prednisolone and Sclerosis, Systemic studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Research Excerpts

Excerpt	Relevance	Reference
" This suggests that treatment of pulmonary fibrosis in SSc with low-dose prednisolone and IV CYC followed by AZA stabilizes lung function in a subset of patients with the disease."	9.12	A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. ( Black, CM; Denton, CP; Desai, S; du Bois, RM; Ellis, RW; Emery, P; Foley, NM; Goh, NS; Herrick, AL; Hoyles, RK; Lees, B; McHugh, NJ; Newlands, P; Pearson, SB; Roberts, C; Veale, DJ; Wells, AU; Wellsbury, J, 2006)
"We herein report a case of systemic sclerosis (SSc)-related pericarditis successfully treated with mycophenolate mofetil (MMF) and low-dose prednisolone (PSL)."	8.12	Successful Treatment of Systemic Sclerosis-related Pericarditis with Mycophenolate Mofetil and Low-dose Prednisolone. ( Higashioka, K; Migita, R; Niiro, H; Ota, T; Uchino, A, 2022)
" This suggests that treatment of pulmonary fibrosis in SSc with low-dose prednisolone and IV CYC followed by AZA stabilizes lung function in a subset of patients with the disease."	5.12	A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. ( Black, CM; Denton, CP; Desai, S; du Bois, RM; Ellis, RW; Emery, P; Foley, NM; Goh, NS; Herrick, AL; Hoyles, RK; Lees, B; McHugh, NJ; Newlands, P; Pearson, SB; Roberts, C; Veale, DJ; Wells, AU; Wellsbury, J, 2006)
" We report a case of a 70-year-old woman, who was diagnosed with diffuse cutaneous systemic sclerosis and psoriasis vulgaris and was treated with oral azathioprine (50 mg/d) and prednisolone (10 mg/d), topical corticosteroids, and calcipotriols."	4.31	Case of systemic sclerosis overlapping with psoriasis. ( Hua, X; Rao, L; Tan, H; Xie, Y; Zhou, P, 2023)
"We herein report a case of systemic sclerosis (SSc)-related pericarditis successfully treated with mycophenolate mofetil (MMF) and low-dose prednisolone (PSL)."	4.12	Successful Treatment of Systemic Sclerosis-related Pericarditis with Mycophenolate Mofetil and Low-dose Prednisolone. ( Higashioka, K; Migita, R; Niiro, H; Ota, T; Uchino, A, 2022)
"Currently, therapy for interstitial lung disease in patients with systemic sclerosis is unsatisfactory."	2.74	High-dose prednisolone and bolus cyclophosphamide in interstitial lung disease associated with systemic sclerosis: a prospective open study. ( Bambery, P; Sharma, A; Sharma, S; Suryanaryana, BS; Wanchu, A, 2009)
"Pulmonary fibrosis in systemic sclerosis (SSc) is thought to be the consequence of interstitial inflammation."	2.73	Oral cyclophosphamide improves pulmonary function in scleroderma patients with fibrosing alveolitis: experience in one centre. ( Beretta, L; Caronni, M; Origgi, L; Ponti, A; Raimondi, M; Scorza, R; Viscuso, T, 2007)
" During first 6 months of the trial, the patients also received prednisolone, which was started at a dosage of 15 mg daily and tapered to zero by the end of the sixth month."	2.72	A randomized unblinded trial of cyclophosphamide versus azathioprine in the treatment of systemic sclerosis. ( Davis, P; Fritzler, M; Kovalenko, W; Nadashkevich, O, 2006)
"Eosinophilic fasciitis is occasionally associated with morphea."	2.66	A case of eosinophilic fasciitis and generalized morphea overlap. ( Watanabe, Y; Yamamoto, M; Yamamoto, T, 2020)
"Disabling pansclerotic morphea of childhood (DPMC) is a rare subtype of juvenile localized scleroderma (JLS) characterized by pansclerosis mainly affecting children under the age of 14."	2.61	Challenges in the diagnosis and treatment of disabling pansclerotic morphea of childhood: case-based review. ( Cox, A; Heaton, V; Munro, J; Renton, WD; Samuel, C; Soh, HJ, 2019)
"A 65-year-old man was diagnosed with systemic sclerosis on the basis of skin thickening and positivity of anti-Scl-70 antibodies."	2.48	A case of sarcoidosis developing as sarcoid myopathy concomitant with systemic sclerosis and review of the literature. ( Kato, T; Kawano, M; Mizushima, I; Ogane, K; Yamagishi, M, 2012)
"Treatment with prednisolone and endoscopic variceal ligation resulted in improvement of her symptoms."	2.43	A case of systemic sclerosis complicated by idiopathic portal hypertension: case report and literature review. ( Akimoto, K; Kawai, S; Nishio, S; Takagi, K; Yoshino, T, 2006)
"In 1995 chronic hepatitis C was diagnosed."	2.42	[A case of Behçet's disease with esophageal ulcers complicated with systemic sclerosis, chronic hepatitis C, and pancytopenia]. ( Adachi, D; Akiba, H; Akiyama, Y; Hirano, M; Mimura, T; Takeishi, M; Yokota, K, 2004)
"A diagnosis of systemic sclerosis was made based on the characteristic skin lesions, interstitial pneumonia and the positivity for anti-Scl-70 antibody."	2.42	[Successful treatment with cyclosporine in a case of progressive interstitial pneumonia associated with systemic sclerosis]. ( Chida, K; Fujisawa, T; Kobayashi, J; Nakamura, H; Nakamura, Y; Saito, T; Suda, T; Suganuma, H; Takashima, Y; Yagi, T, 2003)
"She was diagnosed having interstitial pneumonitis and systemic sclerosis with sclerodactylia of bilateral fingers in December."	2.42	[Case of systemic sclerosis presenting with alveolar hemorrhage and positive anti-neutrophil cytoplasmic myeloperoxidase antibody(MPO-ANCA) without pathological renal involvement]. ( Hara, M; Kamatani, N; Nakajima, A; Nakajima, H; Tanaka, E; Terai, C; Yamada, T, 2003)
"Although there is no cure for systemic sclerosis, the disease is certainly treatable."	2.39	Systemic sclerosis: current pathogenetic concepts and future prospects for targeted therapy. ( , 1996)
"Progressive systemic sclerosis (PSS) is a chronic connective tissue inflammatory disease which commonly attacks the skin and the visceral organs, but rarely the peripheral nervous system."	2.39	Progressive systemic sclerosis associated with multiple mononeuropathy. ( Nitta, Y; Sobue, G, 1996)
"Systemic sclerosis is a multiorgan autoimmune disease that can overlap with other rheumatologic disorders; however, co-occurrence with antineutrophil cytoplasmic antibody-associated vasculitis is rare."	1.91	Glomerulonephritis associated with systemic sclerosis: a case report. ( Atef-Yekta, R; Kavosi, H; Nayebirad, S; Nili, F; Ramandi, A; Salehi, S; Tamartash, Z, 2023)
"In response to treatment, interstitial pneumonia (IP) improved in three patients, stable in seven patients, and deteriorated in one patient."	1.48	Efficacy and safety of combination therapy with prednisolone and oral tacrolimus for progressive interstitial pneumonia with systemic sclerosis: A retrospective study. ( Arawaka, S; Fujiki, Y; Hata, K; Konma, J; Kotani, T; Makino, S; Nagai, K; Shoda, T; Suzuka, T; Takeuchi, T; Yoshida, S, 2018)
"Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are autoimmune diseases that predominantly affect female patients, and therefore fewer investigations have been conducted in men."	1.46	Effect of Corticosteroids and Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic Lupus Erythematosus or Systemic Sclerosis. ( Arnaud, L; Gunnarsson, I; Hellbacher, E; Lundholm, H; Nordin, A; Svenungsson, E; Wikner, J; Zickert, A, 2017)
"She had clinical features of systemic sclerosis (SSc) which was subsequently confirmed on further workup."	1.39	Recurrent cardiac tamponade in a young woman. ( Itolikar, M; Itolikar, SM; Phatak, S; Salagre, S, 2013)
" Consequently, she was diagnosed with liver cirrhosis due to autoimmune hepatitis (AIH) combined with SSc."	1.38	Liver cirrhosis due to autoimmune hepatitis combined with systemic sclerosis. ( Goo, SM; Jang, JY; Jeen, YM; Jeon, CH; Jeong, SW; Kim, SG; Kim, YS; You, BC, 2012)
"Here we report subdural hematoma in two uncommon settings, one patient with systemic sclerosis developing secondary ITP and consequently subdural hematoma and the other patient with chronic ITP developing subdural hematoma in the inter hemispheric region."	1.36	Subdural hematoma associated with immune thrombocytopenic purpura in two different clinical settings. ( Chatterjee, S; Ghosh, A; Ghosh, P; Karmakar, PS, 2010)
"Interstitial lung disease is an important cause of mortality and morbidity in patients with systemic sclerosis (SSc)."	1.35	Early aggressive intra-venous pulse cyclophosphamide therapy for interstitial lung disease in a patient with systemic sclerosis. A case report. ( Browne, P; Kearns, G; O'Connell, P; O'Neill, L; Peshin, R, 2009)
"However, the occurrence of ML in systemic sclerosis (SSc) patients has rarely been reported."	1.35	[Mediastinal large B-cell lymphoma associated with systemic sclerosis]. ( Arai, H; Arai, Y; Iso, H; Mitani, K; Nakamura, Y; Tadokoro, J; Yamagata, T, 2009)
"Prednisolone use was associated with lower serum NO(x) level (OR 0."	1.35	Serum nitric oxide metabolites and disease activity in patients with systemic sclerosis. ( Fung, PC; Lam, YM; Lau, CS; Mok, MY; Ooi, C; Tse, HF; Wong, WS; Wong, Y, 2008)
"A 60-year-old woman with systemic sclerosis, lung fibrosis, and primary biliary cirrhosis was admitted to our hospital because of heart failure."	1.34	Left ventricular aneurysms developed in a patient with systemic sclerosis. ( Hashimoto, K; Miyawaki, S; Nishiyama, S; Taniguchi, Y; Yoshinaga, Y, 2007)
"She was diagnosed as having systemic sclerosis (SSc) based on the skin sclerosis of her arms, chest, and face."	1.32	Improvement of skin sclerosis after occurrence of anticentromere antibody in a patient with diffuse cutaneous systemic sclerosis. ( Echigo, T; Hasegawa, M; Hayakawa, I; Sato, S; Shirasaki, F; Takehara, K, 2004)
"Pharmacological treatment of diffuse systemic sclerosis (SSc) directed at the tissue fibrosis has generally been ineffective."	1.32	The efficacy of oral cyclophosphamide plus prednisolone in early diffuse systemic sclerosis. ( Apras, S; Calguneri, M; Celik, I; Ertenli, I; Kiraz, S; Ozbalkan, Z; Ozturk, MA, 2003)
"A 60-year-old woman with systemic sclerosis (SSc) was admitted because of severe anemia and Raynaud's phenomenon."	1.32	Low-titer cold agglutinin disease with systemic sclerosis. ( Doi, M; Kuwabara, M; Maeda, H; Morimoto, K; Oshima, M, 2004)
"Treatment with prednisolone resulted in a reduction in pulmonary arterial pressure and CXR findings improved 2 months later, but no further effect was observed."	1.32	A case of pulmonary veno-occlusive disease associated with systemic sclerosis. ( Ito, K; Oka, T; Saito, A; Takizawa, H; Yamamoto, K, 2003)
"Scleromyxedema is the consequence of a dermal infiltration by mucine, commonly associated with a monoclonal gammapathy of unknown significance."	1.31	[Cutaneo-systemic papulosclerotic mucinosis (scleromyxedema): remission after extracorporeal photochemotherapy and corticoid bolus]. ( Achin, R; Bacin, F; Beyvin, AJ; D'Incan, M; Demeocq, F; Franck, F; Kanold, J; Souteyrand, P, 2001)
"The nephrotic syndrome is an extremely rare occurrence in systemic sclerosis (SSc)."	1.31	Systemic sclerosis complicated with nephrotic syndrome: relevance with antiribosomal P antibody. ( Hashimoto, T; Hirohata, S; Ohse, T; Takeuchi, A, 2001)
"They are normal in SLE, systemic sclerosis, and vasculitides as well as in non-rheumatic inflammatory controls, but are significantly increased by steroids."	1.31	Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. ( Damas, P; Franchimont, N; Houssiau, FA; Jaspar, JM; Kaiser, MJ; Malaise, MG; Martin y Porras, M; Ribbens, C, 2002)
"The clinical course of fibrosing alveolitis (FA) in patients with systemic sclerosis (SSc) may vary considerably from stable condition for years to continuous fatal progression."	1.30	Pulmonary involvement in diffuse cutaneous systemic sclerosis: broncheoalveolar fluid granulocytosis predicts progression of fibrosing alveolitis. ( Baumann, G; Borges, AC; Fietze, I; John, M; Krause, A; Witt, C, 1999)
"Acute interstitial pneumonia, microangiopathic hemolytic anemia and thrombocytopenia appeared during her clinical course."	1.29	[A case of scleroderma renal crisis with acute interstitial pneumonia, microangiopathic hemolytic anemia and refractory thrombocytopenia]. ( Akiyama, K; Ikeda, S; Kawabata, K; Makino, H; Morita, Y; Nagake, Y; Ota, K; Ota, Z; Sugimoto, H, 1994)
"Fibrosing alveolitis associated with systemic sclerosis (FASSc) is considered to be histologically and radiologically indistinguishable from lone cryptogenic fibrosing alveolitis (CFA)."	1.29	Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. ( Black, CM; Cullinan, P; Du Bois, RM; Hansell, DM; Newman-Taylor, AJ; Rubens, MB; Wells, AU, 1994)
"In cryptogenic fibrosing alveolitis, 4-yr survival was highest in association with CT Grade 1 and higher with CT Grade 2 than with CT Grade 3, independent of the extent of abnormal lung on CT, duration of dyspnea, or severity of depression of DLCO or FVC, p < 0."	1.29	The predictive value of appearances on thin-section computed tomography in fibrosing alveolitis. ( Black, CM; Cullinan, P; du Bois, RM; Hansell, DM; Rubens, MB; Wells, AU, 1993)
"There was a significant association of trauma with childhood-onset scleroderma (P < 0."	1.29	Childhood-onset scleroderma: is it different from adult-onset disease. ( Atherton, D; Black, CM; David, J; Harper, J; Hasson, N; Trivedi, P; Vancheeswaran, R; Woo, P, 1996)
"The pleural effusion was a transudate."	1.29	[Progressive systemic sclerosis associated with massive pleural and pericardial effusion in a 90-year-old woman]. ( Hiramatsu, K; Okumura, S; Takeda, N; Takuno, H; Yasuda, K, 1996)
