prednisolone-hemisuccinate has been researched along with Cerebrovascular-Disorders* in 1 studies
1 other study(ies) available for prednisolone-hemisuccinate and Cerebrovascular-Disorders
| Article | Year |
|---|---|
Separation of serum prednisolone and prednisolone-21-hemisuccinate by extraction and their concurrent determination by radioimmunoassay.
We describe a simple, sensitive, and reliable radioimmunoassay for prednisolone and prednisolone-21-hemisuccinate in serum. The antiserum produced in rabbits to prednisolone-21-hemisuccinate/bovine serum albumin was specific for prednisolone and prednisolone-21-hemisuccinate. A simple dichloromethane extraction permitted the separation of prednisolone from prednisolone-21-hemisuccinate in the serum samples. Interference by cortisol, although not insignificant, is minimized in this assay. We used the method to measure prednisolone and prednisolone-21-hemisuccinate concentrations after a bolus injection of prednisolone-21-hemisuccinate into human beings and mice. Topics: Animals; Cerebrovascular Disorders; Cross Reactions; Humans; Male; Mice; Prednisolone; Radioimmunoassay | 1980 |