Page last updated: 2024-11-07

prednisone and Ataxia

prednisone has been researched along with Ataxia in 22 studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Eligible subjects were randomized to receive twelve cycles of IVIG (IVIG+) or no IVIG (NO-IVIG) in addition to prednisone and neuroblastoma risk-adapted chemotherapy."9.27Intravenous immunoglobulin with prednisone and risk-adapted chemotherapy for children with opsoclonus myoclonus ataxia syndrome associated with neuroblastoma (ANBL00P3): a randomised, open-label, phase 3 trial. ( Cohn, SL; de Alarcon, PA; Hogarty, MD; London, WB; Maris, JM; Matthay, KK; Naranjo, A; Panzer, JA; Park, JR; Tenney, SC, 2018)
"Seventy-nine patients with cyclosporine- and prednisone-dependent myasthenia gravis (MG) after thymectomy received tacrolimus for a mean of 2."9.11Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis. ( Armengol, M; Azem, J; Buera, M; Cervera, C; Fort, JM; López-Cano, M; Ponseti, JM; Vilallonga, R, 2005)
"Eligible subjects were randomized to receive twelve cycles of IVIG (IVIG+) or no IVIG (NO-IVIG) in addition to prednisone and neuroblastoma risk-adapted chemotherapy."5.27Intravenous immunoglobulin with prednisone and risk-adapted chemotherapy for children with opsoclonus myoclonus ataxia syndrome associated with neuroblastoma (ANBL00P3): a randomised, open-label, phase 3 trial. ( Cohn, SL; de Alarcon, PA; Hogarty, MD; London, WB; Maris, JM; Matthay, KK; Naranjo, A; Panzer, JA; Park, JR; Tenney, SC, 2018)
"Seventy-nine patients with cyclosporine- and prednisone-dependent myasthenia gravis (MG) after thymectomy received tacrolimus for a mean of 2."5.11Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis. ( Armengol, M; Azem, J; Buera, M; Cervera, C; Fort, JM; López-Cano, M; Ponseti, JM; Vilallonga, R, 2005)
"Paroxysmal dysarthria-ataxia is a rare neurological condition due to ephaptic transmission, generally appearing in multiple sclerosis patients characterized by stereotyped attacks of slurred speech usually accompanied by ataxia, appearing many times a day."1.40Paroxysmal dysarthria-ataxia in remitting-relapsing Bickerstaff's-like encephalitis. ( Acler, M; Bonetti, B; Cerini, R; Fiaschi, A; Monaco, S; Piffer, S; Richelli, S; Turri, G, 2014)
"Opsoclonus-myoclonus-ataxia syndrome (OMA) in children is most commonly associated with occult neuroblastoma (NB)."1.33Late presentation of opsoclonus-myoclonus-ataxia syndrome in a child with stage 4S neuroblastoma. ( Johnston, DL; Mutch, LS, 2005)
"The ataxic form of chronic inflammatory demyelinating polyradiculoneuropathy (ataxic-CIDP) has been recently described as a subtype of chronic ataxic neuropathy, distinguished by steroid responsiveness and relative preservation of myelinated fibres at sural nerve biopsy."1.33Hyperpyrexia-triggered relapses in an unusual case of ataxic chronic inflammatory demyelinating polyradiculoneuropathy. ( Bertolasi, L; Ferrari, S; Mazzucco, S; Mezzina, C; Rizzuto, N; Tomelleri, G, 2006)
"Susac's syndrome is a rare disorder characterized by the triad of microangiopathy of the brain and retina with hearing loss."1.31Susac's syndrome: beneficial effects of corticosteroid therapy in a Japanese case. ( Hashimoto, Y; Tashima, K; Uchino, M; Uyama, E; Yonehara, T, 2001)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19906 (27.27)18.7374
1990's1 (4.55)18.2507
2000's7 (31.82)29.6817
2010's8 (36.36)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Oh, SJ1
Almeida, DF1
Villa, SC1
de Alarcon, PA1
Matthay, KK1
London, WB1
Naranjo, A1
Tenney, SC1
Panzer, JA1
Hogarty, MD1
Park, JR1
Maris, JM1
Cohn, SL1
Kushner, BH1
Khakoo, Y1
Piffer, S1
Turri, G1
Acler, M1
Richelli, S1
Cerini, R1
Fiaschi, A1
Monaco, S1
Bonetti, B1
Gauthier, AC1
Baehring, JM1
Dickmann, JR1
Eversheim, F1
James, PD1
Black, D1
Kuper, A1
Saibil, F1
Battaglia, T1
De Grandis, E1
Mirabelli-Badenier, M1
Boeri, L1
Morcaldi, G1
Barabino, P1
Intra, C1
Naselli, F1
Pistoia, V1
Veneselli, E1
Conte, M1
Paradas, C1
Morgado, Y1
Gallardo, E1
Juarez, C1
Rojas-García, R1
Ponseti, JM1
Azem, J1
Fort, JM1
López-Cano, M1
Vilallonga, R1
Buera, M1
Cervera, C1
Armengol, M1
Mutch, LS1
Johnston, DL1
Mazzucco, S1
Ferrari, S1
Mezzina, C1
Tomelleri, G1
Bertolasi, L1
Rizzuto, N1
Trautmann, F1
Krämer, G1
Poralla, T1
Eckhardt, R1
Arnold, W1
Meyer zum Büschenfelde, KH1
Villalobos Chaves, F1
Casado Chocán, JL1
Moreno Rojas, A1
Serrano Castro, V1
Maslovsky, I1
Volchek, L1
Blumental, R1
Ducach, A1
Lugassy, G1
Tashima, K1
Uyama, E1
Hashimoto, Y1
Yonehara, T1
Uchino, M1
Yeshurun, M1
Marsot Dupuch, K1
Shapira, Y1
Cederbaum, SD1
Cancilla, PA1
Nielsen, D1
Lippe, BM1
Fierer, J1
Bazely, P1
Braude, AI1
Govindaraj, M1
Piro, AJ1
Wilson, RE1
Hall, TC1
Aliapoulios, MA1
Nevinny, HB1
Moore, FD1
Blain, JG1
Riley, W1
Logothetis, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase III Randomized Trial of Intravenous Gammaglobulin Therapy for Patients With Neuroblastoma Associated Opsoclonus-Myoclonus-Ataxia Syndrome Treated With Chemotherapy and Prednisone[NCT00033293]Phase 353 participants (Actual)Interventional2004-03-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Functional Outcome as Assessed by Age-appropriate Neuropsychological Testing

