prednisone and Benign Mucosal Pemphigoid studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Research Excerpts

Excerpt	Relevance	Reference
"Azathioprine was moderately effective as a single corticosteroid-sparing immunosuppressive agent in terms of control of inflammation and corticosteroid-sparing benefits, but required several months to achieve treatment goals; it seems especially useful for patients with intermediate uveitis."	3.75	Azathioprine for ocular inflammatory diseases. ( Foster, CS; Jabs, DA; Kempen, JH; Levy-Clarke, GA; Liesegang, TL; Newcomb, CW; Nussenblatt, RB; Pasadhika, S; Pujari, SS; Rosenbaum, JT; Suhler, EB; Thorne, JE, 2009)
" The following objective parameters were used to assess the clinical outcome pre- and post-IVIg therapy: number of side effects, frequencies of recurrences and relapses, duration and total dosage of prednisone therapy, and the quality of life."	2.70	Intravenous immunoglobulin therapy in patients with multiple mucosal involvement in mucous membrane pemphigoid. ( Bhol, KC; Razzaque Ahmed, A; Sami, N, 2002)
"The target antigens in cicatricial pemphigoid appear to be lamina lucida proteins involved in human keratinocyte adhesion to extracellular matrix."	2.40	Cicatricial pemphigoid (benign mucous membrane pemphigoid). ( Bergfeld, WF; Terezhalmy, GT, 1998)
" He did not improve until the prednisone dosage was increased to 4 mg per kg per day."	2.37	Cicatricial pemphigoid in a 6-year-old child: report of a case and review of the literature. ( Esterly, NB; Gerson, CR; Greenwald, MJ; Rosenbaum, MM, 1984)
" Systemic corticosteroid dosage was reduced to 10 mg of prednisone or less, while maintaining sustained control of inflammation, in 41% and 55% of patients in 6 months and 1 year respectively."	1.36	Mycophenolate mofetil for ocular inflammation. ( Daniel, E; Foster, CS; Jabs, DA; Kaçmaz, RO; Kempen, JH; Levy-Clarke, GA; Newcomb, CW; Nussenblatt, RB; Pujari, SS; Rosenbaum, JT; Suhler, EB; Thorne, JE, 2010)
"Dapsone was the most commonly used drug (51 patients), followed by methotrexate (24 patients), azathioprine (23 patients), and cyclophosphamide (15 patients); prednisone, always given as adjunctive treatment, was used in 17 patients."	1.31	The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. ( Ahmed, AR; Baltatzis, S; Foster, CS; Miserocchi, E; Roque, MR, 2002)
"Benign mucous membrane pemphigoid is treated with high doses of corticosteroids and immunosuppressive agents."	1.31	Benign mucous membrane pemphigoid--a case report. ( Naidoo, S; Puranwasi, R, 2001)
"The diagnosis of cicatricial pemphigoid requires characteristic lesions and histopathologic evidence of immunoglobulin deposition along the basement membrane, as well as a high index of suspicion."	1.29	Management of airway obstruction in cicatricial pemphigoid. ( Goodman, ML; Lazor, JB; Mackool, BT; Montgomery, WW; Varvares, MA, 1996)
"We found that untreated ocular cicatricial pemphigoid has a variable course and does not necessarily progress."	1.27	Immunosuppressive therapy in ocular cicatricial pemphigoid. ( Brown, SI; Mondino, BJ, 1983)
"Three patients are described with cicatricial pemphigoid and positive immunofluorescence findings in the basement membrane zone of mucous glands of the pharynx, mouth, and nose."	1.27	Mucous gland basement membrane immunofluorescence in cicatricial pemphigoid. ( Bergfeld, WF; Fleming, MG; Tuthill, RJ; Valenzuela, R, 1988)
"This report describes a case of cicatricial pemphigoid with onset at age 5 and involving primarily the mucous membranes of the mouth and eyes."	1.27	Cicatricial pemphigoid. A case of onset at age 5. ( Beutner, E; Friedman, RP; Helm, F; Kumar, V; Moy, W; Schaeffer, ML, 1986)

