Page last updated: 2024-11-07

prednisone and Bipolar Disorder

prednisone has been researched along with Bipolar Disorder in 28 studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.

Research Excerpts

ExcerptRelevanceReference
" We report here the case of a Caucasian woman, aged 66 years, previously diagnosed with Bipolar disorder who developed treatment refractory mania with psychotic feature after being on the immunosuppressive agent, tacrolimus, after kidney transplantation."3.88Treatment-Refractory Mania with Psychosis in a Post-Transplant Patient on Tacrolimus: A Case Report. ( Bordoloi, M; Ithman, M; Malhotra, K; Singh, G, 2018)
" Competing risk adjusted Cox regression analyses were applied, adjusting for sex, age, residence, insurance premium, prednisone, hyperthyroidism, COPD (chronic obstructive pulmonary disease), Charlson comorbidity index, and hospital admission days for any disorder."3.80Association of asthma and bipolar disorder: a nationwide population-based study in Taiwan. ( Chen, VC; Lai, TJ; Lee, CT; Lee, KY; Lin, TC; Stewart, R, 2014)
" We previously reported greater depressive symptom severity, poorer memory and smaller hippocampal volumes in patients with asthma or rheumatic diseases receiving long-term prednisone therapy than in controls."3.74Effects of chronic prednisone therapy on mood and memory. ( Brown, ES; Frol, AB; Johnson, B; Vera, E; Woolston, DJ, 2007)
"The authors studied a 72-year-old man with polymyalgia rheumatica who, after taking 100 mg of prednisone for 3 months, developed a psychosis followed by dementia."3.73Steroid dementia: an overlooked diagnosis? ( Sacks, O; Shulman, M, 2005)
" Olanzapine dosing was flexible beginning at 2."2.71An open-label trial of olanzapine for corticosteroid-induced mood symptoms. ( Brown, ES; Carmody, TJ; Chamberlain, W; Dhanani, N; Paranjpe, P; Sargeant, M, 2004)
"The age at onset of Crohn's disease was highly correlated with the age at onset of affective disorder (r = ."1.28Bipolar disorder and Crohn's disease. ( DePaulo, JR; Holroyd, S, 1990)
" The phenomenon was dose related and markedly diminished in two patients as the dosage of corticosteroid was decreased, despite the fact that the alternate-day regimen was continued."1.26Relationship between alternate-day corticosteroid therapy and behavioral abnormalities. ( Fauci, AS; Sack, DS; Sharfstein, SS, 1982)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19907 (25.00)18.7374
1990's7 (25.00)18.2507
2000's8 (28.57)29.6817
2010's6 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ithman, M1
Malhotra, K1
Bordoloi, M1
Singh, G1
Lin, TC1
Lee, CT2
Lai, TJ1
Lee, KY1
Chen, VC1
Stewart, R1
Gable, M1
Depry, D1
Reich, M1
Girard, E1
Le Rhun, E1
Zapata, E1
Castiella, A1
Zubiaurre, L1
Gordon, JS1
Neyman, KM1
Wells, RD1
Chen, SC1
Fauchais, AL1
Boivin, V1
Hachulla, E1
Michon-Pasturel, U1
Lambert, M1
Queyrel, V1
Hebbar, M1
Hatron, PY1
Devulder, B1
Brown, ES3
Chamberlain, W1
Dhanani, N1
Paranjpe, P1
Carmody, TJ2
Sargeant, M1
Sacks, O1
Shulman, M1
Saraga, M1
Zullino, DF1
Vera, E1
Frol, AB1
Woolston, DJ1
Johnson, B1
Gómez-Herreros, R1
Gotor Sánchez-Luengo, F1
del Valle-Villagrán, J1
Fernández-López, I1
Pies, R1
Peselow, ED1
Fieve, RR1
Deutsch, SI1
Kaufman, M1
Sharfstein, SS1
Sack, DS1
Fauci, AS1
Abbas, A1
Styra, R1
Finkenbine, R1
Gill, HS1
Watts, BV1
Grady, TA1
Abouesh, A1
Hobbs, WR1
Preda, A1
Fazeli, A1
McKay, BG1
Bowers, MB1
Mazure, CM1
Couturier, J1
Steele, M1
Hussey, L1
Pawliuk, G1
Suppes, T1
Khan, DA1
Fisher, G1
Pelonero, AL1
Ferguson, C1
Holroyd, S1
DePaulo, JR1
Viswanathan, R1
Glickman, L1
Minden, SL1
Orav, J1
Schildkraut, JJ1
Venkatarangam, SH1
Kutcher, SP1
Notkin, RM1
Kurland, HD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease[NCT01981889]Phase 453 participants (Actual)Interventional2013-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for prednisone and Bipolar Disorder

