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prednisolone and Otitis Media with Effusion

prednisolone has been researched along with Otitis Media with Effusion in 19 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Otitis Media with Effusion: Inflammation of the middle ear with a clear pale yellow-colored transudate.

Research Excerpts

ExcerptRelevanceReference
"To determine the efficacy of a short course of an adrenocorticosteroid agent (prednisolone) given with amoxicillin as compared with that of amoxicillin alone for the treatment of chronic middle ear effusion (MEE)."5.10Systemic steroid for chronic otitis media with effusion in children. ( Bluestone, CD; Casselbrant, ML; Fireman, P; Kurs-Lasky, M; Mandel, EM; Rockette, HE, 2002)
" The results indicate that in those children treated with hydroxyzine, the rate of relapse was significantly reduced and so was the amount of histamine present in middle ear effusions."5.07Treatment of secretory otitis media with local instillation of hydroxyzine. ( Manolidis, LS; Manolidis, SS; Theoharides, TC; Vliagoftis, H, 1994)
"Oral prednisolone was effective in the treatment of IgG4-related disease."1.40Otologic manifestations of immunoglobulin G4-related disease. ( Fukuda, S; Nakamaru, Y; Takagi, D, 2014)
"Chronic otitis media and facial palsy are rare but well known presenting features of Wegener's granulomatosis."1.35Chronic otitis media and facial paralysis as a presenting feature of Wegener's granulomatosis. ( Balasubramanian, R; Shiva Prasad, BN, 2009)
"A case of WG presenting with bilateral facial paralysis and bilateral serous otitis media is reported."1.34Early diagnosis of Wegener's granulomatosis presenting with bilateral facial paralysis and bilateral serous otitis media. ( Armato, E; Capuzzo, P; Cavaleri, S; Ferri, E; Ianniello, F, 2007)
"Glucocorticoids have been used in the treatment of otitis media with effusion with promising but inconsistent results."1.32Influence of prednisolone on the secretion of mucin from the HT29-MTX cell line. ( Birchall, JP; Fergie, N; Guo, L; Pearson, JP; Sithole, J, 2003)
"Relapsing polychondritis is a rare disease probably of auto-immune etiology comprising inflammatory involvement of cartilage as well as phenomena of vasculitis."1.30ENT manifestations of relapsing polychondritis. ( Gerard, JM; Gerard, M; Namias, B; Rampelberg, O, 1997)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19902 (10.53)18.7374
1990's4 (21.05)18.2507
2000's6 (31.58)29.6817
2010's7 (36.84)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Francis, NA2
Cannings-John, R3
Waldron, CA3
Thomas-Jones, E3
Winfield, T2
Shepherd, V3
Harris, D3
Hood, K3
Fitzsimmons, D3
Roberts, A3
Powell, C2
Gal, M3
Butler, CC3
Powell, CV1
Jones, S1
Takagi, D1
Nakamaru, Y1
Fukuda, S1
Kozan, G1
Aktan, B1
Sakat, MS1
Kurt, S1
Öner, F1
Kara, A1
Tomkinson, A1
Francis, N1
Scheibner, C1
Walch, C1
Shiva Prasad, BN1
Balasubramanian, R1
Vayisoglu, Y1
Gorur, K1
Ozcan, C1
Korlu, S1
Mandel, EM1
Casselbrant, ML1
Rockette, HE1
Fireman, P1
Kurs-Lasky, M1
Bluestone, CD1
Fergie, N1
Guo, L1
Sithole, J1
Pearson, JP1
Birchall, JP1
McCormick, DP2
Saeed, K2
Uchida, T1
Baldwin, CD1
Deskin, R1
Lett-Brown, MA1
Heikkinen, T2
Chonmaitree, T2
Coglianese, CL1
Ferri, E1
Armato, E1
Capuzzo, P1
Cavaleri, S1
Ianniello, F1
Rosenfeld, RM1
Theoharides, TC1
Manolidis, SS1
Vliagoftis, H1
Manolidis, LS1
Rampelberg, O1
Gerard, JM1
Namias, B1
Gerard, M1
Ruohola, A1
Jero, J1
Puhakka, T1
Juvén, T1
Närkiö-Mäkelä, M1
Saxén, H1
Ruuskanen, O2
Puhakka, H1
Haapaniemi, J1
Tuohimaa, P1
Eskola, J1
Bulman, CH1
Kane, RJ1
Srivastva, VN1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00000363]Phase 30 participants InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

10 trials available for prednisolone and Otitis Media with Effusion

ArticleYear
Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial.
    Lancet (London, England), 2018, 08-18, Volume: 392, Issue:10147

    Topics: Administration, Oral; Audiometry; Child; Child, Preschool; Double-Blind Method; Female; Glucocortico

2018
Oral steroids for hearing loss associated with otitis media with effusion in children aged 2-8 years: the OSTRICH RCT.
    Health technology assessment (Winchester, England), 2018, Volume: 22, Issue:61

