (NCT02192827)
Timeframe: 5 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Single Dose Dexamethasone | 14 |
| Two Dose Dexamethasone | 12 |
Will determine number of days to symptom resolution, including missed school days. (NCT02192827)
Timeframe: 5 days
| Intervention | Days (Mean) |
|---|---|
| Single Dose Dexamethasone | 2.4 |
| Two Dose Dexamethasone | 2.5 |
The investigators will determine during phone follow up if patient experienced any side effects related to the Dexamethasone, including vomiting, mood swings, behavior changes, appetite changes, sweating or headache. (NCT02192827)
Timeframe: 5 days
| Intervention | Participants (Count of Participants) | ||||||
|---|---|---|---|---|---|---|---|
| No side effects | Decreased Appetite | Difficulty Sleeping | Mood swings/Agitation | Headache | Other | Multiple | |
| Single Dose Dexamethasone | 71 | 4 | 9 | 7 | 3 | 5 | 17 |
| Two Dose Dexamethasone | 83 | 7 | 0 | 3 | 1 | 4 | 18 |
Duration (in days) of continuous nebulized albuterol. (NCT03900624)
Timeframe: From enrollment through hospital discharge, up to 1 week
| Intervention | days (Median) |
|---|---|
| Methylprednisolone Arm - Standard Care | 1 |
| Dexamethasone Arm - Interventional Arm | 0.8 |
Hospital length of stay measured in days. (NCT03900624)
Timeframe: From enrollment through hospital discharge, up to 1 week
| Intervention | days (Mean) |
|---|---|
| Methylprednisolone Arm - Standard Care | 2.9 |
| Dexamethasone Arm - Interventional Arm | 2.9 |
"Number of participants receiving an adjunctive therapy:~use of non-invasive ventilation (NIV)~terbutaline~inhaled helium~inhaled anesthetic gas~mechanical ventilation~extracorporeal life support" (NCT03900624)
Timeframe: From enrollment through hospital discharge, up to 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Arm - Standard Care | 41 |
| Dexamethasone Arm - Interventional Arm | 16 |
Rates of known corticosteroid-related adverse events including clinically-relevant gastrointestinal bleeding, gastritis, ventilator associated pneumonia, necrotizing enterocolitis, hypertension, hyperglycemia, altered mentation (including hallucinations and delirium), and adrenal insufficiency observed prior to hospital discharge. (NCT03900624)
Timeframe: From enrollment through hospital discharge, up to 1 week
| Intervention | Participants (Count of Participants) | |||||||
|---|---|---|---|---|---|---|---|---|
| Hyperglycemia | Hypertension | Adrenal insufficiency | Altered mentation | Clinically-relevant gastrointestinal bleeding | Gastritis | Necrotizing enterocolitis | Ventilator associated pneumonia | |
| Dexamethasone Arm | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Methylprednisolone Arm | 7 | 1 | 2 | 2 | 0 | 0 | 0 | 0 |
6 reviews available for prednisone and Emergencies
| Article | Year |
|---|---|
First-Line Therapy for Immune Thrombocytopenia.
Topics: Acute Disease; Adolescent; Adult; Autoimmune Diseases; Blood Platelets; Child; Child, Preschool; Dex | 2019 |
A taste of periodic fever syndromes.
Topics: Amyloidosis; Anti-Inflammatory Agents, Non-Steroidal; Carrier Proteins; Colchicine; Cold Temperature | 2013 |
Corticosteroids in acute asthma: past, present, and future.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Adolescent; Adrenal Cortex Hormones | 2003 |
[(Micro-)hematuria (in adults). Main symptoms: evidence of erythrocytes in urine sediment].
Topics: Adult; Age Factors; Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Antineutrophil Cyto | 2005 |
Mixed autoimmune haemolysis in a SLE patient due to aspecific and anti-Jka autoantibodies; case report and review of the literature.
Topics: Adult; Anemia, Hemolytic, Autoimmune; Antibody Specificity; Autoantibodies; Autoantigens; Biopsy; Bl | 2006 |
[Hypo and hypercalcemia as an emergency].
Topics: Calcium; Dihydrotachysterol; Emergencies; Furosemide; Homeostasis; Humans; Hypercalcemia; Hypocalcem | 1975 |
8 trials available for prednisone and Emergencies
| Article | Year |
|---|---|
Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents.
Topics: Adolescent; Anti-Inflammatory Agents; Asthma; Body Height; Bronchodilator Agents; Budesonide; Drug U | 2009 |
Nebulized dexamethasone versus oral prednisone in the emergency treatment of asthmatic children.
Topics: Acute Disease; Administration, Oral; Adolescent; Anti-Asthmatic Agents; Anti-Inflammatory Agents; As | 1995 |
Management of fulminant ulcerative colitis by primary restorative proctocolectomy.
Topics: Acute Disease; Adult; Blood Proteins; Blood Transfusion; Circadian Rhythm; Colitis, Ulcerative; Colo | 1994 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Controlled trial of oral prednisone in the emergency department treatment of children with acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Double-Bl | 1993 |
Comprehensive long-term management program for asthma: effect on outcomes in adult African-Americans.