"Patients with systemic lupus erythematosus (SLE), systemic scleroderma (SSD) and donors were examined for the blood levels of adrenocorticotropic hormone, hydrocortisone, follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, testosterone, progesterone, thyroid-stimulating hormone, triiodothyronine, thyroxin, and insulin."	1.28	[An analysis of the hormonal response during the performance of stress tests in patients with systemic lupus erythematosus and systemic scleroderma]. ( Apanasovich, VG; Bolotina, NG; Dosin, IuM; Grigorchuk, IP; Iagur, VE; Kurchenkova, VI; Lazareva, VI, 1992)
"A higher proportion of the fibrosing alveolitis patients (CFA or FA + PSS) with impaired IFN-gamma production have subsequently shown spontaneous lung functional deterioration."	1.28	In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases. ( Haslam, PL; Prior, C, 1992)
"A 45-year-old woman had recurrent morphea lesions over 10 times in 6 years."	1.28	Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis. ( Mizutani, H; Mizutani, T; Okada, H; Shimizu, M; Tanaka, H, 1992)
"The main group comprised patients with thromboangitis obliterans (23), nonspecific aortoarteritis was recognized in 6 cases, systemic scleroderma and systemic lupus erythematosus in 4, nodular periarteritis in 2."	1.27	[Hemosorption in the complex treatment of rheumatic diseases]. ( Alekseev, VI; Lileeva, MA; Pukhov, AG; Verkhovskii, SIu; Vilianskiĭ, MP, 1985)
"Features of both systemic lupus erythematosus and scleroderma developed in a young Chinese girl while on multiple anticonvulsant therapy."	1.25	Lupus-scleroderma syndrome induced by ethosuximide. ( Chan, HL; Teoh, PC, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	43 (30.94)	18.7374
1990's	30 (21.58)	18.2507
2000's	40 (28.78)	29.6817
2010's	21 (15.11)	24.3611
2020's	5 (3.60)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double Blind Controlled Trial Comparing Rituximab Against Intravenous Cyclophosphamide in Connective Tissue Disease Associated Interstitial Lung Disease[NCT01862926]	Phase 2/Phase 3	104 participants (Actual)	Interventional	2014-11-30	Completed
A Randomized Controlled Trial to Compare the Efficacy of Oral Mycophenolate Mofetil With Placebo in Patients With Systemic Sclerosis Related Early Interstitial Lung Disease[NCT02896205]	Phase 3	41 participants (Actual)	Interventional	2016-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Multiple mononeuropathy associated with systemic sclerosis with vasculitis confirmed by nerve biopsy: a case report]. Rinsho shinkeigaku = Clinical neurology, 2019, Sep-25, Volume: 59, Issue:9 Topics: Aged; Biopsy; Female; Glucocorticoids; Humans; Mononeuropathies; Neural Conduction; Prednisolone; Sc	2019
A case of eosinophilic fasciitis and generalized morphea overlap. Dermatology online journal, 2020, Feb-15, Volume: 26, Issue:2 Topics: Adult; Aged; Antigens, CD34; Eosinophilia; Fasciitis; Female; Glucocorticoids; Humans; Male; Middle	2020
Challenges in the diagnosis and treatment of disabling pansclerotic morphea of childhood: case-based review. Rheumatology international, 2019, Volume: 39, Issue:5 Topics: Antirheumatic Agents; Biological Products; Biopsy; Child, Preschool; Contracture; Edema; Hematopoiet	2019
A case of sarcoidosis developing as sarcoid myopathy concomitant with systemic sclerosis and review of the literature. Modern rheumatology, 2012, Volume: 22, Issue:1 Topics: Aged; Biopsy; Giant Cells; Granuloma; Humans; Kidney Diseases; Male; Muramidase; Muscle, Skeletal; M	2012
Pauci-immune crescentic glomerulonephritis in limited cutaneous systemic sclerosis. Clinical rheumatology, 2012, Volume: 31, Issue:8 Topics: Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Azathioprine; Biopsy; Cyclophosphamide	2012
[Successful treatment with cyclosporine in a case of progressive interstitial pneumonia associated with systemic sclerosis]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2003, Volume: 41, Issue:7 Topics: Cryptogenic Organizing Pneumonia; Cyclosporine; Drug Therapy, Combination; Humans; Immunosuppressive	2003
[Case of systemic sclerosis presenting with alveolar hemorrhage and positive anti-neutrophil cytoplasmic myeloperoxidase antibody(MPO-ANCA) without pathological renal involvement]. Ryumachi. [Rheumatism], 2003, Volume: 43, Issue:4 Topics: Antibodies, Antineutrophil Cytoplasmic; Biomarkers; Chronic Disease; Female; Hemorrhage; Humans; Kid	2003
[Nephropathies in patients with collagen diseases]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 6 Topics: Combined Modality Therapy; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Lupus Erythema	2004
ANCA-related crescentic glomerulonephritis in a patient with scleroderma without marked dermatological change and malignant hypertension. Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:6 Topics: Anti-Inflammatory Agents; Antibodies, Antineutrophil Cytoplasmic; Female; Glomerulonephritis; Humans	2004
[A case of Behçet's disease with esophageal ulcers complicated with systemic sclerosis, chronic hepatitis C, and pancytopenia]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2004, Volume: 27, Issue:3 Topics: Anti-Inflammatory Agents; Behcet Syndrome; Esophageal Diseases; Hepatitis C, Chronic; Humans; Male;	2004
A case of systemic sclerosis complicated by idiopathic portal hypertension: case report and literature review. Modern rheumatology, 2006, Volume: 16, Issue:3 Topics: Ascites; Esophageal and Gastric Varices; Female; Glucocorticoids; Humans; Hypertension, Portal; Liga	2006
Systemic sclerosis: current pathogenetic concepts and future prospects for targeted therapy. Lancet (London, England), 1996, May-25, Volume: 347, Issue:9013 Topics: Collagen; Cyclophosphamide; Female; Gene Expression; Humans; Middle Aged; Prednisolone; Scleroderma,	1996
Progressive systemic sclerosis associated with multiple mononeuropathy. Dermatology (Basel, Switzerland), 1996, Volume: 193, Issue:1 Topics: Aged; Anti-Inflammatory Agents; Axons; Biopsy, Needle; Electrophysiology; Female; Humans; Middle Age	1996
[Scleroderma]. Ryoikibetsu shokogun shirizu, 2000, Issue:31 Topics: Antibodies, Antinuclear; Autoimmunity; Collagen; Cytokines; Diagnosis, Differential; Humans; Penicil	2000
[Indications and limits of long-term therapy with immunosuppressive (and cytostatic) agents in various chronic skin diseases]. Zeitschrift fur arztliche Fortbildung, 1977, Jun-15, Volume: 71, Issue:12 Topics: Arthritis, Reactive; Azathioprine; Chronic Disease; Cyclophosphamide; Dermatomyositis; Humans; Immun	1977
Immunosuppressive therapy. 1. The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5 Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid	1972
The rheumatic diseases in adolescence. Pediatric clinics of North America, 1973, Volume: 20, Issue:4 Topics: Adolescent; Adult; Antimalarials; Arthritis, Rheumatoid; Child; Child, Preschool; Dermatomyositis; D	1973

Article	Year
