Page last updated: 2024-11-06

prednisolone and Opportunistic Infections

prednisolone has been researched along with Opportunistic Infections in 100 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Research Excerpts

ExcerptRelevanceReference
"Thirty-four patients with collagen diseases suffering from onychomycosis were treated with fluconazole and showed remarkable improvement."9.08[Effects of fluconazole on onychomycosis in the patients with collagen diseases]. ( Iwamoto, I; Izumi, H; Nawata, Y; Otawa, M; Sueishi, M; Sugiyama, T; Sumida, T; Takabayashi, K; Tanabe, E; Tomioka, H, 1995)
"A 78-year-old woman with rheumatoid arthritis on TNF-α inhibitor, methotrexate and prednisolone presented with severe but unspecific symptoms such as leg weakness, shivering, bifrontal headache, nausea and staggering."7.96[Neurological symptoms in a patient on anti-TNF therapy, methotrexate and prednisolone for rheumatoid arthritis]. ( Bach, M; Baerwald, C; Schob, S, 2020)
"Thirty-four patients with collagen diseases suffering from onychomycosis were treated with fluconazole and showed remarkable improvement."5.08[Effects of fluconazole on onychomycosis in the patients with collagen diseases]. ( Iwamoto, I; Izumi, H; Nawata, Y; Otawa, M; Sueishi, M; Sugiyama, T; Sumida, T; Takabayashi, K; Tanabe, E; Tomioka, H, 1995)
"A 70-year-old man treated for 6 months with prednisolone for nephrotic syndrome, was referred to our pulmonary division because of a nodule in the right lower lung field."4.81[Pulmonary nocardiosis associated with nephrotic syndrome]. ( Kawamura, T; Mochizuki, Y; Nakahara, Y; Sasaki, S; Tanaka, A; Watanabe, S; Yuugetu, H, 2001)
"A 78-year-old woman with rheumatoid arthritis on TNF-α inhibitor, methotrexate and prednisolone presented with severe but unspecific symptoms such as leg weakness, shivering, bifrontal headache, nausea and staggering."3.96[Neurological symptoms in a patient on anti-TNF therapy, methotrexate and prednisolone for rheumatoid arthritis]. ( Bach, M; Baerwald, C; Schob, S, 2020)
"We present a case of acute upper gastrointestinal haemorrhage in a patient with systemic vasculitis immunosuppressed on cyclophosphamide and prednisolone."3.81Catastrophic gastrointestinal complication of systemic immunosuppression. ( Gangopadhyay, M; Gaya, DR; Smith, LA, 2015)
" The diagnosis of acquired hemophilia A (AHA) was made, and treatment with prednisolone (PSL) was started."3.75[Acquired hemophilia complicated with multiple muscle abscess by Nocardia]. ( Abe, T; Azuma, T; Fujiwara, H; Hato, T; Narumi, H; Yakushijin, Y; Yamanouchi, J; Yasukawa, M, 2009)
"A 78-year-old man administered prednisolone and cyclosporin A for bullous pemphigoid and found in computed tomography (CT) to have a left-lung nodule was suspected of having a fungal infection due to elevated blood (1-->3)-beta-D-glucan."3.75[A case of disseminated nocardiosis followed by pneumocystis pneumonia in a patient prescribed corticosteroid and cyclosporin A and having elevated blood (1-->3)-beta-D-glucan]. ( Harada, S; Hatakeyama, S; Itoyama, S; Kitazawa, T; Koike, K; Ota, Y, 2009)
" We report a case of a 61-year-old man with seronegative rheumatoid arthritis and fibrosing alveolitis on long-term prednisolone who presented with a number of tender, red, subcutaneous nodules on his upper arms and a pustule on his left cheek."3.72Disseminated cutaneous infection with Mycobacterium chelonae in a patient with steroid-dependent rheumatoid arthritis. ( Lamb, SR; Merchant, W; Stables, GI, 2004)
" The infection coincided with neutropenia resulting from pyrazolone treatment."3.67Trichosporon beigelii pneumonia in a neutropenic patient. ( Borras, R; Chiner, E; Franco, J; Marin, J, 1989)
