prednisone has been researched along with Alcoholic Hepatitis in 18 studies
Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
prednisone : A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the impact of metadoxine (MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis (AH)." | 9.20 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. ( Abdo-Francis, JM; Cruz-Herrera, J; Higuera-de la Tijera, F; Pérez-Hernández, JL; Pérez-Torres, E; Salas-Gordillo, F; Serralde-Zúñiga, AE; Servín-Caamaño, AI, 2015) |
| "To determine the pharmacokinetic (PK) profile of manganese (Mn) after a 2-hour intravenous infusion of mangafodipir at 5 micromol/kg body weight and to correlate Mn concentrations with oxidative stress, early decrease in serum total bilirubin concentration, and prothrombin time (PT) in chronic alcoholic patients with acute alcoholic hepatitis." | 9.14 | Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis. ( Batteux, F; Debray, M; Hirt, D; Laurent, A; Pavlovic, S; Poupon, J; Richardet, JP; Sogni, P; Treluyer, JM; Urien, S; Weill, B, 2009) |
| "In this study, we assessed whether there were any survival advantages with a combination treatment of intravenous N-acetylcysteine (NAC) and prednisone over prednisone alone in those with severe alcoholic hepatitis [discriminant function (DF) ≥ 32]." | 7.96 | A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis. ( Alukal, J; Amjad, W; Doycheva, I; Maheshwari, A; Thuluvath, PJ; Yoo, H; Zhang, T, 2020) |
| "To evaluate the impact of metadoxine (MTD) on the 3- and 6-mo survival of patients with severe alcoholic hepatitis (AH)." | 5.20 | Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis. ( Abdo-Francis, JM; Cruz-Herrera, J; Higuera-de la Tijera, F; Pérez-Hernández, JL; Pérez-Torres, E; Salas-Gordillo, F; Serralde-Zúñiga, AE; Servín-Caamaño, AI, 2015) |
| "To determine the pharmacokinetic (PK) profile of manganese (Mn) after a 2-hour intravenous infusion of mangafodipir at 5 micromol/kg body weight and to correlate Mn concentrations with oxidative stress, early decrease in serum total bilirubin concentration, and prothrombin time (PT) in chronic alcoholic patients with acute alcoholic hepatitis." | 5.14 | Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis. ( Batteux, F; Debray, M; Hirt, D; Laurent, A; Pavlovic, S; Poupon, J; Richardet, JP; Sogni, P; Treluyer, JM; Urien, S; Weill, B, 2009) |
| "In this study, we assessed whether there were any survival advantages with a combination treatment of intravenous N-acetylcysteine (NAC) and prednisone over prednisone alone in those with severe alcoholic hepatitis [discriminant function (DF) ≥ 32]." | 3.96 | A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis. ( Alukal, J; Amjad, W; Doycheva, I; Maheshwari, A; Thuluvath, PJ; Yoo, H; Zhang, T, 2020) |
| "Patients with alcoholic hepatitis had a very blunted response." | 1.30 | Tumor necrosis factor and alcoholic liver disease. ( Barve, S; Deaciuc, I; Hill, DB; McClain, CJ, 1998) |
| "Prednisone was administered for five days in falling dosis (1." | 1.26 | Influence of steroids on urea-cycle enzymes in chronic human liver disease. ( Gerok, W; Heimsoeth, H; Maier, KP; Talke, H, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 8 (44.44) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Amjad, W | 1 |
| Alukal, J | 1 |
| Doycheva, I | 1 |
| Zhang, T | 1 |
| Maheshwari, A | 1 |
| Yoo, H | 1 |
| Thuluvath, PJ | 1 |
| Carey, W | 1 |
| Raff, E | 1 |
| Singal, AK | 1 |
| Higuera-de la Tijera, F | 1 |
| Servín-Caamaño, AI | 1 |
| Serralde-Zúñiga, AE | 1 |
| Cruz-Herrera, J | 1 |
| Pérez-Torres, E | 1 |
| Abdo-Francis, JM | 1 |
| Salas-Gordillo, F | 1 |
| Pérez-Hernández, JL | 1 |
| Hirt, D | 1 |
| Richardet, JP | 1 |
| Urien, S | 1 |
| Poupon, J | 1 |
| Sogni, P | 1 |
| Batteux, F | 1 |
| Laurent, A | 1 |
| Pavlovic, S | 1 |
| Debray, M | 1 |
| Treluyer, JM | 1 |
| Weill, B | 1 |
| Spahr, L | 1 |
| Rubbia-Brandt, L | 1 |
| Frossard, JL | 1 |
| Giostra, E | 1 |
| Rougemont, AL | 1 |
| Pugin, J | 1 |
| Fischer, M | 1 |
| Egger, H | 1 |
| Hadengue, A | 1 |
| Natali, G | 1 |
| Trotta, A | 1 |
| Colantonio, D | 1 |
| Cascone, F | 1 |
| Di Lauro, G | 1 |
| Ruggieri, M | 1 |
| Di Pietro, M | 1 |
| Korula, J | 1 |
| Larvol, L | 1 |
| Colardelle, P | 1 |
| Callard, P | 1 |
| Levecq, H | 1 |
| Morgado, MJ | 1 |
| Marques, A | 1 |
| Areias, E | 1 |
| Moura, MC | 1 |
| Achord, JL | 1 |
| Colli, A | 1 |
| Cocciolo, M | 1 |
| Mumoli, N | 1 |
| Zuccoli, E | 1 |
| McClain, CJ | 1 |
| Barve, S | 2 |
| Deaciuc, I | 1 |
| Hill, DB | 1 |
| Maier, KP | 1 |
| Talke, H | 1 |
| Heimsoeth, H | 1 |
| Gerok, W | 1 |
| Magnenat, P | 1 |
| Carey, WD | 1 |
| Asnis, DS | 1 |
| Mollura, JL | 1 |
| Juhl, E | 1 |
| Christensen, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Omega-5 Fatty Acid Supplement on Markers of Inflammation and Oxidative Stress in Patients With Severe Alcoholic Hepatitis Treated With Prednisone[NCT03732586] | 40 participants (Actual) | Interventional | 2018-09-30 | Completed | |||
| Impact of Metadoxine in the Oxidative Stress and Early Mortality in Patients With Severe Alcoholic Hepatitis[NCT02161653] | Phase 4 | 135 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for prednisone and Alcoholic Hepatitis
| Article | Year |
|---|---|
Optimal management of alcoholic hepatitis.