ArticleYear
Sustained corticosteroid- induced mania and psychosis despite cessation: A case study and brief literature review.
    International journal of psychiatry in medicine, 2015, Volume: 50, Issue:4

    Topics: Adrenal Cortex Hormones; Bipolar Disorder; Dexamethasone; Dose-Response Relationship, Drug; Drug Adm

2015

Trials

1 trial available for prednisone and Bipolar Disorder

ArticleYear
An open-label trial of olanzapine for corticosteroid-induced mood symptoms.
    Journal of affective disorders, 2004, Volume: 83, Issue:2-3

    Topics: Adrenal Cortex Hormones; Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Depressive

2004

Other Studies

26 other studies available for prednisone and Bipolar Disorder

ArticleYear
Treatment-Refractory Mania with Psychosis in a Post-Transplant Patient on Tacrolimus: A Case Report.
    Clinical medicine & research, 2018, Volume: 16, Issue:1-2

    Topics: Aged; Antipsychotic Agents; Bipolar Disorder; Female; Graft Rejection; Humans; Immunosuppressive Age

2018
Association of asthma and bipolar disorder: a nationwide population-based study in Taiwan.
    Journal of affective disorders, 2014, Volume: 168

    Topics: Adolescent; Adult; Aged; Anti-Asthmatic Agents; Asthma; Bipolar Disorder; Case-Control Studies; Chil

2014
Breast leptomeningeal metastasis recurrence presenting as a manic episode.
    Palliative & supportive care, 2017, Volume: 15, Issue:2

    Topics: Anti-Inflammatory Agents; Bipolar Disorder; Breast Neoplasms; Female; Humans; Magnetic Resonance Ima

2017
Corticosteroid-induced mania in a patient with autoimmune hepatitis.
    European journal of gastroenterology & hepatology, 2010, Volume: 22, Issue:4

    Topics: Adrenal Cortex Hormones; Bipolar Disorder; Female; Hepatitis, Autoimmune; Humans; Middle Aged; Predn

2010
Drug rash with eosinophilia and systemic symptoms (DRESS syndrome).
    Cutis, 2012, Volume: 89, Issue:4

    Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Drug Eruptions; Drug Hypersensitivity; Eosinophilia;

2012
[Psychiatric complications of corticoid therapy in the elderly over 65 years of age treated for Horton disease].
    La Revue de medecine interne, 2002, Volume: 23, Issue:10

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anxiety Disorders; Bipolar Disorder; Cluster Head

2002
Steroid dementia: an overlooked diagnosis?
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Bipolar Disorder; Brain; Dementia; Diagnosis, Dif

2005
[St. John's Wort, corticosteroids, cocaine, alcohol ... and a first manic episode].
    Praxis, 2005, Jun-08, Volume: 94, Issue:23

    Topics: Adenoma, Pleomorphic; Adult; Alcohol Drinking; Bipolar Disorder; Cocaine; Diagnosis, Differential; D

2005
Effects of chronic prednisone therapy on mood and memory.
    Journal of affective disorders, 2007, Volume: 99, Issue:1-3

    Topics: Adult; Affect; Asthma; Atrophy; Bipolar Disorder; Depressive Disorder; Female; Follow-Up Studies; Hi