High-dose prednisolone and bolus cyclophosphamide in interstitial lung disease associated with systemic sclerosis: a prospective open study. International journal of rheumatic diseases, 2009, Volume: 12, Issue:3 Topics: Adult; Carbon Monoxide; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Glucocorticoids;	2009
Efficacy and safety of intravenous cyclophosphamide pulse therapy with oral prednisolone in the treatment of interstitial lung disease with systemic sclerosis: 4-year follow-up. Modern rheumatology, 2011, Volume: 21, Issue:3 Topics: Administration, Oral; Adult; Aged; Cyclophosphamide; Drug Therapy, Combination; Female; Follow-Up St	2011
Effects of oral cyclophosphamide and prednisolone therapy on the endothelial functions and clinical findings in patients with early diffuse systemic sclerosis. Arthritis and rheumatism, 2003, Volume: 48, Issue:8 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Biomarkers; Cyclophosph	2003
A randomized unblinded trial of cyclophosphamide versus azathioprine in the treatment of systemic sclerosis. Clinical rheumatology, 2006, Volume: 25, Issue:2 Topics: Administration, Oral; Adult; Aged; Azathioprine; Cyclophosphamide; Female; Humans; Immunosuppressive	2006
Oral cyclophosphamide improves pulmonary function in scleroderma patients with fibrosing alveolitis: experience in one centre. Clinical rheumatology, 2007, Volume: 26, Issue:2 Topics: Administration, Oral; Breath Tests; Carbon Monoxide; Cyclophosphamide; Drug Therapy, Combination; Fe	2007
A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis and rheumatism, 2006, Volume: 54, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Aged; Azathioprine; Cyclophosphamide; Double-Blind Method;	2006
A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis and rheumatism, 2006, Volume: 54, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Aged; Azathioprine; Cyclophosphamide; Double-Blind Method;	2006
A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis and rheumatism, 2006, Volume: 54, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Aged; Azathioprine; Cyclophosphamide; Double-Blind Method;	2006
A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis and rheumatism, 2006, Volume: 54, Issue:12 Topics: Administration, Oral; Adolescent; Adult; Aged; Azathioprine; Cyclophosphamide; Double-Blind Method;	2006
Cyclophosphamide with low or high dose prednisolone for systemic sclerosis lung disease. The Journal of rheumatology, 2002, Volume: 29, Issue:2 Topics: Ambulatory Care; Anti-Inflammatory Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug	2002
[Effectiveness of long-term use of dimethyl sulfoxide in the complex treatment of patients with systemic scleroderma]. Terapevticheskii arkhiv, 1985, Volume: 57, Issue:8 Topics: Adolescent; Adult; Clinical Trials as Topic; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; D	1985
Immunosuppressive therapy. 1. The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5 Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid	1972

Article	Year
Successful Treatment of Systemic Sclerosis-related Pericarditis with Mycophenolate Mofetil and Low-dose Prednisolone. Internal medicine (Tokyo, Japan), 2022, Oct-15, Volume: 61, Issue:20 Topics: Aged; Female; Humans; Mycophenolic Acid; Pericardial Effusion; Pericarditis; Prednisolone; Scleroder	2022
Case of systemic sclerosis overlapping with psoriasis. International journal of rheumatic diseases, 2023, Volume: 26, Issue:6 Topics: Aged; Azathioprine; Female; Humans; Prednisolone; Psoriasis; Scleroderma, Diffuse; Scleroderma, Syst	2023
Glomerulonephritis associated with systemic sclerosis: a case report. Journal of medical case reports, 2023, Feb-08, Volume: 17, Issue:1 Topics: Adult; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytopl	2023
Comparison of therapeutic effects of combination therapy with prednisolone and tacrolimus or azathioprine on progressive interstitial pneumonia with systemic sclerosis. Modern rheumatology, 2022, Feb-28, Volume: 32, Issue:2 Topics: Azathioprine; Drug Therapy, Combination; Fibrosis; Humans; Immunosuppressive Agents; Lung Diseases,	2022
Serum LL-37 levels correlate with the efficacy of i.v. cyclophosphamide pulse for skin sclerosis and interstitial lung disease in systemic sclerosis. The Journal of dermatology, 2017, Volume: 44, Issue:4 Topics: Administration, Oral; Aged; Antimicrobial Cationic Peptides; Cathelicidins; Cyclophosphamide; Female	2017
Risk factors and outcome of Thai patients with scleroderma renal crisis: a disease duration-matched case control study. International journal of rheumatic diseases, 2017, Volume: 20, Issue:10 Topics: Adult; Aged; Cardiomyopathies; Chi-Square Distribution; Disease Progression; Female; Glucocorticoids	2017
An atypical case of scleroderma. British journal of hospital medicine (London, England : 2005), 2017, Oct-02, Volume: 78, Issue:10 Topics: Cyclophosphamide; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Administration Rou	2017
Efficacy and safety of combination therapy with prednisolone and oral tacrolimus for progressive interstitial pneumonia with systemic sclerosis: A retrospective study. Modern rheumatology, 2018, Volume: 28, Issue:6 Topics: Administration, Oral; Adult; Aged; Disease Progression; Drug Therapy, Combination; Female; Humans; J	2018
Overlapping Syndrome of Systemic Scleroderma and Cryoglobulinemic Vasculitis. The American journal of medicine, 2019, Volume: 132, Issue:6 Topics: Cryoglobulinemia; Female; Glucocorticoids; Humans; Methylprednisolone; Middle Aged; Prednisolone; Sc	2019
[Rapidly progressive pulmonary arterial hypertension associated with systemic sclerosis : a case report]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2013, Volume: 36, Issue:3 Topics: Aged; Disease Progression; Female; Humans; Hypertension, Pulmonary; Prednisolone; Scleroderma, Syste	2013
Recurrent cardiac tamponade in a young woman. BMJ case reports, 2013, Nov-29, Volume: 2013 Topics: Adult; Cardiac Tamponade; Cardiomegaly; Cyclophosphamide; Female; Humans; Hypothyroidism; Nifedipine	2013
Systemic sclerosis: comparison of efficacy of oral cyclophosphamide and azathioprine on skin score and pulmonary involvement-a retrospective study. Rheumatology international, 2014, Volume: 34, Issue:12 Topics: Administration, Oral; Adult; Aged; Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female	2014
Steroid-induced scleroderma renal crisis in an at-risk patient. BMJ case reports, 2014, Nov-13, Volume: 2014 Topics: Acute Kidney Injury; Aged; Antibodies, Antinuclear; DNA Topoisomerases, Type I; Fatal Outcome; Glome	2014
Unilateral acquired Brown's syndrome in systemic scleroderma: An unusual cause for diplopia. Indian journal of ophthalmology, 2015, Volume: 63, Issue:11 Topics: Adult; Diplopia; Female; Glucocorticoids; Humans; Ocular Motility Disorders; Prednisolone; Scleroder	2015
