prednisolone and Pregnancy studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
"Promethazine reduces the symptoms of hyperemesis gravidarum faster than prednisolone, but during prolonged treatment, prednisolone has at least the same effects on the symptoms and less drug side-effects."	9.11	The efficacy low dose of prednisolone in the treatment of hyperemesis gravidarum. ( Faghihzadeh, S; Hosseiney, FS; Ziaei, S, 2004)
"During pregnancy the placental 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) enzyme inactivates prednisolone by interconversion into prednisone, protecting the fetus from high levels of prednisolone."	9.11	The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. ( Bruinse, HW; Franx, A; Huisjes, AJ; Schobben, AF; van Runnard Heimel, PJ, 2005)
"Low-dose prednisolone treatment in addition to the standard protocol before and after embryo replacement does not appear to have a significant effect on pregnancy or implantation rates."	9.10	Low dose prednisolone administration in routine ICSI patients does not improve pregnancy and implantation rates. ( Anniballo, R; Cobellis, L; Ferrero, S; Greco, E; Iacobelli, M; Rienzi, L; Ubaldi, F, 2002)
" In the present study 20 infertile women with polycystic ovary syndrome were prospectively randomized in a placebo-controlled study to receive either placebo or prednisolone 10 mg at night, during standard in-vitro fertilization (IVF) treatment."	9.09	Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. ( Carlström, K; Fridström, M; Hillensjö, T; Sjöblom, P, 1999)
" The study assessed the effect of prednisolone treatment on the concentration of VEGF, pregnancy outcomes and variants of VEGF SNPs."	7.96	The effect of prednisolone on endometrial VGEF concentrations, Gene polymorphisms and pregnancy outcome in women with polycystic ovary syndrome: A retrospective cohort study. ( Aldakheel, FM; Bi, H; Sawsan Aloahd, M, 2020)
"This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment."	7.91	The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study. ( Cooper, S; Laird, SM; Li, TC; Mariee, N; Metwally, M, 2019)
"8%) pregnancies, and these patients had a significantly higher dose of prednisolone, hypocomplementemia, lower estimated glomerular filtration rate, past history of lupus nephritis, and complication with antiphospholipid syndrome."	7.88	The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus. ( Fujikawa, K; Fukui, S; Horai, Y; Ichinose, K; Iwamoto, N; Kawakami, A; Kawashiri, SY; Kitajima, Y; Koga, T; Masuzaki, H; Nakamura, H; Nishino, A; Origuchi, T; Sato, S; Tamai, M; Umeda, M; Yasuhi, I, 2018)
"This observational, retrospective, single-center cohort study aimed to assess pregnancy outcome in women with antiphospholipid antibodies who were treated with hydroxychloroquine in addition to conventional treatment during pregnancy."	7.83	The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. ( Cuadrado, MJ; Hunt, BJ; Khamashta, MA; Lliso, G; Sciascia, S; Talavera-Garcia, E, 2016)
"The objective of this study was to assess pregnancy outcome in women with a history of refractory antiphospholipid antibody-associated pregnancy loss(es) who were treated with early low-dose prednisolone in addition to aspirin and heparin."	7.77	First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss. ( Bramham, K; Hunt, BJ; Khamashta, M; Nelson-Piercy, C; Thomas, M, 2011)
"To investigate the effect of prednisolone on HELLP syndrome by assessing several markers of the inflammatory response and hepatic damage associated with HELLP syndrome."	7.74	HELLP syndrome is associated with an increased inflammatory response, which may be inhibited by administration of prednisolone. ( Bruinse, HW; Franx, A; Heijnen, CJ; Huisjes, AJ; Kavelaars, A; Peters, WH; van Runnard Heimel, PJ, 2008)
"In a 32-year-old woman, alopecia universalis went into unequivocal remission during pregnancy and prednisolone therapy."	7.69	Alopecia universalis with remission during pregnancy and prednisolone therapy. ( Aizawa, T; Asanuma, N; Hashizume, K; Sakurai, A, 1997)
"A 27-year-old woman with anti-phospholipid antibody syndrome, whose first pregnancy had ended in intrauterine fetal death, was treated with prednisolone 0."	7.68	[Fetal survival after the corticosteroid and low-dose aspirin regimen in a case of anti-phospholipid antibody syndrome]. ( Maruyama, I; Maruyama, Y; Okadome, T; Osame, M; Shimmyozu, K; Tara, M, 1990)
"The effects of prednisolone and ACTH on in vitro oxygen consumption and aerobic and anaerobic glycolysis of human placentas of early pregnancy were studied."	7.66	[The effect of prednisolone and ACTH on the in vitro metabolism of human placenta from early pregnancy (author's transl)]. ( Csaba, IF; Nagy, P, 1981)
"A case of a woman affected by a nephrotic postnephritic syndrome and treated during pregnancy with cortisone and prednisolone, is reported."	7.66	Nephrotic syndrome in pregnancy: cortisone and prednisolone treatment: clinical case. ( Enrichi, M; Marchesoni, D; Mozzanega, B, 1981)
" Treatment with antimalarials and folic acid is usually followed by a rapid remission, but response is slow in about 25% of patients and haemolysis continues uncontrolled in about 5%."	7.65	Severe haemolytic anaemia in pregnancy in Nigerians treated with prednisolone. ( Allan, NC; Fleming, AF, 1969)
"Acquired haemophilia A (AHA) is a rare bleeding disorder, characterised by the presence of autoantibodies to clotting factor VIII (FVIII)."	5.72	Acquired Hemophilia A following Pfizer-BioNTech SARS CoV-2 mRNA vaccine, successfully treated with prednisolone and rituximab. ( Gilbar, PJ; Mangos, HM; Murali, A; Wong, P, 2022)
" Pregnancy with SLE is associated with an increase risk of adverse maternal and fetal outcomes."	5.40	Safety of tacrolimus treatment during pregnancy and lactation in systemic lupus erythematosus: a report of two patients. ( Izumi, Y; Migita, K; Miyashita, T, 2014)
"Prednisolone or IVIG was then added to the tube with E:T ratio of 50:1 to assess suppressive effect."	5.35	Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity. ( Abdalla, HI; Bansal, A; Bhaskaran, S; Ford, B; Sumar, N; Thum, MY, 2008)
"Treatment with prednisolone (7."	5.30	[A case of antiphospholipid antibody syndrome successfully treated with prednisolone and low-dose aspirin, with subsequent normal pregnancy]. ( Maeda, T; Maesima, E; Yamada, Y; Yamamoto, M; Yukawa, S, 1997)
"A case of full blown systemic lupus erythematosus (SLE) was treated with steroid."	5.29	Danazol for thrombocytopenia in pregnancy with underlying systemic lupus erythematosus. ( Bumpenboon, T; Chanchairujira, T; Insiripong, S, 1996)
"We did a statistical analysis and found that oral immunosuppressants (including cyclosporine A or prednisolone) can improve pregnancy outcomes in patients with idiopathic RM, increase live birth rate and ongoing pregnancy rate, and reduce miscarriage rate."	5.22	Oral immunosuppressants improve pregnancy outcomes in women with idiopathic recurrent miscarriage: A meta-analysis. ( Hang, F; Liao, M; Ma, N; Qin, A; Qin, R; Qin, W; Zhao, Y, 2022)
"A combination of oral prednisolone and low molecular weight heparin may have a significant effect on pregnancy and implantation rates in prior unexplained, failed implantation."	5.19	Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure? ( El-Refaeey, AA; Fawzy, M, 2014)
"Through a non-randomized clinical trial, we examined the theoretical benefit of the coadministration of low molecular weight heparin (LMWH) and prednisolone on pregnancy outcomes in women with previously failed IVF/ICSI cycles."	5.17	Addition of prednisolone and heparin in patients with failed IVF/ICSI cycles: a preliminary report of a clinical trial. ( Chrelias, C; Creatsa, M; Iliodromiti, Z; Kassanos, D; Siristatidis, C; Varounis, C; Vrachnis, N, 2013)
"To test whether adjuvant therapy with acetylsalicylic acid (ASA) and prednisolone (ASA+Pred) could improve the outcome of IVF in good-pregnancy prognosis patients."	5.13	Low-dose acetylsalicylic acid plus prednisolone as an adjuvant treatment in IVF: a prospective, randomized study. ( Dolfin, E; Gennarelli, G; Holte, JG; Lantieri, T; Massobrio, M; Revelli, A; Tur-Kaspa, I, 2008)
"To investigate the effects of short-term low-dose aspirin and/or steroid use on implantation and pregnancy rates in nonselected intracytoplasmic sperm injection (ICSI) cycles."	5.12	Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study. ( Atabekoglu, CS; Berker, B; Duvan, CI; Ozmen, B; Satiroglu, H, 2006)
"Promethazine reduces the symptoms of hyperemesis gravidarum faster than prednisolone, but during prolonged treatment, prednisolone has at least the same effects on the symptoms and less drug side-effects."	5.11	The efficacy low dose of prednisolone in the treatment of hyperemesis gravidarum. ( Faghihzadeh, S; Hosseiney, FS; Ziaei, S, 2004)
"During pregnancy the placental 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) enzyme inactivates prednisolone by interconversion into prednisone, protecting the fetus from high levels of prednisolone."	5.11	The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. ( Bruinse, HW; Franx, A; Huisjes, AJ; Schobben, AF; van Runnard Heimel, PJ, 2005)
"Although the effectiveness of prednisolone therapy for severe hyperemesis gravidarum has been demonstrated, there is no consensus on how to assess severity to justify such treatment, nor any information on whether such therapy affects birth weight."	5.10	Management of hyperemesis gravidarum: the importance of weight loss as a criterion for steroid therapy. ( Moran, P; Taylor, R, 2002)
" In the present study 20 infertile women with polycystic ovary syndrome were prospectively randomized in a placebo-controlled study to receive either placebo or prednisolone 10 mg at night, during standard in-vitro fertilization (IVF) treatment."	5.09	Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. ( Carlström, K; Fridström, M; Hillensjö, T; Sjöblom, P, 1999)
"The effects of prednisolone on pregnancy outcome are open to debate."	4.91	Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis. ( Dan, S; Hong, L; Hongbo, C; Jiaxiong, W; Shenmin, Y; Wei, W; Yichao, S, 2015)