2007
[Fludrocortisone resistance in a patient with Addison disease and bipolar disorder treated with lithium].
    Medicina clinica, 2007, Mar-17, Volume: 128, Issue:10

    Topics: Addison Disease; Adrenocorticotropic Hormone; Adult; Bipolar Disorder; Drug Interactions; Drug Resis

2007
Persistent bipolar illness after steroid administration.
    Archives of internal medicine, 1981, Volume: 141, Issue:8

    Topics: Adult; Bipolar Disorder; Colitis, Ulcerative; Female; Glucocorticoids; Humans; Methylprednisolone; M

1981
Coexistent manic symptoms and multiple sclerosis.
    Psychosomatics, 1981, Volume: 22, Issue:9

    Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Drug Therapy, Combination; Female; Humans;

1981
Relationship between alternate-day corticosteroid therapy and behavioral abnormalities.
    JAMA, 1982, Dec-10, Volume: 248, Issue:22

    Topics: Adult; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Inf

1982
Valproate prophylaxis against steroid induced psychosis.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1994, Volume: 39, Issue:3

    Topics: Adult; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans

1994
Case of mania due to prednisone-clarithromycin interaction.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1997, Volume: 42, Issue:7

    Topics: Adult; Anti-Bacterial Agents; Bipolar Disorder; Clarithromycin; Drug Interactions; Female; Glucocort

1997
Tramadol-induced mania.
    The American journal of psychiatry, 1997, Volume: 154, Issue:11

    Topics: Adult; Back Pain; Bipolar Disorder; Female; Humans; Prednisone; Recurrence; Tramadol

1997
Clarithromycin-induced mania.
    The American journal of psychiatry, 1998, Volume: 155, Issue:11

    Topics: Bipolar Disorder; Clarithromycin; Depressive Disorder; Female; Haloperidol; Humans; Lithium; Middle

1998
Lamotrigine as prophylaxis against steroid-induced mania.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:10

    Topics: Adult; Anti-Inflammatory Agents; Antimanic Agents; Bipolar Disorder; Contraindications; Female; Huma

1999
Steroid-induced mania in an adolescent: risk factors and management.
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2001,Summer, Volume: 8, Issue:2

    Topics: Adolescent; Anti-Bacterial Agents; Asthma; Bipolar Disorder; Clarithromycin; Drug Interactions; Fema

2001
Mood changes during prednisone bursts in outpatients with asthma.
    Journal of clinical psychopharmacology, 2002, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Affect; Asthma; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship

2002
Mania precipitated by prednisone and bromocriptine.
    General hospital psychiatry, 1991, Volume: 13, Issue:5

    Topics: Adult; Bipolar Disorder; Bromocriptine; Cesarean Section; Female; Humans; Lactation; Prednisone; Pre

1991
Bipolar disorder and Crohn's disease.
    The Journal of clinical psychiatry, 1990, Volume: 51, Issue:10

    Topics: Adult; Age Factors; Bipolar Disorder; Crohn Disease; Female; Humans; Male; Middle Aged; Prednisone;

1990
Clonazepam in the treatment of steroid-induced mania in a patient after renal transplantation.
    The New England journal of medicine, 1989, Feb-02, Volume: 320, Issue:5

    Topics: Adult; Bipolar Disorder; Clonazepam; Humans; Kidney Transplantation; Male; Postoperative Complicatio

1989
Hypomanic reactions to ACTH and prednisone treatment for multiple sclerosis.
    Neurology, 1988, Volume: 38, Issue:10

    Topics: Adrenocorticotropic Hormone; Adult; Bipolar Disorder; Female; Humans; Male; Multiple Sclerosis; Pred

1988
Secondary mania with steroid withdrawal.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1988, Volume: 33, Issue:7

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bipolar Disorder; Dose-Response Relationship,

1988
Physiologic treatment of depressive reactions: a pilot study.
    The American journal of psychiatry, 1965, Volume: 122, Issue:4

    Topics: Bipolar Disorder; Depression; Humans; Prednisone; Psychological Tests; Psychotherapy; Schizophrenia;

1965