"Patients with rheumatoid arthritis are at higher risk for serious infections and death from infection than the general public."2.48Infections and biologic therapy in rheumatoid arthritis: our changing understanding of risk and prevention. ( Winthrop, KL, 2012)
"A 56-year-old Japanese man with ulcerative colitis and a history of Sweet's syndrome who was taking prednisolone and azathioprine presented with a moderate exacerbation of ulcerative colitis, abdominal pain, diarrhea, and bloody stools along with cytomegalovirus infection."1.91Ulcerative colitis successfully treated with vedolizumab in the presence of comorbid opportunistic infections: a case report. ( Ichimori, T; Ishikawa, Y; Nagano, S; Oki, Y; Uchida, K; Yamada, T, 2023)
"High rates of varicella screening and immunisation within a PIBD population are possible, resulting in a reduction in hospital admissions for varicella treatment."1.56A Decade of Varicella Screening Within a Paediatric Inflammatory Bowel Disease Population. ( Al-Hourani, G; Armstrong, L; Barclay, AR; Curtis, L; Delahunty, C; Eccleston, A; Flynn, DM; Garrick, V; Gervais, L; Hansen, R; Harris, RE; Hegde, V; Merrick, V; Russell, RK; Tayler, R, 2020)
" Preventative measures are not usually required in patients who receive a short high-dosed treatment (30 mg PED in 7 days) or prednisolone at a dosage of < 15 mg/day."1.48[Infections during glucocorticoid use]. ( den Hoed, CM; Minderhoud, TC; Schurink, CAM; van Daele, PLA; van Meer, MPA; van Thiel, RJ, 2018)
" We investigated whether high-dose MZR is effective and safe for renal transplant patients in conjunction with cyclosporine (CsA), basiliximab, and corticosteroids."1.43Efficacy and Safety of High-Dose Mizoribine Combined With Cyclosporine, Basiliximab, and Corticosteroids in Renal Transplantation: A Japanese Multicenter Study. ( Akioka, K; Fujisawa, M; Fukuda, Y; Horimi, T; Ito, SI; Nakatani, T; Nishimura, K; Sugitani, A; Uchida, K; Ushigome, H; Yoshimura, N; Yuzawa, K, 2016)
"There are reports on patients with systemic lupus erythematosus (SLE) with aspergillosis; however, aspergillosis-related pneumothorax has not been reported in SLE."1.40The development of pulmonary aspergillosis and pneumothorax in a patient with neutropenic systemic lupus erythematosus and successful treatment of the first case. ( Barutcu, E; Celik, AD; Pamuk, GE; Pamuk, ON, 2014)
"Mucormycosis is a devastating fungal infection commonly seen in immunocompromised individuals, including those with NHL, but it is affecting the same region has been reported very rarely."1.38T cell non-Hodgkin's lymphoma with colesional mucormycosis presenting as palatal perforation: a case report. ( Agarwal, PK; Aggarwal, S; Dhawan, S; Garg, A; Khan, AA; Siraj, F, 2012)
"Patient was started on NIH protocol for lupus nephritis on which he was doing well."1.37Young male with systemic lupus erythematosus presenting with sensorineural deafness with immune suppression induced miliary tuberculosis. ( Chatterjee, S; Ghosh, A; Kundu, S; Mitra, R, 2011)
"Compared to SLE without PCP, those with PCP infection have significantly higher activity index by MEX-SLEDAI (13."1.35Risk factors of Pneumocystis jeroveci pneumonia in patients with systemic lupus erythematosus. ( Janwityanujit, S; Lertnawapan, R; Nantiruj, K; Totemchokchyakarn, K, 2009)
"Pulmonary nocardiosis was clinically suspected because we detected nocardia from Gram staining of sputum."1.34[A case of pulmonary nocardiosis cured by early sulfamethoxazole-trimethoprim therapy]. ( Katakura, H; Kojima, M; Matsui, Y; Sakai, N; Wada, H; Yamanaka, A, 2007)