Unprecedented success of rituximab therapy for prednisolone- and immunosuppressant-resistant systemic sclerosis-associated interstitial lung disease. Scandinavian journal of rheumatology, 2017, Volume: 46, Issue:3 Topics: Female; Glucocorticoids; Humans; Immunologic Factors; Lung; Lung Diseases, Interstitial; Prednisolon	2017
Effect of Corticosteroids and Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic Lupus Erythematosus or Systemic Sclerosis. Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Aged; Case-Control Studies; Cluster Analysis; Cross-Sectional Studie	2017
Noncrescentic ANCA-associated renal crisis in systemic sclerosis. Clinical nephrology, 2008, Volume: 70, Issue:2 Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Diagnosis, Differential; Female; Glomerulonephritis; G	2008
Early aggressive intra-venous pulse cyclophosphamide therapy for interstitial lung disease in a patient with systemic sclerosis. A case report. Clinical rheumatology, 2009, Volume: 28 Suppl 1 Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Cyclophosphamide; Humans; Infusions, In	2009
[Mediastinal large B-cell lymphoma associated with systemic sclerosis]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2009, Volume: 50, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Female; Humans	2009
Coexistence of recurrent generalized morphea and systemic sclerosis. Acta dermato-venereologica, 2009, Volume: 89, Issue:3 Topics: Aged; Glucocorticoids; Humans; Male; Prednisolone; Recurrence; Scleroderma, Localized; Scleroderma,	2009
[Case of systemic sclerosis sine scleroderma showing pulmonary venula lesion that suggests pulmonary veno-occlusive disease]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2009, Volume: 47, Issue:5 Topics: Aged; Female; Humans; Hypertension, Pulmonary; Methylprednisolone; Prednisolone; Pulmonary Veno-Occl	2009
Clinical and subclinical atherosclerosis in systemic sclerosis: consequences of previous corticosteroid treatment. Scandinavian journal of rheumatology, 2010, Volume: 39, Issue:6 Topics: Adrenal Cortex Hormones; Adult; Atherosclerosis; Carotid Artery Diseases; Collagen Type III; E-Selec	2010
Subdural hematoma associated with immune thrombocytopenic purpura in two different clinical settings. The Journal of the Association of Physicians of India, 2010, Volume: 58 Topics: Adult; Female; Glucocorticoids; Hematoma, Subdural; Humans; Magnetic Resonance Imaging; Middle Aged;	2010
Systemic sclerosis in aquaporin-4 antibody-positive longitudinally extensive transverse myelitis. Journal of the neurological sciences, 2011, Apr-15, Volume: 303, Issue:1-2 Topics: Anti-Inflammatory Agents; Aquaporin 4; Autoantibodies; Brain; Facial Nerve Diseases; Female; Humans;	2011
Liver cirrhosis due to autoimmune hepatitis combined with systemic sclerosis. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2012, Volume: 59, Issue:1 Topics: Anti-Inflammatory Agents; Antibodies, Antinuclear; Esophageal and Gastric Varices; Female; Gastroint	2012
Recurrent bronchiolitis obliterans organizing pneumonia in a patient with limited cutaneous systemic sclerosis. Rheumatology international, 2002, Volume: 22, Issue:5 Topics: Aged; Biopsy, Needle; Cryptogenic Organizing Pneumonia; Female; Follow-Up Studies; Humans; Immunohis	2002
Corticosteroid-induced scleroderma renal crisis. The Medical journal of Australia, 2002, Oct-21, Volume: 177, Issue:8 Topics: Acute Kidney Injury; Female; Glucocorticoids; Humans; Middle Aged; Prednisolone; Renal Dialysis; Scl	2002
A case of juvenile systemic sclerosis with disease onset at six months old. Clinical rheumatology, 2003, Volume: 22, Issue:2 Topics: Age of Onset; Anti-Inflammatory Agents; DNA Topoisomerases, Type I; Humans; Infant; Male; Prednisolo	2003
[Favorable effects of prednisolone (deltacortril) in a case of progressive diffuse scleroderma]. Belgisch tijdschrift voor geneeskunde, 1956, May-01, Volume: 12, Issue:9 Topics: Basidiomycota; Prednisolone; Scleroderma, Diffuse; Scleroderma, Localized; Scleroderma, Systemic; St	1956
Acroparaesthesiae in sclerodactyly and carpal tunnel syndrome treated with prednisolone. Scottish medical journal, 1957, Volume: 2, Issue:11 Topics: Carpal Tunnel Syndrome; Disease; Paresthesia; Prednisolone; Scleroderma, Systemic; Wrist	1957
Acute pancreatitis complicating prednisolone therapy. Lancet (London, England), 1958, Dec-06, Volume: 2, Issue:7058 Topics: Humans; Pancreatitis; Prednisolone; Scleroderma, Systemic	1958
[TREATMENT OF COLLAGEN DISEASES]. Prensa medica argentina, 1963, Mar-29, Volume: 50 Topics: Arthritis; Arthritis, Rheumatoid; Autoimmune Diseases; Chloroquine; Collagen Diseases; Dermatomyosit	1963
[TRIAMCINOLONE IN ARTICULAR RHEUMATISM]. Hospital (Rio de Janeiro, Brazil), 1963, Volume: 64 Topics: Arthritis; Arthritis, Rheumatoid; Bursitis; Dexamethasone; Dupuytren Contracture; Fibromyalgia; Gout	1963
[ON HYPOPLASTIC AND APLASTIC ANEMIAS]. Zdravookhranenie Belorussii, 1963, Volume: 9 Topics: Adrenocorticotropic Hormone; Anemia, Aplastic; Blood Transfusion; Leukemia; Leukemia, Myeloid; Predn	1963
[THE ELECTROLYTE COMPOSITION OF THE BLOOD SERUM AND ADRENOCORTICAL FUNCTION IN PATIENTS WITH COLLAGEN DISEASES]. Terapevticheskii arkhiv, 1963, Volume: 35 Topics: Arthritis; Blood Chemical Analysis; Collagen Diseases; Electrolytes; Humans; Lupus Erythematosus, Sy	1963
DIFFUSE PULMONARY GRANULOMATOSES AND FIBROSES. Modern treatment, 1964, Volume: 1 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Beryllium; C	1964
SCLERODERMA. Nursing times, 1964, Jul-17, Volume: 60 Topics: Drug Therapy; Ethinyl Estradiol; Humans; Prednisolone; Scleroderma, Systemic	1964
The action of ACTH, cortisone and prednisone on the connective tissue of normal and sclerodermic human skin. The Journal of investigative dermatology, 1960, Volume: 34 Topics: Adrenocorticotropic Hormone; Connective Tissue; Cortisone; Humans; Prednisolone; Prednisone; Sclerod	1960
A case of pulmonary veno-occlusive disease associated with systemic sclerosis. Respirology (Carlton, Vic.), 2003, Volume: 8, Issue:3 Topics: Aged; Anti-Inflammatory Agents; Cardiac Catheterization; Diagnosis, Differential; Fatal Outcome; Hum	2003
The efficacy of oral cyclophosphamide plus prednisolone in early diffuse systemic sclerosis. Clinical rheumatology, 2003, Volume: 22, Issue:4-5 Topics: Administration, Oral; Adult; Cohort Studies; Cyclophosphamide; Dose-Response Relationship, Drug; Dru	2003
Low-titer cold agglutinin disease with systemic sclerosis. Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:2 Topics: Anemia, Hemolytic, Autoimmune; Coombs Test; Female; Glucocorticoids; Humans; Middle Aged; Prednisolo	2004