"The Bayley Scales of infant development mental scale best score of two time points will be used in the analysis. For a given patient, this score will be used to calculate the change from baseline." (NCT00033293)
Timeframe: Changes from baseline to the better of 6 months or 1 year

InterventionChange in Bayley's score (Mean)
Arm I (Chemotherapy, Immunoglobulin Therapy)117.5
Arm II (Chemotherapy, Observation)100.75

Motor Coordination as Assessed by Neurological Examination and Vineland Adaptive Behavior Scale (VABS)

"The best score at the two time points will be used in this analysis. For a given patient, this best score will be used to calculate the change from baseline. The mean change from baseline for each treatment group will be calculated." (NCT00033293)
Timeframe: Changes from baseline to the better of 6 months or 1 year

InterventionChange in VABS score (Mean)
Arm I (Chemotherapy, Immunoglobulin Therapy)84.53
Arm II (Chemotherapy, Observation)144.73

Number of Responders

A multi-stage design followed by a test of proportions between the treatment arms (chemo vs. chemo + therapeutic immune globulin (IVIG)) will be performed. The first stage of the multi-stage design will also function as an early stopping rule for insufficient activity of chemotherapy in OMA. (NCT00033293)
Timeframe: Changes from baseline to 2 months, 6 months, and 1 year

Interventionparticipants (Number)
Arm I (Chemotherapy, Immunoglobulin Therapy)21
Arm II (Chemotherapy, Observation)11

Tumor Outcome in Terms of Event-free Survival (EFS) Rate Defined as a Relapse or Progression of Neuroblastoma, a Second Malignancy, or Death

EFS rate for neuroblastoma event from time of study enrollment. (NCT00033293)
Timeframe: Up to 3 years

Intervention3 year EFS (Number)
Arm I (Chemotherapy, Immunoglobulin Therapy)92.3
Arm II (Chemotherapy, Observation)96.0

Tumor Outcome in Terms of Overall Survival (OS) Rate

OS rate from time of study enrollment. (NCT00033293)
Timeframe: Up to 3 years

Intervention3 year OS (Number)
Arm I (Chemotherapy, Immunoglobulin Therapy)100
Arm II (Chemotherapy, Observation)96.0

Trials

2 trials available for prednisone and Ataxia

ArticleYear
Intravenous immunoglobulin with prednisone and risk-adapted chemotherapy for children with opsoclonus myoclonus ataxia syndrome associated with neuroblastoma (ANBL00P3): a randomised, open-label, phase 3 trial.
    The Lancet. Child & adolescent health, 2018, Volume: 2, Issue:1

    Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Child; Child, Pres

2018
Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis.
    Neurology, 2005, May-10, Volume: 64, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Ataxia; Autoantibodies; Cyclos

2005

Other Studies

20 other studies available for prednisone and Ataxia

ArticleYear
Monosialosyl Antibody in a Case Mimicking CANOMAD Syndrome.
    Journal of clinical neuromuscular disease, 2019, Volume: 21, Issue:1

    Topics: Adult; Anemia, Hemolytic, Autoimmune; Anti-Inflammatory Agents; Ataxia; Autoantibodies; Autoantigens

2019
Enigmatic entities: opsoclonus myoclonus ataxia syndrome linked to neuroblastoma.
    The Lancet. Child & adolescent health, 2018, Volume: 2, Issue:1

    Topics: Ataxia; Child; Humans; Immunoglobulins, Intravenous; Neuroblastoma; Opsoclonus-Myoclonus Syndrome; P