"Brain MRI revealed multiple brain abscesses at more than 20 sites."1.33[Pulmonary nocardiosis complicated with multiple brain abscess]. ( Aida, S; Kanoh, S; Kobayashi, H; Motoyoshi, K; Shimokawaji, T, 2005)
"Gas gangrene is extremely rare in patients with ulcerative colitis or Crohn's disease and immunosuppression."1.33[Gas gangrene with ulcerative colitis under immunosuppressive therapy: report of a case]. ( Freitag, M; Jackisch, T; Ludwig, K, 2006)
" Although corticosteroid therapy has been reported to be effective in some CCE patients, the indications of steroid therapy, dosage of corticosteroids, duration of the treatment, or efficacy of prophylactic administration of antibiotics are not yet established."1.33[Pulmonary infection of Pneumocystis carinii and Cytomegalo virus in the treatment of cholesterol crystal embolism]. ( Fujii, M; Fujita, Y; Kitamura, H; Matsui, I; Okuno, A; Yamamoto, R, 2006)
"In early pulmonary alveolar proteinosis with focal opacity, HRCT can demonstrate the substantial findings of alveolar proteinosis such as a crazy-paving appearance or geographic distribution."1.33[Radiological findings in initial pulmonary alveolar proteinosis detected in the post-treatment course of nocardiosis]. ( Aida, S; Kanoh, S; Kobayashi, H; Motoyoshi, K; Sugimoto, C, 2006)
"The occurrence of opportunistic infections is not rare during the treatment of connective tissue diseases, including dermatomyositis because of the patient's immunosuppression."1.33Cytomegalovirus infection complicating immunosuppressive therapy for dermatomyositis. ( Aiba, S; Hashimoto, A; Okuyama, R; Tagami, H; Watanabe, H, 2006)
"We present the case of a patient with Crohn's disease under immunosuppressive therapy who developed a spontaneous covered spleen rupture in the course of a septic shock with DIG due to a Varizella zoster infection."1.32[Functional asplenia after severe varicella zoster-infection diagnosis by colour Doppler ultrasound]. ( Arnold, R; Diedrich, J; Eissele, R; Görg, C, 2003)
"Patients with systemic lupus erythematosus (SLE) are usually exposed to high doses of corticosteroids and eventually develop defective cellular immunity that increases the risk for active tuberculosis."1.32An overwhelming pulmonary fungus ball in a systemic lupus erythematosus patient. ( Boztosun, Y; Kiris, A; Kocakoc, E; Ozcakar, L; Ozgocmen, S; Yildirim, N, 2003)
"Pulmonary nocardiosis is difficult to diagnose and should be considered in the differential diagnosis, especially in an immunocompromised host."1.31Pulmonary nocardiosis in a patient treated with corticosteroid therapy. ( Endoh, S; Kasai, T; Narushima, M; Ohtsuka, H; Suzuki, H; Tomita, S; Tsuzura, Y; Yamada, M, 2002)
"The history revealed an anaplastic anemia."1.29[Mycotic retrobulbar neuritis]. ( Kössling, S; Meier, P; Nenning, H; Penk, A, 1994)
"Prednisolone alone was the most effective on minimal change NS in the elderly."1.29Nephrotic syndrome in the elderly--clinicopathological study. ( Hara, K; Harada, T; Ozono, Y; Taguchi, T; Taura, K; Yamaguchi, K, 1994)
"The possibility of nocardiosis should be considered in the differential diagnosis of such patients."1.29Disseminated subcutaneous Nocardia asteroides abscesses in a patient after bone marrow transplantation. ( Fujiyama, Y; Hiramitu, Y; Hodohara, K; Hosoda, S; Kitoh, K; Sugiura, H; Sumiyoshi, K, 1993)
"Children with malignancy have a high incidence of pneumonia and pneumonitis and death is rare if the patient does not have terminal malignant disease."1.28Pneumonia and pneumonitis in childhood malignancy. ( Eden, OB; Elton, R; Shaw, NJ, 1992)

