prednisolone and Postintubation Croup studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Research Excerpts

Excerpt	Relevance	Reference
" Although common practice, evidence to support treatment of croup with prednisolone is scant."	9.17	The comparative effectiveness of prednisolone and dexamethasone for children with croup: a community-based randomized trial. ( Baty, J; Conlon, B; Garbutt, JM; Gentry, S; Leege, E; Mandrell, K; Schechtman, KB; Sterkel, R; Stunk, RC, 2013)
"To ascertain whether a single oral dose of prednisolone was equivalent to a single oral dose of dexamethasone (matched for potency) in children with mild to moderate croup."	9.12	Prednisolone versus dexamethasone in croup: a randomised equivalence trial. ( Geelhoed, G; Sparrow, A, 2006)
"To compare the effectiveness of dexamethasone versus prednisone or prednisolone on hospital resource utilization for children hospitalized with acute croup."	8.12	Comparative Effectiveness of Dexamethasone Versus Prednisone in Children Hospitalized With Acute Croup. ( Berry, JG; Hall, M; Jiang, W, 2022)
"To determine the duration of stridor at rest (SAR) after the administration of oral prednisolone (1 mg/kg) to children admitted to hospital with croup from the ED."	7.72	How long does stridor at rest persist in croup after the administration of oral prednisolone? ( Kelly, AM; Parker, R; Powell, CV, 2004)
" Although common practice, evidence to support treatment of croup with prednisolone is scant."	5.17	The comparative effectiveness of prednisolone and dexamethasone for children with croup: a community-based randomized trial. ( Baty, J; Conlon, B; Garbutt, JM; Gentry, S; Leege, E; Mandrell, K; Schechtman, KB; Sterkel, R; Stunk, RC, 2013)
"To ascertain whether a single oral dose of prednisolone was equivalent to a single oral dose of dexamethasone (matched for potency) in children with mild to moderate croup."	5.12	Prednisolone versus dexamethasone in croup: a randomised equivalence trial. ( Geelhoed, G; Sparrow, A, 2006)
"A short cut review was carried out to establish whether oral dexamethasone is better than oral prednisolone at improving outcome in children with mild to moderate croup."	4.82	Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Type of oral cortiosteroid in mild to moderate croup. ( Corfield, A; Teece, S, 2003)
"To compare the effectiveness of dexamethasone versus prednisone or prednisolone on hospital resource utilization for children hospitalized with acute croup."	4.12	Comparative Effectiveness of Dexamethasone Versus Prednisone in Children Hospitalized With Acute Croup. ( Berry, JG; Hall, M; Jiang, W, 2022)
"To determine the duration of stridor at rest (SAR) after the administration of oral prednisolone (1 mg/kg) to children admitted to hospital with croup from the ED."	3.72	How long does stridor at rest persist in croup after the administration of oral prednisolone? ( Kelly, AM; Parker, R; Powell, CV, 2004)
"Croup affects about 3% of children per year, usually between the ages of 6 months and 3 years, and 75% of infections are caused by parainfluenza virus."	2.50	Croup. ( Johnson, DW, 2014)
"The introduction of steroids in the treatment of croup has seen a significant reduction in hospital admissions and improved outcomes for children."	2.46	Croup - assessment and management. ( Rajapaksa, S; Starr, M, 2010)
"Prednisolone base tablets were rated least palatable and were least well tolerated."	1.48	Observational study on the palatability and tolerability of oral prednisolone and oral dexamethasone in children in Saudi Arabia and the UK. ( Alanazi, M; Aljebab, F; Choonara, I; Conroy, S, 2018)
" Commonest dosage regimens were 0."	1.35	Croup management in Australia and New Zealand: a PREDICT study of physician practice and clinical practice guidelines. ( Babl, FE; Borland, ML; Esson, AD; Sheriff, N, 2008)

Research

Studies (25)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Additional Health Care

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (20.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	5 (20.00)	29.6817
2010's	9 (36.00)	24.3611
2020's	4 (16.00)	2.80