" There is also a subgroup of women with APS and recurrent fetal loss with no response to the standard antithrombotic therapy; in this group the materno-fetal prognosis could be improved by the addition of low-dose prednisolone during the first trimester of pregnancy."	4.89	Clinical advances of interest in the diagnosis and treatment of patients with antiphospholipid syndrome. ( Khamashta, MA; Rodríguez García, JL, 2013)
" In 16/17 cases with pre-pregnancy recognition, intravenous gammaglobulin (IVGG) was administered antenatally (gestation at commencement ranging from 13 to 26 weeks) with adjuvant prednisolone in three cases."	4.88	A review of the contemporary management of fetal and neonatal alloimmune thrombocytopenia in an Australian tertiary obstetric hospital. ( Cook, TJ; Dickinson, JE; Qiu, CC, 2012)
"MODE OF ACTION OF URSODEOXYCHOLIC ACID: In cholestasis, the impaired biliary secretion of toxic bile acids causes their accumulation in the liver and a subsequent hepatic failure."	4.81	[Treatment of cholestatic liver diseases]. ( Gatzen, M; Pausch, J, 2002)
" The study assessed the effect of prednisolone treatment on the concentration of VEGF, pregnancy outcomes and variants of VEGF SNPs."	3.96	The effect of prednisolone on endometrial VGEF concentrations, Gene polymorphisms and pregnancy outcome in women with polycystic ovary syndrome: A retrospective cohort study. ( Aldakheel, FM; Bi, H; Sawsan Aloahd, M, 2020)
"This retrospective study of prospectively collected data examines the effect of prednisolone therapy on raised uterine Natural Killer cell (uNK) concentrations and pregnancy outcomes in women with recurrent miscarriage (RM) and recurrent implantation failure (RIF) after IVF/ICSI treatment."	3.91	The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study. ( Cooper, S; Laird, SM; Li, TC; Mariee, N; Metwally, M, 2019)
"8%) pregnancies, and these patients had a significantly higher dose of prednisolone, hypocomplementemia, lower estimated glomerular filtration rate, past history of lupus nephritis, and complication with antiphospholipid syndrome."	3.88	The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus. ( Fujikawa, K; Fukui, S; Horai, Y; Ichinose, K; Iwamoto, N; Kawakami, A; Kawashiri, SY; Kitajima, Y; Koga, T; Masuzaki, H; Nakamura, H; Nishino, A; Origuchi, T; Sato, S; Tamai, M; Umeda, M; Yasuhi, I, 2018)
"In this retrospective case series, we found no evidence of prolonged effects of maternal prednisolone use during pregnancy on the neonatal hypothalamic-pituitary-adrenal axis."	3.85	Maternal use of prednisolone is unlikely to be associated with neonatal adrenal suppression-a single-center study of 16 cases. ( Bocca, G; de Vetten, L; Kema, IP; van Stuijvenberg, M, 2017)
"This observational, retrospective, single-center cohort study aimed to assess pregnancy outcome in women with antiphospholipid antibodies who were treated with hydroxychloroquine in addition to conventional treatment during pregnancy."	3.83	The impact of hydroxychloroquine treatment on pregnancy outcome in women with antiphospholipid antibodies. ( Cuadrado, MJ; Hunt, BJ; Khamashta, MA; Lliso, G; Sciascia, S; Talavera-Garcia, E, 2016)
"The overall, clinical pregnancy and live birth rate in ATA-positive patients receiving prednisolone supplementation was significantly higher when confronted with ATA-positive untreated subjects (60."	3.81	In women with thyroid autoimmunity, does low-dose prednisolone administration, compared with no adjuvant therapy, improve in vitro fertilization clinical results? ( Arrivi, C; Greco, E; Litwicka, K; Mencacci, C; Varricchio, MT, 2015)
" Because the patient was allergic to mesalazine, adalimumab (ADA) was used as maintenance therapy during pregnancy, following prednisolone as remission induction therapy."	3.79	Maintenance of the remission stage of Crohn's disease with adalimumab therapy during pregnancy. ( Ebi, M; Joh, T; Kamiya, T; Katano, T; Kataoka, H; Mizoshita, T; Mori, Y; Ozeki, K; Tanida, S; Tsukamoto, H, 2013)
"The objective of this study was to assess pregnancy outcome in women with a history of refractory antiphospholipid antibody-associated pregnancy loss(es) who were treated with early low-dose prednisolone in addition to aspirin and heparin."	3.77	First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss. ( Bramham, K; Hunt, BJ; Khamashta, M; Nelson-Piercy, C; Thomas, M, 2011)
"To investigate the effect of prednisolone on HELLP syndrome by assessing several markers of the inflammatory response and hepatic damage associated with HELLP syndrome."	3.74	HELLP syndrome is associated with an increased inflammatory response, which may be inhibited by administration of prednisolone. ( Bruinse, HW; Franx, A; Heijnen, CJ; Huisjes, AJ; Kavelaars, A; Peters, WH; van Runnard Heimel, PJ, 2008)
" Low dose aspirin of 81 mg per every 3 day and prednisolone of 12 mg per every 2 day maintained her aortitis in good control through pregnancy."	3.74	Sudden cardiac arrest during cesarean section due to epidural anaesthesia using ropivacaine: a case report. ( Fukuda, I; Furuya, K; Matsuda, H; Yoshida, M, 2008)
"We present a case of fetal death in a 28-year-old pregnant woman being treated with intravenous prednisolone for VKH disease."	3.74	[Fetal death following high-dose systemic steroid therapy in a pregnant patient with Vogt-Koyanagi-Harada disease]. ( Ashida, T; Gotoh, N; Ohta, K; Oka, K; Yonezawa, H, 2007)
"To evaluate the association of antinuclear antibodies (ANA) with outcome of in vitro fertilization-embryo transfer (IVF-ET) as well as the effect of short-term immunosuppression with prednisolone on implantation, clinical pregnancy and live birth rates following IVF-ET."	3.73	Results of prednisolone given to improve the outcome of in vitro fertilization-embryo transfer in women with antinuclear antibodies. ( Taniguchi, F, 2005)
"To elucidate the efficacy of the treatment using a Japanese-modified Chinese herbal medicine, Sairei-to, and low-dose aspirin with or without a corticosteroid hormone for the patients with adverse pregnancy histories positive for anti-phospholipid antibodies."	3.73	Prophylactic therapy for patients with reproductive failure who were positive for anti-phospholipid antibodies. ( Ishii, K; Kikuchi, A; Nonaka, T; Ooki, I; Takakuwa, K; Tamura, M; Tamura, N; Tanaka, K, 2006)
"We treated four pregnancy cases positive for antiphospholipid antibodies (APLs) who had experienced recurrent second trimester fetal or neonatal losses using a Japanese modified Chinese herbal medicine, Sairei-to, low dose aspirin and adrenocorticosteroid hormone."	3.72	Effect of sairei-to combined with aspirin and prednisolone on four recurrent reproductive failure women who are positive for anti-phospholipid antibodies. ( Adachi, H; Ishii, K; Kurabayasi, T; Kurata, H; Natsume, N; Takaki, Y; Takakuwa, K; Tamura, M; Tanaka, K, 2003)
"Intraocular pressure was monitored by Perkins applanation tonometry in a group of 12 cows receiving topically administered prednisolone acetate in 1 eye 3 times a day for a period of 49 days after the establishment of baseline IOP values."	3.72	Steroid-induced ocular hypertension in normal cattle. ( Candia, OA; Danias, J; Gerometta, R; Malgor, LA; Mittag, T; Podos, SM; Wu, B, 2004)
"Prednisolone is widely used to treat medical conditions in pregnancy, despite the lack of long-term safety studies on infants."	3.72	Infant cortisol response after prolonged antenatal prednisolone treatment. ( Fisk, NM; Glover, V; Miller, NM; Williamson, C, 2004)
" During pregnancy she was treated with a daily dosage of prednisolone 15 mg."	3.70	Successful pregnancy and delivery in a case of systemic lupus erythematosus treated with immunoadsorption therapy and cyclosporin A. ( Kodama, N; Maeshima, E; Mune, M; Yamada, Y; Yukawa, S, 1999)
" The question of whether anti-GM3 antibodies might exert influence in APLs-positive recurrent pregnancy loss patients who are undergoing prednisolone and aspirin (PSL/ASA) treatment was investigated."	3.69	Clinical significance of anti-GM3 antibodies in recurrent pregnancy loss with elevated level of antiphospholipid antibodies. ( Aoki, K; Aoyama, T; Kunimatsu, M; Ozaki, Y, 1995)
"This prospective study is an attempt to address the issues of whether or not antiphospholipid antibodies (aPL) constitute a significant risk factor for pregnancy in individuals with systemic lupus erythematosus (SLE) and whether or not combination therapy of high-dose prednisolone (PSL) and low-dose acetylsalicylic acid (ASA) offers efficient control."	3.69	A prospective study on pregnancy risk of antiphospholipid antibodies in association with systemic lupus erythematosus. ( Aoki, K; Hayashi, Y; Ogasawara, M, 1995)
" During her second pregnancy she was treated with prednisolone, azathioprine, and plasmapheresis, and levels of anti-SSA and anti-SSB antibodies fell significantly."	3.69	Successful outcome of pregnancy after treatment of maternal anti-Ro (SSA) antibodies with immunosuppressive therapy and plasmapheresis. ( Bink-Boelkens, MT; Kallenberg, CG; Meilof, JF; van der Leij, JN; Visser, GH, 1994)
"In a 32-year-old woman, alopecia universalis went into unequivocal remission during pregnancy and prednisolone therapy."	3.69	Alopecia universalis with remission during pregnancy and prednisolone therapy. ( Aizawa, T; Asanuma, N; Hashizume, K; Sakurai, A, 1997)
"We examined the relation between the spontaneous remission and prednisolone-induced suppression of lupus anticoagulant (LAC) or anticardiolipin antibody (ACA) and pregnancy outcome in 5 LAC-positive women."	3.68	Lupus anticoagulant (LAC) and its relation to pregnancy outcome: a report of five cases. ( Hasegawa, M; Ihara, Y; Inamori, K; Itoh, H; Mandai, M; Mori, T; Niwa, H; Okagaki, A; Sagawa, N, 1993)
" Combined chemotherapy (BHAC-DMP) including the total dose (440 mg) of daunorubicin (DNR) resulted in intrauterine fetal death at 19 weeks of gestation."	3.68	[Two cases of acute promyelocytic leukemia in pregnancy and the effect of anthracyclines on fetal development]. ( Abe, Y; Goto, T; Katsuno, M; Miyoshi, T; Muta, K; Nishimura, J; Sadamura, S; Taguchi, F; Takatsuki, H; Umemura, T, 1992)
" Immunoadsorbent plasmapheresis with a dextran sulphate column was used to remove lupus anticoagulant, anticardiolipin antibodies, and antibodies to DNA during her fourth pregnancy in combination with low doses of aspirin and prednisolone."	3.68	Immunoadsorbent plasmapheresis for a patient with antiphospholipid syndrome during pregnancy. ( Hashimoto, H; Hirose, S; Kobayashi, S; Mokuno, C; Tamura, N; Tsuda, H, 1992)
