Page last updated: 2024-11-07

prednisone and Alzheimer Disease

prednisone has been researched along with Alzheimer Disease in 16 studies

Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"The authors studied a 72-year-old man with polymyalgia rheumatica who, after taking 100 mg of prednisone for 3 months, developed a psychosis followed by dementia."3.73Steroid dementia: an overlooked diagnosis? ( Sacks, O; Shulman, M, 2005)
"Baseline responses on the Alzheimer's Disease Assessment Scale - Cognitive, Clinical Dementia Rating, and the Mini-Mental State Examination were obtained from two clinical trials (n = 138 and n = 351)."2.74Agreement in cognitive and clinical assessments in Alzheimer's disease. ( Aisen, PS; Tractenberg, RE, 2009)
"The inflammatory hypothesis of Alzheimer's disease (AD), which is supported both by basic laboratory evidence and epidemiological studies, suggests that treatment with anti-inflammatory drugs may reduce the risk or slow the progression of AD."1.31Anti-inflammatory therapy for Alzheimer's disease: implications of the prednisone trial. ( Aisen, PS, 2000)
"The dementia was characterized by deficits in memory retention, attention, concentration, mental speed and efficiency, and occupational performance."1.27Reversible steroid dementia in patients without steroid psychosis. ( Alexander, B; MacIndoe, JH; Varney, NR, 1984)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's3 (18.75)18.2507
2000's10 (62.50)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alisky, JM1
Tractenberg, RE1
Aisen, PS5
Hartung, B1
Grass, H1
de la Riva, P1
Moreno, F1
Carrera, N1
Barandiarán, M1
Arruti, M1
Martí-Massó, JF1
Berg, JD2
Craft, S1
Peskind, ER1
Sano, M2
Teri, L1
Mulnard, RA1
Thomas, RG2
Thal, LJ2
Sacks, O1
Shulman, M1
Incalzi, RA1
Gambassi, G1
Bernabei, R1
Varney, NR1
Alexander, B1
MacIndoe, JH1
Caselli, RJ2
Scheithauer, BW2
O'Duffy, JD1
Peterson, GC1
Westmoreland, BF1
Davenport, PA1
Keimowitz, RM1
Davis, KL1
Schafer, K1
Campbell, K1
Weiner, MF1
Farlow, MR1
Grundman, M1
Koch, HJ1
Szecsey, A1
Bowles, CA1
Trenerry, MR1
Meyer, FB1
Smigielski, JS1
Rodriguez, M1
Wolkowitz, OM1
Rubinow, DR1
Breier, A1
Doran, AR1
Davis, C1
Pickar, D1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pilot Study of Immunomodulatory Versus Antiinflammatory Therapy in Alzheimer's Disease[NCT00013650]Phase 160 participants Interventional2001-03-22Completed
Multicenter Trial of Prednisone in Alzheimer's Disease[NCT00000178]Phase 30 participants InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for prednisone and Alzheimer Disease

ArticleYear
Anti-inflammatory agents in Alzheimer's disease.
    Current neurology and neuroscience reports, 2002, Volume: 2, Issue:5

    Topics: Alzheimer Disease; Anti-Inflammatory Agents; Celecoxib; Humans; Hydroxychloroquine; Prednisone; Pyra

2002

Trials

4 trials available for prednisone and Alzheimer Disease

ArticleYear
Agreement in cognitive and clinical assessments in Alzheimer's disease.
    Dementia and geriatric cognitive disorders, 2009, Volume: 27, Issue:4

    Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Cognition; Cognition Disorders; Cohort Studies; D

2009
Steroid-induced elevation of glucose in Alzheimer's disease: relationship to gender, apolipoprotein E genotype and cognition.
    Psychoneuroendocrinology, 2003, Volume: 28, Issue:1

    Topics: Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Blood Glucose; Cognition; Estrogen

2003
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
    Neurology, 2000, Feb-08, Volume: 54, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F

2000
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
    Neurology, 2000, Feb-08, Volume: 54, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F

2000
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
    Neurology, 2000, Feb-08, Volume: 54, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F

2000
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
    Neurology, 2000, Feb-08, Volume: 54, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F

2000
A randomized controlled trial of prednisone in Alzheimer's disease.
    Neurology, 2000, Oct-10, Volume: 55, Issue:7

    Topics: Aged; Alzheimer Disease; Blood Proteins; Eosinophil Granule Proteins; Female; Humans; Male; Middle A

2000

Other Studies

11 other studies available for prednisone and Alzheimer Disease

ArticleYear
Do not overlook polymyalgia rheumatica as a cause for immobility in poorly communicating dementia patients.
    Southern medical journal, 2008, Volume: 101, Issue:12

    Topics: Accidental Falls; Aged; Alzheimer Disease; Anti-Inflammatory Agents; Communication Disorders; Diagno

2008
[Demented patient with strangulation marks. Was it a crime?].
    MMW Fortschritte der Medizin, 2009, Sep-03, Volume: 151, Issue:36

    Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Asphyxia; Aspirin; Blood Coagulation Tests; Diagn

2009
[Response to treatment with corticoids in a case of inflammatory amyloid angiopathy without performing a biopsy].
    Revista de neurologia, 2012, Oct-01, Volume: 55, Issue:7

    Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Biopsy; Cerebral Amyloid Angiopathy; Diagnosis, Differen

2012
Steroid dementia: an overlooked diagnosis?
    Neurology, 2005, Feb-22, Volume: 64, Issue:4

    Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Bipolar Disorder; Brain; Dementia; Diagnosis, Dif

2005
Ruffled hair and fever in an old woman with Alzheimer's disease.
    Aging clinical and experimental research, 2005, Volume: 17, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents; Cognition; Disease Progression

2005
Reversible steroid dementia in patients without steroid psychosis.
    The American journal of psychiatry, 1984, Volume: 141, Issue:3

    Topics: Adult; Aged; Alzheimer Disease; Attention; Cognition Disorders; Cortisone; Dementia; Diagnosis, Diff

1984
Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease.
    Mayo Clinic proceedings, 1993, Volume: 68, Issue:9

    Topics: Aged; Alzheimer Disease; Chronic Disease; Diagnosis, Differential; Female; Humans; Meningoencephalit

1993
Dementia improvement with cytotoxic chemotherapy. A case of Alzheimer disease and multiple myeloma.
    Archives of neurology, 1997, Volume: 54, Issue:4

    Topics: Alzheimer Disease; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Hum

1997
Anti-inflammatory therapy for Alzheimer's disease: implications of the prednisone trial.
    Acta neurologica Scandinavica. Supplementum, 2000, Volume: 176

    Topics: Alzheimer Disease; Anti-Inflammatory Agents; Cognition Disorders; Cyclooxygenase 2; Humans; Inflamma

2000
The treatable dementia of Sjögren's syndrome.
    Annals of neurology, 1991, Volume: 30, Issue:1

    Topics: Alzheimer Disease; Dementia; Diagnostic Errors; Female; Hallucinations; Humans; Meningoencephalitis;

1991
Prednisone decreases CSF somatostatin in healthy humans: implications for neuropsychiatric illness.
    Life sciences, 1987, Oct-19, Volume: 41, Issue:16

    Topics: Adrenocorticotropic Hormone; Adult; Alzheimer Disease; Depression; Female; Humans; Hydrocortisone; M

1987