Page last updated: 2024-11-06

prednisolone and Spinal Fractures

prednisolone has been researched along with Spinal Fractures in 27 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Spinal Fractures: Broken bones in the vertebral column.

Research Excerpts

ExcerptRelevanceReference
"Glucocorticoid treatment for steroid-dependent nephrotic syndrome (NS) is associated with severe adverse effects, such as bone fractures and epidural lipomatosis."5.32Effectiveness of high trough levels of cyclosporine for 5 months in a case of steroid-dependent nephrotic syndrome with severe steroid toxicity. ( Arisaka, O; Kano, K; Nishikura, K; Shimizu, A; Shiraiwa, T; Tomita, S; Ueda, Y; Yamada, Y, 2004)
"The aim of the study was an analysis of the frequency of oral steroids prescription to patients with bronchial asthma treated in hospital and of vertebral fractures and deformations as the result of GCS-induced osteoporosis in patients with bronchial asthma taking prednisolone tablets for at least 6 months."3.70[Osteoporotic fracture of the vertebral body in patients with steroid dependent bronchial asthma]. ( Lebedeva, MK; Lesniak, OM; Lezhnina, MB; Piven', AI, 2000)
"The adverse effects of oral corticosteroids are widely recognised but there are few quantitative data on which to base advice to patients."2.70Adverse effects of oral corticosteroids in relation to dose in patients with lung disease. ( Cooper, S; Hubbard, R; Lewis, SA; Oborne, J; Pringle, M; Tattersfield, AE; Walsh, LJ; Wong, CA, 2001)
"Systemic mastocytosis is a rare cause of vertebral fractures in young men."1.35Multimodal therapy for vertebral involvement of systemic mastocytosis. ( Brendel, C; Hamann, C; Hofbauer, LC; Krüger, A; Neubauer, A; Ramaswamy, A; Schnabel, M, 2009)
"4), while the risk factor for OFH was a recent maximum GC dosage (>1."1.35Notable difference between the development of vertebral fracture and osteonecrosis of the femoral head in patients treated with high-dose glucocorticoids for systemic rheumatic diseases. ( Amano, K; Kameda, H; Nagasawa, H; Ogawa, H; Sekiguchi, N; Suzuki, K; Takei, H; Takeuchi, T, 2009)
"Glucocorticoid treatment for steroid-dependent nephrotic syndrome (NS) is associated with severe adverse effects, such as bone fractures and epidural lipomatosis."1.32Effectiveness of high trough levels of cyclosporine for 5 months in a case of steroid-dependent nephrotic syndrome with severe steroid toxicity. ( Arisaka, O; Kano, K; Nishikura, K; Shimizu, A; Shiraiwa, T; Tomita, S; Ueda, Y; Yamada, Y, 2004)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (7.41)18.2507
2000's17 (62.96)29.6817
2010's8 (29.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wong, SC1
Catto-Smith, AG1
Zacharin, M1
Omata, Y1
Hagiwara, F1
Nishino, J1
Matsudaira, K1
Kadono, Y1
Juji, T1
Mori, T1