Research

Studies (100)

TimeframeStudies, this research(%)All Research%
pre-19906 (6.00)18.7374
1990's21 (21.00)18.2507
2000's48 (48.00)29.6817
2010's19 (19.00)24.3611
2020's6 (6.00)2.80

Authors

AuthorsStudies
Oki, Y1
Nagano, S1
Ishikawa, Y1
Yamada, T1
Ichimori, T1
Uchida, K2
Harris, RE1
Curtis, L1
Hegde, V1
Garrick, V1
Gervais, L1
Armstrong, L1
Delahunty, C1
Eccleston, A1
Al-Hourani, G1
Flynn, DM1
Merrick, V1
Barclay, AR1
Tayler, R1
Hansen, R1
Russell, RK1
Kimura, R1
Yamada, N1
Yoshida, Y1
Ito, A1
Horie, T1
Anzawa, K1
Mochizuki, T1
Yamamoto, O1
Bach, M1
Schob, S1
Baerwald, C1
Phanish, MK1
Hull, RP1
Andrews, PA1
Popoola, J1
Kingdon, EJ1
MacPhee, IAM1
Larroquette, M1
Issa, N1
Gabriel, F1
Camou, F1
Terayama, Y1
Matsuura, T1
Ozaki, K1
Minderhoud, TC1
van Meer, MPA1
van Thiel, RJ1
den Hoed, CM1
van Daele, PLA1
Schurink, CAM1
Kniazev, OV1
Lazebnik, LB1
Parfenov, AI1
Ruchkina, IN1
Shcherbakov, PL1
Konopliannikov, AG1
Mikhaĭlova, ZF1
Khomeriki, SG1
Khan, AA1
Garg, A1
Dhawan, S1
Agarwal, PK1
Siraj, F1
Aggarwal, S1
Ohyama, Y1
Kumode, T1
Eguchi, G1
Yamaguchi, T1
Maeda, Y1
Sumida, K1
Ubara, Y1
Muso, E1
Katagiri, S1
Yoshizawa, S1
Gotoh, M1
Nakamura, I1
Ohyashiki, K1
Pamuk, ON1
Pamuk, GE1
Barutcu, E1
Celik, AD1
Smith, LA1
Gangopadhyay, M1
Gaya, DR1
Cartron, G1
Hourcade-Potelleret, F1
Morschhauser, F1
Salles, G1
Wenger, M1
Truppel-Hartmann, A1
Carlile, DJ1
Ushigome, H1
Nishimura, K1
Akioka, K1
Fukuda, Y1
Yuzawa, K1
Fujisawa, M1
Sugitani, A1
Ito, SI1
Nakatani, T1
Horimi, T1
Yoshimura, N1
Tourret, J1
Willing, BP1
Dion, S1
MacPherson, J1
Denamur, E1
Finlay, BB1
Lertnawapan, R1
Totemchokchyakarn, K1
Nantiruj, K1
Janwityanujit, S1
Yamanouchi, J1
Abe, T1
Azuma, T1
Narumi, H1
Fujiwara, H1
Yakushijin, Y1
Hato, T1
Yasukawa, M1
Namdar, T1
Mailänder, P1
Lange, T1
Harada, S1
Hatakeyama, S1
Kitazawa, T1
Itoyama, S1
Ota, Y1
Koike, K1
Kobashigawa, JA1
Kiyosaki, KK1
Patel, JK1
Kittleson, MM1
Kubak, BM1
Davis, SN1
Kawano, MA1
Ardehali, AA1
Kudo, T1
Aoyagi, Y1
Fujii, T1
Ohtsuka, Y1
Nagata, S1
Shimizu, T2
Böttcher, A1
Guder, E1
Just, T1
Kundu, S1
Mitra, R1
Chatterjee, S1
Ghosh, A1
Sugiura, K1
Sugiura, N1
Yagi, T1
Iguchi, M1
Ohno, H1
Miyazaki, Y1
Akiyama, M1
Winthrop, KL1
Seta, N1
Nawata, M1
Wada, R1
Mori, K1
Sekigawa, I1
Iida, N1
Maeda, M1
Hashimoto, H1
Tanaka, H1
Suzuki, K1
Nakahata, T1
Tateyama, T1
Sugimoto, K1
Ito, E1
Waga, S1
Cheng, CL1
Song, KP1
Chee, SP1
Chan, TK1
Diedrich, J1
Görg, C1
Eissele, R1
Arnold, R1
López-Duarte, M1
Insunza, A1
Conde, E1
Iriondo, A1
Mazorra, F1
Zubizarreta, A1