Augmented production of transforming growth factor-beta by cultured peripheral blood mononuclear cells from patients with systemic sclerosis. Archives of dermatological research, 2004, Volume: 296, Issue:2 Topics: Adult; Case-Control Studies; Cells, Cultured; Female; Humans; Leukocytes, Mononuclear; Male; Middle	2004
Improvement of skin sclerosis after occurrence of anticentromere antibody in a patient with diffuse cutaneous systemic sclerosis. Clinical rheumatology, 2004, Volume: 23, Issue:4 Topics: Administration, Oral; Adult; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Centromer	2004
Bilateral acquired Brown syndrome in systemic scleroderma. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2005, Volume: 9, Issue:2 Topics: Diplopia; Female; Follow-Up Studies; Glucocorticoids; Humans; Injections; Magnetic Resonance Imaging	2005
Clinical characteristics of juvenile systemic sclerosis in Japanese. The Journal of rheumatology, 2005, Volume: 32, Issue:9 Topics: Adolescent; Adult; Age Distribution; Age of Onset; Biopsy, Needle; Child; Child, Preschool; Cohort S	2005
[Case of protein-losing gastroenteropathy associated with scleroderma in which central serous chorioretinopathy developed]. Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2001, Volume: 24, Issue:3 Topics: Adult; Chorioretinitis; Female; Humans; Methylprednisolone; Prednisolone; Protein-Losing Enteropathi	2001
Pseudoscleroderma associated with cancer. Clinical and experimental dermatology, 2006, Volume: 31, Issue:3 Topics: Adenocarcinoma; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell	2006
Drug eruption due to bosentan in a patient with systemic sclerosis. Modern rheumatology, 2006, Volume: 16, Issue:3 Topics: Anti-Inflammatory Agents; Antihypertensive Agents; Bosentan; Drug Eruptions; Endothelin Receptor Ant	2006
A case of systemic sclerosis complicated by autoimmune hemolytic anemia. Modern rheumatology, 2006, Volume: 16, Issue:3 Topics: Aged; Anemia, Hemolytic, Autoimmune; Female; Glucocorticoids; Humans; Prednisolone; Scleroderma, Sys	2006
Serum nitric oxide metabolites and disease activity in patients with systemic sclerosis. Clinical rheumatology, 2008, Volume: 27, Issue:3 Topics: Adult; Anti-Inflammatory Agents; Biomarkers; Case-Control Studies; Female; Humans; Male; Middle Aged	2008
Left ventricular aneurysms developed in a patient with systemic sclerosis. Modern rheumatology, 2007, Volume: 17, Issue:6 Topics: Antihypertensive Agents; Coronary Aneurysm; Coronary Angiography; Diuretics; Drug Therapy, Combinati	2007
[Case of scleroderma with rapid progressive glomerulonephritis associated with both MPO-ANCA and anti-GBM antibodies]. Nihon Jinzo Gakkai shi, 2008, Volume: 50, Issue:1 Topics: Aged; Antibodies, Antineutrophil Cytoplasmic; Autoantibodies; Biomarkers; Disease Progression; Glome	2008
Systemic sclerosis associated with generalized vasculitis and hypopituitarism. Rheumatology international, 2008, Volume: 28, Issue:11 Topics: Anti-Inflammatory Agents; Female; Humans; Hypopituitarism; Hypothyroidism; Middle Aged; Prednisolone	2008
Relapsing organising pneumonitis in a man with primary biliary cirrhosis, CREST syndrome, and chronic pancreatitis. Thorax, 1983, Volume: 38, Issue:4 Topics: Chronic Disease; Humans; Liver Cirrhosis, Biliary; Male; Middle Aged; Pancreatitis; Pneumonia; Predn	1983
Glucose intolerance in patients with chronic inflammatory diseases is normalized by glucocorticoids. Acta medica Scandinavica, 1983, Volume: 213, Issue:5 Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Blood Glucose; Connective Tissue Diseases; Female; G	1983
[Scleroderma]. Fel'dsher i akusherka, 1980, Volume: 45, Issue:3 Topics: Adult; Female; Humans; Prednisolone; Scleroderma, Systemic	1980
Anti-poly(G) . poly(C) antibodies in the serum of patients with systemic lupus erythematosus. Clinical immunology and immunopathology, 1982, Volume: 22, Issue:3 Topics: Adult; Aged; Antibodies; Antibody Specificity; Arthritis, Rheumatoid; Binding Sites, Antibody; Chrom	1982
[Multifocal idiopathic fibrosis]. Problemy tuberkuleza, 1994, Issue:5 Topics: Adult; Diagnosis, Differential; Drug Therapy, Combination; Humans; Male; Penicillamine; Prednisolone	1994
Sclerodermatous syndrome after occupational exposure to herbicides--response to systemic steroids. Clinical and experimental dermatology, 1994, Volume: 19, Issue:6 Topics: Herbicides; Humans; Male; Middle Aged; Occupational Diseases; Prednisolone; Scleroderma, Systemic	1994
[A case of scleroderma renal crisis with acute interstitial pneumonia, microangiopathic hemolytic anemia and refractory thrombocytopenia]. Nihon Jinzo Gakkai shi, 1994, Volume: 36, Issue:9 Topics: Acute Disease; Acute Kidney Injury; Anemia, Hemolytic; Fatal Outcome; Female; Humans; Lung Diseases,	1994
Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis. American journal of respiratory and critical care medicine, 1994, Volume: 149, Issue:6 Topics: Adult; Age Factors; Bias; Biopsy; Blood Gas Analysis; Cyclophosphamide; Drug Therapy, Combination; D	1994
The predictive value of appearances on thin-section computed tomography in fibrosing alveolitis. The American review of respiratory disease, 1993, Volume: 148, Issue:4 Pt 1 Topics: Adult; Aged; Chi-Square Distribution; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; L	1993
Plasma concentration of human atrial natriuretic hormone in patients with connective tissue diseases. Clinical rheumatology, 1993, Volume: 12, Issue:2 Topics: Adult; Arthritis, Rheumatoid; Atrial Natriuretic Factor; Creatinine; Electrocardiography; Female; He	1993
A sclerodermatous syndrome with unusual features following prolonged occupational exposure to organic solvents. The British journal of dermatology, 1993, Volume: 128, Issue:2 Topics: Azathioprine; Chemical Industry; Humans; Male; Middle Aged; Occupational Diseases; Prednisolone; Scl	1993
Chromosome abnormalities in peripheral lymphocytes from patients with progressive systemic sclerosis. Rheumatology international, 1993, Volume: 12, Issue:6 Topics: Adult; Aged; Asian People; Base Sequence; Cells, Cultured; Chromosome Aberrations; Chromosome Disord	1993
Childhood-onset scleroderma: is it different from adult-onset disease. Arthritis and rheumatism, 1996, Volume: 39, Issue:6 Topics: Adolescent; Adult; Age of Onset; Anti-Inflammatory Agents; Antirheumatic Agents; Autoantibodies; Chi	1996
[A case of steroid tuberculosis in systemic scleroderma]. Problemy tuberkuleza, 1996, Issue:2 Topics: Adult; Female; Humans; Prednisolone; Recurrence; Scleroderma, Systemic; Time Factors; Tuberculosis,	1996
Bronchoalveolar lavage for evaluation and management of scleroderma disease of the lung. American journal of respiratory and critical care medicine, 1996, Volume: 154, Issue:2 Pt 1 Topics: Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cyclophosphamide; Drug T	1996