" Low birth weight were observed after the medication of prednisolone and a manifestation of the ulcerous colitis during the gravidity."	3.68	[Pregnancy and chronic inflammatory bowel diseases]. ( Hänert, E; Schneider, W, 1991)
"A 27-year-old woman with anti-phospholipid antibody syndrome, whose first pregnancy had ended in intrauterine fetal death, was treated with prednisolone 0."	3.68	[Fetal survival after the corticosteroid and low-dose aspirin regimen in a case of anti-phospholipid antibody syndrome]. ( Maruyama, I; Maruyama, Y; Okadome, T; Osame, M; Shimmyozu, K; Tara, M, 1990)
" Ovulation and pregnancy occurred subsequent to a treatment with Estradiolvalerianate -Norgestrel and clomiphen in 15 patients, in 32 patients after administration of a combination of clomiphen and Bromocriptine."	3.67	[Additive therapy in ovulation induction with clomiphene]. ( Huber, H; Schneider, WH, 1984)
" The studies were performed to examine a possible difference between right and left oviducts, age-related differences, changes due to the menstrual cycle and pregnancy, and the effects of various drugs such as antibiotics, urokinase and corticosteroid (prednisolone)."	3.67	[Cilium movement of human oviduct]. ( Yamaoka, S, 1987)
"The authors examined the effect of prednisolone-salium succinate administered on the 17th or 18th day of pregnancy on the adrenal function of newborn rats."	3.66	[The effect of glucocorticoid treatment during pregnancy on adrenal function in newborn rats (author's transl)]. ( Bódis, J; Csaba, I; Drozgyik, I; Novák, P; Szabó, I, 1982)
"The influence of prenatal exposure to the synthetic glucocorticoid prednisolone (PRED) was examined in female offspring of mice administered the drug on Days 13-18 of pregnancy."	3.66	Deleterious effects of prenatal prednisolone exposure upon morphological and behavioral development of mice. ( Gandelman, R; Rosenthal, C, 1981)
"A case of a woman affected by a nephrotic postnephritic syndrome and treated during pregnancy with cortisone and prednisolone, is reported."	3.66	Nephrotic syndrome in pregnancy: cortisone and prednisolone treatment: clinical case. ( Enrichi, M; Marchesoni, D; Mozzanega, B, 1981)
" Men with renal transplants receiving azathioprine and prednisolone fathered 13 pregnancies, resulting in 11 offspring; one was a mongol; there were two spontaneous abortions, including a twin pregnancy."	3.66	Cytogenetic analysis on children born of parents treated with immunosuppressive drugs. ( McGeown, MG; Nevin, NC, 1978)
" Treatment with antimalarials and folic acid is usually followed by a rapid remission, but response is slow in about 25% of patients and haemolysis continues uncontrolled in about 5%."	3.65	Severe haemolytic anaemia in pregnancy in Nigerians treated with prednisolone. ( Allan, NC; Fleming, AF, 1969)
"The concentrations of free and protein-bound L-tryptophan were measured in sera from normal subjects, patients with rheumatoid arthritis, pregnant women, and patients with jaundice."	3.65	Mode of action of antirheumatic drugs. ( Dawkins, PD; Hamilton, EB; McArthur, JN; Smith, MJ, 1971)
"Clinically equivalent doses of hydrocortisone, prednisolone, and dexamethasone have progressively increasing teratogenic activity as judged by their ability to induce cleft palate in the offspring of pregnant mice treated with these drugs during the middle period of gestation."	3.64	CLEFT PALATE IN THE MOUSE: A TERATOGENIC INDEX OF GLUCOCORTICOID POTENCY. ( DIGEORGE, AM; PINSKY, L, 1965)
"THE USE OF A ROUTINE ASSAY FOR URINARY STEROIDS IS DESCRIBED THAT IS THOUGHT TO SATISFY THE FOLLOWING NEEDS: the measurement of low levels of 17-hydroxycorticosteroid excretion; the assessment of adrenocortical activity during prednisolone therapy; the diagnosis of the adrenogenital syndrome and the monitoring of its treatment using any available urine specimen; the very early diagnosis of pregnancy using any available urine specimen."	3.64	Routine multipurpose gas chromatographic assay for urinary corticosteroids. ( Murphy, D; West, HF, 1968)
"The prednisolone dose was increased to 15 mg/day, and hydroxychloroquine (200 mg/day) was administered."	2.82	Congenital cytomegalovirus infection after maternal primary infection in a patient with systemic lupus erythematosus: A case report and literature review. ( Fujiki, Y; Fujita, D; Hiramatsu, Y; Isoda, K; Kotani, T; Nakamura, E; Takeuchi, T; Wada, Y, 2022)
"Idiopathic recurrent miscarriage is defined as 3 consecutive pregnancy losses with no contributing features found on investigations."	2.74	Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium. ( Alfirevic, Z; Drury, J; Quenby, S; Tang, AW; Turner, MA, 2009)
"Pregnancy was successfully carried out in 12/12 (100%) SLE-RSA patients with a mean Apgar score of 8."	2.73	Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion. ( Cipriani, P; De Carolis, C; Fontana, L; Giacomelli, R; Greco, E; Kröegler, B; Perricone, C; Perricone, R, 2008)
"Treatment with Prednisolone priming and Interferon, improved both the time and rate of seroconversion compared to no treatment or Interferon alone, suggesting that this combination of drugs might have an immunomodulatory effect."	2.72	Long-term follow-up of hepatitis B carrier children treated with interferon and prednisolone. ( Ballard, AL; Boxall, EH; Davies, P; Kelly, DA; Sira, J, 2006)
"Prednisolone (5 mg) was administered orally, daily for 3-6 months in men with significant antisperm antibodies."	2.68	Effect of low dose continuous corticosteroid therapy in men with antisperm antibodies on spermatozoal quality and conception rate. ( Abdul Hamada, B; al-Qattan, F; Omu, AE, 1996)
"Nevertheless, we know that spontaneous preterm labor is a syndrome attributable to multiple pathologic processes and most of them are yet to be understood."	2.66	Eosinophilic gastroenteritis in pregnancy: A review of the literature. ( Amadori, R; Pirisi, M; Rapetti, R; Stampini, V; Surico, D; Vigone, A, 2020)
"A pregnancy was significantly less likely when the pre-operative serum antisperm antibody titre was 512 or more, but no decrease in fertility was seen with titres below this."	2.65	Reversal of vasectomy: the effects of sperm antibodies on subsequent fertility. ( Hendry, WF; Kingscott, MM; Parslow, JM; Royle, MG; Wallace, DM, 1981)
"Although the symptoms of systemic lupus erythematosus (SLE) worsen during pregnancy, few previous studies have reported lupus enteritis in pregnant women with SLE."	2.55	Lupus enteritis during pregnancy: A case-based review. ( Arata, N; Kaneshige, T; Kitami, M; Mito, A; Murashima, A; Nagakawa, A; Sago, H, 2017)
"Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0."	2.53	Interventions for treating hyperemesis gravidarum. ( Barton, SJ; Berghella, V; Boelig, RC; Edwards, SJ; Kelly, AJ; Saccone, G, 2016)
"Differing study populations, lack of statistical power, method of data presentation (per couple or per cycle), the use of additional medications and differing dosage regimes contribute to data heterogeneity and suggest a cautious approach to data interpretation."	2.50	Interventions to improve reproductive outcomes in women with elevated natural killer cells undergoing assisted reproduction techniques: a systematic review of literature. ( Barbosa, MA; Baumgarten, MN; Brosens, J; Campbell, B; Martins, WP; Polanski, LT; Quenby, S; Raine-Fenning, N, 2014)
"There was a brief recurrence of vomiting, diarrhea, and oral ulcers at 2 months old."	2.47	Neonatal Behçet's disease without maternal history. ( Chang, YS; Chiang, BL; Yang, YH, 2011)
"Evans' syndrome, the coexistence of immune thrombocytopenia (ITP) with autoimmune haemolytic anaemia (AIHA), is rare in pregnancy, with a few published cases."	2.46	Evans' syndrome in pregnancy: a systematic literature review and two new cases. ( Hunt, BJ; Lefkou, E; Nelson-Piercy, C, 2010)
"Rosacea fulminans (RF) is a rare facial dermatosis characterized by the sudden onset of severe facial inflammation consisting of numerous pustules, cystic swellings and coalescing sinuses."	2.46	Differing obstetric outcomes of rosacea fulminans in pregnancy: report of three cases with review of pathogenesis and management. ( Anstey, AV; Gonsalves, R; Jarrett, R, 2010)
"Randomized controlled trials comparing any corticosteroid with placebo, no treatment, or other drug; or comparing one corticosteroid with another corticosteroid or dosage in women with HELLP syndrome."	2.46	Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy. ( Chandra, S; Dowswell, T; Hofmeyr, GJ; Woudstra, DM, 2010)
" Consensus may end there, as there is no clear-cut "best" route of administration or dosing schedule."	2.45	Relapse management in multiple sclerosis. ( Thrower, BW, 2009)
" Finally, theoretical assumptions about the potential pharmacokinetic changes of glucocorticoids in pregnancy and their application to clinical settings are discussed."	2.44	Pharmacokinetics of corticosteroids during pregnancy. ( Ghulmiyyah, LM; Hankins, GD; Pacheco, LD; Snodgrass, WR, 2007)
"Erythema nodosum is the most frequent clinicopathological variant of the panniculitides."	2.42	[Erythema nodosum association with malignant lymphoma]. ( Griniūte, R; Pileckyte, M, 2003)
"Women with ulcerative colitis who are pregnant have many concerns, such as the effect of the gestational period on UC, the effect of UC on the pregnancy, and the safety of drugs used to control the disease."	2.40	[Ulcerative colitis and pregnancy]. ( Ida, A; Koyama, K, 1999)
"Autoimmune diseases are relatively common in women, and tend to occur in the childbearing years."	2.39	Autoimmune disease and pregnancy. ( Jones, WR, 1994)
"Dermatomyositis is a rare disease complicating pregnancy."	2.38	Dermatomyositis and pregnancy. Case report and review of the literature. ( Ishii, N; Kawaguchi, T; Nakajima, H; Ono, H, 1991)
"Positive b-hCG, miscarriage, and live birth rates were similar between groups as Group A vs."	1.91	Low Molecular Weight Heparin-Aspirin-Prednisolone Combination Does Not Increase the Live Birth Rate in Recurrent Implantation Failure: A Retrospective Cohort Study. ( Aslan, K; Avci, B; Cakir, C; Cinar, C; Kasapoglu, I; Uncu, G, 2023)