Kocakoc, E1
Ozgocmen, S1
Kiris, A1
Ozcakar, L1
Boztosun, Y1
Yildirim, N1
Akutsu, M1
Fujioka, T1
Kurihara, T1
Oharasei, T1
Takahashi, H1
Lamb, SR1
Stables, GI1
Merchant, W1
Takabayashi, K3
Hanaoka, H1
Kotanidou, AN1
Zakynthinos, E1
Andrianakis, I1
Zervakis, D1
Kokotsakis, I1
Argyrakos, T1
Argiropoulou, A1
Margariti, G1
Douzinas, E1
Kubota, Y1
Sano, M1
Nakazato, S1
Tsuneyoshi, N1
Tomimasu, R1
Kuwahara, N1
Fukushima, N1
Funai, N1
Suga, K1
Sueoka, E1
Holtkamp, M1
Okuducu, AF1
Klingebiel, R1
Ploner, CJ1
Eisendle, K1
Fritsch, P1
Tanaka, Y3
Takahashi, S1
Takahashi, T1
Kuragano, T1
Nagura, Y1
Fujita, T1
Nakayama, T1
Matsumoto, K1
Iliopoulos, A1
Kedikoglou, S1
Laxanis, S1
Kourouklis, S1
Katsaros, E1
Shimokawaji, T1
Kobayashi, H2
Kanoh, S2
Motoyoshi, K2
Aida, S2
Kaşifoğlu, T1
Korkmaz, C1
Ozkan, R1
Hirose, I1
Ymamaguchi, H1
Inaguma, D1
Ono, K1
Shimada, S1
Kawada, J1
Shiraki, K1
Kimura, H1
Kawakami, K1
Ito, R1
Watanabe, Y1
Goto, T1
Enomoto, T1
Azuma, A1
Matsumoto, A1
Nei, T1
Hiramatsu, K1
Abe, S1
Usuki, J1
Kudoh, S1
Jackisch, T1
Freitag, M1
Ludwig, K1
Saito, K1
Okuno, A1
Yamamoto, R1
Matsui, I1
Kitamura, H1
Fujita, Y1
Fujii, M1
Yang, CD1
Wang, XD1
Ye, S1
Gu, YY1
Bao, CD1
Wang, Y1
Chen, SL1
Chen, HS1
Tsai, WP1
Leu, HS1
Ho, HH1
Liou, LB1
Sugimoto, C1
Ichiyasu, H1
Yamamura, A1
Honda, M1
Okamoto, S1
Tsumori, K1
Okamoto, T1
Sato, K1
Matsumoto, M1
Kohrogi, H1
Hashimoto, A1
Okuyama, R1
Watanabe, H1
Tagami, H1
Aiba, S1
Howman, R1
Kulkarni, H1
Lateef, A1
Vasoo, S1
Boey, ML1
Wada, H1
Sakai, N1
Matsui, Y1
Kojima, M1
Katakura, H1
Yamanaka, A1
Maronn, ML1
Corden, T1
Drolet, BA1
Hasselbach, HC1
Fickenscher, H1
Nölle, B1
Roider, J1
Nawata, Y1
Sumida, T1
Izumi, H1
Otawa, M1
Iwamoto, I1
Tanabe, E1
Tomioka, H2
Sugiyama, T2
Sueishi, M1
Nenning, H1
Meier, P1
Penk, A1
Kössling, S1
Ozono, Y1
Harada, T1
Yamaguchi, K1
Taura, K1
Hara, K1
Taguchi, T1
Hodohara, K1
Fujiyama, Y1
Hiramitu, Y1
Sumiyoshi, K1
Kitoh, K1
Hosoda, S1
Sugiura, H1
Morland, BJ1
Shaw, PJ1
Späth, M1
Schollmeyer, P1
Yanase, K1
Nakamura, M1
Toyoda, T1
Dote, K1
Tsunami, A1
Hisaoka, N1
Maruyama, T1
Shikanai, K1
Maruyama, S1
Ueno, K1
Machet, L1
Jan, V1
Machet, MC1
Vaillant, L1
Lorette, G1
Teuber, G1
Schwarting, A1
Mildenberger, P1
Schmidt-Brücken, G1
Moll, R1
Bornemann, A1
Wandel, E1
Wanitschke, R1
Meyer zum Büschenfelde, KH1
Khatchatourian, M1
Seaton, TL1
Schneider, T1
Strupp, R1
Kühnen, E1
Jochem, C1
Boesken, WH1
Neumann, UP1
Knoop, M1
Lang, M1
Bechstein, WO1
Langrehr, JM1
Raakow, R1
Neuhaus, P1
Veness, MJ1
Tsang, KW1
Lam, PS1
Yuen, KY1
