prednisone has been researched along with Disc, Herniated in 15 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "CSF levels of myelin basic protein (MBP) and intrathecally produced CSF IgG (de novo IgG) were measured in 11 chronic progressive multiple sclerosis patients with a deteriorating course of the disease for at least 6 months preceding observation and a reference group of 17 neurological patients suffering from disc herniation." | 7.67 | The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis. ( Doesburg, W; Hommes, OR; Lamers, KJ; Uitdehaag, BM; von Geel, WJ; Wevers, RA, 1988) |
| "CSF levels of myelin basic protein (MBP) and intrathecally produced CSF IgG (de novo IgG) were measured in 11 chronic progressive multiple sclerosis patients with a deteriorating course of the disease for at least 6 months preceding observation and a reference group of 17 neurological patients suffering from disc herniation." | 3.67 | The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis. ( Doesburg, W; Hommes, OR; Lamers, KJ; Uitdehaag, BM; von Geel, WJ; Wevers, RA, 1988) |
| "The prednisone-treated group showed an adjusted mean 6." | 2.80 | Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial. ( Ackerson, L; Avins, AL; Carragee, E; Carver, R; Firtch, W; Goldberg, H; Hamilton, L; Maratukulam, A; Pressman, A; Smith, W; Tyburski, M; Won, LA, 2015) |
| "Prednisone was the conventional medicine and electroacupuncture was applied at GV07 and GV02-1 at 0." | 1.36 | Clinical effect of additional electroacupuncture on thoracolumbar intervertebral disc herniation in 80 paraplegic dogs. ( Choi, SH; Han, HJ; Jang, HY; Jeong, SW; Kim, JY; Lee, B; Yoon, HY, 2010) |
| "Dorsolateral spinal cord compression associated with articular process hypertrophy was the most common feature of cervical vertebral malformation-malarticulation in the seven Bernese mountain dogs evaluated." | 1.35 | Cervical vertebral malformation-malarticulation syndrome in the Bernese mountain dog: clinical and magnetic resonance imaging features. ( Diaz, J; Eagleson, JS; Kent, M; Levine, JM; Platt, SR; Schatzberg, SJ; Sharp, NJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cattaneo, D | 1 |
| Cheli, S | 1 |
| Fusi, M | 1 |
| Clementi, E | 1 |
| Gervasoni, C | 1 |
| Gialanella, B | 1 |
| Prometti, P | 1 |
| Ferlucci, C | 1 |
| Chen, J | 1 |
| Wen, GJ | 1 |
| Zeng, LF | 1 |
| Xiao, PR | 1 |
| Chen, ZQ | 1 |
| Li, Y | 1 |
| Goldberg, H | 1 |
| Firtch, W | 1 |
| Tyburski, M | 1 |
| Pressman, A | 1 |
| Ackerson, L | 1 |
| Hamilton, L | 1 |
| Smith, W | 1 |
| Carver, R | 1 |
| Maratukulam, A | 1 |
| Won, LA | 1 |
| Carragee, E | 1 |
| Avins, AL | 1 |
| Cohen, SP | 1 |
| Fumeaux, T | 1 |
| Eagleson, JS | 1 |
| Diaz, J | 1 |
| Platt, SR | 1 |
| Kent, M | 1 |
| Levine, JM | 1 |
| Sharp, NJ | 1 |
| Schatzberg, SJ | 1 |
| Han, HJ | 1 |
| Yoon, HY | 1 |
| Kim, JY | 1 |
| Jang, HY | 1 |
| Lee, B | 1 |
| Choi, SH | 1 |
| Jeong, SW | 1 |
| NEBO, F | 2 |
| JUENEMANN, C | 1 |
| PERALES, J | 1 |
| FIGUEROA, L | 1 |
| JAKLITSCH, H | 1 |
| Renard, D | 1 |
| Bonafe, A | 1 |
| Heroum, C | 1 |
| Hayashi, AM | 1 |
| Matera, JM | 1 |
| Fonseca Pinto, AC | 1 |
| Lamers, KJ | 1 |
| Uitdehaag, BM | 1 |
| Hommes, OR | 1 |
| Doesburg, W | 1 |
| Wevers, RA | 1 |
| von Geel, WJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methylprednisolone Taper to Treat Delayed Post-Operative Recovery After Total Knee Arthroplasty: a Double-Blind Randomized Controlled Trial[NCT05113901] | Phase 4 | 4 participants (Actual) | Interventional | 2022-03-03 | Terminated (stopped due to Extremely low participation, decided to focus on similar study instead) | ||
| A Corticosteroid Taper for Acute Sciatica Treatment (The ACT FAST Study)[NCT00668434] | Phase 2 | 269 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Adverse outcomes including infection, avascular necrosis, and 90-day readmission rates (NCT05113901)
Timeframe: within 90 days after initial total knee arthroplasty
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Taper | 0 |
| Placebo Taper | 0 |
Manipulations under anesthesia (MUAs) following total knee arthroplasty surgery and treatment (NCT05113901)
Timeframe: within 90 days after initial total knee arthroplasty
| Intervention | Participants (Count of Participants) |
|---|---|
| Methylprednisolone Taper | 0 |
| Placebo Taper | 0 |
Single Assessment Numeric Evaluation (SANE), a single-question patient rating of 0-100, scoring their function to the area being treated. Zero represents a poor functional knee and 100 is the best functioning. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 89.5 |
UCLA activity score, on a scale of 1 to 10 where 10 is the most active patient with examples of activities (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 5.25 |
VR-12: Assesses physical functioning, physical/ mental limitations. Scored as summary of mental and physical, measure in standard deviations. The scale range is 0 to 100, where a score of 100 represents the best physical and mental health and zero is the worst outcome. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 50.28 |
Forgotten Joint Score (FJS) is a survey scored ranging from 0 to 100, where a high score indicates a high degree of a forgetting they have an artificial joint, which is an ideal outcome. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 57.82 |
Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR), a survey given to patients standard of care containing 7 questions. The score ranges from 0 to 100 where zero represents total disability and 100 represents a perfect knee health. (NCT05113901)
Timeframe: 6 weeks after treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 72.12 |
Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR), a survey given to patients standard of care containing 7 questions. The score ranges from 0 to 100 where zero represents total disability and 100 represents a perfect knee health. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 50.04 |
Single Assessment Numeric Evaluation (SANE), a single-question patient rating of 0-100, scoring their function to the area being treated. Zero represents a poor functional knee and 100 is the best functioning. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 29.5 |
Veterans Rand 12-Item Health Survey (VR-12), a survey of 12 questions to measure health relating to patient's quality of life. Scored as summary of mental and physical, measure in standard deviations. The scale range is 0 to 100, where a score of 100 represents the best physical and mental health and zero is the worst outcome. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 38.73 |
Forgotten Joint Score (FJS) is a survey scored ranging from 0 to 100, where a high score indicates a high degree of a forgetting they have an artificial joint, which is an ideal outcome. (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 91.67 |
UCLA activity score, on a scale of 1 to 10 where 10 is the most active patient with examples of activities (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 4.25 |
"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee.~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group. At 3 weeks post treatment, only 3 of the 4 subjects enrolled were still part of the study." (NCT05113901)
Timeframe: 3 weeks post treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 68.33 |
"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee.~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group. This is a standard of care survey available on all subjects." (NCT05113901)
Timeframe: 6 weeks post treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 78.75 |
"Using daily defense and veterans pain rating scale (DVPRS) on a scale of 1 to 10, 10 being the worst.~Please note, only one patient made it to the 6 week post treatment mark of the 4 enrolled. The study was terminated and none of the patients were randomized to the placebo group. All other patients followed up but were not interested in continuing. No range could be provided given only one subject answered and completed this visit" (NCT05113901)
Timeframe: 6 weeks post treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 1.93 |
"Knee society score (KSS); done standard of care on a scale of 0-100, where 100 means a more functional knee~**Please note, the study was terminated early, only 4 subjects were enrolled and none were randomized to the placebo group." (NCT05113901)
Timeframe: pre treatment
| Intervention | score on a scale (Mean) |
|---|---|
| Methylprednisolone Taper | 66.25 |
"Using Daily Visual Analogue Scale (VAS) pain score, which measures intensity of pain on a scale of 0 (no pain) to 10 (worst pain possible).~**Please note, this study was terminated early, only enrolling 4 patients, none were randomized to the placebo group." (NCT05113901)
Timeframe: Days 1 through 6 following treatment
| Intervention | score on a scale (Mean) | |||||
|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | |
| Methylprednisolone Taper | 2.33 | 3 | 1.33 | 1.33 | 1.67 | 2.3 |
"Range of motion (ROM) from pre-treatment to six weeks following treatment. Patients started treatment after total knee replacement surgery and presented to clinic with at least one inclusion criteria to be enrolled. Range of motion in degrees is taken at each visit by a clinician (standard of care), starting at zero degrees (straight leg) to about 135 degrees. The ROM was documented as part of consenting and enrollment into study. Subjects returned to the office at 6 weeks post treatment where ROM was performed in a clinic setting once again and documented. ROM is done using a goniometer by a clinician in each clinic.~This study was terminated early, therefore of the 4 enrolled, zero were randomized to the placebo group. Only 1 of the four subjects completed the 6 weeks, however, ROM was captured on all as standard of care." (NCT05113901)
Timeframe: Baseline, Week 6 Following Treatment
| Intervention | Range of Motion in Degrees (Mean) | |
|---|---|---|
| Pre treatment | Post treatment | |
| Methylprednisolone Taper | 82.5 | 112 |
The Oswestry Disability Index, v2 is a back-pain-specific measure of disability and functional status. It is measured on a 0-to-100 scale, with higher numbers indicating greater disability. (NCT00668434)
Timeframe: Baseline, Week 3 follow-up
| Intervention | units on a scale (Mean) |
|---|---|
| Prednisone | -19.0 |
| Placebo | -13.3 |
The Oswestry Disability Index, v2 is a back-pain-specific measure of disability and functional status. It is measured on a 0-to-100 scale, with higher numbers indicating greater disability. (NCT00668434)
Timeframe: Baseline, Week 52 follow-up
| Intervention | units on a scale (Mean) |
|---|---|
| Prednisone | -37.8 |
| Placebo | -30.4 |
Ordinal scale of average level of pain as perceived by the participant over the prior 3 days; measured on a 0-to-10 scale, with higher numbers indicating greater pain. (NCT00668434)
Timeframe: Baseline, Week 3 follow-up
| Intervention | units on a scale (Mean) |
|---|---|
| Prednisone | -3.0 |
| Placebo | -2.8 |
Ordinal scale of average level of pain as perceived by the participant over the prior 3 days; measured on a 0-to-10 scale, with higher numbers indicating greater pain. (NCT00668434)
Timeframe: Baseline, Week 52 follow-up
| Intervention | units on a scale (Mean) |
|---|---|
| Prednisone | -5.2 |
| Placebo | -4.6 |
3 trials available for prednisone and Disc, Herniated
| Article | Year |
|---|---|
[Efficacy analysis of sacral canal injection in patients with lumbar disc herniation associated with non-sciatica].