"Azathioprine was found to be toxic and teratogenic for the rat embryos beginning at a dose of 1 µg/ml."	1.72	( Acar, H; Fazliogullari, Z; Karabulut, AK; Unver Dogan, N; Uysal, II, 2022)
"Acquired haemophilia A (AHA) is a rare bleeding disorder, characterised by the presence of autoantibodies to clotting factor VIII (FVIII)."	1.72	Acquired Hemophilia A following Pfizer-BioNTech SARS CoV-2 mRNA vaccine, successfully treated with prednisolone and rituximab. ( Gilbar, PJ; Mangos, HM; Murali, A; Wong, P, 2022)
"Prednisolone was administered to 33% of patients with a median dose of 0 (0-2."	1.62	Simplified disease activity index and clinical disease activity index before and during pregnancy correlate with those at postpartum in patients with rheumatoid arthritis. ( Fujita, D; Hata, K; Hiramatsu, Y; Kotani, T; Matsumura, Y; Nakamura, E; Takeuchi, T; Tokai, N; Wada, Y; Yoshikawa, A, 2021)
"Eosinophilia is a characteristic-albeit not universal-finding."	1.62	Eosinophilic fasciitis in a pregnant woman with corticosteroid dependence and good response to infliximab. ( Aguilar-García, J; Blázquez-Sánchez, N; Fernández-Canedo, I; Fúnez-Liébana, R; Jiménez-García, N; Romero-Gómez, C, 2021)
"The original disease was biliary atresia in all recipients."	1.56	Pregnancy Outcomes Following Pediatric Liver Transplantation: A Single-Center Experience in Japan. ( Hirata, Y; Katano, T; Miyahara, G; Naya, I; Okada, N; Onishi, Y; Sakuma, Y; Sanada, Y; Sata, N; Yamada, N, 2020)
"The pregnancy was achieved after the use of assisted reproductive technology."	1.56	Autoimmune Polyglandular Syndrome Type 2 and Pregnancy. ( Chaveeva, P; Milcheva, R; Staynova, R; Yanachkova, V, 2020)
"A 28-year-old woman with a chronic hepatitis B virus infection developed nephrotic syndrome in her second month of pregnancy, with urinary protein levels of 3 to 10 g/d that continued into her postpartum period."	1.51	Successful entecavir plus prednisolone treatment for hepatitis B virus-associated membranoproliferative glomerulonephritis: A case report. ( Akanuma, T; Akihisa, T; Amemiya, N; Honda, K; Horita, S; Inoue, T; Ito, Y; Kataoka, H; Kawachi, K; Kawasoe, K; Makabe, S; Manabe, S; Matsui, K; Mitobe, M; Mochizuki, T; Moriyama, T; Nitta, K; Ohara, M; Sato, M; Sawada, A; Suzuki, T, 2019)
"Susac syndrome is a rare disorder caused by autoimmune-mediated occlusions of microvessels in the brain, retina and inner ear."	1.51	[Susac syndrome, a rare cause of encephalopathy]. ( Aranda Martínez, A; Paviolo, JP, 2019)
"Renal biopsy during pregnancy is not always necessary for initiation of steroid therapy."	1.46	Steroid Pulse Therapy for De Novo Minimal Change Disease During Pregnancy. ( Aoki, M; Asami, Y; Hirose, M; Imai, S; Kawaharamura, K; Oida, K; Sakai, R; Sato, H; Shiro, R; Suzuki, T; Taguchi, N; Yano, H; Yasuda, M, 2017)
"When pregnancy was confirmed, TCZ was terminated as soon as possible in all patients."	1.43	Tocilizumab and pregnancy: Four cases of pregnancy in young women with rheumatoid arthritis refractory to anti-TNF biologics with exposure to tocilizumab. ( Goto, M; Kaneko, K; Murashima, A; Sugitani, M, 2016)
"In this study, it was aimed to investigate the toxic and teratogenic effects of cyclosporine A and tacrolimus and their combinations with prednisolone using an in vitro rat embryo culture technique."	1.43	Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone. ( Acar, H; Fazliogullari, Z; Karabulut, AK; Unver Dogan, N; Uysal, II, 2016)
"A newborn from a mother with active Behcet's disease during pregnancy, who develops vasomotor phenomena (Raynaud) with oral ulcerations in the second day of life."	1.43	Neonatal Behçet's disease with Raynaud phenomenon. ( Fernández-Fructuoso, JR; Gil-Sánchez, S; Gómez-Santos, E; Leante-Castellanos, JL; Lloreda-García, JM; Sevilla-Denia, S, 2016)
"Myasthenia gravis is a chronic autoimmune disease of neuromuscular transmission resulting in fatigable skeletal muscle weakness."	1.42	New diagnosis myasthenia gravis and preeclampsia in late pregnancy. ( Balson, IF; Dennis, AT; Ozcan, J, 2015)
"A patient with idiopathic thrombocytopenic purpura had a previous history of interrupted pregnancy due to severe thrombocytopenia, and was unresponsive to high doses of corticosteroids and intravenous immunoglobulin."	1.42	Successful prevention of exacerbation of thrombocytopenia in a pregnant patient with idiopathic thrombocytopenic purpura by anticoagulation treatment. ( Hisano, M; Sago, H; Tsukada, N; Yamaguchi, K, 2015)
"The number of cases of aPL-related pregnancy complications that physicians have intervened was relatively small."	1.42	The participations of the physicians on the diagnosis and treatments of antiphospholipid related pregnancy morbidities in Japan: from the result of nationwide survey. ( Amengual, O; Atsumi, T; Bohgaki, T; Horita, T; Kaneko, K; Murashima, A; Nakanishi, I; Nozawa, K; Oku, K; Oomura, K; Sugiura-Ogasawara, M; Yasuda, S, 2015)
"Postpartum hemorrhage is a common cause of maternal mortality."	1.40	Immunoadsorption for pregnancy-associated severe acquired hemophilia. ( Goldmann, G; Marquardt, N; Oldenburg, J; Ulrich-Merzenich, G; Zeitler, H, 2014)
"AOSD and PRCA in pregnancy are rare conditions."	1.40	Newly diagnosed adult-onset Still's disease with pure red cell aplasia in pregnancy. ( Hassan, MF; Moussa, M, 2014)
" Pregnancy with SLE is associated with an increase risk of adverse maternal and fetal outcomes."	1.40	Safety of tacrolimus treatment during pregnancy and lactation in systemic lupus erythematosus: a report of two patients. ( Izumi, Y; Migita, K; Miyashita, T, 2014)
"The authors report a rare case of pemphigus vulgaris in a pregnant lady and neonatal pemphigus in her child, both of whom were treated successfully."	1.38	Pemphigus vulgaris in a pregnant woman and her neonate. ( Ibrahim, SB; Kanagasabai, S; Umakanth, S; Yashodhara, BM, 2012)
"Idiopathic granulomatous mastitis is an inflammatory mass in the breast."	1.37	A case of granulomatous mastitis with erythema nodosum and arthritis. ( Karimifar, M; Mahzouni, P; Salesi, M; Salimi, F, 2011)
"Shrinking lung syndrome is characterized by pulmonary compromise secondary to unilateral or bilateral paralysis of the diaphragm."	1.37	Shrinking lung syndrome in pregnancy complicated by antiphospholipid antibody syndrome. ( Brost, BC; DeStephano, CC; Meena, M; Watson, WJ, 2011)
"Prednisolone treatment reduces endometrial vascular maturation and angiogenic growth factor expression in women with RM with increased uNK cells."	1.37	Prednisolone treatment reduces endometrial spiral artery development in women with recurrent miscarriage. ( Bulmer, JN; Drury, JA; Innes, BA; Lash, GE; Quenby, S; Robson, SC, 2011)
"Prednisolone was found to improve the rate of live births, although it was also a predictor of prematurity."	1.36	Pregnancy outcome in 396 pregnancies in patients with SLE in Saudi Arabia. ( Al Arfaj, AS; Khalil, N, 2010)
"Psoriatic arthritis may be treated during pregnancy with glucocorticosteroids, especially with prednisone or prednisolone."	1.36	[Active psoriatic arthritis during pregnancy: challenges and limitations of pharmacotherapy]. ( Matuszewska, A; Misterska-Skóra, M; Wiland, P, 2010)
"Takayasu's arteritis is a rare but potentially life-threatening disorder which may present for the first time in pregnancy."	1.35	Basic clinical examination skills may save lives. ( Cunnane, G; McCarthy, EM, 2008)
"A 28-year-old woman with type 1 diabetes on insulin therapy developed left oculomotor nerve palsy in the fourth month of pregnancy."	1.35	[Recurrent multiple cranial nerve palsy in a gravida with type 1 diabetes, that remitted after delivery and with steroid therapy]. ( Kuzuhara, S; Nakano, C; Sasaki, R; Shindo, A; Sugiyama, T; Taniguchi, A, 2008)
"Cogan's syndrome is a rare multisystem disorder of unknown etiology which is characterized by nonsyphilitic interstitial keratitis, vestibuloauditory dysfunction and systemic vasculitis."	1.35	A rare case of uneventful pregnancy in a woman with Cogan's syndrome. ( Bakalianou, K; Danilidou, K; Iavazzo, C; Kondi-Pafiti, A; Papadias, K; Salakos, N, 2008)
"Prednisolone or IVIG was then added to the tube with E:T ratio of 50:1 to assess suppressive effect."	1.35	Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity. ( Abdalla, HI; Bansal, A; Bhaskaran, S; Ford, B; Sumar, N; Thum, MY, 2008)
"We describe a patient with limited Wegener's granulomatosis (WG) presenting during pregnancy with aggressive cutaneous involvement."	1.35	Successful treatment of new onset Wegener's granulomatosis with IVIG (intravenous immunoglobulin) during pregnancy: a case report. ( Kim, SY; Kolasinski, SL; Linton, JM, 2008)
" However, this sensitivity was not satisfactory for corticosterone during pharmacokinetic studies involving dexamethasone due to its strong adrenosuppressive effect."	1.34	Quantification of dexamethasone and corticosterone in rat biofluids and fetal tissue using highly sensitive analytical methods: assay validation and application to a pharmacokinetic study. ( Jusko, WJ; Samtani, MN, 2007)
"Devic's neuromyelitis optica is related to nosologic problems with multiple sclerosis."	1.34	[Devic's neuro-optic myelitis and pregnancy]. ( Bencherifa, F; Berraho, A; Bourassi, A; Mellal, Z, 2007)
"Prednisolone treatment significantly reduced the number of CD56 cells in the endometrium, from a median of 14% (before) to 9% (after) (P=."	1.33	Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. ( Bates, M; Farquharson, R; Kalumbi, C; Quenby, S; Vince, G, 2005)
"A case of pemphigoid gestationis, a rare autoimmune disease unique to pregnancy, is described."	1.33	A case of gestational diabetes arising following treatment with glucocorticosteroids for pemphigoid gestationis. ( Bhatti, NR; Heazell, AE; Sinha, A, 2005)
"Pregnancy is an initiating event for acute thrombotic thrombocytopaenic purpura (TTP)."	1.33	Successful management of pregnancy in women with a history of thrombotic thrombocytopaenic purpura. ( Cohen, H; Lee, R; Machin, S; Mackie, I; Scully, M; Starke, R, 2006)
"Pregnancy is relatively safe in women with SLE in remission but should be considered as a high-risk pregnancy."	1.33	Outcome of pregnancy in patients with systemic lupus erythematosus. ( Chen, CP; Chen, TL; Lee, CS; Lin, CJ; Wong, CH, 2006)