2018
Paroxysmal dysarthria-ataxia in remitting-relapsing Bickerstaff's-like encephalitis.
    Journal of the neurological sciences, 2014, Jun-15, Volume: 341, Issue:1-2

    Topics: Aged; Ataxia; Autoimmune Diseases of the Nervous System; Brain Stem; Dysarthria; Encephalitis; Femal

2014
Hashimoto's encephalopathy mimicking Creutzfeldt-Jakob disease.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2017, Volume: 35

    Topics: Anti-Inflammatory Agents; Ataxia; Cognition Disorders; Confusion; Creutzfeldt-Jakob Syndrome; Diagno

2017
Steroid responsive psychotic depression.
    The Australian and New Zealand journal of psychiatry, 2009, Volume: 43, Issue:7

    Topics: Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Ataxia; Benzodiaze

2009
D-lactic acidosis and ataxia in a man with Crohn disease.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2010, Feb-23, Volume: 182, Issue:3

    Topics: Acidosis, Lactic; Anti-Inflammatory Agents; Antidiarrheals; Ataxia; Crohn Disease; Diagnosis, Differ

2010
Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2012, Volume: 16, Issue:2

    Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Antibodies, Monoclonal, Murine-Derived; Ataxi

2012
Prednisone can worsen ataxic neuropathy with anti-disialosyl IgM antibodies.
    Muscle & nerve, 2011, Volume: 44, Issue:5

    Topics: Antigens, Surface; Ataxia; Humans; Immunoglobulin M; Male; Middle Aged; Oligosaccharides; Polyneurop

2011
Late presentation of opsoclonus-myoclonus-ataxia syndrome in a child with stage 4S neuroblastoma.
    Journal of pediatric hematology/oncology, 2005, Volume: 27, Issue:6

    Topics: Ataxia; Humans; Immunoglobulins, Intravenous; Infant; Male; Neuroblastoma; Paraneoplastic Syndromes,

2005
Hyperpyrexia-triggered relapses in an unusual case of ataxic chronic inflammatory demyelinating polyradiculoneuropathy.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2006, Volume: 27, Issue:3

    Topics: Anti-Inflammatory Agents; Ataxia; Electromyography; Fever; Humans; Immunoglobulins, Intravenous; Imm

2006
[Systemic lupus erythematosus. Brown-Sequard syndrome, spinal ataxia and peripheral polyneuropathy as the sole manifestations].
    Deutsche medizinische Wochenschrift (1946), 1984, Jun-29, Volume: 109, Issue:26

    Topics: Aged; Antibodies, Antinuclear; Ataxia; Autoantibodies; Azathioprine; DNA; Female; Humans; Liver Cirr

1984
[Miller-Fisher syndrome and encephalitis of the brain stem].
    Neurologia (Barcelona, Spain), 1995, Volume: 10, Issue:2

    Topics: Ataxia; Brain Stem; Child; Electroencephalography; Electromyography; Encephalitis; Facial Paralysis;

1995
Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease.
    European journal of haematology, 2001, Volume: 66, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Bleomycin; Combined Modality Therapy;

2001
Susac's syndrome: beneficial effects of corticosteroid therapy in a Japanese case.
    Internal medicine (Tokyo, Japan), 2001, Volume: 40, Issue:2

    Topics: Adult; Anti-Inflammatory Agents; Asian People; Asthma; Ataxia; Brain; Cognition Disorders; Confusion

2001
Acute cerebellar syndrome following intermediate-dose cytarabine.
    British journal of haematology, 2001, Volume: 113, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Brain; Cisp

2001
Familial poliodystrophy, mitochondrial myopathy, and lactate acidemia.
    Neurology, 1975, Volume: 25, Issue:7

    Topics: Adolescent; Ataxia; Cerebral Cortex; Child; Child, Preschool; Diazepam; Diffuse Cerebral Sclerosis o

1975
Herpes B virus encephalomyelitis presenting as ophthalmic zoster. A possible latent infection reactivated.
    Annals of internal medicine, 1973, Volume: 79, Issue:2

    Topics: Animals; Antibodies; Aphasia; Ataxia; Cerebrospinal Fluid Proteins; Cytarabine; Diagnosis, Different

1973
Multiple-drug reactions in tuberculosis--an illustrative case.
    Tubercle, 1968, Volume: 49, Issue:4

    Topics: Adult; Agranulocytosis; Aminosalicylic Acids; Antitubercular Agents; Ataxia; Cycloserine; Deafness;

1968
Toxicity studies of fluorouracil used with adrenalectomy in breast cancer.
    Archives of surgery (Chicago, Ill. : 1960), 1972, Volume: 105, Issue:1

    Topics: Adrenalectomy; Adult; Aged; Alopecia; Ataxia; Blood Platelet Disorders; Breast Neoplasms; Diarrhea;

1972
Optic nerve manifestations of sarcoidosis.
    Archives of neurology, 1965, Volume: 13, Issue:3

    Topics: Adult; Ataxia; Facial Paralysis; Female; Humans; Middle Aged; Neurologic Manifestations; Optic Atrop

1965