prednisone has been researched along with Cryptogenic Infantile Spasms in 43 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Excerpt | Relevance | Reference |
---|---|---|
"Prednisone therapy is a safe and effective adjunctive treatment for epilepsy." | 5.32 | Prednisone therapy in pediatric epilepsy. ( Sinclair, DB, 2003) |
"We assessed the long-term cognitive and seizure outcomes of 37 patients with cryptogenic infantile spasms (onset, age 3 to 9 months) receiving standardized treatment regimen of high-dose tetracosactide depot, 1 mg IM every 48 h for 2 weeks, with a subsequent 8- to 10-week slow taper and followed by oral prednisone, 10 mg/day for a month, with a subsequent slow taper for 5 months or until the infant reached the age of 1 year, whichever came later." | 3.72 | Long-term cognitive outcomes of a cohort of children with cryptogenic infantile spasms treated with high-dose adrenocorticotropic hormone. ( Ariel, R; Danziger, Y; Kivity, S; Lerman, P; Mimouni, M; Shinnar, S, 2004) |
"We reviewed the clinical features and laboratory findings of 27 infants with infantile spasms treated with adrenocorticotropic hormone or prednisone during febrile episodes in order to evaluate the incidence of bacteremia, the risk of serious infection, determination of whether serious infections can be identified at presentation and the outcome of febrile episodes." | 3.68 | Risk of infection during adrenocorticotropic hormone treatment in infants with infantile spasms. ( Alpert, G; Garty, BZ; Kivity, S; Rachmel, A; Shamir, R, 1993) |
"Although West syndrome is well known clinical epileptic syndrome, there is no agreement about the first- and second-line treatments." | 2.44 | Update of the medical treatment of West syndrome. ( Chiarelli, F; Coppola, GG; Iannetti, P; Manco, R; Mingione, S; Verrotti, A, 2007) |
"Data from published research were extracted and evaluated according to study design, sample size, dosing regimen, outcome measures, and treatment efficacy and safety." | 2.39 | Treatment of infantile spasms. ( Casto, DT; Haines, ST, 1994) |
"Infantile spasms are classified as a "generalized" seizure disorder in the international classification system, which suggests that the underlying brain abnormality causing the seizures also must be diffuse or generalized." | 2.38 | Treatment of infantile spasms: medical or surgical? ( Chugani, HT; Peacock, WJ; Shewmon, DA; Shields, WD, 1992) |
"These hormones have an effect on seizures, and seizures have an effect on these hormones." | 2.38 | Effect of non-sex hormones on neuronal excitability, seizures, and the electroencephalogram. ( Holmes, GL, 1991) |
"Adrenal insufficiency is frequent and can potentially lead to an adrenal crisis in this population." | 1.72 | Adrenal insufficiency among children treated with hormonal therapy for infantile spasms. ( Chrestian, N; Doré-Brabant, G; Laflamme, G; Millette, M; Osterman, B, 2022) |
" Clinical response in short-term follow-up was independent of prednisone dosage and underlying etiology." | 1.72 | Cohort study of infantile epileptic spasms syndrome: etiological analysis and treatment of corticosteroids. ( Cheng, M; Hong, S; Jiang, L; Jiang, Y; Li, T; Liang, X; Liao, S; Luo, Y; Zhong, M; Zou, N, 2022) |
"Prednisone therapy is a safe and effective adjunctive treatment for epilepsy." | 1.32 | Prednisone therapy in pediatric epilepsy. ( Sinclair, DB, 2003) |
"ACTH completely controlled seizures in all patients with infantile spasms and hypsarhythmia and 74% of those with other types of seizures." | 1.27 | ACTH and prednisone in childhood seizure disorders. ( Benton, JW; Myers, GJ; Snead, OC, 1983) |
"Histidinemia was well-documented through biochemical assays." | 1.25 | Infantile spasms associated with histidinemia. ( Cohen, ME; Duffner, PK, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 19 (44.19) | 18.7374 |