Ooi, CC1
Lam, W1
Ip, M1
Jamil, B1
Nicholls, KM1
Becker, GJ1
Walker, RG1
Kim, HC1
Park, SB1
Kim, HT1
Cho, WH1
Park, CH1
Matsumori, A1
Nishiya, K1
Tahara, K1
Yamasaki, H1
Hashimoto, K1
Mitsunaka, H1
Tokuda, M1
Takahara, J1
Matoba, K1
Miyawaki, S1
Sekhar, U1
Madan, M1
Ranjitham, M1
Abraham, G1
Eapen, G1
Ohashi, H1
Ohno, R1
Sadikot, RT1
Doré, P1
Arnold, AG1
Remport, A1
Sasvári, I1
Toronyi, E1
Borka, P1
Lázár, N1
Járay, J1
Perner, F1
Saito, T1
Seo, S1
Kanda, Y1
Shoji, N1
Ogasawara, T1
Murakami, J1
Tanosaki, R1
Tobinai, K1
Takaue, Y1
Mineishi, S1
Yuugetu, H1
Mochizuki, Y1
Nakahara, Y1
Tanaka, A1
Kawamura, T1
Watanabe, S1
Sasaki, S1
Ohira, S1
Isoda, K1
Hamanaka, H1
Takahashi, K1
Nishimoto, K1
Mizutani, H1
Narushima, M1
Suzuki, H1
Kasai, T1
Tsuzura, Y1
Tomita, S1
Endoh, S1
Yamada, M1
Ohtsuka, H1
Shaw, NJ1
Elton, R1
Eden, OB1
Waldmann, KD1
Clerc, D1
Brousse, C1
Mariette, X1
Bennet, P1
Bisson, M1
Crellin, AM1
Shareef, DS1
Maher, EJ1
Scholz, D1
Blank, W1
Bärwolf, C1
Ditscherlein, G1
Christenfeld, R1
Hüller, H1
Marin, J1
Chiner, E1
Franco, J1
Borras, R1
Koike, T1
Kurasawa, K1
Yamazaki, S1
Matsumura, R1
Yoshida, H1
Yoshida, S1
Ohshima, H1
Pyrig, LA1
Rudenko, AV2
Nikonova, NA1
Kudriavskaia, VM2
Saksonov, SI1
Meshcheriakova, EV1
Baras, ES1
Beker, OM1
Mourad, G1
Legendre, C1
Argiles, A1
Bonardet, A1
Mion, C1
Pyrit, LA1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-Label, Multi-Centre, Randomised, Phase Ib Study to Investigate the Safety and Efficacy of RO5072759 Given in Combination With CHOP, FC or Bendamustine Chemotherapy in Patients With CD20+ B-Cell Follicular Non-Hodgkin's Lymphoma[NCT00825149]Phase 1137 participants (Actual)Interventional2009-02-28Completed
An Open-label, Multicentre, Nonrandomized, Dose-escalating Phase I/II Study, With a Randomized Phase II Part, to Investigate the Safety and Tolerability of RO5072759 Given as Monotherapy in Patients With CD20+ Malignant Disease.[NCT00517530]Phase 1/Phase 2134 participants (Actual)Interventional2007-09-30Completed
A Randomized, Controlled Trial Evaluating the Role of ImmuKnow® in the Management of Immunosuppressants Regarding Opportunistic Infections and Acute Rejection in the Renal Transplant Patient[NCT01424345]Phase 440 participants (Anticipated)Interventional2011-12-31Terminated (stopped due to The PI is relocating to another State/ another hospital)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Area Under the Concentration-time Curve of Obinutuzumab Administered on Day 1 of Cycle 1 in Phase I of the Study

