Compounds > prednisone
Page last updated: 2024-11-07

prednisone and Contracture

prednisone has been researched along with Contracture in 7 studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Contracture: Prolonged shortening of the muscle or other soft tissue around a joint, preventing movement of the joint.

Research Excerpts

ExcerptRelevanceReference
"We investigated the effect of high-dose prednisone therapy in 33 boys with Duchenne muscular dystrophy."7.67Clinical investigation of Duchenne muscular dystrophy. Interesting results in a trial of prednisone. ( Brooke, MH; Fenichel, GM; Florence, JM; Griggs, RC; Kaiser, KK; Mendell, JR; Miller, JP; Moxley, RT; Pandya, S; Signore, L, 1987)
"We investigated the effect of high-dose prednisone therapy in 33 boys with Duchenne muscular dystrophy."3.67Clinical investigation of Duchenne muscular dystrophy. Interesting results in a trial of prednisone. ( Brooke, MH; Fenichel, GM; Florence, JM; Griggs, RC; Kaiser, KK; Mendell, JR; Miller, JP; Moxley, RT; Pandya, S; Signore, L, 1987)
"A 58-year-old white female who had regional enteritis for many years insidiously developed scleroderma."1.26Systemic sclerosis and regional enteritis occurring simultaneously. ( Shaps, RS; Stoopler, M, 1976)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bloom, JL1
Lin, C1
Imundo, L1
Guthery, S1
Stepenaskie, S1
Galambos, C1
Lowichik, A1
Bohnsack, JF1
Geffen, DB1
Horowitz, J1
Shaps, RS1
Stoopler, M1
Grisanti, MW1
Moore, TL1
Osborn, TG1
Haber, PL1
Brooke, MH1
Fenichel, GM1
Griggs, RC1
Mendell, JR1
Moxley, RT1
Miller, JP1
Kaiser, KK1
Florence, JM1
Pandya, S1
Signore, L1
Richier, JL1
Guérin, D1
Leblay, R1
Pony, JC1
Jamison, DL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Duchenne Muscular Dystrophy: Double-blind Randomized Trial to Find Optimum Steroid Regimen[NCT01603407]Phase 3196 participants (Actual)Interventional2013-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

6 Minute Walk Test

Measures the total distance walked in 6 minutes averaged over all post-baseline follow-up visits through Month 36. (NCT01603407)
Timeframe: Average of Months 3, 6, 12, 18, 24, 30 and 36 visits

Interventionmeters (Least Squares Mean)
Daily Prednisone384.95
Daily Deflazacort384.17
Intermittent Prednisone346.81

Forced Vital Capacity

Forced vital capacity was measured during a spirometry test. Forced expiratory volume (FEV) measures how much air a person can exhale during a forced breath. Forced vital capacity (FVC) is the total amount of air exhaled during the FEV test. (NCT01603407)
Timeframe: Average of Months 3, 6, 12, 18, 24, 30 and 36 visits

Interventionliters (Least Squares Mean)
Daily Prednisone1.4
Daily Deflazacort1.4
Intermittent Prednisone1.5

Fractional Shortening Percent

Measured by trans-thoracic echocardiogram and 12-lead ECG. (NCT01603407)
Timeframe: 36 months

Interventionpercentage of fractional shortening (Least Squares Mean)
Daily Prednisone33.74
Daily Deflazacort34.01
Intermittent Prednisone34.33

Heart Rate

Measured by trans-thoracic echocardiogram and 12-lead ECG. (NCT01603407)
Timeframe: 36 months

Interventionbpm (Least Squares Mean)
Daily Prednisone94.10
Daily Deflazacort93.52
Intermittent Prednisone91.65

Left Ventricular Ejection Fraction Percent

Measured by trans-thoracic echocardiogram and 12-lead ECG. (NCT01603407)
Timeframe: 36 months

Interventionpercentage of ejection fraction (Least Squares Mean)
Daily Prednisone61.88
Daily Deflazacort62.65
Intermittent Prednisone62.45

North Star Ambulatory Assessment (NSAA) Score

"The North Star Ambulatory Assessment (NSAA) is a 17-item rating scale that is used to measure functional motor abilities in ambulant children with Duchenne Muscular Dystrophy (DMD). It is usually used to monitor the progression of the disease and treatment effects.~The activities are graded as follows:~2 - Normal - no obvious modification of activity~1 - Modified method but achieves goal independent of physical assistance from another 0 - Unable to achieve independently This scale is ordinal with 34 as the maximum score indicating fully-independent function." (NCT01603407)
Timeframe: Average of Months 3, 6, 12, 18, 24, 30 and 36 visits

Interventionscore on a scale (Least Squares Mean)
Daily Prednisone23.7
Daily Deflazacort24.0
Intermittent Prednisone20.7

Number of Participants Who Tolerated the Regimen

The number of participants who completed 36 months of follow-up on the originally assigned dosage (for weight) of study medication. (NCT01603407)
Timeframe: 3 years

InterventionParticipants (Count of Participants)
Daily Prednisone36
Daily Deflazacort36
Intermittent Prednisone37

Participant Body Mass Index

(NCT01603407)
Timeframe: 36 months

Interventionkilograms/square meter (Least Squares Mean)
Daily Prednisone18.9
Daily Deflazacort18.3
Intermittent Prednisone18.1