1990's | 8 (18.60) | 18.2507 |
2000's | 6 (13.95) | 29.6817 |
2010's | 5 (11.63) | 24.3611 |
2020's | 5 (11.63) | 2.80 |
Authors | Studies |
---|---|
Doré-Brabant, G | 1 |
Laflamme, G | 1 |
Millette, M | 1 |
Osterman, B | 1 |
Chrestian, N | 1 |
Jiang, Y | 1 |
Zou, N | 1 |
Luo, Y | 1 |
Cheng, M | 1 |
Liao, S | 1 |
Hong, S | 2 |
Liang, X | 1 |
Zhong, M | 1 |
Li, T | 2 |
Jiang, L | 2 |
Li, J | 1 |
Gao, Y | 1 |
Cao, J | 1 |
Cai, F | 1 |
Zhai, X | 1 |
Chang, YH | 1 |
Chen, C | 1 |
Chen, SH | 1 |
Shen, YC | 1 |
Kuo, YT | 1 |
Li, S | 1 |
Zhong, X | 1 |
Kelley, SA | 1 |
Yi, Z | 1 |
Wu, H | 1 |
Yu, X | 1 |
Zha, J | 1 |
Chen, H | 1 |
Chen, Y | 2 |
Zhong, J | 1 |
Mahmoud, AA | 1 |
Rizk, TM | 1 |
Mansy, AA | 1 |
Ali, JA | 1 |
Al-Tannir, MA | 1 |
Yi, ZS | 1 |
Wu, HP | 1 |
Yu, XY | 1 |
Zhong, JM | 1 |
Eidlitz-Markus, T | 1 |
Snir, M | 2 |
Kivity, S | 3 |
Goldberg-Stern, H | 1 |
Haimi-Cohen, Y | 1 |
Zeharia, A | 2 |
Friling, R | 1 |
Weinberger, D | 1 |
Lusky, M | 1 |
Mimouni, M | 2 |
Gaaton, D | 1 |
Sinclair, DB | 1 |
SCHMIDT, G | 1 |
KIORBOE, E | 1 |
DAMGAARD, K | 1 |
PALUDAN, J | 1 |
Lerman, P | 1 |
Ariel, R | 1 |
Danziger, Y | 1 |
Shinnar, S | 2 |
Eneli, I | 1 |
West, M | 1 |
Sigal, Y | 1 |
Martel, JN | 1 |
Lazerson, J | 1 |
Halthore, SN | 1 |
LaBeaud, AD | 1 |
Leonard, EG | 1 |
McComsey, GA | 1 |
Verrotti, A | 1 |
Manco, R | 1 |
Coppola, GG | 1 |
Mingione, S | 1 |
Chiarelli, F | 1 |
Iannetti, P | 1 |
Farwell, J | 1 |
Milstein, J | 1 |
Opheim, K | 1 |
Smith, E | 1 |
Glass, S | 1 |
Snead, OC | 2 |
Benton, JW | 1 |
Myers, GJ | 1 |
Hrachovy, RA | 3 |
Frost, JD | 3 |
Kellaway, P | 3 |
Zion, TE | 3 |
Chevrie, JJ | 1 |
Haines, ST | 1 |
Casto, DT | 1 |
Shamir, R | 1 |
Garty, BZ | 1 |
Rachmel, A | 1 |
Alpert, G | 1 |
Baram, TZ | 1 |
Mitchell, WG | 1 |
Tournay, A | 1 |
Hanson, RA | 1 |
Horton, EJ | 1 |
Appleton, RE | 1 |
Berg, AT | 1 |
Antoniuk, SA | 1 |
Bruck, I | 1 |
Spessatto, A | 1 |
Halick, SM | 1 |
de Bruyn, LR | 1 |
Meister, E | 1 |
de Paola, D | 1 |
Zion, T | 1 |
Duffner, PK | 1 |
Cohen, ME | 1 |
Shapira, Y | 1 |
Cederbaum, SD | 1 |
Cancilla, PA | 1 |
Nielsen, D | 1 |
Lippe, BM | 1 |
Feng, Y | 1 |
Shields, WD | 1 |
Shewmon, DA | 1 |
Chugani, HT | 1 |
Peacock, WJ | 1 |
Holmes, GL | 1 |
Glaze, DG | 2 |
Rutgers, AW | 1 |
Links, TP | 1 |
le Coultre, R | 1 |
Begeer, JH | 1 |
Robinson, RO | 1 |
Swaiman, KF | 1 |
Oftedal, SI | 1 |
Danielsen, J | 1 |
Klein, R | 1 |
Fischer, HU | 1 |
Schütze, I | 1 |
Bannert, N | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
Predictor of Clinical Response to Acthar in Myositis: Phase II of Acthar Clinical Trial[NCT03414086] | 20 participants (Actual) | Observational | 2017-11-06 | Completed | |||
An Open Label, Multi-centered, Randomized Phase 2 Study to Evaluate the Safety, Tolerability and Bioactivity of Subcutaneous ACTH GeL in PAtients With Scleritis: The ATLAS Study[NCT03465111] | Phase 2 | 30 participants (Anticipated) | Interventional | 2019-01-01 | Recruiting | ||
Open Label Proof of Concept Study to Evaluate Efficacy and Safety of Adrenocorticotropic Hormone Gel in Refractory Dermatomyositis or Polymyositis[NCT01906372] | Phase 2 | 12 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
3 of any of the 6 core set measures (CSM) improved by ≥ 20%, with no more than 2 CSM worsening by ≥25% (worsening measure cannot include the MMT). The DOI should be met at least once on any of the 6 follow up visits and maintained until week 24. Subjects not meeting DOI during the trial are treatment failures. (NCT01906372)
Timeframe: Primary end point: IMACS preliminary definition of improvement (DOI)
Intervention | Participants (Count of Participants) |
---|---|
Acthar Gel | 7 |
Mean change in glucocorticoid dose (equivalent prednisone dose) at 24 weeks compared to baseline. (NCT01906372)