Authors	Studies
Jiang, W	1
Hall, M	1
Berry, JG	1
Tanaka, Y	1
Hirano, K	1
Sekino, E	1
Shimane, T	1
Kobayashi, H	1
Aregbesola, A	1
Tam, CM	1
Kothari, A	1
Le, ML	1
Ragheb, M	1
Klassen, TP	3
Vardhan, SH	1
Aljebab, F	1
Alanazi, M	1
Choonara, I	1
Conroy, S	1
Gates, A	1
Gates, M	1
Vandermeer, B	1
Johnson, C	1
Hartling, L	1
Johnson, DW	3
Garbutt, JM	1
Conlon, B	1
Sterkel, R	1
Baty, J	1
Schechtman, KB	1
Mandrell, K	1
Leege, E	1
Gentry, S	1
Stunk, RC	1
Beubler, E	1
Dittrich, P	1
Gelbart, B	1
Parsons, S	1
Sarpal, A	1
Ninova, P	1
Butt, W	2
Borland, ML	1
Babl, FE	1
Sheriff, N	1
Esson, AD	1
Rajapaksa, S	1
Starr, M	1
Parker, C	1
Russell, KF	1
Liang, Y	1
O'Gorman, K	1
Corfield, A	1
Teece, S	1
Parker, R	1
Powell, CV	1
Kelly, AM	1
Sparrow, A	1
Geelhoed, G	1
Fifoot, AA	1
Ting, JY	1
Richter, K	2
Truckenbrodt, H	1
Krasovitskiĭ, ZI	1
Karel'shteĭn, IE	1
Tibballs, J	1
Shann, FA	1
Landau, LI	1
Freezer, N	1
Phelan, P	1
Kairys, SW	1
Olmstead, EM	1
O'Connor, GT	1
Margraf, O	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Outdoor Cold Air Exposure Versus Room Temperature for Croup Symptoms in Pediatric Emergency Departments: a Randomized Controlled Trial[NCT05668364]		118 participants (Actual)	Interventional	2016-11-01	Completed
Community Care for Croup (RCT)[NCT01042145]	Phase 4	87 participants (Actual)	Interventional	2009-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The primary outcome was the % of participants who had additional health care for croup within 11 days of randomization assessed by self-report. This dichotomous variable was positive if any of the following occurred: office visit, ED visit or hospitalization for croup care. (NCT01042145)
Timeframe: 11 days

Duration of Croup Symptoms

Nights With Disturbed Sleep

Number of Participants With Reported Side Effects

Parental Stress

Intervention	percentage of participants (Number)
Prednisone	7
Dexamethasone	2

Intervention	days (Mean)
Prednisone	2.2
Dexamethasone	2.8

Intervention	nights (Mean)
Prednisone	1.21
Dexamethasone	0.68

Intervention	percentage of participants (Number)
Prednisone	26
Dexamethasone	24

Parental stress due to the child's illness was rated using a 4-point categorical scale (ranging from 3-very stressed to 0-not stressed). We report days until the stress rating was 0. (NCT01042145)
Timeframe: 12 days

Article	Year
Glucocorticoids for croup in children. The Cochrane database of systematic reviews, 2023, 01-10, Volume: 1 Topics: Adolescent; Child; Croup; Dexamethasone; Epinephrine; Glucocorticoids; Humans; Prednisolone; Randomi	2023
Glucocorticoids for croup in children. The Cochrane database of systematic reviews, 2018, 08-22, Volume: 8 Topics: Adolescent; Beclomethasone; Betamethasone; Budesonide; Child; Child, Preschool; Croup; Dexamethasone	2018
Croup. BMJ clinical evidence, 2014, Sep-29, Volume: 2014 Topics: Adrenal Cortex Hormones; Budesonide; Cough; Croup; Epinephrine; Helium; Humans; Humidity; Oxygen; Pr	2014
Croup - assessment and management. Australian family physician, 2010, Volume: 39, Issue:5 Topics: Administration, Inhalation; Administration, Oral; Australia; Child; Child, Preschool; Croup; Drug Th	2010
Glucocorticoids for croup. The Cochrane database of systematic reviews, 2011, Jan-19, Issue:1 Topics: Androstadienes; Budesonide; Child; Croup; Dexamethasone; Epinephrine; Fluticasone; Glucocorticoids;	2011
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Type of oral cortiosteroid in mild to moderate croup. Emergency medicine journal : EMJ, 2003, Volume: 20, Issue:3 Topics: Anti-Inflammatory Agents; Child, Preschool; Croup; Dexamethasone; Emergencies; Evidence-Based Medici	2003

Article	Year
The comparative effectiveness of prednisolone and dexamethasone for children with croup: a community-based randomized trial. Clinical pediatrics, 2013, Volume: 52, Issue:11 Topics: Anti-Inflammatory Agents; Child, Preschool; Comparative Effectiveness Research; Croup; Dexamethasone	2013
'ToPDoG' is in progress. Emergency medicine journal : EMJ, 2010, Volume: 27, Issue:12 Topics: Administration, Oral; Croup; Dexamethasone; Drug Combinations; Humans; Prednisolone	2010
Prednisolone versus dexamethasone in croup: a randomised equivalence trial. Archives of disease in childhood, 2006, Volume: 91, Issue:7 Topics: Administration, Oral; Anti-Inflammatory Agents; Child; Child, Preschool; Croup; Dexamethasone; Doubl	2006
Comparison between single-dose oral prednisolone and oral dexamethasone in the treatment of croup: a randomized, double-blinded clinical trial. Emergency medicine Australasia : EMA, 2007, Volume: 19, Issue:1 Topics: Child; Child, Preschool; Croup; Dexamethasone; Double-Blind Method; Female; Glucocorticoids; Humans;	2007
Placebo-controlled trial of prednisolone in children intubated for croup. Lancet (London, England), 1992, Sep-26, Volume: 340, Issue:8822 Topics: Age Factors; Airway Obstruction; Child; Child, Preschool; Croup; Double-Blind Method; Female; Humans	1992
Steroid treatment of laryngotracheitis: a meta-analysis of the evidence from randomized trials. Pediatrics, 1989, Volume: 83, Issue:5 Topics: Child, Preschool; Clinical Trials as Topic; Croup; Dexamethasone; Dose-Response Relationship, Drug;	1989