Topics: Adrenal Cortex Hormones; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Beclomethasone; Black or A | 1996 |
Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Adolescent; Albuterol; Anti-Inflamm | 1998 |
Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Adolescent; Albuterol; Anti-Inflamm | 1998 |
Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Adolescent; Albuterol; Anti-Inflamm | 1998 |
Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma.
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Adolescent; Albuterol; Anti-Inflamm | 1998 |
Effect of a short course of prednisone in the prevention of early relapse after the emergency room treatment of acute asthma.
Topics: Acute Disease; Administration, Oral; Adult; Asthma; Clinical Protocols; Double-Blind Method; Drug Ad | 1991 |
Early intervention with short courses of prednisone to prevent progression of asthma in ambulatory patients incompletely responsive to bronchodilators.
Topics: Adolescent; Adult; Ambulatory Care; Asthma; Bronchodilator Agents; Child; Child, Preschool; Double-B | 1987 |
45 other studies available for prednisone and Emergencies
| Article | Year |
|---|---|
Systemic Lupus Erythematosus Presenting as Acute Lupus Pneumonitis.
Topics: Acute Disease; Aged; Chest Pain; Diagnosis, Differential; Dyspnea; Emergencies; Female; Fever; Human | 2018 |
Diffuse large B cell lymphoma and schistosomiasis: a rare simultaneous occurrence.
Topics: Abdomen, Acute; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxoru | 2019 |
Successful management of transcatheter aortic valve implantation by platelet transfusions in a nonagenarian patient with severe autoimmune factor V deficiency.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Anticoagulants; Aortic Valve Stenosis; Atrial Fibrillation | 2019 |
[Uveal effusion induced by escitalopram].
Topics: Acute Disease; Aged; Atropine; Brimonidine Tartrate; Choroid Diseases; Ciliary Body; Citalopram; Dru | 2015 |
Upper Airway Obstruction Requiring Emergent Tracheostomy Secondary to Laryngeal Sarcoidosis: A Case Report.
Topics: Adult; Airway Obstruction; Emergencies; Female; Glucocorticoids; Humans; Laryngeal Diseases; Laryngo | 2017 |
[Anesthetic management in a pregnant woman suffering from idiopathic thrombocytopenic purpura].
Topics: Adult; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthesia, Obstetrical; Blood Loss, Surgica | 2009 |
Primary non-Hodgkin's lymphoma of rectum presenting with rectal prolapse.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Child; Colonic Polyps; Combi | 2009 |
Case report: Langerhans cell histiocytosis presenting as massive cervical adenopathy and retropharyngeal thickening: importance of chest radiography and coordinated airway and anesthetic management.
Topics: Airway Obstruction; Anesthesia, Intravenous; Anesthetics, Dissociative; Combined Modality Therapy; D | 2010 |
[HTA-pre-eclampsia-postpartum haemolytic-uraemic syndrome: good results can be achieved].
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Anti-Inflammatory Agents; Antihypertensive Agents; C | 2010 |
[Cyclophosphamide-induced lupus flare in diffuse proliferative lupus nephropathy].
Topics: Acute Disease; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Edema; | 2011 |
[Clinical features and prognosis of patients with scleroderma renal crisis].
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihyperten | 2011 |
Facial reversal reaction: a dermatological emergency.
Topics: Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; B-Lymphocytes; CD3 Complex; Clofazim | 2012 |
Interpeduncular fossa lipoma: a novel cause of oculomotor nerve palsy in childhood.
Topics: Asthma; Blepharoptosis; Emergencies; Humans; Infant; Infratentorial Neoplasms; Lipoma; Magnetic Reso | 2012 |
Prenatal suspicion of Kaposiform hemangioendo-thelioma in siblings: different clinical manifestation and emergency relief.
Topics: Anemia; Anti-Inflammatory Agents; Blood Transfusion, Intrauterine; Cesarean Section; Diagnosis, Diff | 2012 |
[Rosuvastatin-induced erythema multiforme].
Topics: Anti-Inflammatory Agents; Arthralgia; Drug Hypersensitivity; Drug Substitution; Emergencies; Erythem | 2013 |
[Acute ischemia after intraarterial drug injection].
Topics: Acute Disease; Adult; Amputation, Surgical; Anti-Inflammatory Agents; Anticoagulants; Central Nervou | 2004 |
Tumor lysis syndrome.
Topics: Aged; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dehydration; Do | 2007 |
Management of rheumatic heart disease in tropical countries.
Topics: Adolescent; Adult; Aspirin; Child; Child, Preschool; Costs and Cost Analysis; Digoxin; Diuretics; Em | 1983 |
Cardiac tamponade in systemic juvenile rheumatoid arthritis requiring emergency pericardiectomy.
Topics: Arthritis, Juvenile; Cardiac Catheterization; Cardiac Tamponade; Child; Echocardiography; Emergencie | 1984 |
[Children's emergencies--what to do?].
Topics: Abdomen, Acute; Aerosols; Child, Preschool; Chloral Hydrate; Cold Temperature; Coma; Croup; Diazepam | 1982 |
Expired nitric oxide levels during treatment of acute asthma.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Airway Obstruction; Asthma; Beclomethasone; Case-Cont | 1995 |
Asthma treatment in the emergency department.
