prednisone has been researched along with Astrocytoma in 14 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is no benefit to the treatment of high-grade astrocytomas in children with eight-drugs-in-1-day chemotherapy compared with CCNU, vincristine, and prednisone." | 9.08 | Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. ( Bertolone, SJ; Boyett, JM; Cherlow, JM; Finlay, JL; Geyer, JR; McGuire, P; Milstein, JM; Tefft, M; Wisoff, JH; Yates, AJ, 1995) |
| "There is no benefit to the treatment of high-grade astrocytomas in children with eight-drugs-in-1-day chemotherapy compared with CCNU, vincristine, and prednisone." | 5.08 | Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group. ( Bertolone, SJ; Boyett, JM; Cherlow, JM; Finlay, JL; Geyer, JR; McGuire, P; Milstein, JM; Tefft, M; Wisoff, JH; Yates, AJ, 1995) |
| "Patients with anaplastic astrocytoma had a median survival of 27 months as compared to 8 months for patients with glioblastoma." | 2.65 | Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. ( Chang, CH; Horton, J; Kramer, S; Nelson, JS; Perez-Tamayo, R; Salazer, O; Schoenfeld, D; Tsukada, Y; Weinstein, A, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertolone, SJ | 2 |
| Yates, AJ | 3 |
| Boyett, JM | 3 |
| Wallace, D | 1 |
| Finlay, JL | 3 |
| Varan, A | 1 |
| Akyüz, C | 1 |
| Akalan, N | 1 |
| Atahan, L | 1 |
| Söylemezoglu, F | 1 |
| Selek, U | 1 |
| Yalçin, B | 1 |
| Kutluk, T | 1 |
| Büyükpamukçu, M | 1 |
| Chang, CH | 1 |
| Horton, J | 1 |
| Schoenfeld, D | 1 |
| Salazer, O | 1 |
| Perez-Tamayo, R | 1 |
| Kramer, S | 1 |
| Weinstein, A | 1 |
| Nelson, JS | 1 |
| Tsukada, Y | 1 |
| Cangir, A | 3 |
| Ragab, AH | 1 |
| Steuber, P | 1 |
| Land, VJ | 1 |
| Berry, DH | 1 |
| Krischer, JP | 1 |
| Trigg, ME | 1 |
| Swanson, JD | 1 |
| Letellier, MA | 1 |
| Geyer, JR | 2 |
| Turski, PA | 1 |
| Allen, JC | 1 |
| Packer, RJ | 1 |
| Wisoff, JH | 1 |
| Milstein, JM | 1 |
| McGuire, P | 1 |
| Cherlow, JM | 1 |
| Tefft, M | 1 |
| Kochi, M | 1 |
| Ushio, Y | 1 |
| Kratzer, W | 1 |
| Fischer, W | 1 |
| Sposto, R | 1 |
| Ertel, IJ | 1 |
| Jenkin, RD | 1 |
| Boesel, CP | 1 |
| Venes, JL | 1 |
| Ortega, JA | 1 |
| Evans, AE | 1 |
| Wara, W | 1 |
| Hammond, D | 1 |
| Levin, VA | 1 |
| Stokes, DC | 1 |
| Shenep, JL | 1 |
| Horowitz, ME | 1 |
| Hughes, WT | 1 |
| van Eys, J | 2 |
| Baram, TZ | 1 |
| Bruner, JM | 1 |
| Martinez-Prieto, J | 1 |
| Coody, D | 1 |
| Smith, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II, Single Arm, Open Label Clinical Trial With Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas[NCT01574092] | Phase 2 | 39 participants (Actual) | Interventional | 2009-11-30 | Completed | ||
| A Phase I Trial of Lenalidomide and Radiotherapy in Children With Diffuse Intrinsic Pontine Gliomas and High-grade Gliomas[NCT01222754] | Phase 1 | 29 participants (Actual) | Interventional | 2010-11-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for prednisone and Astrocytoma
| Article | Year |
|---|---|
[Chemo-radiotherapy for malignant brain tumors].
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Central Nervous System | 2002 |
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
5 trials available for prednisone and Astrocytoma
| Article | Year |
|---|---|
Combined modality therapy for poorly differentiated gliomas of the posterior fossa in children: a Children's Cancer Group report.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cell Differentiation; Cereb | 2003 |
Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study.
Topics: Adult; Age Factors; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carmustine; Clinical Trials | 1983 |
Pre-irradiation chemotherapy in children with high-grade astrocytoma: tumor response to two cycles of the '8-drugs-in-1-day' regimen. A Childrens Cancer Group study, CCG-945.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Che | 1994 |
Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine, and prednisone with the eight-drugs-in-1-day regimen. Childrens Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Che | 1995 |
The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: results of a randomized trial. A report from the Childrens Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi | 1989 |
7 other studies available for prednisone and Astrocytoma
| Article | Year |
|---|---|
Astrocytic tumors in children: treatment results from a single institution.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi | 2007 |
Combination chemotherapy with vincristine (NSC-67574), procarbazine (NSC-77213), prednisone (NSC-10023) with or without nitrogen mustard (NSC-762)(MOPP vs OPP) in children with recurrent brain tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Follow-Up | 1984 |
Metastasis of an optic glioma through a ventriculoperitoneal shunt.
Topics: Antineoplastic Agents; Ascites; Astrocytoma; Child, Preschool; Cranial Nerve Neoplasms; Drug Therapy | 1983 |
[Aseptic meningitis following fourth ventricle surgery (author's transl)].
Topics: Astrocytoma; Cerebellar Neoplasms; Cerebral Ventricles; Child; Ependymoma; Female; Humans; Male; Med | 1978 |
Presentation of Pneumocystis carinii pneumonia as unilateral hyperlucent lung.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child, Preschool; Huma | 1988 |
Salvage chemotherapy for recurrent primary brain tumors in children.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Child; Chi | 1988 |
MOPP regimen as primary chemotherapy for brain tumors in infants.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; | 1985 |