Timeframe: Steroid sparing effect and safety and tolerability at 24 weeks compared to baseline
Intervention | mg (Mean) | |
---|---|---|
Follow Up 24 weeks | Baseline | |
Acthar Gel | 2.3 | 18.5 |
8 reviews available for prednisone and Cryptogenic Infantile Spasms
Article | Year |
---|---|
Effectiveness of corticosteroids versus adrenocorticotropic hormone for infantile spasms: a systematic review and meta-analysis.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Humans; Infant; Pred | 2019 |
Prednisolone/prednisone as adrenocorticotropic hormone alternative for infantile spasms: a meta-analysis of randomized controlled trials.
Topics: Adrenocorticotropic Hormone; Humans; Infant; Parasympatholytics; Prednisolone; Prednisone; Randomize | 2020 |
Update of the medical treatment of West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Glu | 2007 |
Treatment of infantile spasms.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; gamma-A | 1994 |
Does antiepileptic drug therapy prevent the development of "chronic" epilepsy?
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Child; Chronic Disease; Epilepsy; Humans; Infan | 1996 |
Treatment of infantile spasms: medical or surgical?
Topics: Adrenocorticotropic Hormone; Cerebral Cortex; Child; Child, Preschool; Electroencephalography; Human | 1992 |
Effect of non-sex hormones on neuronal excitability, seizures, and the electroencephalogram.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Electroencephalography; Epilepsy; Hum | 1991 |
Myoclonus.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diagnosis, Differential; Electroen | 1985 |
9 trials available for prednisone and Cryptogenic Infantile Spasms
Article | Year |
---|---|
Ineffectiveness of topiramate and levetiracetam in infantile spasms non-responsive to steroids. Open labeled randomized prospective study.
Topics: Anticonvulsants; Cross-Over Studies; Drug Administration Schedule; Drug Therapy, Combination; Female | 2013 |
Efficacy and tolerability of high-dose prednisone in Chinese children with infantile spasms.
Topics: Anticonvulsants; Child, Preschool; Female; Glucocorticoids; Humans; Infant; Male; Prednisone; Spasms | 2015 |
Double-blind study of ACTH vs prednisone therapy in infantile spasms.
Topics: Adrenocorticotropic Hormone; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; | 1983 |
Therapy of infantile spasms.
Topics: Adrenocorticotropic Hormone; Clinical Trials as Topic; Humans; Infant; Prednisone; Spasms, Infantile | 1984 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Cross-Over Studies; Drug Administration Sched | 1996 |
[West syndrome: clinical and electroencephalographic follow up of 70 patients and response to its treatment with adrenocorticotropic hormone, prednisone, vigabatrin, nitrazepam and valproate].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Child; Child, Preschool; Electroenc | 2000 |
A controlled study of prednisone therapy in infantile spasms.
Topics: Cerebral Hemorrhage; Child; Child Development; Child, Preschool; Clinical Trials as Topic; Down Synd | 1979 |
Infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain Damage, Chronic; Brain Diseases; Child, Preschoo | 1985 |
The effects of ACTH and corticosteroids on epileptiform disorders.
Topics: Adolescent; Adrenocorticotropic Hormone; Clinical Trials as Topic; Desoxycorticosterone; Electroence | 1970 |
26 other studies available for prednisone and Cryptogenic Infantile Spasms
Article | Year |
---|---|
Adrenal insufficiency among children treated with hormonal therapy for infantile spasms.
Topics: Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenocorticotropic Hormone; Child; Humans; Hydrocor | 2022 |
Cohort study of infantile epileptic spasms syndrome: etiological analysis and treatment of corticosteroids.