"Her pregnancy was managed with anticoagulant therapy and she delivered a healthy infant."	1.32	Graves' disease associated with anticardiolipin antibody positivity and acquired protein S deficiency. ( Kanmatsuse, K; Kokubun, S; Nakayama, T; Yamamoto, T, 2003)
"Dermatomyositis in pregnancy is rare."	1.32	Dermatomyositis developing in the first trimester of pregnancy. ( Choi, JH; Han, JH; Park, HS; Park, IW; Shin, YS; Suh, CH; Suh, YJ, 2003)
"Herpes gestationis, also known as Pemphigoid gestationis, is a rare autoimmune disease of pregnancy."	1.32	Herpes gestationis. ( Addar, MH; Faiz, SA; Nainar, SI, 2004)
"We analyze the case of herpes gestationis to 36 year-old woman, which started on 24th week of 5th gestation."	1.31	[Case of herpes gestationis in 5th pregnancy]. ( Vaitkeviciene, S; Vaitkevicius, P; Vaitkevicius, V, 2002)
"Idiopathic pulmonary fibrosis is typically seen in older individuals."	1.31	Successful outcome of pregnancy in idiopathic pulmonary fibrosis. ( Aggarwal, AN; Jindal, SK; Sharma, CP; Vashisht, K, 2002)
"However, in a pregnant patient with VKH syndrome, the effects of high-dose corticosteroids on the fetus are controversial."	1.31	Vogt-Koyanagi-Harada syndrome in a pregnant patient treated with high-dose systemic corticosteroids. ( Doi, M; Matsubara, H; Uji, Y, 2000)
"A normal pregnancy was achieved."	1.31	Primary infertility in 45-year-old man with untreated 21-hydroxylase deficiency: successful outcome with glucocorticoid therapy. ( Tiitinen, A; Välimäki, M, 2002)
"Treatment with prednisolone (7."	1.30	[A case of antiphospholipid antibody syndrome successfully treated with prednisolone and low-dose aspirin, with subsequent normal pregnancy]. ( Maeda, T; Maesima, E; Yamada, Y; Yamamoto, M; Yukawa, S, 1997)
"Glanzmann's thrombasthenia is an autosomal recessive, inherited platelet function disorder."	1.30	Pregnancy in a patient of Glanzmann's thrombasthenia with antiplatelet antibodies. ( Choudhry, VP; Kashyap, R; Kriplani, A; Saxena, R; Takkar, D, 1997)
"She was eventually diagnosed as MCTD when she was found to have polymyositis by EMG and serum CK."	1.30	[Two cases with SLE and MCTD developed after a long period of chronic arthritis that was initially diagnosed as JRA]. ( Hokonohara, M; Imanaka, H; Maeno, N; Miyata, K; Mori, H; Nakae, Y; Nerome, Y; Shigemori, M; Takei, S, 1997)
"As a strategy to treat patients with multiple sclerosis in their third trimester of pregnancy, it is appropriate to evaluate disease activity using MRI and to start steroid pulse therapy after delivery."	1.30	[A case of multiple sclerosis with relapses during the third trimester of pregnancy]. ( Hirade, S; Inoue, H; Nagasawa, H; Takashima, S, 1997)
"The association of Wegener's granulomatosis and pregnancy is rare and poses unique therapeutic challenges, particularly when active disease presents in early pregnancy."	1.30	Relapse of Wegener's granulomatosis in the first trimester of pregnancy: a case report. ( Garg, OP; Gupta, R; Kumar, A; Mohan, A; Singal, VK, 1998)
"Aplastic anaemia in pregnancy is an extremely rare condition with high maternal morbidity and mortality rates."	1.30	A case of aplastic anaemia in pregnancy. ( Ang, HY; Ho, HK; Linn, YC, 1999)
"The coincidence of HELLP syndrome and cortical blindness is an uncommon but very dramatic event, for the patient as well as the obstetrician."	1.30	Acute onset of blindness during labor: report of a case of transient cortical blindness in association with HELLP syndrome. ( Ebert, AD; Entezami, M; Hopp, HS; Runkel, S; Weitzel, HK, 1999)
"The rate of the intrauterine growth retardation was significantly higher than that observed in pregnancies with normal complement activity."	1.30	Hypocomplementemia correlates with intrauterine growth retardation in systemic lupus erythematosus. ( Ebina, Y; Fujimoto, S; Kato, EH; Kishida, T; Kobashi, G; Kobayashi, N; Sakuragi, N; Tsutsumi, A; Yamada, H, 1999)
" These patients were receiving prednisolone at a mean dosage of 9."	1.29	[Outcome of patients with chronic systemic lupus erythematosus]. ( Arakawa, M; Honma, T; Ito, S; Kikuchi, M; Nakano, M; Ozawa, T; Saeki, T; Sato, T; Watanabe, T, 1995)
"Herpes gestationis is a rare disease in pregnancy."	1.29	Herpes gestationis: one of the rare skin lesions in pregnancy. ( Doi, SA; Jamiyah, H; Naganathan, K, 1994)
"Twenty-six had idiopathic thrombocytopenic purpura (ITP), gave birth to 33 infants, of which 22 were by spontaneous vaginal delivery, eight by lower segment cesarean section, and two by forceps."	1.29	Risk of thrombocytopenia in the infants of mothers with idiopathic thrombocytopenia. ( al Herbish, AS; al-Mobaireek, K; al-Mofada, SM; al-Momen, AK; Kides, E; Osman, ME, 1994)
"In a multi-centre prospective study of systemic lupus erythematosus and pregnancy in France, 117 cases were identified from 1987 to 1992."	1.29	Pregnancy and its outcome in systemic lupus erythematosus. ( Bletry, O; Godeau, P; Le Thi Huong, D; Piette, JC; Wechsler, B, 1994)
"A patient with acute myelocytic leukemia diagnosed at the 23rd week of gestation received combination chemotherapy, and carried the pregnancy to successful delivery at the 34th week."	1.29	Acute myelogenous leukemia in pregnancy: fetal blood sampling and early effects of chemotherapy. ( Imai, A; Kawabata, I; Morishita, S; Tamaya, T, 1994)
"Of these, 50 had severe oligozoospermia or azoospermia, and another 30 had oligozoospermia; 67 had significantly raised serum antisperm antibody titres."	1.29	Unilateral testicular obstruction: orchidectomy or reconstruction? ( Hendry, WF; Lowe, DG; Parkinson, MC; Parslow, JM, 1994)
"Dapsone was taken by patients during 11 pregnancies, and no adverse effects were seen."	1.29	Linear IgA disease and pregnancy. ( Collier, PM; Kelly, SE; Wojnarowska, F, 1994)
"The case of a woman suffering from progressive diaphyseal dysplasia is presented."	1.29	Progressive diaphyseal dysplasia (Camurati-Engelmann's disease). Improvement of clinical signs and of bone scintigraphy during pregnancy. ( Bossuyt, A; De Vits, A; Keymeulen, B; Somers, G; Verbruggen, LA, 1994)
"The patient had experienced hepatic infarction during her first pregnancy and had repeated hepatic infarction during her third pregnancy."	1.29	Hepatic infarction during pregnancy complicated by antiphospholipid syndrome. ( Kinoshita, K, 1993)
"A case of full blown systemic lupus erythematosus (SLE) was treated with steroid."	1.29	Danazol for thrombocytopenia in pregnancy with underlying systemic lupus erythematosus. ( Bumpenboon, T; Chanchairujira, T; Insiripong, S, 1996)
"Clinical brain tumors become symptomatic or show acceleration of symptoms in pregnant women less often when compared with those in non-pregnant women."	1.29	Primary brain malignant lymphoma newly diagnosed during pregnancy. ( Imai, A; Kawabata, I; Tamaya, T, 1995)
"We describe the case of a patient with systemic lupus erythematosus, treated by corticosteroids, who presented during two successive pregnancies with serological reactivation of toxoplasmosis associated with fetal lesions."	1.29	Recurrent congenital toxoplasmosis in a woman with lupus erythematosus. ( Blanc, B; Boubli, L; Casta, M; Chagnon, C; Cravello, L; D'Ercole, C; Franck, J; Harle, JR; Leclaire, M, 1995)
" We emphasise that the accuracy especially of the CRP for early prediction of silent infection in preterm labour does not seem to be impaired by this corticosteroid in a dosage usually administered for prevention of respiratory distress syndrome."	1.29	[Does lung maturation therapy with 16-methylene-prednisolone modify maternal infection parameters in threatened premature labor?]. ( Heyl, W; Rath, W; Reister, F; Winkler, M, 1996)
"All the untreated congenital hemangiomas (n = 24) regressed by the time the infants were 14 months of age, leaving either atrophic skin or extra skin."	1.29	Congenital hemangioma: evidence of accelerated involution. ( Boon, LM; Enjolras, O; Mulliken, JB, 1996)
"Without glucocorticoid treatment, the pregnancy rate per cycle and implantation rate per embryo in antibody-positive patients were 10."	1.29	Successful glucocorticoid treatment for patients with abnormal autoimmunity on in vitro fertilization and embryo transfer. ( Ando, T; Asada, Y; Furuhashi, M; Kondo, I; Suganuma, N; Tomoda, Y, 1996)
"Prednisolone was most effective with a response rate of 82%, but the required dose was often high and the effect was not sustained after withdrawal."	1.29	Collagenous colitis: a retrospective study of clinical presentation and treatment in 163 patients. ( Abrahamsson, H; Bohr, J; Eriksson, S; Järnerot, G; Tysk, C, 1996)
"Pregnancy is associated with specific immunological tolerance to fetal antigens suggesting that immunoregulatory processes during pregnancy can induce specific immunological unresponsiveness."	1.29	Specific immune tolerance during pregnancy after renal transplantation. ( Barenbrock, M; Fischer, T; Schobel, H, 1996)
"Asthma in pregnancy is not uncommon and it may take a severe course in some pregnancies."	1.28	Artificial ventilatory management in a severe, pregnant asthmatic--a case report. ( Askari, A; Chatterjee, TK; Chopra, MP; Gruteke, P; Nwokolo, FF, 1992)
"Then a sudden and rapidly worsening preeclampsia led to admission and delivery."	1.28	Pregnancy and postpartum after kidney transplantation and cyclosporin therapy--review of the literature adding a new case. ( Bung, P; Molitor, D, 1991)
"We present a case of pemphigus vulgaris which developed during pregnancy."	1.28	Pemphigus vulgaris associated with pregnancy. A case report from Japan. ( Aoki, T; Fuke, Y; Hayashi, A; Nakayama, M; Okano, M; Takijiri, C; Wada, Y, 1990)
"A 25-year-old woman was diagnosed as acute myeloblastic leukemia (M1 in FAB classification) in May 1983, and treated with DCMP regimen, which led to the complete remission."	1.28	[Successful pregnancy after 6 years complete remission in patient with acute myeloblastic leukemia]. ( Fujita, N; Gotoh, H; Inaba, T; Itoh, K; Murakami, S; Nakagawa, M; Nakanishi, S; Oku, N; Shimazaki, C, 1991)
"We describe a fatal case of systemic lupus erythematosus (SLE) developing cerebral and systemic necrotizing vasculitis during pregnancy."	1.28	Severe cerebral and systemic necrotizing vasculitis developing during pregnancy in a case of systemic lupus erythematosus. ( Fukuda, J; Kitagawa, Y; Matsuoka, Y; Mizushima, Y; Suzuki, Y, 1990)