    Topics: Administration, Oral; Audiometry; Child; Child, Preschool; Cost-Benefit Analysis; Double-Blind Metho

2018
Oral steroids for the resolution of otitis media with effusion (OME) in children (OSTRICH): study protocol for a randomised controlled trial.
    Trials, 2016, Mar-01, Volume: 17, Issue:1

    Topics: Administration, Oral; Age Factors; Child; Child, Preschool; Clinical Protocols; Cost-Benefit Analysi

2016
Systemic steroid for chronic otitis media with effusion in children.
    Pediatrics, 2002, Volume: 110, Issue:6

    Topics: Acoustic Impedance Tests; Amoxicillin; Audiometry; Child; Child, Preschool; Chronic Disease; Double-

2002
Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment.
    International journal of pediatric otorhinolaryngology, 2003, Volume: 67, Issue:3

    Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ceftriaxone; Child; Child, Preschool

2003
Otoscopic and tympanometric findings in acute otitis media yielding dry tap at tympanocentesis.
    The Pediatric infectious disease journal, 2004, Volume: 23, Issue:11

    Topics: Acoustic Impedance Tests; Acute Disease; Ceftriaxone; Child; Child, Preschool; Diagnosis, Differenti

2004
Nonsurgical management of surgical otitis media with effusion.
    The Journal of laryngology and otology, 1995, Volume: 109, Issue:9

    Topics: Administration, Oral; Anti-Bacterial Agents; Cefpodoxime Proxetil; Ceftizoxime; Child, Preschool; Dr

1995
Treatment of secretory otitis media with local instillation of hydroxyzine.
    International archives of allergy and immunology, 1994, Volume: 103, Issue:1

    Topics: Child; Child, Preschool; Female; Histamine; Humans; Hydroxyzine; Injections; Male; Mast Cells; Otiti

1994
Oral prednisolone is an effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes.
    The Journal of pediatrics, 1999, Volume: 134, Issue:4

    Topics: Acute Disease; Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents; C

1999
Peroral prednisolone in the treatment of middle-ear effusion in children: a double-blind study.
    Auris, nasus, larynx, 1985, Volume: 12 Suppl 1

    Topics: Administration, Oral; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Drug C

1985

Other Studies

9 other studies available for prednisolone and Otitis Media with Effusion

ArticleYear
Otologic manifestations of immunoglobulin G4-related disease.
    The Annals of otology, rhinology, and laryngology, 2014, Volume: 123, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Asthma; Eosinophils; Female; Glucocorticoids;

2014
Effect of systemic clarithromycin and prednisolone on histamine-induced otitis media in guinea pigs.
    Acta oto-laryngologica, 2015, Volume: 135, Issue:10

    Topics: Animals; Anti-Bacterial Agents; Clarithromycin; Cytokines; Disease Models, Animal; Dose-Response Rel

2015
[Not Available].
    Laryngo- rhino- otologie, 2016, Volume: 95, Issue:3

    Topics: Aged; Audiometry, Pure-Tone; Cyclophosphamide; Diagnosis, Differential; Drug Resistance, Microbial;

2016
Chronic otitis media and facial paralysis as a presenting feature of Wegener's granulomatosis.
    Singapore medical journal, 2009, Volume: 50, Issue:4

    Topics: Administration, Oral; Adult; Biopsy; Chronic Disease; Cyclophosphamide; Diagnosis, Differential; Dru

2009
Unusual complication of otitis media with effusion: facial nerve paralysis.
    The Journal of craniofacial surgery, 2011, Volume: 22, Issue:4

    Topics: Ampicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents; Child, Preschool; Facial Nerve Diseases

2011
Influence of prednisolone on the secretion of mucin from the HT29-MTX cell line.
    Clinical otolaryngology and allied sciences, 2003, Volume: 28, Issue:1

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Cell Culture Techniques; Cell Differentiation; Enz

2003
Early diagnosis of Wegener's granulomatosis presenting with bilateral facial paralysis and bilateral serous otitis media.
    Auris, nasus, larynx, 2007, Volume: 34, Issue:3

    Topics: Administration, Oral; Antibodies, Antineutrophil Cytoplasmic; Cyclophosphamide; Diagnosis, Different

2007
ENT manifestations of relapsing polychondritis.
    Acta oto-rhino-laryngologica Belgica, 1997, Volume: 51, Issue:2

    Topics: Anti-Inflammatory Agents; Azathioprine; Cochlear Diseases; Ear Diseases; Ear, External; Humans; Immu

1997
The ENT manifestations of systemic vasculitis.
    The Journal of laryngology and otology, 1985, Volume: 99, Issue:9

    Topics: Azathioprine; Deafness; Ear Diseases; Female; Humans; Male; Middle Aged; Nose Diseases; Otitis Media

1985