Nakayama, H1
Nagase, Y1
Hirose, J1
Yasui, T1
Matsumoto, T1
Matsui, T1
Tohma, S1
Tanaka, S1
Ishida, O1
Furuya, T1
Inoue, E1
Ochi, K1
Ikari, K1
Taniguchi, A1
Yamanaka, H1
Momohara, S1
Wang, B1
Guo, H1
Yuan, L1
Huang, D1
Zhang, H1
Hao, D1
Ashida, A1
Fujii, Y1
Matsumura, H1
Tamai, H1
Hélaine, L1
Cadic, A1
Magro, E1
Simon, A1
Kiss, G1
Gueret, G1
Arvieux, CC1
Sugiyama, T3
Tatsuno, I3
Suzuki, S3
Yoshida, T3
Tanaka, T3
Sueishi, M3
Saito, Y1
Hayashi, K1
Yamamoto, M1
Murakawa, Y1
Yamauchi, M2
Kaji, H2
Yamaguchi, T1
Sugimoto, T2
Krüger, A1
Hamann, C1
Brendel, C1
Ramaswamy, A1
Schnabel, M1
Neubauer, A1
Hofbauer, LC1
Kameda, H1
Amano, K1
Nagasawa, H1
Ogawa, H1
Sekiguchi, N1
Takei, H1
Suzuki, K1
Takeuchi, T1
Phillips, PJ1
Burnet, S1
Suyama, K2
Mayama, T1
Hashimoto, N1
Tsugeno, H2
Fujita, T1
Goto, B1
Sugishita, T1
Hosaki, Y1
Ashida, K1
Mitsunobu, F1
Tanizaki, Y1
Shiratori, Y1
Walsh, LJ2
Lewis, SA2
Wong, CA2
Cooper, S2
Oborne, J2
Cawte, SA1
Harrison, T1
Green, DJ1
Pringle, M2
Hubbard, R2
Tattersfield, AE2
Tanaka, I1
Oshima, H1
Kano, K1
Yamada, Y1
Shiraiwa, T1
Shimizu, A1
Nishikura, K1
Arisaka, O1
Tomita, S1
Ueda, Y1
Bassingthwaighte, C1
Bird, S1
Chihara, K1
Lezhnina, MB1
Lesniak, OM1
Piven', AI1
Lebedeva, MK1
Sambrook, P1
Raj, A1
Hunter, D1
Naganathan, V1
Mason, R1
Robinson, B1
de Nijs, RN1
Jacobs, JW1
Bijlsma, JW1
Lems, WF1
Laan, RF1
Houben, HH1
ter Borg, EJ1
Huisman, AM1
Bruyn, GA1
van Oijen, PL1
Westgeest, AA1
Algra, A1
Hofman, DM1
Gallacher, SJ1
Fenner, JA1
Anderson, K1
Adamson, BB1
Banham, SW1
Boyle, IT1
Curley, RK1
Holden, CA1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Bone Density in Children With IBD Treated With Amorphous Calcium or Commercial Crystalline Calcium: A Prospective Randomized Multicenter Trial[NCT02470663]0 participants (Actual)Interventional2015-07-31Withdrawn (stopped due to company and Sheba did not reach an agreement)
Radiofrequency Ablation of the Medial Branch Nerve as a Novel Treatment for Posterior Element Pain From Vertebral Compression Fractures[NCT03651804]Phase 460 participants (Anticipated)Interventional2019-04-10Suspended (stopped due to Difficulty recruiting members)
Vertebral Fracture and Osteonecrosis of the Femoral Head Associated With High-dose Glucocorticoid Therapy[NCT00679978]60 participants (Actual)Observational2001-01-31Completed
"Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD - a Randomized, Double-blind, Non-inferiority Study (The RECUT-Trial)"[NCT02386735]470 participants (Anticipated)Interventional2015-03-31Recruiting
A Prospective Baseline Assessment of the Risk of Osteoporosis in Patients With Chronic Obstructive Lung Disease and Outcomes After 2 Years; a Pilot Study[NCT01161680]30 participants (Actual)Observational2010-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for prednisolone and Spinal Fractures