"Although Crohn's disease may decrease fertility, female reproductive ability is normal in UC."	1.27	Medical and surgical treatment of inflammatory bowel disease in pregnancy. ( Warsof, SL, 1983)
" Immunosuppression was generally reduced in the second trimester and was temporarily increased above the maintenance dosage after delivery."	1.27	[Pregnancy after kidney transplantation. Report of 6 successful cases with multiple risk factors]. ( Hengst, P; May, G; Mebel, M; Schilling, H; Schmitt, E; Scholz, D, 1983)
"Prednisolone treatment did not alter the number of somatic cells in milk or reduce the inflammatory response of experimentally infected cows."	1.27	Excretion of [3H]prednisolone in clinically normal and experimentally infected bovine udders. ( Geleta, JN; Mercer, HD; Shimoda, W, 1984)
"83 prednisolone-treated and 57 control children of a previous study demonstrating benefits of antenatal steroid prophylaxis of IRDS were reexamined at the age of 6 years."	1.27	Normal physical and mental development of 6-year-old children whose mothers were treated antenatally with prednisolone. ( Adamovich, K; Arató, J; Horváth, I; Ostorharics-Horváth, G; Papp, K, 1984)
"She had had varicella eruption one month before the onset of the disease."	1.27	Acute retinal necrosis syndrome following chickenpox in pregnant woman. ( Matsuo, N; Matsuo, T; Ohno, A, 1988)
"Few cases of dermatomyositis affecting pregnancy have been reported."	1.27	Dermatomyositis in pregnancy. A case report. ( England, MJ; Perlmann, T; Veriava, Y, 1986)
"A 32-year-old woman was treated for Burkitt's lymphoma diagnosed during the 22nd week of pregnancy."	1.26	Normal infant after combination chemotherapy including teniposide for Burkitt's lymphoma in pregnancy. ( Funnell, CF; Hope, DM; Humphrey, DC; Lowenthal, RM; Stewart, IG, 1982)
" Six dosage levels were selected: 0."	1.26	Comparative pulmonary surfactant-inducing effect of three corticosteroids in the near-term rat. ( Anderson, GG; Ashikaga, T; Cidlowski, JA; Lamden, MP, 1981)
"The hyperenzymemia in ketosis-affected animals, in animals with liver injuries as well as in cows subjected to starving or prednisolon treatment was substantiated by the higher activity of SGOT."	1.26	[Serum alkaline phosphatase and transaminase activity in cows with clinical ketosis]. ( Vasilov, B, 1977)
"Prednisolone treatment did not result in significantly increased P50 values."	1.26	Effect of prednisolone treatment on selected respiratory parameters and cardiac output in prematurely delivered neonatal lambs. ( Culver, DH; Thompson, FN; van Kampen, M, 1978)
"Treatment with prednisolone did not appear to have any effect on the length of the follicular phase or on ovulation."	1.26	Urinary oestrogen excretion, oestrous behaviour and ovulation in heifers treated with prednisolone during pro-oestrus and oestrus. ( Tomasgard, G, 1976)
"Etiology, diagnosis and therapy of the consumption coagulopathy as well as the coagulopathy of production are dealed with."	1.26	[Blood coagulation in newborns (author's transl)]. ( Exadaktylos, P; Verron, G, 1976)
"(b) Certain cases of Sheehan's syndrome appear to have impaired endogenous TRH reserve or transport."	1.25	Assessment of thyrotropin-releasing hormone and thyrotropin reserve in man. ( Nicoloff, JT; Singer, PA, 1973)

Research

Studies (731)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Number of Control and Treated Participants With Successful Live Births Following Conventional IVF or ICSI Cycles

Timeframe	Studies, this research(%)	All Research%
pre-1990	315 (43.09)	18.7374
1990's	160 (21.89)	18.2507
2000's	117 (16.01)	29.6817
2010's	110 (15.05)	24.3611
2020's	29 (3.97)	2.80

Authors	Studies
Yang, ST	1
Yeh, CC	1
Lee, WL	1
Lee, FK	1
Chang, CC	1
Wang, PH	1
Fazliogullari, Z	2
Karabulut, AK	2
Unver Dogan, N	2
Uysal, II	2
Acar, H	2
Nakamura, E	2
Isoda, K	1
Kotani, T	2
Hiramatsu, Y	2
Wada, Y	3
Fujiki, Y	1
Fujita, D	2
Takeuchi, T	4
Murali, A	1
Wong, P	1
Gilbar, PJ	1
Mangos, HM	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Intravenous Immunoglobulin and Prednisolone to Women With Unexplained Recurrent Pregnancy Loss After Assisted Reproductive Technology Treatment: a Randomised, Double-blind, Placebo-controlled Trial[NCT04701034]	Phase 2	74 participants (Anticipated)	Interventional	2021-02-06	Recruiting
Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss[NCT04558268]	Phase 2/Phase 3	242 participants (Anticipated)	Interventional	2020-12-31	Not yet recruiting
A Three-arm, Multicenter, Open-label Randomized Controlled Trial of Hydroxychloroquine and Low-dose Prednisone on Recurrent Spontaneous Abortion With Undifferentiated Connective Tissue Diseases: Protocol for the Immunosuppressant Regimens for Living FEtus[NCT03671174]		420 participants (Anticipated)	Interventional	2019-08-02	Recruiting
A Multicenter, Double-blind, Randomized and Parallel Controlled Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Miscarriage With Antiphospholipid Syndrome[NCT04624269]	Phase 4	384 participants (Anticipated)	Interventional	2020-12-01	Not yet recruiting
The Lupus prEGnAnCY Cohort: An International Prospective Cohort of Lupus Pregnancies[NCT03746028]		100 participants (Anticipated)	Observational [Patient Registry]	2018-06-06	Recruiting
Outcome of Idiopathic Pulmonary Fibrosis With Pregnancy[NCT04775277]		63 participants (Actual)	Observational	2018-12-01	Completed
Influence of Local Biopsy of the Endometrium Prior to Controlled Ovarian Stimulation for IVF or ICSI Procedure on the Rates of Embryo Implantation, Clinical Pregnancy and Live Birth in ART[NCT01064193]	Phase 3	190 participants (Actual)	Interventional	2010-02-28	Completed
Improvement in Pregnancy Outcomes in Immunologically Infertile Male Patients Undergoing Prednisolone Treatment and Conventional IVF Preceded by Sperm Penetration Assay: A Randomized Controlled Trial[NCT02935738]		241 participants (Actual)	Interventional	2014-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Live birth rates in treated and control patients undergoing conventional IVF or ICSI cycles as determined by the sperm penetration assay (SPA) of hamster zone free ova (NCT02935738)
Timeframe: Nine months (pregnancy term) after the in vitro fertilization.

Intervention	participants (Number)
Prednisolone Treated Men / Positive SPA / IVF	18
Prednisolone Treated Men / Negative SPA / ICSI	13
Control Men / Positive SPA / IVF	8
Control Men / Negative SPA / ICSI	9

Article	Year
Congenital cytomegalovirus infection after maternal primary infection in a patient with systemic lupus erythematosus: A case report and literature review. Lupus, 2022, Volume: 31, Issue:2 Topics: Antibodies, Viral; Cytomegalovirus; Cytomegalovirus Infections; Female; Humans; Immunoglobulin G; Lu	2022
Oral immunosuppressants improve pregnancy outcomes in women with idiopathic recurrent miscarriage: A meta-analysis. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:7 Topics: Abortion, Habitual; Cyclosporine; Female; Humans; Immunosuppressive Agents; Live Birth; Prednisolone	2022
Chronic histiocytic intervillositis (CHI): current treatments and perinatal outcomes, a systematic review and a meta-analysis. Frontiers in endocrinology, 2022, Volume: 13 Topics: Abortion, Spontaneous; Adalimumab; Aspirin; Female; Heparin, Low-Molecular-Weight; Humans; Hydroxych	2022
Glucocorticoid supplementation during ovulation induction for assisted reproductive technology: a systematic review and meta-analysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2023, Volume: 36, Issue:2 Topics: Adjuvants, Pharmaceutic; Dietary Supplements; Female; Glucocorticoids; Humans; Infertility, Female;	2023
Evans Syndrome and pregnancy: A case report with literature review. JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:7 Topics: Adult; Anemia, Hemolytic, Autoimmune; Anti-Inflammatory Agents; Female; Humans; Prednisolone; Pregna	2019
Successful Immunochemotherapy for Burkitt Lymphoma During Pregnancy as a Bridge to Postpartum High-Dose Methotrexate Therapy: A Case Report and Review of the Literature. Clinical lymphoma, myeloma & leukemia, 2020, Volume: 20, Issue:6 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cyclophosphamide; Cytarabin	2020
Eosinophilic gastroenteritis in pregnancy: A review of the literature. European journal of obstetrics, gynecology, and reproductive biology, 2020, Volume: 248 Topics: Adult; Anti-Inflammatory Agents; Enteritis; Eosinophilia; Female; Gastritis; Humans; Obstetric Labor	2020
Immunotherapy to improve pregnancy outcome in women with abnormal natural killer cell levels/activity and recurrent miscarriage or implantation failure: A systematic review and meta-analysis. Journal of reproductive immunology, 2020, Volume: 142 Topics: Abortion, Habitual; Embryo Implantation; Emulsions; Etanercept; Female; Humans; Immunoglobulins, Int	2020
A case of recurrence of adult-onset Still's disease in the third trimester: a case report and literature review. BMC pregnancy and childbirth, 2021, Feb-24, Volume: 21, Issue:1 Topics: Adult; Female; Glucocorticoids; Humans; Methylprednisolone; Prednisolone; Pregnancy; Pregnancy Compl	2021
Thymoglobulin-Resistant T-Cell-Mediated Acute Rejection in a Pregnant Renal Transplant Recipient: Case Report and Review of the Literature. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2019, Volume: 17, Issue:Suppl 1 Topics: Acute Disease; Adult; Antilymphocyte Serum; Drug Resistance; Drug Substitution; Drug Therapy, Combin	2019
Interventions to improve reproductive outcomes in women with elevated natural killer cells undergoing assisted reproduction techniques: a systematic review of literature. Human reproduction (Oxford, England), 2014, Volume: 29, Issue:1 Topics: Adjuvants, Immunologic; Female; Humans; Immunoglobulins, Intravenous; Killer Cells, Natural; Prednis	2014
Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. Journal of internal medicine, 2014, Volume: 275, Issue:2 Topics: Acute Disease; Addison Disease; Adrenal Cortex; Adrenal Insufficiency; Algorithms; Autoantibodies; A	2014
Effect of Prednisolone Administration on Patients with Unexplained Recurrent Miscarriage and in Routine Intracytoplasmic Sperm Injection: A Meta-Analysis. American journal of reproductive immunology (New York, N.Y. : 1989), 2015, Volume: 74, Issue:1 Topics: Abortion, Habitual; Embryo Implantation; Female; Humans; Killer Cells, Natural; Leukocyte Count; Liv	2015