Article	Year
Comparative Effectiveness of Dexamethasone Versus Prednisone in Children Hospitalized With Acute Croup. Hospital pediatrics, 2022, 10-01, Volume: 12, Issue:10 Topics: Adrenal Cortex Hormones; Child; Croup; Dexamethasone; Glucocorticoids; Hospitalization; Humans; Infa	2022
Case Report: A 29-Year-Old Pregnant Woman at 24 Weeks of Gestation Presenting with Laryngotracheitis and COVID-19 Due to the R.1 Variant of SARS-CoV-2. The American journal of case reports, 2022, Oct-18, Volume: 23 Topics: Adult; Cough; COVID-19; Croup; Epinephrine; Female; Humans; Prednisolone; Pregnancy; Pregnant Women;	2022
Prednisolone vs dexamethsone in croup. The Journal of pediatrics, 2020, Volume: 216 Topics: Administration, Oral; Croup; Dexamethasone; Glucocorticoids; Humans; Prednisolone	2020
Observational study on the palatability and tolerability of oral prednisolone and oral dexamethasone in children in Saudi Arabia and the UK. Archives of disease in childhood, 2018, Volume: 103, Issue:1 Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Croup; Dexamethasone; Female; Glu	2018
About the Therapy of Laryngotracheitis (Croup): Significance of Rectal Dosage Forms. Pharmacology, 2015, Volume: 95, Issue:5-6 Topics: Administration, Rectal; Croup; Dosage Forms; Glucocorticoids; Humans; Prednisolone; Prednisone	2015
Intensive care management of children intubated for croup: a retrospective analysis. Anaesthesia and intensive care, 2016, Volume: 44, Issue:2 Topics: Child, Preschool; Critical Care; Croup; Humans; Infant; Intubation, Intratracheal; Prednisolone; Ret	2016
Croup management in Australia and New Zealand: a PREDICT study of physician practice and clinical practice guidelines. Pediatric emergency care, 2008, Volume: 24, Issue:7 Topics: Australia; Child; Croup; Dexamethasone; Emergency Medicine; Epinephrine; Female; Glucocorticoids; Ho	2008
How long does stridor at rest persist in croup after the administration of oral prednisolone? Emergency medicine Australasia : EMA, 2004, Volume: 16, Issue:2 Topics: Administration, Oral; Child; Child, Preschool; Croup; Emergencies; Glucocorticoids; Humans; Infant;	2004
[Children's emergencies--what to do?]. Fortschritte der Medizin, 1982, Jul-22, Volume: 100, Issue:27-28 Topics: Abdomen, Acute; Aerosols; Child, Preschool; Chloral Hydrate; Cold Temperature; Coma; Croup; Diazepam	1982
[Therapy of croup syndrome]. Deutsche medizinische Wochenschrift (1946), 1979, Jan-26, Volume: 104, Issue:4 Topics: Ampicillin; Bronchitis; Child; Child, Preschool; Croup; Epiglottis; Humans; Infant; Laryngitis; Pred	1979
[Use of neuroleptic drugs and glucocorticoids in complex treatment of croup in children]. Pediatriia, 1976, Issue:1 Topics: Child, Preschool; Chlorpromazine; Croup; Drug Evaluation; Drug Therapy, Combination; Female; Humans;	1976
Steroids in croup: do they increase the incidence of successful extubation? Anaesthesia and intensive care, 1990, Volume: 18, Issue:2 Topics: Adolescent; Airway Obstruction; Child; Child, Preschool; Croup; Female; Humans; Incidence; Infant; I	1990
[Therapy of stenosing laryngo-tracheobronchitis (croup)]. Fortschritte der Medizin, 1974, Sep-12, Volume: 92, Issue:25 Topics: Anti-Bacterial Agents; Asphyxia; Child; Croup; Humans; Hypnotics and Sedatives; Intubation, Intratra	1974

prednisolone and Postintubation Croup