Blood samples were taken on Day 1 (pre-infusion, end of infusion, 3-6 hours post-infusion) of Cycle 1. Nonlinear mixed-effects modeling (with NONMEM software) was used to analyze the pooled samples for dose-concentration-time data of obinutuzumab. (NCT00517530)
Timeframe: Day 1 of Cycle 1

Interventionµm/ml*day (Geometric Mean)
400 mg - Phase I, NHL459
800 mg - Phase I, NHL993
1200 mg - Phase I, NHL1057
2000 mg - Phase I, NHL146

Duration of Response by Disease Type in Phase II of the Study

Duration of complete response was defined as the time from the first complete or partial response until disease progression (PD) or death, whichever occurred first. For non-Hodgkin's lymphoma participants, PD was defined as >= 50% increase from nadir in the sum of the products of the greatest diameters (SPD) of any previously identified abnormal node for participants with a partial response or non-responders or the appearance of any new lesion during or at the end of therapy. For chronic lymphocytic leukemia participants, PD was defined as: (1) A >= 50% increase from nadir in the SPD of any previously involved nodes, or in a single involved node, or the size of other lesions (eg, splenic or hepatic nodules); a lymph node with a short axis of < 1.0 cm must increase by >= 50% and to a size of 1.5×1.5 cm or > 1.5 cm in the longest axis. (2) Appearance of any new lesion > 1 cm in the short axis. (4) A new site that is PET-positive with histological confirmation. (NCT00517530)
Timeframe: by the end of the follow-up period in Phase II of the study (within 3 years, 4 months)

Interventiondays (Median)
Phase II, iNHL523
Phase II, aNHL298
Phase II, CLL272.5

Participants With Event-Free Survival (EFS) in Phase II of the Study

EFS is defined as the time from start of treatment to disease progression/relapse, death or, in case of early withdrawal from the treatment period, the (end) date of last dose, whatever comes first. (NCT00517530)
Timeframe: by the end of the follow-up period in Phase II of the study (within 3 years, 4 months)

Interventionparticipants (Number)
400/400 mg - Phase II, iNHL5
1600/800 mg - Phase II, iNHL6
400/400 mg - Phase II, aNHL2
1600/800 mg - Phase II, aNHL3
1000/1000 mg - Phase II, CLL4

Percentage of Participants Who Experienced a Dose-limiting Toxicity in Phase I of the Study

Dose-limiting toxicities were defined as obinutuzumab-related adverse events occurring within the first 28 days of each administration of obinutuzumab, with the exception of B-cell depletion and lymphopenia which are expected outcomes of treatment with obinutuzumab. (NCT00517530)
Timeframe: Baseline to 28 days after the last infusion of obinutuzumab (up to 6 months)

Interventionpercentage of participants (Number)
50/100 mg - Phase I, NHL0
100/200 mg - Phase I, NHL0
200/400 mg - Phase I, NHL0
400/800 mg - Phase I, NHL0
800/1200 mg - Phase I, NHL0
1200/2000 mg - Phase I, NHL0
1600/800 mg - Phase I, NHL0
400/800 mg - Phase I, CLL0
800/1200 mg - Phase I, CLL0
1200/2000 mg - Phase I, CLL0
1000/1000 mg - Phase I, CLL0

Percentage of Participants With Best Overall Response in Phase II of the Study

Best overall response (BOR) was defined as the percentage of participants with a complete response (CR) or partial response (PR) (NCT00517530)
Timeframe: by Cutoff Date: 31 March 2012 (within 3 years, 4 months)

Interventionpercentage of participants (Number)
400/400 mg - Phase II, iNHL33.3
1600/800 mg - Phase II, iNHL63.6
400/400 mg - Phase II, aNHL23.8
1600/800 mg - Phase II, aNHL36.8
1000/1000 mg - Phase II, CLL30.0

Percentage of Participants With Partial Response (PR) in Phase II of the Study

A PR was defined as a >=50% decrease in SPD of the 6 largest nodes or nodal masses; no increase in size of other nodes, liver, or spleen; regression of splenic and hepatic nodules by >=50% in their SPD or, for single nodules, in the long axis (CLL only); and no new disease sites. (NCT00517530)
Timeframe: by Cutoff Date: 31 March 2012 (within 3 years, 4 months)

Interventionpercentage of participants (Number)
400/400 mg - Phase II, iNHL22.2
1600/800 mg - Phase II, iNHL40.9
400/400 mg - Phase II, aNHL9.5
1600/800 mg - Phase II, aNHL21.1
1000/1000 mg - Phase II, CLL25.0