Lupus enteritis during pregnancy: A case-based review. Modern rheumatology, 2017, Volume: 27, Issue:6 Topics: Abdomen, Acute; Adult; Anti-Inflammatory Agents; Antibodies, Antinuclear; Enteritis; Female; Humans;	2017
Interventions for treating hyperemesis gravidarum. The Cochrane database of systematic reviews, 2016, May-11, Issue:5 Topics: Acupuncture Therapy; Adrenal Cortex Hormones; Antiemetics; Female; Humans; Hydrocortisone; Hyperemes	2016
Granulomatosis with polyangiitis presenting with pelvic mass leading to total hysterectomy: A case-letter. Joint bone spine, 2017, Volume: 84, Issue:1 Topics: Abdominal Pain; Adult; Biopsy, Needle; Cesarean Section; Cyclophosphamide; Diagnosis, Differential;	2017
[Pregnancy and lactation in rheumatoid arthritis]. Nihon rinsho. Japanese journal of clinical medicine, 2016, Volume: 74, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Pro	2016
Corticosteroid therapy in assisted reproduction - immune suppression is a faulty premise. Human reproduction (Oxford, England), 2016, Volume: 31, Issue:10 Topics: Abortion, Habitual; Embryo Implantation; Endometrium; Female; Humans; Immunosuppressive Agents; Pred	2016
Relapse management in multiple sclerosis. The neurologist, 2009, Volume: 15, Issue:1 Topics: Adrenocorticotropic Hormone; Clinical Protocols; Demyelinating Diseases; Disease Management; Female;	2009
Anti-phospholipid antibodies and other immunological causes of recurrent foetal loss--a review of literature of various therapeutic protocols. American journal of reproductive immunology (New York, N.Y. : 1989), 2009, Volume: 62, Issue:1 Topics: Abortion, Spontaneous; Anti-Inflammatory Agents; Antibodies, Antiphospholipid; Aspirin; Clinical Tri	2009
Evans' syndrome in pregnancy: a systematic literature review and two new cases. European journal of obstetrics, gynecology, and reproductive biology, 2010, Volume: 149, Issue:1 Topics: Adult; Anemia, Hemolytic, Autoimmune; Coombs Test; Female; Humans; Immunoglobulin G; Prednisolone; P	2010
Differing obstetric outcomes of rosacea fulminans in pregnancy: report of three cases with review of pathogenesis and management. Clinical and experimental dermatology, 2010, Volume: 35, Issue:8 Topics: Abortion, Induced; Acne Vulgaris; Adult; Anti-Bacterial Agents; Dermatologic Agents; Diabetes, Gesta	2010
Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy. The Cochrane database of systematic reviews, 2010, Sep-08, Issue:9 Topics: Adrenal Cortex Hormones; Betamethasone; Dexamethasone; Female; HELLP Syndrome; Humans; Maternal Mort	2010
Neonatal Behçet's disease without maternal history. Clinical rheumatology, 2011, Volume: 30, Issue:12 Topics: Adult; Behcet Syndrome; Female; Genital Diseases, Female; Humans; Infant, Newborn; Oral Ulcer; Predn	2011
A review of the contemporary management of fetal and neonatal alloimmune thrombocytopenia in an Australian tertiary obstetric hospital. The Australian & New Zealand journal of obstetrics & gynaecology, 2012, Volume: 52, Issue:4 Topics: Adult; Female; Fetal Diseases; Fetus; Humans; Immunoglobulins, Intravenous; Infant, Newborn; Intracr	2012
Clinical advances of interest in the diagnosis and treatment of patients with antiphospholipid syndrome. Revista clinica espanola, 2013, Volume: 213, Issue:2 Topics: Anti-Inflammatory Agents; Anticoagulants; Antiphospholipid Syndrome; Female; Fibrinolytic Agents; He	2013
Prednisolone for repeated implantation failure associated with high natural killer cell levels. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2012, Volume: 32, Issue:6 Topics: Abortion, Spontaneous; Adult; Anti-Inflammatory Agents; Embryo Implantation; Female; Humans; Killer	2012
[Erythema nodosum association with malignant lymphoma]. Medicina (Kaunas, Lithuania), 2003, Volume: 39, Issue:5 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Diagnosis, Dif	2003
THE ADRENAL CORTEX AND REPRODUCTIVE FUNCTIONS. Modern trends in human reproductive physiology, 1963, Volume: 15 Topics: Addison Disease; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormon	1963
[INSULIN ANTIBODIES]. Saishin igaku. Modern medicine, 1964, Volume: 19 Topics: Adrenocorticotropic Hormone; Animals; Autoimmune Diseases; Diabetes Mellitus; Diabetic Angiopathies;	1964
Pregnancy outcome in patients with adult onset Still's disease. The Journal of rheumatology, 2004, Volume: 31, Issue:11 Topics: Adult; Anti-Inflammatory Agents; Female; Humans; Prednisolone; Pregnancy; Pregnancy Complications; P	2004
Pharmacokinetics of corticosteroids during pregnancy. American journal of perinatology, 2007, Volume: 24, Issue:2 Topics: Blood Volume; Female; Glucocorticoids; Humans; Kidney; Methylprednisolone; Prednisolone; Pregnancy;	2007
Glucocorticoids in milk: a review. Endocrinologia experimentalis, 1983, Volume: 17, Issue:3-4 Topics: Adrenocorticotropic Hormone; Animals; Biological Transport; Cattle; Colostrum; Corticosterone; Dexam	1983
Immunology and biochemistry of the Regan isoenzyme. The Prostate, 1980, Volume: 1, Issue:4 Topics: Alkaline Phosphatase; Amniotic Fluid; Animals; Butyrates; Cell Cycle; Cells, Cultured; Chorionic Gon	1980
Outcomes of pregnancy and the management of immunosuppressive agents to minimize fetal risks in organ transplant patients. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:12 Topics: Azathioprine; Cyclosporine; Female; Fetal Growth Retardation; Fetus; Humans; Immunosuppressive Agent	1994
[Herpes gestationis. Clinical spectrum and diagnostic possibilities]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1995, Volume: 46, Issue:3 Topics: Adult; Autoantigens; Betamethasone; Blotting, Western; Complement C3; Female; Fluorescent Antibody T	1995
Autoimmune disease and pregnancy. The Australian & New Zealand journal of obstetrics & gynaecology, 1994, Volume: 34, Issue:3 Topics: Aspirin; Autoimmune Diseases; Embryonic and Fetal Development; Female; Heparin; Humans; Maternal-Fet	1994
[The clinical feature and the fetal therapy of congenital complete A-V block (CCAVB) associated with maternal anti-SSA (B) antibody]. Nihon Sanka Fujinka Gakkai zasshi, 1994, Volume: 46, Issue:12 Topics: Adult; Antibodies, Antinuclear; Dexamethasone; Female; Fetal Diseases; Heart Block; Humans; Infant,	1994
[Thyroiditis]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1994, Jan-18, Volume: 83, Issue:3 Topics: Female; Humans; Hyperthyroidism; Male; Prednisolone; Pregnancy; Puerperal Disorders; Thyroiditis; Th	1994
[Pathogenesis on infertility; its immunological aspects]. Nihon Sanka Fujinka Gakkai zasshi, 1993, Volume: 45, Issue:8 Topics: Abortion, Spontaneous; Antibodies, Antiphospholipid; Aspirin; Autoimmune Diseases; Cytokines; Female	1993
Kimura's disease and minimal-change nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:7 Topics: Adult; Angiolymphoid Hyperplasia with Eosinophilia; Female; Humans; Kidney; Nephrosis, Lipoid; Predn	1996
Prenatal diagnosis of Blackfan-Diamond syndrome: case report and review of the literature. Prenatal diagnosis, 1996, Volume: 16, Issue:4 Topics: Adult; Cardiomegaly; Cordocentesis; Fanconi Anemia; Female; Genes, Dominant; Humans; Hydrops Fetalis	1996
[A case report of pregnancy complicated with adult Still's disease]. Nihon Sanka Fujinka Gakkai zasshi, 1996, Volume: 48, Issue:6 Topics: Adult; Female; Humans; Infant, Newborn; Male; Prednisolone; Pregnancy; Pregnancy Complications; Preg	1996
Benefits of low-dose corticosteroids in rheumatoid arthritis. Bulletin on the rheumatic diseases, 1997, Volume: 46, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A	1997
Recurrent post-partum pulmonary eosinophilia. Thorax, 1997, Volume: 52, Issue:12 Topics: Adult; Anti-Inflammatory Agents; Asthma; Chronic Disease; Female; Humans; Lung; Prednisolone; Pregna	1997
[Ulcerative colitis and pregnancy]. Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female; Fertility; Humans; Immu	1999
Fetal treatment of congenital heart block ascribed to anti-SSA antibody: case reports with observation of cardiohemodynamics and review of the literature. American journal of reproductive immunology (New York, N.Y. : 1989), 1999, Volume: 42, Issue:4 Topics: Adult; Antibodies, Antinuclear; Autoantigens; Dexamethasone; Echocardiography; Female; Fetal Disease	1999
[Herpes gestationis]. Ryoikibetsu shokogun shirizu, 2000, Issue:31 Topics: Autoantigens; Collagen Type XVII; Diagnosis, Differential; Female; Humans; Immunoglobulin G; Non-Fib	2000
[Treatment of cholestatic liver diseases]. Medizinische Klinik (Munich, Germany : 1983), 2002, Mar-15, Volume: 97, Issue:3 Topics: Adult; Age Factors; Anti-Inflammatory Agents; Azathioprine; Bile; Child; Cholagogues and Choleretics	2002
[Myasthenia gravis and antiacetylcholine receptor antibody (author's transl)]. Horumon to rinsho. Clinical endocrinology, 1979, Volume: 27, Issue:8 Topics: Adult; Animals; Autoantibodies; Cattle; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchan	1979
Inflammatory bowel disease presenting in pregnancy. The Australian & New Zealand journal of obstetrics & gynaecology, 1992, Volume: 32, Issue:1 Topics: Adult; Colitis, Ulcerative; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Prednisolone;	1992
[Intravascular platelet transfusion in utero for the treatment of immunologic thrombocytopenic purpura: a case report]. Nihon Sanka Fujinka Gakkai zasshi, 1991, Volume: 43, Issue:3 Topics: Adult; Blood Transfusion, Intrauterine; Cesarean Section; Chorionic Villi Sampling; Female; gamma-Gl	1991
Dermatomyositis and pregnancy. Case report and review of the literature. Dermatologica, 1991, Volume: 183, Issue:2 Topics: Adult; Antibodies, Antinuclear; Aspartate Aminotransferases; Biopsy; Creatine Kinase; Dermatomyositi	1991
Antirheumatic medication during lactation. British journal of rheumatology, 1985, Volume: 24, Issue:3 Topics: Anti-Inflammatory Agents; Aspirin; Breast Feeding; Diclofenac; Female; Half-Life; Humans; Indoleacet	1985
The present status of steroid aerosols. The Journal of the Association of Physicians of India, 1985, Volume: 33, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aerosols; Animals; Asthma; Beclomethasone;	1985