Participant Height

(NCT01603407)
Timeframe: 36 months

Interventioncentimeters (Least Squares Mean)
Daily Prednisone116.8
Daily Deflazacort115.3
Intermittent Prednisone119.9

Participant Weight

(NCT01603407)
Timeframe: 36 months

Interventionkilograms (Least Squares Mean)
Daily Prednisone26.3
Daily Deflazacort24.9
Intermittent Prednisone26.3

PR Interval

Measured by trans-thoracic echocardiogram and 12-lead ECG. (NCT01603407)
Timeframe: 36 months

Interventionmilliseconds (Least Squares Mean)
Daily Prednisone115.59
Daily Deflazacort116.87
Intermittent Prednisone117.90

Quality of Life - Parent

Quality of life was measured by parent/guardian self-report for all children utilizing the PEDSQL measurement tool. This is a 23-question tool. Scores can range from 0 to 100, with higher scores indicating better quality of life for the child. (NCT01603407)
Timeframe: Average of Months 12, 24, and 36 visits

Interventionscore on a scale (Least Squares Mean)
Daily Prednisone64.88
Daily Deflazacort63.71
Intermittent Prednisone61.33

Quality of Life- Child

Quality of life was measured by child self-report in children age 5 and older utilizing the PEDSQL measurement tool. This is a 23-question tool. Scores can range from 0 to 100, with higher scores indicating better quality of life. (NCT01603407)
Timeframe: Average of Months 12, 24, and 36 visits

Interventionscore on a scale (Least Squares Mean)
Daily Prednisone67.39
Daily Deflazacort64.96
Intermittent Prednisone65.07

Range of Motion (Goniometry) of Left Ankle

Range of motion at the ankle joint in dorsiflexion measured in degrees from plantigrade averaged over all post-baseline visits. (NCT01603407)
Timeframe: Average of Months 3, 6, 12, 18, 24, 30 and 36 visits

Interventiondegrees (Mean)
Daily Prednisone4.39
Daily Deflazacort3.29
Intermittent Prednisone2.67

Range of Motion (Goniometry) of Right Ankle

Range of motion at the ankle joint in dorsiflexion measured in degrees from plantigrade averaged over all post-baseline visits. (NCT01603407)
Timeframe: Average of Months 3, 6, 12, 18, 24, 30 and 36 visits

Interventiondegrees (Mean)
Daily Prednisone4.05
Daily Deflazacort2.81
Intermittent Prednisone2.29

Rise From the Floor Velocity

Reciprocal of time to rise from the floor (NCT01603407)
Timeframe: Average of Months 3, 6, 12, 18, 24, 30 and 36 visits

Interventionrise/sec (Least Squares Mean)
Daily Prednisone0.24
Daily Deflazacort0.24
Intermittent Prednisone0.18

Treatment Satisfaction Questionnaire for Medication (TSQM) Global Satisfaction With Treatment Score

The TSQM Global Satisfaction with Treatment is a 14-item questionnaire that ranges from 0 - 100 with higher scores indicating better outcomes. (NCT01603407)
Timeframe: Average of Months 3, 6, 12, 18, 24, 30 and 36 visits

Interventionscore on a scale (Least Squares Mean)
Daily Prednisone71.2
Daily Deflazacort67.8
Intermittent Prednisone65.1

Reviews

1 review available for prednisone and Contracture

ArticleYear
Eosinophilic fasciitis in children.
    Seminars in arthritis and rheumatism, 1989, Volume: 19, Issue:3

    Topics: Child, Preschool; Contracture; Eosinophilia; Fasciitis; Humans; Joint Diseases; Male; Prednisone; Sk

1989

Other Studies

6 other studies available for prednisone and Contracture

ArticleYear
H syndrome: 5 new cases from the United States with novel features and responses to therapy.
    Pediatric rheumatology online journal, 2017, Oct-17, Volume: 15, Issue:1

    Topics: Adult; Antibodies, Monoclonal, Humanized; Azathioprine; Child; Child, Preschool; Contracture; Diagno

2017
Gemcitabine-induced severe extremity edema with muscle contractures and subsequent prevention with prednisone.
    The Israel Medical Association journal : IMAJ, 2000, Volume: 2, Issue:7

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Contracture; Deoxycytidine; Drug Interactions; Edem

2000
Systemic sclerosis and regional enteritis occurring simultaneously.
    The American journal of gastroenterology, 1976, Volume: 65, Issue:6

    Topics: Colostomy; Contracture; Crohn Disease; Female; Hand Deformities, Acquired; Humans; Middle Aged; Post

1976
Clinical investigation of Duchenne muscular dystrophy. Interesting results in a trial of prednisone.
    Archives of neurology, 1987, Volume: 44, Issue:8

    Topics: Adolescent; Child; Child, Preschool; Contracture; Drug Evaluation; Electromyography; Humans; Male; M

1987
[Therapeutic effect of alpha-tocopher- yl-quinone on muscular disorders of hyperthyroidism and of prolonged treatment by corticoids and antimitotics].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1969, Apr-26, Volume: 45, Issue:20

    Topics: Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents; Asthenia; Busulfan; Chlorambucil; Cobal

1969
Minor epileptic status with contractures.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:11

    Topics: Child; Contracture; Electroencephalography; Epilepsy; Female; Humans; Intelligence; Phenytoin; Predn

1973