[Progressive systemic sclerosis associated with massive pleural and pericardial effusion in a 90-year-old woman]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 1996, Volume: 33, Issue:7 Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Female; Humans; Pericardial Effusion; Pleural Eff	1996
Circadian variations of plasma levels of blood coagulation/fibrinolysis molecular markers in progressive systemic sclerosis (PSS). Journal of dermatological science, 1996, Volume: 13, Issue:1 Topics: Adult; Aged; alpha-2-Antiplasmin; Antifibrinolytic Agents; Antithrombin III; beta-Thromboglobulin; B	1996
Elevated serum tumor necrosis factor-alpha levels in patients with systemic sclerosis: association with pulmonary fibrosis. The Journal of rheumatology, 1997, Volume: 24, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Female; Humans; Male; Middle Aged; Prednis	1997
Reduced protein tyrosine phosphatase (PTPase) activity of CD45 on peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE). Clinical and experimental immunology, 1997, Volume: 109, Issue:1 Topics: Adult; Aniline Compounds; Anti-Inflammatory Agents; Female; Fluorescent Antibody Technique, Indirect	1997
Myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibodies -- related scleroderma renal crisis treated with double-filtration plasmapheresis. Internal medicine (Tokyo, Japan), 1997, Volume: 36, Issue:7 Topics: Acute Kidney Injury; Antibodies, Antineutrophil Cytoplasmic; Anticoagulants; Autoimmune Diseases; Bi	1997
Calcitonin and mandibular bone resorption in systemic sclerosis. The Journal of rheumatology, 1999, Volume: 26, Issue:3 Topics: Bone Resorption; Calcitonin; Captopril; Female; Humans; Jaw; Mandible; Middle Aged; Pain; Prednisolo	1999
Pulmonary involvement in diffuse cutaneous systemic sclerosis: broncheoalveolar fluid granulocytosis predicts progression of fibrosing alveolitis. Annals of the rheumatic diseases, 1999, Volume: 58, Issue:10 Topics: Bronchoalveolar Lavage Fluid; Cell Count; Female; Glucocorticoids; Granulocytes; Humans; Logistic Mo	1999
[Cutaneo-systemic papulosclerotic mucinosis (scleromyxedema): remission after extracorporeal photochemotherapy and corticoid bolus]. Annales de dermatologie et de venereologie, 2001, Volume: 128, Issue:1 Topics: Combined Modality Therapy; Female; Glucocorticoids; Humans; Middle Aged; Myxedema; Photopheresis; Pr	2001
Calcinosis universalis in a case of progressive systemic sclerosis. The Journal of the Association of Physicians of India, 1998, Volume: 46, Issue:5 Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, Needle; Calcinosis; D	1998
[A case of recurrent hemophagocytic syndrome complicated with systemic sclerosis: relationship between disease activity and serum level of IL-18]. Ryumachi. [Rheumatism], 2001, Volume: 41, Issue:3 Topics: Adult; Biomarkers; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Interleukin-18; Prednisolone;	2001
Systemic sclerosis complicated with nephrotic syndrome: relevance with antiribosomal P antibody. Rheumatology international, 2001, Volume: 21, Issue:1 Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Autoantibodies; Autoantigens; Complement C3;	2001
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment. Annals of the rheumatic diseases, 2002, Volume: 61, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Arthritis, Psoriatic; Arthritis, Rheumatoid; Biomarkers; C-Reactive	2002
[Hyperergic collagenoses. Clinical aspects, differential diagnosis and therapy (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1977, Oct-21, Volume: 119, Issue:42 Topics: Adolescent; Adult; Age Factors; Aged; Azathioprine; Child; Collagen Diseases; Cyclophosphamide; Derm	1977
Treatment of generalized scleroderma with combined traditional Chinese and western medicine: report of 30 cases. Chinese medical journal, 1979, Volume: 92, Issue:6 Topics: Adult; Aged; Female; Humans; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional;	1979
Mixed connective tissue disease in childhood. A clinical and serologic survey. The Journal of pediatrics, 1977, Volume: 90, Issue:6 Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Antibodies, Antinuclear; Antigens, Viral; Child; C	1977
Scleroderma treated with immunosuppressive drugs. The British journal of dermatology, 1979, Volume: 101 Suppl 17 Topics: Antilymphocyte Serum; Azathioprine; Female; Humans; Immunosuppressive Agents; Middle Aged; Prednisol	1979
Lupus-scleroderma syndrome induced by ethosuximide. Archives of disease in childhood, 1975, Volume: 50, Issue:8 Topics: Adolescent; Anemia; Epilepsy, Tonic-Clonic; Ethosuximide; Female; Humans; Lupus Erythematosus, Syste	1975
[Long-term clinical-dispensary treatment of patients with systemic scleroderma]. Terapevticheskii arkhiv, 1976, Volume: 48, Issue:6 Topics: Adolescent; Adult; Cyclophosphamide; Drug Evaluation; Female; Heparin; Humans; Male; Middle Aged; Pr	1976
Progressive systemic sclerosis and polymyositis. Proceedings of the Royal Society of Medicine, 1976, Volume: 69, Issue:11 Topics: Dermatomyositis; Female; Humans; Middle Aged; Myositis; Prednisolone; Scleroderma, Systemic	1976
Scleroderma cerebritis, an unusual manifestation of progressive systemic sclerosis. Diseases of the nervous system, 1975, Volume: 36, Issue:2 Topics: Adult; Cerebral Hemorrhage; Chlorpromazine; Delirium; Delusions; Electroencephalography; Female; Hal	1975
[An analysis of the hormonal response during the performance of stress tests in patients with systemic lupus erythematosus and systemic scleroderma]. Terapevticheskii arkhiv, 1992, Volume: 64, Issue:5 Topics: Adrenocorticotropic Hormone; Female; Hormones; Humans; Lupus Erythematosus, Systemic; Male; Predniso	1992
In vivo levels and in vitro production of interferon-gamma in fibrosing interstitial lung diseases. Clinical and experimental immunology, 1992, Volume: 88, Issue:2 Topics: Adult; Aged; Bronchoalveolar Lavage Fluid; Female; Humans; In Vitro Techniques; Interferon-alpha; In	1992
[Plasmapheresis in polymyositis and progressive systemic sclerosis]. Nihon rinsho. Japanese journal of clinical medicine, 1992, Volume: 50 Suppl Topics: Cyclophosphamide; Humans; Leukapheresis; Myositis; Plasmapheresis; Prednisolone; Scleroderma, System	1992
[Therapeutic possibilities in systemic scleroderma]. Zeitschrift fur arztliche Fortbildung, 1992, Mar-10, Volume: 86, Issue:5 Topics: Antibodies, Antinuclear; Autoantibodies; Azathioprine; Combined Modality Therapy; Dose-Response Rela	1992
Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis. The Journal of dermatology, 1992, Volume: 19, Issue:5 Topics: Female; Humans; Middle Aged; Penicillamine; Prednisolone; Recurrence; Scleroderma, Localized; Sclero	1992