[Diagnostic and therapeutic possibilities in alopecia]. Wiener medizinische Wochenschrift (1946), 1969, Feb-08, Volume: 119, Issue:6 Topics: Administration, Topical; Alopecia; Anemia, Hypochromic; Anti-Inflammatory Agents; Climacteric; Derma	1969
[Multiple sclerosis]. Nederlands tijdschrift voor geneeskunde, 1974, Oct-05, Volume: 118, Issue:40 Topics: Adrenocorticotropic Hormone; Diseases in Twins; Female; Humans; Immunoglobulins; Multiple Sclerosis;	1974
Protection by catatoxic steroids against cyclophosphamide-induced organ lesions. Virchows Archiv. A, Pathology. Pathologische Anatomie, 1970, Volume: 351, Issue:3 Topics: Adrenal Glands; Animals; Body Weight; Bone Marrow; Cyclophosphamide; Desoxycorticosterone; Enzyme In	1970
[Side-effects of cortisone derivatives]. Der Internist, 1967, Volume: 8, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Aldosterone; Betamethasone; Cortisone; Dexamethasone; Female; Humans	1967
Advances in paediatrics. The Practitioner, 1968, Volume: 201, Issue:204 Topics: Asphyxia; Blood Transfusion, Intrauterine; Child; Cyclophosphamide; Erythroblastosis, Fetal; Female;	1968
Immunosuppressive drugs in rheumatoid arthritis. Annals of internal medicine, 1969, Volume: 71, Issue:1 Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressi	1969

Article	Year
Intravenous immunoglobulin and prednisolone to women with unexplained recurrent pregnancy loss after assisted reproductive technology treatment: a protocol for a randomised, double-blind, placebo-controlled trial. BMJ open, 2022, 09-22, Volume: 12, Issue:9 Topics: Abortion, Habitual; Double-Blind Method; Female; Humans; Immunoglobulins, Intravenous; Prednisolone;	2022
Improvement in pregnancy outcomes in couples with immunologically male infertility undergoing prednisolone treatment and conventional in vitro fertilization preceded by sperm penetration assay: a randomized controlled trial. Endocrine, 2017, Volume: 58, Issue:3 Topics: Adult; Animals; Cricetinae; Female; Fertility Agents, Male; Fertilization in Vitro; Humans; Infertil	2017
A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant. Human reproduction (Oxford, England), 2013, Volume: 28, Issue:7 Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Feasibility Studies; Female; Glucocorticoids; Huma	2013
Addition of prednisolone and heparin in patients with failed IVF/ICSI cycles: a preliminary report of a clinical trial. Human fertility (Cambridge, England), 2013, Volume: 16, Issue:3 Topics: Abortion, Spontaneous; Administration, Intravaginal; Administration, Oral; Adult; Anticoagulants; Ea	2013
Does combined prednisolone and low molecular weight heparin have a role in unexplained implantation failure? Archives of gynecology and obstetrics, 2014, Volume: 289, Issue:3 Topics: Administration, Oral; Adult; Anticoagulants; Drug Therapy, Combination; Embryo Implantation; Female;	2014
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial. Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4 Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th	2014
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial. Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4 Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th	2014
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial. Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4 Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th	2014
Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial. Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4 Topics: Abortion, Habitual; Administration, Oral; Adult; Aspirin; CD56 Antigen; Double-Blind Method; Drug Th	2014
Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium. Trials, 2009, Nov-10, Volume: 10 Topics: Abortion, Habitual; Clinical Protocols; Double-Blind Method; Endometrium; Female; Humans; Killer Cel	2009
The efficacy low dose of prednisolone in the treatment of hyperemesis gravidarum. Acta obstetricia et gynecologica Scandinavica, 2004, Volume: 83, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Confidence Intervals; Dose-Response Relationship, Drug; Dru	2004
The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. Placenta, 2005, Volume: 26, Issue:10 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Anti-Inflammatory Agents; Female; Fetus; HELLP Syndrome	2005
Does addition of low-dose aspirin and/or steroid as a standard treatment in nonselected intracytoplasmic sperm injection cycles improve in vitro fertilization success? A randomized, prospective, placebo-controlled study. Journal of assisted reproduction and genetics, 2006, Volume: 23, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response Rel	2006
Long-term follow-up of hepatitis B carrier children treated with interferon and prednisolone. Journal of medical virology, 2006, Volume: 78, Issue:7 Topics: Adolescent; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Carrier State; Chil	2006
Low-dose acetylsalicylic acid plus prednisolone as an adjuvant treatment in IVF: a prospective, randomized study. Fertility and sterility, 2008, Volume: 90, Issue:5 Topics: Adult; Anti-Inflammatory Agents; Arteries; Aspirin; Embryo Implantation; Female; Fertility Agents, F	2008
Intravenous immunoglobulin therapy in pregnant patients affected with systemic lupus erythematosus and recurrent spontaneous abortion. Rheumatology (Oxford, England), 2008, Volume: 47, Issue:5 Topics: Abortion, Habitual; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antibodies	2008
The management of puerperal haemorrhoids. A double-blind clinical trial of Anacal rectal ointment. The Practitioner, 1980, Volume: 224, Issue:1344 Topics: Administration, Topical; Anesthetics, Local; Anti-Inflammatory Agents; Clinical Trials as Topic; Dis	1980
Prenatal prophylaxis of hyaline membrane disease with prednisolone: advantages and disadvantages. Biological research in pregnancy and perinatology, 1983, Volume: 4, Issue:3 Topics: Clinical Trials as Topic; Congenital Abnormalities; Female; Gestational Age; Humans; Hyaline Membran	1983
Reversal of vasectomy: the effects of sperm antibodies on subsequent fertility. British journal of urology, 1981, Volume: 53, Issue:6 Topics: Agglutination Tests; Autoantibodies; Clinical Trials as Topic; Female; Fertility; Humans; Hydrocorti	1981
Oral steroid therapy for subfertile males with antisperm antibodies in the semen: prediction of the responders. Human reproduction (Oxford, England), 1995, Volume: 10, Issue:1 Topics: Administration, Oral; Adult; Autoantibodies; Female; Humans; Immunoglobulin A; Immunoglobulin G; Inf	1995
A comparison of intrauterine insemination in superovulated cycles to intercourse in couples where the male is receiving steroids for the treatment of autoimmune infertility. Fertility and sterility, 1995, Volume: 63, Issue:6 Topics: Autoantibodies; Autoimmunity; Coitus; Cross-Over Studies; Female; Humans; Infertility, Male; Insemin	1995
An N-of-1 trial for treatment of hyperemesis gravidarum. British journal of obstetrics and gynaecology, 1996, Volume: 103, Issue:5 Topics: Adult; Antiemetics; Ascorbic Acid; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Hy	1996
Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies. European journal of obstetrics, gynecology, and reproductive biology, 1996, Volume: 65, Issue:2 Topics: Adult; Autoantibodies; Autoimmune Diseases; Female; Glucocorticoids; Humans; Immunosuppressive Agent	1996
Low-dose prednisolone does not improve the outcome of in-vitro fertilization in male immunological infertility. Human reproduction (Oxford, England), 1995, Volume: 10, Issue:12 Topics: Adult; Anti-Inflammatory Agents; Autoantibodies; Embryo Transfer; Female; Fertilization in Vitro; Hu	1995
Effect of low dose continuous corticosteroid therapy in men with antisperm antibodies on spermatozoal quality and conception rate. European journal of obstetrics, gynecology, and reproductive biology, 1996, Volume: 69, Issue:2 Topics: Adult; Autoantibodies; Cohort Studies; Female; Glucocorticoids; Humans; Infertility, Male; Male; Pre	1996
Effect of prednisolone on serum and follicular fluid androgen concentrations in women with polycystic ovary syndrome undergoing in-vitro fertilization. Human reproduction (Oxford, England), 1999, Volume: 14, Issue:6 Topics: Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Fertili	1999
Randomised, double-blind, placebo-controlled trial of corticosteroids for the treatment of hyperemesis gravidarum. BJOG : an international journal of obstetrics and gynaecology, 2001, Volume: 108, Issue:1 Topics: Administration, Oral; Blood Glucose; Double-Blind Method; Female; Glucocorticoids; Humans; Hyperemes	2001
Management of hyperemesis gravidarum: the importance of weight loss as a criterion for steroid therapy. QJM : monthly journal of the Association of Physicians, 2002, Volume: 95, Issue:3 Topics: Adult; Birth Weight; Drug Administration Schedule; Female; Glucocorticoids; Humans; Hyperemesis Grav	2002
Low dose prednisolone administration in routine ICSI patients does not improve pregnancy and implantation rates. Human reproduction (Oxford, England), 2002, Volume: 17, Issue:6 Topics: Adult; Anti-Inflammatory Agents; Embryo Implantation; Embryo Transfer; Female; Glucocorticoids; Huma	2002
Effectiveness of prednisolone/aspirin therapy for recurrent aborters with antiphospholipid antibody. Human reproduction (Oxford, England), 1992, Volume: 7, Issue:2 Topics: Abortion, Habitual; Adult; Antibodies; Antiphospholipid Syndrome; Aspirin; Cardiolipins; Drug Evalua	1992
The administration of glucocorticoids for the prevention of ovarian hyperstimulation syndrome in in vitro fertilization: a prospective randomized study. Fertility and sterility, 1992, Volume: 58, Issue:2 Topics: Adult; Chorionic Gonadotropin; Embryo Transfer; Estradiol; Female; Fertilization in Vitro; Glucocort	1992
Comparison of prednisolone and placebo in subfertile men with antibodies to spermatozoa. Lancet (London, England), 1990, Jan-13, Volume: 335, Issue:8681 Topics: Agglutination Tests; Autoantibodies; Double-Blind Method; Drug Administration Schedule; Drug Evaluat	1990
Immunosuppression supports implantation of zona pellucida dissected human embryos. Fertility and sterility, 1990, Volume: 53, Issue:4 Topics: Clinical Trials as Topic; Embryo Implantation; Embryo Transfer; Female; Fertilization in Vitro; Huma	1990

prednisolone and Pregnancy