prednisolone-hemisuccinate has been researched along with Shock* in 4 studies
4 other study(ies) available for prednisolone-hemisuccinate and Shock
Article | Year |
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Pharmacokinetics of prednisolone sodium succinate and its metabolites in normovolemic and hypovolemic dogs.
Tritium-labeled prednisolone sodium succinate was administered IV to 4 healthy, awake, nonsplenectomized dogs. The concentration of prednisolone and its metabolites in the plasma were measured for 10 hours. Forty-one percent of the blood volume of these dogs was removed, and plasma prednisolone was measured again. The data before and after hemorrhage were fitted to a 2-compartment open model. From plasma profiles, a rapid distributional phase, followed by a slower phase, was observed in control and shock groups. Volume of the central compartment of prednisolone before and after hemorrhage was 165 ml/kg of body weight and 110 ml/kg, respectively; and the difference was significant (P less than 0.05). The rate of total body clearance of prednisolone before and after hemorrhage was 3.96 ml/min/kg and 2.53 ml/min/kg, respectively; the difference was significant. The mean plasma half-lives for prednisolone sodium succinate and its metabolites, before and after hemorrhage, were 166 and 197 minutes, respectively; the difference was not significant. The mean half-life data indicated that prednisolone sodium succinate may be repeated in a patient 2.5 to 3 hours after onset of treatment if signs of hypovolemic shock reappear. Topics: Animals; Dog Diseases; Dogs; Female; Injections, Intravenous; Male; Prednisolone; Shock | 1985 |
[WATER-SOLUBLE PREDNISOLONE SODIUM SUCCINATE IN THE TREATMENT OF COLLAPSE EPISODES DURING MYOCARDIAL INFARCT].
Topics: Electrocardiography; Geriatrics; Humans; Myocardial Infarction; Prednisolone; Shock; Water | 1963 |
[Research on the potentiating effects of beta-mercaptoethylamine on the anti-shock action of prednisolone sodium succinate].
Topics: Cysteamine; Mercaptoethylamines; Prednisolone; Research; Shock | 1960 |
[A study on substitution therapy in surgery with prednisolone sodium succinate].
Topics: Prednisolone; Shock; Surgical Procedures, Operative | 1959 |