Topics: Adrenal Cortex Hormones; Child; Cohort Studies; Dexamethasone; Humans; Infant; Methylprednisolone; P | 2022 |
Efficacy analysis of oral dexamethasone in the treatment of infantile spasms and infantile spasms related Lennox-Gastaut syndrome.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child; Dexamethasone; Electro | 2023 |
Corticosteroids and ACTH for infantile spasms: are we closer to equipoise?
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Humans; Prednisolone; Prednisone; Randomized C | 2020 |
High-dose prednisone therapy for infantile spasms and late-onset epileptic spasms in China: The addition of topiramate provides no benefit.
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Drug Therapy, Combination; Female; Glucocorticoids; | 2019 |
Long-term follow-up for ophthalmologic sequelae in children treated with corticosteroids for infantile spasms.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Age Factors; Child; Child, Preschool; Eye Diseases; | 2012 |
Elevated intraocular pressure associated with steroid treatment for infantile spasms.
Topics: Administration, Oral; Antihypertensive Agents; Cosyntropin; Female; Glucocorticoids; Humans; Infant; | 2003 |
Prednisone therapy in pediatric epilepsy.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Male; Prednisone; | 2003 |
[TWITCH-NODDING-SALAAM CONVULSIONS AND THEIR PROGNOSIS AFTER HORMONAL TREATMENT].
Topics: Adrenocorticotropic Hormone; Child; Electroencephalography; Epilepsy; Humans; Infant; Prednisone; Pr | 1964 |
[Infantile spasms with hypsarrhythmia treated with prednisone].
Topics: Child; Epilepsy; Humans; Infant; Myoclonus; Prednisone; Spasms, Infantile | 1960 |
Autopsy findings in a child with infantile spasms and hypsarrhythmia with a survey of the effect of ACTH.
Topics: Adrenocorticotropic Hormone; Autopsy; Child; Electroencephalography; Epilepsy; Humans; Hypoxia, Brai | 1961 |
Long-term cognitive outcomes of a cohort of children with cryptogenic infantile spasms treated with high-dose adrenocorticotropic hormone.
Topics: Administration, Oral; Brain; Child; Child, Preschool; Cognition Disorders; Cohort Studies; Cosyntrop | 2004 |
Index of suspicion.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Bronchial Diseases; Diagnosis, Differential; | 2006 |
Adrenocorticotropic hormone controls infantile spasms independently of cortisol stimulation.
Topics: Adrenocorticotropic Hormone; Humans; Hydrocortisone; Infant; Prednisone; Spasms, Infantile | 1984 |
ACTH and prednisone in childhood seizure disorders.
Topics: Adrenocorticotropic Hormone; Child, Preschool; Humans; Infant; Prednisone; Seizures; Spasms, Infanti | 1983 |
Risk of infection during adrenocorticotropic hormone treatment in infants with infantile spasms.
Topics: Adrenocorticotropic Hormone; Bacteremia; Bacterial Infections; Female; Fever; Humans; Infant; Male; | 1993 |
The treatment of infantile spasms by paediatric neurologists in the UK and Ireland.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anticonvulsants; gamma-Aminobutyric Acid; Hum | 1996 |
Infantile spasms associated with histidinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Electroencephalography; Histidine; Humans; In | 1975 |
Familial poliodystrophy, mitochondrial myopathy, and lactate acidemia.
Topics: Adolescent; Ataxia; Cerebral Cortex; Child; Child, Preschool; Diazepam; Diffuse Cerebral Sclerosis o | 1975 |
[Infantile spasms. A retrospective study of 105 cases].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Electroencephalography; Evoked Potentials, Aud | 1992 |
Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone.
Topics: Adrenocorticotropic Hormone; Child, Preschool; Developmental Disabilities; Electroencephalography; H | 1988 |
Behavioural disturbances after effective ACTH-treatment of the dancing-eyes syndrome.
Topics: Adrenocorticotropic Hormone; Depression; Humans; Infant; Male; Prednisone; Spasms, Infantile; Syndro | 1988 |
Seizures and steroids.
Topics: Adrenocorticotropic Hormone; Child; Humans; Infant; Prednisone; Spasms, Infantile | 1985 |
Steroid treatment of infantile spasms with hypsarrhythmia.
Topics: Adrenocorticotropic Hormone; Electroencephalography; Female; Humans; Infant; Male; Prednisone; Spasm | 1967 |
Infantile spasms and hypsarhythmia treated with corticosteroids.
Topics: Adrenocorticotropic Hormone; Brain Diseases; Cerebral Ventriculography; Electroencephalography; Huma | 1965 |
[Childhood hypoglycemia with convulsions].
Topics: Blood Glucose; Child, Preschool; Electroencephalography; Epinephrine; Fasting; Female; Glucagon; Hum | 1974 |