prednisone has been researched along with Alzheimer Disease in 16 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors studied a 72-year-old man with polymyalgia rheumatica who, after taking 100 mg of prednisone for 3 months, developed a psychosis followed by dementia." | 3.73 | Steroid dementia: an overlooked diagnosis? ( Sacks, O; Shulman, M, 2005) |
| "Baseline responses on the Alzheimer's Disease Assessment Scale - Cognitive, Clinical Dementia Rating, and the Mini-Mental State Examination were obtained from two clinical trials (n = 138 and n = 351)." | 2.74 | Agreement in cognitive and clinical assessments in Alzheimer's disease. ( Aisen, PS; Tractenberg, RE, 2009) |
| "The inflammatory hypothesis of Alzheimer's disease (AD), which is supported both by basic laboratory evidence and epidemiological studies, suggests that treatment with anti-inflammatory drugs may reduce the risk or slow the progression of AD." | 1.31 | Anti-inflammatory therapy for Alzheimer's disease: implications of the prednisone trial. ( Aisen, PS, 2000) |
| "The dementia was characterized by deficits in memory retention, attention, concentration, mental speed and efficiency, and occupational performance." | 1.27 | Reversible steroid dementia in patients without steroid psychosis. ( Alexander, B; MacIndoe, JH; Varney, NR, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 10 (62.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alisky, JM | 1 |
| Tractenberg, RE | 1 |
| Aisen, PS | 5 |
| Hartung, B | 1 |
| Grass, H | 1 |
| de la Riva, P | 1 |
| Moreno, F | 1 |
| Carrera, N | 1 |
| Barandiarán, M | 1 |
| Arruti, M | 1 |
| Martí-Massó, JF | 1 |
| Berg, JD | 2 |
| Craft, S | 1 |
| Peskind, ER | 1 |
| Sano, M | 2 |
| Teri, L | 1 |
| Mulnard, RA | 1 |
| Thomas, RG | 2 |
| Thal, LJ | 2 |
| Sacks, O | 1 |
| Shulman, M | 1 |
| Incalzi, RA | 1 |
| Gambassi, G | 1 |
| Bernabei, R | 1 |
| Varney, NR | 1 |
| Alexander, B | 1 |
| MacIndoe, JH | 1 |
| Caselli, RJ | 2 |
| Scheithauer, BW | 2 |
| O'Duffy, JD | 1 |
| Peterson, GC | 1 |
| Westmoreland, BF | 1 |
| Davenport, PA | 1 |
| Keimowitz, RM | 1 |
| Davis, KL | 1 |
| Schafer, K | 1 |
| Campbell, K | 1 |
| Weiner, MF | 1 |
| Farlow, MR | 1 |
| Grundman, M | 1 |
| Koch, HJ | 1 |
| Szecsey, A | 1 |
| Bowles, CA | 1 |
| Trenerry, MR | 1 |
| Meyer, FB | 1 |
| Smigielski, JS | 1 |
| Rodriguez, M | 1 |
| Wolkowitz, OM | 1 |
| Rubinow, DR | 1 |
| Breier, A | 1 |
| Doran, AR | 1 |
| Davis, C | 1 |
| Pickar, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Immunomodulatory Versus Antiinflammatory Therapy in Alzheimer's Disease[NCT00013650] | Phase 1 | 60 participants | Interventional | 2001-03-22 | Completed | ||
| Multicenter Trial of Prednisone in Alzheimer's Disease[NCT00000178] | Phase 3 | 0 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for prednisone and Alzheimer Disease
| Article | Year |
|---|---|
Anti-inflammatory agents in Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Celecoxib; Humans; Hydroxychloroquine; Prednisone; Pyra | 2002 |
4 trials available for prednisone and Alzheimer Disease
| Article | Year |
|---|---|
Agreement in cognitive and clinical assessments in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Cognition; Cognition Disorders; Cohort Studies; D | 2009 |
Steroid-induced elevation of glucose in Alzheimer's disease: relationship to gender, apolipoprotein E genotype and cognition.
Topics: Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Blood Glucose; Cognition; Estrogen | 2003 |
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F | 2000 |
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F | 2000 |
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F | 2000 |
A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dose-Response Relationship, Drug; Double-Blind Method; F | 2000 |
A randomized controlled trial of prednisone in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Blood Proteins; Eosinophil Granule Proteins; Female; Humans; Male; Middle A | 2000 |
11 other studies available for prednisone and Alzheimer Disease
| Article | Year |
|---|---|
Do not overlook polymyalgia rheumatica as a cause for immobility in poorly communicating dementia patients.
Topics: Accidental Falls; Aged; Alzheimer Disease; Anti-Inflammatory Agents; Communication Disorders; Diagno | 2008 |
[Demented patient with strangulation marks. Was it a crime?].
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Asphyxia; Aspirin; Blood Coagulation Tests; Diagn | 2009 |
[Response to treatment with corticoids in a case of inflammatory amyloid angiopathy without performing a biopsy].
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Biopsy; Cerebral Amyloid Angiopathy; Diagnosis, Differen | 2012 |
Steroid dementia: an overlooked diagnosis?
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Bipolar Disorder; Brain; Dementia; Diagnosis, Dif | 2005 |
Ruffled hair and fever in an old woman with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents; Cognition; Disease Progression | 2005 |
Reversible steroid dementia in patients without steroid psychosis.
Topics: Adult; Aged; Alzheimer Disease; Attention; Cognition Disorders; Cortisone; Dementia; Diagnosis, Diff | 1984 |
Chronic inflammatory meningoencephalitis should not be mistaken for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Chronic Disease; Diagnosis, Differential; Female; Humans; Meningoencephalit | 1993 |
Dementia improvement with cytotoxic chemotherapy. A case of Alzheimer disease and multiple myeloma.
Topics: Alzheimer Disease; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Hum | 1997 |
Anti-inflammatory therapy for Alzheimer's disease: implications of the prednisone trial.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Cognition Disorders; Cyclooxygenase 2; Humans; Inflamma | 2000 |
The treatable dementia of Sjögren's syndrome.
Topics: Alzheimer Disease; Dementia; Diagnostic Errors; Female; Hallucinations; Humans; Meningoencephalitis; | 1991 |
Prednisone decreases CSF somatostatin in healthy humans: implications for neuropsychiatric illness.
Topics: Adrenocorticotropic Hormone; Adult; Alzheimer Disease; Depression; Female; Humans; Hydrocortisone; M | 1987 |