prednisone has been researched along with Anemia, Congenital Hypoplastic, Of Blackfan And Diamond in 7 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 40 to 50% of DBA patients, congenital abnormalities mostly in the cephalic area and in thumbs and upper limbs have been described." | 1.36 | Diamond-Blackfan anemia, ribosome and erythropoiesis. ( Da Costa, L; Leblanc, T; Mohandas, N; Moniz, H; Simansour, M; Tchernia, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Wan, Y | 1 |
| Gong, X | 1 |
| Cheng, S | 1 |
| Yin, Z | 1 |
| Gao, Y | 1 |
| Li, J | 1 |
| Zong, S | 1 |
| Zhang, Y | 1 |
| Chen, Y | 1 |
| Zheng, R | 1 |
| Zhu, X | 1 |
| Yoo, YS | 1 |
| Lee, NH | 1 |
| Choi, YB | 1 |
| Velez, KA | 1 |
| Johnson, T | 1 |
| Wennemer, HK | 1 |
| Da Costa, L | 1 |
| Moniz, H | 1 |
| Simansour, M | 1 |
| Tchernia, G | 1 |
| Mohandas, N | 1 |
| Leblanc, T | 1 |
| Keel, SB | 1 |
| Phelps, S | 1 |
| Sabo, KM | 1 |
| O'Leary, MN | 1 |
| Kirn-Safran, CB | 1 |
| Abkowitz, JL | 1 |
| El-Beshlawy, A | 1 |
| Ibrahim, IY | 1 |
| Rizk, S | 1 |
| Eid, K | 1 |
| ELEFANT, E | 1 |
| JEKLEROVA, J | 1 |
| JANELE, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/II, Open-Label Study to Determine Safety and Efficacy of Sotatercept (ACE-011) in Adults With Red Blood Cell Transfusion- Dependent Diamond Blackfan Anemia[NCT01464164] | Phase 1/Phase 2 | 19 participants (Actual) | Interventional | 2012-01-31 | Terminated (stopped due to Supporter terminated the study due to no active patients (secondary to travel restrictions due to COVID).) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Complete response is transfusion independence with hemoglobin >9 gm/dl; partial response is transfusion dependence with hemoglobin < 9gm/dl with an increase in reticulocyte count over baseline (NCT01464164)
Timeframe: 9 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Sotatercept Cohort 1 | 0 |
| Sotatercept Cohort 2 | 0 |
| Sotatercept Cohort 3 | 0 |
| Sotatercept With Prednisone Boost Cohort 4a | 0 |
| Sotatercept Cohort 4b | 0 |
| Sotatercept With Prednisone Boost Cohort 5a | 0 |
| Sotatercept Cohort 5b | 0 |
Assess severity of adverse events and relationship to sotatercept according to the currently active minor version of the NCI Common Terminology for Adverse Events version 4.0 (NCT01464164)
Timeframe: 9 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Sotatercept Cohort 1 | 0 |
| Sotatercept Cohort 2 | 0 |
| Sotatercept Cohort 3 | 0 |
| Sotatercept With Prednisone Boost Cohort 4a | 0 |
| Sotatercept Cohort 4b | 0 |
| Sotatercept With Prednisone Boost Cohort 5a | 0 |
| Sotatercept Cohort 5b | 0 |
7 other studies available for prednisone and Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
| Article | Year |
|---|---|
Short Stature in Patients with Diamond-Blackfan Anemia: A Cross-Sectional Study.
Topics: Abnormalities, Multiple; Adolescent; Age Factors; Anemia, Diamond-Blackfan; Child; Child, Preschool; | 2022 |
Bochdalek hernia with Diamond-Blackfan anemia associated with RPS19 gene mutation: A case report.
Topics: Anemia, Diamond-Blackfan; Bone Marrow Cells; Bone Marrow Examination; Erythrocyte Transfusion; Gluco | 2019 |
Images. Bilateral total hip replacement in a teenager with Diamond Blackfan anemia.
Topics: Adolescent; Anemia, Diamond-Blackfan; Arthroplasty, Replacement, Hip; Femur Head Necrosis; Glucocort | 2009 |
Diamond-Blackfan anemia, ribosome and erythropoiesis.
Topics: Anemia; Anemia, Diamond-Blackfan; Anemia, Macrocytic; Blood Transfusion; Bone Marrow; Chromosomes, H | 2010 |
Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis.
Topics: Agranulocytosis; Alleles; Anemia, Diamond-Blackfan; Anemia, Macrocytic; Animals; Chromosome Deletion | 2012 |
Study of 22 Egyptian patients with Diamond-Blackfan anemia, corticosteroids, and cyclosporin therapy results.
Topics: Age of Onset; Anemia, Diamond-Blackfan; Child; Child, Preschool; Cyclosporine; Drug Therapy, Combina | 2002 |
[CONGENITAL HYPOPLASTIC ERYTHROID ANEMIA IN INFANTS].
Topics: Anemia; Anemia, Diamond-Blackfan; Blood Transfusion; Hematopoietic System; Humans; Infant; Prednison | 1964 |