Topics: Adult; Female; Humans; Injections, Spinal; Intervertebral Disc Displacement; Lidocaine; Lumbar Verte | 2013 |
Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Gl | 2015 |
Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Gl | 2015 |
Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Gl | 2015 |
Oral steroids for acute radiculopathy due to a herniated lumbar disk: a randomized clinical trial.
Topics: Acute Disease; Administration, Oral; Adult; Aged; Double-Blind Method; Female; Follow-Up Studies; Gl | 2015 |
Evaluation of electroacupuncture treatment for thoracolumbar intervertebral disk disease in dogs.
Topics: Animals; Anti-Inflammatory Agents; Decompression, Surgical; Dog Diseases; Dogs; Early Ambulation; El | 2007 |
12 other studies available for prednisone and Disc, Herniated
| Article | Year |
|---|---|
Different effects of glucocorticoids on darunavir plasma concentrations.
Topics: Cytochrome P-450 CYP3A; Darunavir; Drug Combinations; Drug Interactions; Glucocorticoids; HIV Infect | 2019 |
Low back pain radiating to the leg: an atypical cause.
Topics: Amines; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclohexanecarbox | 2013 |
Oral steroids for improved function but not pain in acute radiculopathy due to disc herniation.
Topics: Female; Glucocorticoids; Humans; Intervertebral Disc Displacement; Lumbar Vertebrae; Male; Prednison | 2015 |
[What is the role of oral steroids in the treatment of acute sciatic?].
Topics: Female; Glucocorticoids; Humans; Intervertebral Disc Displacement; Lumbar Vertebrae; Male; Prednison | 2015 |
Cervical vertebral malformation-malarticulation syndrome in the Bernese mountain dog: clinical and magnetic resonance imaging features.
Topics: Animals; Anti-Inflammatory Agents; British Columbia; Cervical Vertebrae; Diagnosis, Differential; Do | 2009 |
Clinical effect of additional electroacupuncture on thoracolumbar intervertebral disc herniation in 80 paraplegic dogs.
Topics: Acupuncture Points; Animals; Back Pain; Dogs; Electroacupuncture; Glucocorticoids; Intervertebral Di | 2010 |
[Vertebral rheumatism. Comparative therapeutic, value of corticosteroids, phenylbutazone and the combination of butazolidine and prednisone].
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Humans; Intervertebral Disc Displacement; Osteoarthr | 1963 |
[Vertebral rheumatisms. Comparative therapeutic value of corticoids, phenylbutazone, and combined butazolidine and prednisone].
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Humans; Intervertebral Disc Displacement; Osteoarthr | 1963 |
COMBINATION OF CHLOROQUINE, PREDNISONE AND ASPIRIN IN THE TREATMENT OF ARTICULAR AND NON-ARTICULAR RHEUMATISM, AND LOW BACK PAIN AND SCIATICA.
Topics: Arthritis; Arthritis, Rheumatoid; Aspirin; Chloroquine; Humans; Intervertebral Disc Displacement; Jo | 1963 |
[THOUGHTS ON THE CONSERVATIVE THERAPY OF VERTEBRAL SYNDROMES].
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Atropine; Caffeine; Ergot Alkaloids; Humans; Int | 1964 |
Transient lesion in the splenium of the corpus callosum after oral corticoid therapy.
Topics: Administration, Oral; Anti-Inflammatory Agents; Arginine Vasopressin; Confusion; Corpus Callosum; De | 2007 |
The short-term effect of an immunosuppressive treatment on CSF myelin basic protein in chronic progressive multiple sclerosis.
Topics: Adult; Aged; Cyclophosphamide; Drug Therapy, Combination; Humans; Immunoglobulin G; Intervertebral D | 1988 |