Topics: Administration, Oral; Asthma; Child; Emergencies; Emergency Service, Hospital; Humans; Prednisone | 1994 |
Polymyalgia rheumatica and giant cell arteritis in emergency department patients.
Topics: Aged; Emergencies; Female; Giant Cell Arteritis; Humans; Male; Polymyalgia Rheumatica; Prednisone | 1993 |
Intracerebral hemorrhage in an infant with idiopathic thrombocytopenic purpura: approach to the surgical management.
Topics: Cerebral Hemorrhage; Craniotomy; Emergencies; Female; Humans; Immunoglobulins, Intravenous; Infant; | 1993 |
The therapeutic value of HPA-1a-negative platelet transfusion in post-transfusion purpura complicated by life-threatening haemorrhage.
Topics: Antigens, Human Platelet; Combined Modality Therapy; Critical Care; Emergencies; Female; Gastrointes | 1995 |
Steroids and asthma.
Topics: Acute Disease; Administration, Inhalation; Adrenergic beta-Agonists; Asthma; Child; Child, Preschool | 1996 |
Controlling asthma. Highlights of the 1999 Canadian Asthma Consensus Report.
Topics: Administration, Topical; Adrenergic beta-Agonists; Adult; Aminophylline; Anti-Asthmatic Agents; Anti | 2000 |
Modern treatment of bronchial asthma.
Topics: Adrenal Cortex Hormones; Aerosols; Ambulatory Care; Asthma; Bronchodilator Agents; Cromolyn Sodium; | 1978 |
Blast cell crisis in acute or chronic leukemia.
Topics: Adult; Age Factors; Allopurinol; Antineoplastic Agents; Cerebral Hemorrhage; Child; Emergencies; Hum | 1976 |
Results of emergency surgical management of hemorrhagic duodenal ulcer.
Topics: Adolescent; Adult; Aged; Aspirin; Duodenal Ulcer; Emergencies; Female; Gastrectomy; Gastroscopy; Hum | 1975 |
[Diagnosis and therapy of dyspnea--special viewpoints for juveniles].
Topics: Anti-Bacterial Agents; Bronchitis; Child, Preschool; Diagnosis, Differential; Drainage; Dyspnea; Eme | 1975 |
[Thyroid lymphoma. A medical emergency].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Emergencies; Female; | 1992 |
Acute asthma: emergency department management and prospective evaluation of outcome.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Emergen | 1990 |
Idiopathic anaphylaxis. A clinical summary of 175 patients.
Topics: Adolescent; Adult; Aged; Anaphylaxis; Child; Emergencies; Epinephrine; Female; Follow-Up Studies; Hi | 1990 |
Treatment of decompensated chronic obstructive pulmonary disease in the emergency department--correlation between clinical features and prognosis.
Topics: Aged; Bronchodilator Agents; Critical Care; Dyspnea; Emergencies; Female; Humans; Lung Diseases, Obs | 1991 |
The impact of prednisone in life-threatening idiopathic anaphylaxis: reduction in acute episodes and medical costs.
Topics: Acute Disease; Adolescent; Adult; Anaphylaxis; Emergencies; Epinephrine; Female; Histamine H1 Antago | 1989 |
Dermatologic emergencies.
Topics: Aged; Dermatitis, Contact; Dermatitis, Exfoliative; Emergencies; Erythema; Histamine H1 Antagonists; | 1986 |
The effect of initial management of hyperleukocytosis on early complications and outcome of children with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; | 1988 |
Idiopathic anaphylaxis: classification, evaluation, and treatment of 123 patients.
Topics: Adolescent; Adult; Aged; Airway Obstruction; Anaphylaxis; Angioedema; Child; Drug Administration Sch | 1988 |
Acute orbital pseudotumor: ocular emergency on a general medical service.
Topics: Acute Disease; Diagnosis, Differential; Emergencies; Female; Humans; Inflammation; Middle Aged; Orbi | 1987 |
Natural history of asthma in patients requiring long-term systemic corticosteroids.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Beclomethasone; Drug Administrat | 1986 |
Emergency administration of radiocontrast media in high-risk patients.
Topics: Anaphylaxis; Contrast Media; Diphenhydramine; Emergencies; Humans; Prednisone; Premedication; Risk | 1986 |
Prednisone in emergency treatment of malignant exophthalmos.
Topics: Adult; Aged; Emergencies; Female; Graves Disease; Humans; Prednisone; Prognosis | 1966 |
Grand rounds: Intraperitoneal infection and emergency operation in patients on long-term corticosteroid therapy.
Topics: Abscess; Arthritis, Rheumatoid; Emergencies; Humans; Laparotomy; Male; Methylprednisolone; Middle Ag | 1974 |
Bronchial asthma. Treatment of the acute attack and status asthmaticus in children.
Topics: Aerosols; Aminophylline; Asthma; Bicarbonates; Blood Gas Analysis; Bronchodilator Agents; Child; Eme | 1972 |