[A case of progressive systemic sclerosis and Sjögren's syndrome complicated by parkinsonism with special reference to the beneficial effect of corticosteroid]. Rinsho shinkeigaku = Clinical neurology, 1991, Volume: 31, Issue:11 Topics: Aged; Drug Resistance; Female; Humans; Levodopa; Parkinson Disease; Prednisolone; Scleroderma, Syste	1991
[Bronchoalveolar lavage in patients with systemic scleroderma and systemic lupus erythematosus: characterization of cell activity by cytofluorometry, chemiluminescence and differential cell count]. Zeitschrift fur Erkrankungen der Atmungsorgane, 1991, Volume: 176, Issue:1 Topics: Adult; Azathioprine; B-Lymphocyte Subsets; Bronchoalveolar Lavage Fluid; Female; Flow Cytometry; Hum	1991
[Diagnosis and clinical symptoms of systemic lupus erythematosus and overlap syndrome]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1990, Oct-10, Volume: 79, Issue:10 Topics: Antibodies, Antinuclear; Captopril; Humans; Lupus Erythematosus, Systemic; Mixed Connective Tissue D	1990
[Interstitial lung disease in systemic lupus erythematosus, progressive systemic sclerosis and dermatomyositis]. Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48, Issue:3 Topics: Dermatomyositis; Humans; Lupus Erythematosus, Systemic; Prednisolone; Prognosis; Pulmonary Fibrosis;	1990
[Hemosorption in the complex treatment of rheumatic diseases]. Terapevticheskii arkhiv, 1985, Volume: 57, Issue:8 Topics: Adult; Aortitis; Combined Modality Therapy; Connective Tissue Diseases; Dextrans; Female; Follow-Up	1985
[Therapy of rheumatic diseases with inosiplex]. Immunitat und Infektion, 1986, Volume: 14, Issue:3 Topics: Adult; Aged; Antibodies, Antinuclear; Autoimmune Diseases; Collagen Diseases; Complement System Prot	1986
[Secondary amyloidosis associated with overlap syndrome of rheumatoid arthritis, progressive systemic sclerosis and polymyositis]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1989, Volume: 78, Issue:9 Topics: Amyloidosis; Arthritis, Rheumatoid; Dimethyl Sulfoxide; Female; Humans; Kidney; Middle Aged; Myositi	1989
[Microangiopathic hemolytic anemia associated with progressive systemic sclerosis]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 1988, Volume: 29, Issue:8 Topics: Acute Kidney Injury; Anemia, Hemolytic; Female; Humans; Middle Aged; Prednisolone; Scleroderma, Syst	1988
[Clinical study of autoimmune diseases: recent trends--with special reference to progress in immunological tests and therapeutic methods. Systemic autoimmune diseases. 2) Systemic scleroderma and polymyositis]. Nihon rinsho. Japanese journal of clinical medicine, 1988, Volume: 46, Issue:4 Topics: Antibodies, Antinuclear; Antibody Formation; Autoantibodies; Humans; Immunity, Cellular; Immunosuppr	1988
Studies on the mechanism of action of asiaticoside (Madecassol) on experimental granulation tissue and cultured fibroblasts and its clinical application in systemic scleroderma. Acta dermato-venereologica, 1972, Volume: 52, Issue:2 Topics: Adolescent; Adult; Animals; Carrageenan; Collagen; Connective Tissue; Cytoplasmic Granules; Female;	1972
[The mutual effects of scleroderma diffusum and pregnancy]. Zentralblatt fur Gynakologie, 1969, Apr-19, Volume: 91, Issue:16 Topics: Abortion, Spontaneous; Adrenocorticotropic Hormone; Adult; Female; Humans; Prednisolone; Pregnancy;	1969
Scleroderma. Bulletin of the Calcutta School of Tropical Medicine, 1970, Volume: 18, Issue:4 Topics: Acridines; Adrenocorticotropic Hormone; Adult; Amino Alcohols; Female; Humans; Isoxsuprine; Predniso	1970
Long-term effect of corticosteroids on cardiac function. Japanese heart journal, 1974, Volume: 15, Issue:5 Topics: Adolescent; Adult; Arthritis, Rheumatoid; Collagen Diseases; Cushing Syndrome; Electrocardiography;	1974
Treatment of progressive systemic sclerosis with a synthetic weak estrogen: cyclofenil (Sexovid). Report of a case. Acta medica Scandinavica, 1974, Volume: 196, Issue:6 Topics: Administration, Oral; Cresols; Cyclofenil; Drug Therapy, Combination; Estradiol Congeners; Humans; J	1974
Monoclonal gammopathy penicillamine-induced polymyositis and systemic sclerosis. Archives of dermatology, 1974, Volume: 110, Issue:2 Topics: Aged; Biopsy; Humans; Hypergammaglobulinemia; Japan; Male; Myositis; Penicillamine; Prednisolone; Sc	1974
[Treatment of dermatoses with 6-methyl-prednisolone acetate ointment]. Minerva medica, 1972, Jan-17, Volume: 63, Issue:3 Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents; Child; Dermatitis; Eczema; Female; H	1972
Diffuse haemorrhagic gastritis in scleroderma. The Medical journal of Australia, 1971, Aug-14, Volume: 2, Issue:7 Topics: Blood Transfusion; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged	1971
[Clinico-theoretical bases of steroid therapy of collagen diseases]. Vestnik Akademii meditsinskikh nauk SSSR, 1969, Volume: 24, Issue:7 Topics: Arthritis, Rheumatoid; Collagen Diseases; Humans; Lupus Erythematosus, Systemic; Prednisolone; Pyraz	1969
Progressive systemic sclerosis (scleroderma). Australasian annals of medicine, 1970, Volume: 19, Issue:2 Topics: Adult; Asian People; China; Edema; Female; Gastrointestinal Diseases; Heart Diseases; Humans; Joint	1970
[Collagen diseases. On clinical aspects and theapy of disseminated lupus erythematosus, progressive scleroderma and dermatomyositis]. Hippokrates, 1969, Aug-31, Volume: 40, Issue:16 Topics: Collagen Diseases; Dermatomyositis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic;	1969
Scleroderma in a boy of nine. Journal of the Indian Medical Association, 1966, Aug-01, Volume: 47, Issue:3 Topics: Child; Humans; India; Male; Prednisolone; Scleroderma, Systemic	1966

prednisolone and Sclerosis, Systemic

Research Excerpts

Research

Studies (139)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Higashioka, K	1
Migita, R	1
Ota, T	1
Uchino, A	1
Niiro, H	1
Xie, Y	1
Hua, X	1
Tan, H	1
Rao, L	1
Zhou, P	1
Nayebirad, S	1
Ramandi, A	1
Nili, F	1
Atef-Yekta, R	1
Tamartash, Z	1
Salehi, S	1
Kavosi, H	1
Kano, Y	1
Kato, H	1
Koike, H	1
Katsuno, M	1
Oguri, T	1
Yuasa, H	1
Watanabe, Y	2
Yamamoto, M	2
Yamamoto, T	1
Kiboshi, T	1
Kotani, T	2
Konma, J	2
Makino, H	3
Matsuda, S	1
Suzuka, T	2
Wada, Y	1
Shiba, H	1
Hata, K	2
Shoda, T	2
Takeuchi, T	3
Takahashi, T	2
Asano, Y	2
Taniguchi, T	2
Yoshizaki, A	2
Sato, S	6
Wangkaew, S	1
Lertthanaphok, S	1
Puntana, S	1
Noppakun, K	1
Stavrou, C	1
Wincup, C	1
Kravvas, G	1
Manson, J	1
Fujiki, Y	1
Nagai, K	1
Yoshida, S	1
Makino, S	1
Arawaka, S	1
Horino, T	1
Hamada-Ode, K	1
Ichii, O	1
Terada, Y	1
Soh, HJ	1
Samuel, C	1
Heaton, V	1
Renton, WD	1
Cox, A	1
Munro, J	1
Ishida, M	1
Miyamura, T	1
Kaieda, T	1
Kimura, D	1
Nakamura, A	1
Takahama, S	1
Kiyasu, J	1
Minami, R	1
Suematsu, E	1
Itolikar, SM	1
Salagre, S	1
Phatak, S	1
Itolikar, M	1
Poormoghim, H	1
Rezaei, N	1
Sheidaie, Z	1
Almasi, AR	1
Moradi-Lakeh, M	1
Almasi, S	1
Andalib, E	1
Toescu, SM	1
Mansell, A	1
Dinneen, E	1
Persey, M	1
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