Research

Studies (36)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants Achieving Treatment Success After Switching to Other Medication (Phase II, 0-6 Months)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (22.22)	18.7374
1990's	8 (22.22)	18.2507
2000's	13 (36.11)	29.6817
2010's	7 (19.44)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Lee, J	1
Seiffert-Sinha, K	1
Attwood, K	1
Sinha, AA	1
Apostolopoulos, N	1
Sinard, J	1
Kombo, N	1
Sambhara, D	1
Lee, JH	1
Pantanelli, SM	1
Narbutt, J	1
Ciepłowska, K	1
Drewnik, A	1
Olejniczak-Staruch, I	1
Słowik-Rylska, M	1
Kowalewski, C	1
Woźniak, K	1
Lesiak, A	1
Liu, A	1
Yang, DJ	1
Hsu, S	1
Thorne, JE	5
Woreta, FA	1
Jabs, DA	5
Anhalt, GJ	2
Pasadhika, S	1
Kempen, JH	4
Newcomb, CW	2
Liesegang, TL	1
Pujari, SS	2
Rosenbaum, JT	3
Foster, CS	4
Levy-Clarke, GA	3
Nussenblatt, RB	3
Suhler, EB	3
Daniel, E	2
Kaçmaz, RO	1
Roufas, A	1
Kim, P	1
Reeves, D	1
Sutton, G	1
Udoetuk, JD	1
Dai, Y	1
Ying, GS	1
Gangaputra, S	1
Stoopler, ET	1
Sollecito, TP	1
DeRossi, SS	1
Uchino, Y	1
Kanekura, T	1
Takeda, K	1
Shimada, H	1
Inoue, M	1
Hashimoto, T	1
Kanzaki, T	1
Goldstein, AT	1
Klingman, D	1
Burrows, LJ	1
Qazi, FA	1
Nguyen, QD	1
Dunn, JP	1
Ojha, J	1
Bhattacharyya, I	1
Stewart, C	1
Katz, J	1
Mondino, BJ	1
Brown, SI	1
Roenigk, R	1
Vance, JC	1
Ahmed, AR	4
Salm, M	1
Larson, R	1
Kaplan, R	1
Rosenbaum, MM	1
Esterly, NB	1
Greenwald, MJ	1
Gerson, CR	1
Vincent, SD	1
Lilly, GE	1
Baker, KA	1
Warren, SD	1
Lesher, JL	1
Lazor, JB	1
Varvares, MA	1
Montgomery, WW	1
Goodman, ML	1
Mackool, BT	1
Carrozzo, M	2
Carbone, M	2
Broccoletti, R	2
Garzino-Demo, P	1
Gandolfo, S	2
Olsen, KE	1
Holland, EJ	1
Terezhalmy, GT	1
Bergfeld, WF	2
Castellano, S	1
Conrotto, D	1
Colón, JE	1
Miserocchi, E	1
Baltatzis, S	1
Roque, MR	1
Sami, N	1
Bhol, KC	1
Razzaque Ahmed, A	1
Puranwasi, R	1
Naidoo, S	1
Kirtschig, G	1
Murrell, D	1
Wojnarowska, F	1
Khumalo, N	1
Edwards, L	1
Hays, S	1
Fleming, MG	1
Valenzuela, R	1
Tuthill, RJ	1
Moy, W	1
Kumar, V	1
Friedman, RP	1
Schaeffer, ML	1
Beutner, E	1
Helm, F	1
Hombal, SM	1
Pawlofsky, C	1
Simon, M	1
Fartasch, M	1
Keller, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial[NCT01829295]	Phase 3	216 participants (Actual)	Interventional	2013-08-31	Completed
Myfortic (Enteric-coated Mycophenolate Sodium) for the Treatment of Non-infectious Intermediate Uveitis - a Prospective, Controlled, Randomized Multicenter Trial[NCT01092533]	Phase 3	44 participants (Actual)	Interventional	2010-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Controlled ocular inflammation (≤ 0.5+ anterior chamber cells, ≤ 0.5+ vitreous haze, no active retinal/choroidal lesions in both eyes) with 7.5 mg/day of oral prednisone and ≤ 2 drops/day of topical 1% prednisolone acetate for patients who crossed over to other medication following treatment failure at 6 months (or earlier). (NCT01829295)
Timeframe: 6 Months

Number of Participants Achieving Treatment Success at 12 Months on Same Medication (Phase I, 6-12 Months)

Intervention	Participants (Count of Participants)
Switched Over to Methotrexate	20
Switched Over to Mycophenolate Mofetil	7

Controlled ocular inflammation (≤ 0.5+ anterior chamber cells, ≤ 0.5+ vitreous haze, no active retinal/choroidal lesions in both eyes) with 7.5 mg/day of oral prednisone and ≤ 2 drops/day of topical 1% prednisolone acetate in patients who were a treatment success at the primary outcome of 6 months. (NCT01829295)
Timeframe: 12 Months

Number of Participants Achieving Treatment Success at 6 Months (Phase I, 0-6 Months)

