prednisone has been researched along with Anemia, Macrocytic in 10 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Anemia, Macrocytic: Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 40 to 50% of DBA patients, congenital abnormalities mostly in the cephalic area and in thumbs and upper limbs have been described." | 1.36 | Diamond-Blackfan anemia, ribosome and erythropoiesis. ( Da Costa, L; Leblanc, T; Mohandas, N; Moniz, H; Simansour, M; Tchernia, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Da Costa, L | 1 |
| Moniz, H | 1 |
| Simansour, M | 1 |
| Tchernia, G | 1 |
| Mohandas, N | 1 |
| Leblanc, T | 1 |
| Keel, SB | 1 |
| Phelps, S | 1 |
| Sabo, KM | 1 |
| O'Leary, MN | 1 |
| Kirn-Safran, CB | 1 |
| Abkowitz, JL | 1 |
| IMERSLUND, O | 1 |
| BJORNSTAD, P | 1 |
| DUNEA, G | 1 |
| NAKAMOTO, S | 1 |
| STRAFFON, RA | 1 |
| FIGUEROA, JE | 1 |
| VERSACI, AA | 1 |
| SHIBAGAKI, M | 1 |
| KOLFF, WJ | 1 |
| Haggard, ME | 1 |
| Lockhart, LH | 1 |
| Scott-Moncrieff, JC | 1 |
| Reagan, WJ | 1 |
| Glickman, LT | 1 |
| DeNicola, DB | 1 |
| Harrington, D | 1 |
| Hanna, MD | 1 |
| Mattheis, PJ | 1 |
| Garg, SK | 1 |
| Amorosi, EL | 1 |
| Karpatkin, S | 1 |
| Pavkovceková, O | 1 |
| Tischler, V | 1 |
| Prekop, R | 1 |
| Jacina, J | 1 |
| Campbell, DC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/II, Open-Label Study to Determine Safety and Efficacy of Sotatercept (ACE-011) in Adults With Red Blood Cell Transfusion- Dependent Diamond Blackfan Anemia[NCT01464164] | Phase 1/Phase 2 | 19 participants (Actual) | Interventional | 2012-01-31 | Terminated (stopped due to Supporter terminated the study due to no active patients (secondary to travel restrictions due to COVID).) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complete response is transfusion independence with hemoglobin >9 gm/dl; partial response is transfusion dependence with hemoglobin < 9gm/dl with an increase in reticulocyte count over baseline (NCT01464164)
Timeframe: 9 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Sotatercept Cohort 1 | 0 |
| Sotatercept Cohort 2 | 0 |
| Sotatercept Cohort 3 | 0 |
| Sotatercept With Prednisone Boost Cohort 4a | 0 |
| Sotatercept Cohort 4b | 0 |
| Sotatercept With Prednisone Boost Cohort 5a | 0 |
| Sotatercept Cohort 5b | 0 |
Assess severity of adverse events and relationship to sotatercept according to the currently active minor version of the NCI Common Terminology for Adverse Events version 4.0 (NCT01464164)
Timeframe: 9 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Sotatercept Cohort 1 | 0 |
| Sotatercept Cohort 2 | 0 |
| Sotatercept Cohort 3 | 0 |
| Sotatercept With Prednisone Boost Cohort 4a | 0 |
| Sotatercept Cohort 4b | 0 |
| Sotatercept With Prednisone Boost Cohort 5a | 0 |
| Sotatercept Cohort 5b | 0 |
10 other studies available for prednisone and Anemia, Macrocytic
| Article | Year |
|---|---|
Diamond-Blackfan anemia, ribosome and erythropoiesis.
Topics: Anemia; Anemia, Diamond-Blackfan; Anemia, Macrocytic; Blood Transfusion; Bone Marrow; Chromosomes, H | 2010 |
Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis.
Topics: Agranulocytosis; Alleles; Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Chromosome Deletion | 2012 |
FAMILIAL VITAMIN B12 MALABSORPTION.
Topics: Anemia; Anemia, Macrocytic; Child; Cobalt Isotopes; Genetics, Medical; Hematinics; Humans; Infant; M | 1963 |
RENAL HOMOTRANSPLANTATION IN 24 PATIENTS.
Topics: Anemia; Anemia, Macrocytic; Antineoplastic Agents; Azathioprine; Blood Group Incompatibility; Cadave | 1965 |
Megaloblastic anemia and orotic aciduria. A hereditary disorder of pyrimidine metabolism responsive to uridine.
Topics: Anemia, Macrocytic; Bone Marrow Examination; Growth; Humans; Infant; Intellectual Disability; Male; | 1967 |
Treatment of nonregenerative anemia with human gamma-globulin in dogs.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Animals; Biopsy, Needle; Bone Marrow; Dog Diseases; Dogs; F | 1995 |
Unusual transient erythroblastopenia in a nine year old boy.
Topics: Anemia, Macrocytic; Blood Cell Count; Child; Diagnosis, Differential; Erythroblasts; Hematocrit; Hem | 1990 |
Use of the megathrombocyte as an index of megakaryocyte number.
Topics: Anemia, Aplastic; Anemia, Hypochromic; Anemia, Macrocytic; Blood Cell Count; Blood Platelets; Cell C | 1971 |
[Fanconi syndrome (anemia) in two siblings].
Topics: Agar; Anemia, Aplastic; Anemia, Macrocytic; Child; Fanconi Syndrome; Female; Humans; Immunoelectroph | 1968 |
Megaloblastic anemia.
Topics: Anemia, Macrocytic; Humans; Prednisone; Vitamin B 12 | 1968 |