Topics: Algorithms; Drug Therapy, Combination; Evidence-Based Medicine; Glucocorticoids; Hepatitis, Alcoholi | 2014 |
[Acute alcoholic hepatitis complicated by cardiac arrhythmia. Alcohol, hepatitis, hypomagnesemia, torsades de pointes, corticotherapy].
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Drug Therapy, Combination; Female; Hepatitis, Alcohol | 1994 |
Review of alcoholic hepatitis, and its treatment.
Topics: Alcoholism; Anabolic Agents; Colchicine; Enteral Nutrition; Ethanol; Female; Food, Formulated; Gluca | 1993 |
3 trials available for prednisone and Alcoholic Hepatitis
| Article | Year |
|---|---|
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Metadoxine improves the three- and six-month survival rates in patients with severe alcoholic hepatitis.
Topics: Adult; Alcohol Abstinence; Alcohol Deterrents; Drug Administration Schedule; Drug Combinations; Drug | 2015 |
Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Anesthetics, Local; Antineoplastic Combined Chemotherapy Pro | 2009 |
Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Apoptosis; Biop | 2002 |
12 other studies available for prednisone and Alcoholic Hepatitis
| Article | Year |
|---|---|
A Combination of N-Acetylcysteine and Prednisone Has No Benefit Over Prednisone Alone in Severe Alcoholic Hepatitis: A Retrospective Analysis.
Topics: Acetylcysteine; Adult; Anti-Inflammatory Agents; Drug Monitoring; Drug Therapy, Combination; Female; | 2020 |
Know When to Hold 'em, Know When to Treat 'em, Know When to Cut 'em: Why Severe Alcoholic Hepatitis Is Becoming a Surgical Disease.
Topics: Acetylcysteine; Hepatitis, Alcoholic; Humans; Prednisone; Retrospective Studies | 2020 |
[Leukemoid reaction in a case of severe acute alcoholic hepatitis].
Topics: Adult; Female; Hepatitis, Alcoholic; Hepatomegaly; Humans; Leukemoid Reaction; Liver; Prednisone; Sp | 1982 |
Tuberculous peritonitis complicating corticosteroid therapy for acute alcoholic hepatitis.
Topics: Acute Disease; Adult; Female; Glucocorticoids; Hepatitis, Alcoholic; Humans; Peritonitis, Tuberculou | 1995 |
[Acute alcoholic hepatitis and leukemoid reaction].
Topics: Blood Cell Count; Female; Hematologic Tests; Hepatitis, Alcoholic; Hepatomegaly; Humans; Leukemoid R | 1993 |
Kaposi's sarcoma in severe alcoholic hepatitis.
Topics: Female; Glucocorticoids; Hepatitis, Alcoholic; Humans; Liver Neoplasms; Middle Aged; Prednisone; Sar | 1997 |
Tumor necrosis factor and alcoholic liver disease.
Topics: Animals; Cytokines; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; | 1998 |
Influence of steroids on urea-cycle enzymes in chronic human liver disease.
Topics: Arginase; Argininosuccinate Synthase; Hepatitis; Hepatitis, Alcoholic; Humans; Ligases; Liver; Ornit | 1978 |
[Immunosuppressive drugs in the treatment of liver diseases (author's transl)].
Topics: Aspartate Aminotransferases; Azathioprine; Chronic Disease; Hepatitis; Hepatitis, Alcoholic; Humans; | 1979 |
Steroids in alcoholic hepatitis: another salvo of data.
Topics: Acute Disease; Hepatitis, Alcoholic; Humans; Prednisone | 1992 |
Acute febrile alcoholic hepatitis treated with corticosteroids.
Topics: Acute Disease; Fever; Hepatitis, Alcoholic; Humans; Male; Middle Aged; Prednisone | 1992 |
Anti-inflammatory and immunosuppressive treatment of alcoholic liver disease.
Topics: Colchicine; Female; Hepatitis, Alcoholic; Humans; Liver Cirrhosis, Alcoholic; Liver Diseases, Alcoho | 1985 |