ArticleYear
Pathological fractures in paediatric patients with inflammatory bowel disease.
    European journal of pediatrics, 2014, Volume: 173, Issue:2

    Topics: Adolescent; Body Height; Body Weight; Bone Density; Child; Colitis, Ulcerative; Crohn Disease; Dipho

2014
[Recommendations for the diagnosis and treatment of glucocorticoid-induced osteoporosis].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 2

    Topics: Bone Density; Bone Resorption; Diphosphonates; Glucocorticoids; Humans; Practice Guidelines as Topic

2004

Trials

6 trials available for prednisolone and Spinal Fractures

ArticleYear
Vertebral fractures affect functional status in postmenopausal rheumatoid arthritis patients.
    Journal of bone and mineral metabolism, 2014, Volume: 32, Issue:6

    Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Bone Density; Bone Density Conservation Agent

2014
A prospective randomized controlled study comparing the pain relief in patients with osteoporotic vertebral compression fractures with the use of vertebroplasty or facet blocking.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2016, Volume: 25, Issue:11

    Topics: Aged; Aged, 80 and over; Anesthetics, Local; Back Pain; Disability Evaluation; Female; Fractures, Co

2016
Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women.
    Calcified tissue international, 2008, Volume: 82, Issue:3

    Topics: Administration, Oral; Adult; Cushing Syndrome; Dose-Response Relationship, Drug; Female; Glucocortic

2008
Adverse effects of oral corticosteroids in relation to dose in patients with lung disease.
    Thorax, 2001, Volume: 56, Issue:4

    Topics: Administration, Oral; Aged; Asthma; Cross-Sectional Studies; Dose-Response Relationship, Drug; Femal

2001
Osteoporosis with low dose corticosteroids: contribution of underlying disease effects and discriminatory ability of ultrasound versus bone densitometry.
    The Journal of rheumatology, 2001, Volume: 28, Issue:5

    Topics: Absorptiometry, Photon; Bone Density; Female; Fractures, Spontaneous; Glucocorticoids; Humans; Male;

2001
Prevalence of vertebral deformities and symptomatic vertebral fractures in corticosteroid treated patients with rheumatoid arthritis.
    Rheumatology (Oxford, England), 2001, Volume: 40, Issue:12

    Topics: Aged; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Glucocorticoids; Humans; Male; Middle

2001

Other Studies

19 other studies available for prednisolone and Spinal Fractures

ArticleYear
Risk factors for established vertebral fractures in Japanese patients with rheumatoid arthritis: Results from a large prospective observational cohort study.
    Modern rheumatology, 2015, Volume: 25, Issue:3

    Topics: Adult; Age Factors; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Incidence

2015
A case of multiple vertebral compression fractures due to glucocorticoid-induced osteoporosis in a pediatric patient with nephrotic syndrome
.
    International journal of clinical pharmacology and therapeutics, 2017, Volume: 55, Issue:3

    Topics: Bone Density; Child; Drug Administration Schedule; Fractures, Compression; Glucocorticoids; Humans;

2017
[Vision loss after spine surgery: a case report].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2

    Topics: Accidental Falls; Adult; Alcoholic Intoxication; Blindness; Fracture Fixation, Internal; Humans; Mal

2009
Incidence of symptomatic vertebral fracture with high-dose glucocorticoid treatment in the Chiba-Shimoshizu Rheumatic Cohort between 1986 and 2006.
    Endocrine journal, 2009, Volume: 56, Issue:4

    Topics: Adult; Aged; Cohort Studies; Collagen Diseases; Female; Glucocorticoids; Humans; Incidence; Japan; M

2009
Bone fragility in male glucocorticoid-induced osteoporosis is not defined by bone mineral density.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009, Volume: 20, Issue:11

    Topics: Absorptiometry, Photon; Adult; Aged; Aged, 80 and over; Body Mass Index; Bone Density; Drug Administ

2009
Multimodal therapy for vertebral involvement of systemic mastocytosis.
    Spine, 2009, Aug-01, Volume: 34, Issue:17

    Topics: Adult; Back Pain; Biomarkers; Biopsy; Bone Density; Bone Density Conservation Agents; Diphosphonates

2009
Notable difference between the development of vertebral fracture and osteonecrosis of the femoral head in patients treated with high-dose glucocorticoids for systemic rheumatic diseases.
    Internal medicine (Tokyo, Japan), 2009, Volume: 48, Issue:22