Article	Year
Cicatricial pemphigoid in a 6-year-old child: report of a case and review of the literature. Pediatric dermatology, 1984, Volume: 2, Issue:1 Topics: Adolescent; Adult; Aged; Basement Membrane; Child; Child, Preschool; Complement C3; Dapsone; Diagnos	1984
Clinical, historic, and therapeutic features of cicatricial pemphigoid. A literature review and open therapeutic trial with corticosteroids. Oral surgery, oral medicine, and oral pathology, 1993, Volume: 76, Issue:4 Topics: Aged; Autoantibodies; Autoimmune Diseases; Basement Membrane; Clobetasol; Complement C3; Female; Hum	1993
Cicatricial pemphigoid (benign mucous membrane pemphigoid). Quintessence international (Berlin, Germany : 1985), 1998, Volume: 29, Issue:7 Topics: Adult; Anti-Infective Agents; Dapsone; Diagnosis, Differential; Epidermolysis Bullosa Acquisita; Fem	1998
Interventions for mucous membrane pemphigoid/cicatricial pemphigoid and epidermolysis bullosa acquisita: a systematic literature review. Archives of dermatology, 2002, Volume: 138, Issue:3 Topics: Cyclophosphamide; Dapsone; Drug Therapy, Combination; Epidermolysis Bullosa Acquisita; Glucocorticoi	2002

Article	Year
Clinical, historic, and therapeutic features of cicatricial pemphigoid. A literature review and open therapeutic trial with corticosteroids. Oral surgery, oral medicine, and oral pathology, 1993, Volume: 76, Issue:4 Topics: Aged; Autoantibodies; Autoimmune Diseases; Basement Membrane; Clobetasol; Complement C3; Female; Hum	1993
Systemic corticosteroid therapy of oral vesiculoerosive diseases (OVED). An open trial. Minerva stomatologica, 1998, Volume: 47, Issue:10 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Autoimmune Diseases; Erythema Multiforme; Female;	1998
Intravenous immunoglobulin therapy in patients with multiple mucosal involvement in mucous membrane pemphigoid. Clinical immunology (Orlando, Fla.), 2002, Volume: 102, Issue:1 Topics: Aged; Conjunctiva; Female; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Mouth; Mucous Me	2002