    Topics: Bone Density; Bone Density Conservation Agents; Etidronic Acid; Female; Femur Head Necrosis; Glucoco

2009
Belinda's back pain.
    Australian family physician, 2010, Volume: 39, Issue:7

    Topics: Absorptiometry, Photon; Adult; Back Pain; Bone Density; Bone Density Conservation Agents; Diphosphon

2010
Incidence of symptomatic vertebral fractures in women of childbearing age newly treated with high-dose glucocorticoid.
    Gender medicine, 2010, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Cardiovascular Diseases; Cohort Studies; Confi

2010
Age, initial dose and dose increase are independent risk factors for symptomatic vertebral fractures in glucocorticoid-treated male patients.
    Internal medicine (Tokyo, Japan), 2011, Volume: 50, Issue:8

    Topics: Adult; Age Factors; Aged; Autoimmune Diseases; Case-Control Studies; Cohort Studies; Dose-Response R

2011
Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2002, Volume: 13, Issue:8

    Topics: Administration, Oral; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bone and Bones; Bone Dens

2002
The impact of oral corticosteroid use on bone mineral density and vertebral fracture.
    American journal of respiratory and critical care medicine, 2002, Sep-01, Volume: 166, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Age Distribution; Aged; Aged, 80 and over; Bone De

2002
The impact of oral corticosteroid use on bone mineral density and vertebral fracture.
    American journal of respiratory and critical care medicine, 2002, Sep-01, Volume: 166, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Age Distribution; Aged; Aged, 80 and over; Bone De

2002
The impact of oral corticosteroid use on bone mineral density and vertebral fracture.
    American journal of respiratory and critical care medicine, 2002, Sep-01, Volume: 166, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Age Distribution; Aged; Aged, 80 and over; Bone De

2002
The impact of oral corticosteroid use on bone mineral density and vertebral fracture.
    American journal of respiratory and critical care medicine, 2002, Sep-01, Volume: 166, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Age Distribution; Aged; Aged, 80 and over; Bone De

2002
[The patient suffers from rheumatism for many years. It also makes the bones brittle].
    MMW Fortschritte der Medizin, 2002, Oct-10, Volume: 144, Issue:41

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Diphosphonates; Female; Glucocorticoids; Humans; Ma

2002
Effectiveness of high trough levels of cyclosporine for 5 months in a case of steroid-dependent nephrotic syndrome with severe steroid toxicity.
    Nephrology (Carlton, Vic.), 2004, Volume: 9, Issue:6

    Topics: Child, Preschool; Cyclosporine; Female; Glucocorticoids; Humans; Lipomatosis; Nephrotic Syndrome; Pr

2004
Rufo v Hosking [2004] NSWCA 391.
    Journal of law and medicine, 2005, Volume: 13, Issue:1

    Topics: Dexamethasone; Humans; Lupus Erythematosus, Systemic; Malpractice; New South Wales; Osteoporosis; Pr

2005
Loss of chance: what loss?
    Australian family physician, 2006, Volume: 35, Issue:5

    Topics: Adolescent; Allergy and Immunology; Dexamethasone; Family Practice; Female; Glucocorticoids; Humans;

2006
[Osteoporotic fracture of the vertebral body in patients with steroid dependent bronchial asthma].
    Klinicheskaia meditsina, 2000, Volume: 78, Issue:9

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Asthma; Female; H

2000
Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study.
    Thorax, 1992, Volume: 47, Issue:3

    Topics: Absorptiometry, Photon; Asthma; Bone Density; Female; Humans; Osteoporosis; Osteoporosis, Postmenopa

1992
Steroid-resistant bullous pemphigoid treated with cyclosporin A.
    Clinical and experimental dermatology, 1991, Volume: 16, Issue:1

    Topics: Aged; Cyclosporins; Drug Resistance; Female; Humans; Osteoporosis; Pemphigoid, Bullous; Prednisolone

1991