Article	Year
A Retrospective Study of Patient-Reported Data of Bullous Pemphigoid and Mucous Membrane Pemphigoid From a US-Based Registry. Frontiers in immunology, 2019, Volume: 10 Topics: Aged; Autoantibodies; Autoimmune Diseases; Female; Humans; Immunosuppressive Agents; Male; Middle Ag	2019
Bilateral Cicatrizing Conjunctivitis in a Middle-aged Man. JAMA ophthalmology, 2018, 06-01, Volume: 136, Issue:6 Topics: Cicatrix; Conjunctivitis; Diagnosis, Differential; Drug Therapy, Combination; Glucocorticoids; Human	2018
Atypical case of mucous membrane pemphigoid in a 26-year-old man. BMJ case reports, 2018, Sep-12, Volume: 2018 Topics: Adult; Diagnosis, Differential; Glucocorticoids; Humans; Immunohistochemistry; Male; Mucous Membrane	2018
Cicatricial pemphigoid vegetans in a Polish woman. International journal of dermatology, 2015, Volume: 54, Issue:8 Topics: Abdomen; Adult; Anti-Inflammatory Agents; Female; Humans; Immunoglobulin A; Immunoglobulin G; Pemphi	2015
A quick and simple serum test to differentiate bullous pemphigoid, epidermolysis bullosa acquisita, and anti-epiligrin cicatricial pemphigoid. Dermatology online journal, 2008, Jul-15, Volume: 14, Issue:7 Topics: Aged; Azathioprine; Cell Adhesion Molecules; Complement C3; Diagnosis, Differential; Drug Therapy, C	2008
Treatment of ocular mucous membrane pemphigoid with immunosuppressive drug therapy. Ophthalmology, 2008, Volume: 115, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Conjunctival Diseases; Cyclophosphamide; Female; Humans; Immunosuppr	2008
Azathioprine for ocular inflammatory diseases. American journal of ophthalmology, 2009, Volume: 148, Issue:4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Child; Female; Follow-Up Studies; Humans;	2009
Mycophenolate mofetil for ocular inflammation. American journal of ophthalmology, 2010, Volume: 149, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Child; Female;	2010
A rare unilateral case of ocular mucous membrane pemphigoid. Cornea, 2010, Volume: 29, Issue:12 Topics: Biopsy; Complement C3; Conjunctivitis; Drug Therapy, Combination; Epistaxis; Eyelid Diseases; Fluore	2010
Risk of corticosteroid-induced hyperglycemia requiring medical therapy among patients with inflammatory eye diseases. Ophthalmology, 2012, Volume: 119, Issue:8 Topics: Cohort Studies; Female; Follow-Up Studies; Glucocorticoids; Humans; Hyperglycemia; Hypoglycemic Agen	2012
Desquamative gingivitis: early presenting symptom of mucocutaneous disease. Quintessence international (Berlin, Germany : 1985), 2003, Volume: 34, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Biopsy; Clobetasol; Dapsone; Diagnosis	2003
A case of antiepiligrin cicatricial pemphigoid with nephrotic syndrome. The Journal of dermatology, 2004, Volume: 31, Issue:3 Topics: Aged; Autoantibodies; Biopsy, Needle; Cell Adhesion Molecules; Female; Follow-Up Studies; Humans; Im	2004
Mucous membrane pemphigoid of the vulva. Obstetrics and gynecology, 2005, Volume: 105, Issue:5 Pt 2 Topics: Biopsy, Needle; Drug Therapy, Combination; Female; Fluorescent Antibody Technique, Direct; Follow-Up	2005
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology, 2005, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Child; Conjunctival Diseases; Drug Therapy, Combination; Female; Glucocorti	2005
Cicatricial pemphigoid with severe gingival and laryngeal involvement in an 18-year-old female. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2007, Volume: 104, Issue:3 Topics: Adolescent; Anti-Inflammatory Agents; Dyspnea; Epistaxis; Female; Gingival Diseases; Humans; Larynge	2007
Immunosuppressive therapy in ocular cicatricial pemphigoid. American journal of ophthalmology, 1983, Volume: 96, Issue:4 Topics: Aged; Azathioprine; Cyclophosphamide; Eye Diseases; Female; Humans; Immunosuppressive Agents; Male;	1983
Cicatricial pemphigoid. Minnesota medicine, 1983, Volume: 66, Issue:9 Topics: Aged; Dapsone; Diagnosis, Differential; Female; Humans; Pemphigoid, Benign Mucous Membrane; Predniso	1983
Localized cicatricial pemphigoid (Brunsting-Perry). A transplantation experiment. Archives of dermatology, 1984, Volume: 120, Issue:7 Topics: Administration, Oral; Basement Membrane; Female; Humans; Immunoglobulin G; Microscopy, Fluorescence;	1984
Cicatricial pemphigoid. Southern medical journal, 1993, Volume: 86, Issue:4 Topics: Aged; Azathioprine; Dapsone; Fluorescent Antibody Technique; Humans; Male; Mouth Mucosa; Pemphigoid,	1993
Management of airway obstruction in cicatricial pemphigoid. The Laryngoscope, 1996, Volume: 106, Issue:8 Topics: Adult; Airway Obstruction; Anti-Inflammatory Agents; Azathioprine; Chronic Disease; Diagnosis, Diffe	1996
[Therapeutic management of mucous membrane pemphigoid. Report of 11 cases]. Minerva stomatologica, 1997, Volume: 46, Issue:10 Topics: Administration, Oral; Administration, Topical; Adult; Aged; Chlorhexidine; Clobetasol; Female; Human	1997
The association between ocular cicatricial pemphigoid and rheumatoid arthritis. Cornea, 1998, Volume: 17, Issue:5 Topics: Age of Onset; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Corneal Ulcer; C	1998
Comparison between intravenous immunoglobulin and conventional immunosuppressive therapy regimens in patients with severe oral pemphigoid: effects on disease progression in patients nonresponsive to dapsone therapy. Archives of dermatology, 2001, Volume: 137, Issue:9 Topics: Adult; Aged; Dapsone; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunization, Pa	2001
The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. Ophthalmology, 2002, Volume: 109, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Azathi	2002
Benign mucous membrane pemphigoid--a case report. SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 2001, Volume: 56, Issue:11 Topics: Adult; Anti-Inflammatory Agents; Diagnosis, Differential; Female; Gingival Diseases; Gingivitis, Nec	2001
Vulvar cicatricial pemphigoid as a lichen sclerosus imitator. A case report. The Journal of reproductive medicine, 1992, Volume: 37, Issue:6 Topics: Administration, Oral; Administration, Topical; Biopsy; Diagnosis, Differential; Female; Humans; Midd	1992
Mucous gland basement membrane immunofluorescence in cicatricial pemphigoid. Archives of dermatology, 1988, Volume: 124, Issue:9 Topics: Aged; Basement Membrane; Female; Fluorescent Antibody Technique; Humans; Immunoglobulin G; Male; Mid	1988
Cicatricial pemphigoid. A case of onset at age 5. Journal of periodontology, 1986, Volume: 57, Issue:1 Topics: Child, Preschool; Female; Gingivitis; Humans; Immunoglobulins; Mouth Diseases; Mouth Mucosa; Pemphig	1986
Cicatricial pemphigoid. International journal of dermatology, 1986, Volume: 25, Issue:2 Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Aged; Female; Fluorescent Antibody Technique; Huma	1986
Disseminated cicatricial pemphigoid. Dermatologica, 1985, Volume: 171, Issue:4 Topics: Azathioprine; Drug Therapy, Combination; Humans; Male; Middle Aged; Pemphigoid, Benign Mucous Membra	1985

prednisone and Benign Mucosal Pemphigoid