Progression-free Survival (PFS) in Phase II of the Study

PFS was defined as the time from start of treatment to disease progression (PD) or death due to any cause, whichever occurred first. For non-Hodgkin's lymphoma participants, PD was defined as >= 50% increase from nadir in the sum of the products of the greatest diameters (SPD) of any previously identified abnormal node for participants with a partial response or non-responders or the appearance of any new lesion during or at the end of therapy. For chronic lymphocytic leukemia participants, PD was defined as: (1) A >= 50% increase from nadir in the SPD of any previously involved nodes, or in a single involved node, or the size of other lesions (eg, splenic or hepatic nodules); a lymph node with a short axis of < 1.0 cm must increase by >= 50% and to a size of 1.5×1.5 cm or > 1.5 cm in the longest axis. (2) Appearance of any new lesion > 1 cm in the short axis. (4) A new site that is positron emission tomography (PET)-positive with histological confirmation. (NCT00517530)
Timeframe: by the end of the follow-up period in Phase II of the study (within 3 years, 4 months)

Interventiondays (Median)
400/400 mg - Phase II, iNHL182
1600/800 mg - Phase II, iNHL361
400/400 mg - Phase II, aNHL78
1600/800 mg - Phase II, aNHL83
1000/1000 mg - Phase II, CLL324

Maximum Plasma Concentration (Cmax) of Obinutuzumab in CLL Patients

(NCT00517530)
Timeframe: at Cycle 1 Day 1, Cycle 1 Day 8 and Cycle 8 (over 168 days)

,,,
Interventionmicrograms/mL (Geometric Mean)
Cycle 1 Day 1 (n=3,3,3,0)Cycle 1 Day 8 (n=0,0,3,3)Cycle 8 (n=3,3,3,4)
1200 mg - Phase I, CLL307437741
2000 mg - Phase I, CLLNA7351730
400 mg - Phase I, CLL216NA485
800 mg - Phase I, CLL210NA573

Maximum Plasma Concentration (Cmax) of Obinutuzumab in NHL Participants

Obinutuzumab serum pharmacokinetic (PK) parameters in NHL participants following ascending doses. (NCT00517530)
Timeframe: at Cycle 1 Day 1, Cycle 1 Day 8 and Cycle 8 (over 168 days)

,,,
Interventionµm/ml*day (Geometric Mean)
Cycle 1 Day 1 (n=4,6,6,0)Cycle 1 Day 8 (n=0,4,6,6)Cycle 8 (n=0,5,5,5)
1200 mg - Phase I, NHL3074491070
2000 mg - Phase I, NHLNA7141380
400 mg - Phase I, NHL134NANA
800 mg - Phase I, NHL234367698

Percentage of Participants With Complete Response (CR/CRu/CRi) in Phase II of the Study

A complete response was defined as the disappearance of all evidence of disease (NHL) and symptoms; normalization of biochemical abnormalities (NHL); regression of lymph nodes and nodal masses to normal size; decrease of nodes in the sum of the products of the greatest diameters (SPD); regression in size of the spleen and/or liver, should not be palpable, and disappearance of nodules related to lymphoma (CLL). Complete/unconfirmed (CRu) response includes NHL patients with one or more of the following: 1) a residual lymph node mass greater than 1.5 cm in greatest transverse diameter that has regressed by more than 75% in the SPD; 2) Indeterminate bone marrow (increased number or size of aggregates without cytologic or architectural atypia). Complete Response with Incomplete Bone Marrow Recovery (CRi) was measured only in patients with CLL. (NCT00517530)
Timeframe: by Cutoff Date: 31 March 2012 (within 3 years, 4 months)

,,,,
Interventionpercentage of participants (Number)
CRCRuCRi
1000/1000 mg - Phase II, CLL5.0NA0.0
1600/800 mg - Phase II, aNHL15.80.0NA
1600/800 mg - Phase II, iNHL13.69.1NA
400/400 mg - Phase II, aNHL9.54.8NA
400/400 mg - Phase II, iNHL5.65.6NA

Percentage of Retreated Participants With Response

Patients who might benefit from retreatment were allowed to be treated again at the request of the investigator. (NCT00517530)
Timeframe: by Cutoff Date: 25 November 2013 (within 4 years, 2 months)

Interventionpercentage of participants (Number)
Best overall responseComplete responsePartial response
Retreated Participants622338

Pharmacodynamics: Participants With Peripheral B-cell Recovery After Having Had Depletion at End of Treatment During Phase II of the Study

B-cell depletion was defined in two ways: definition 1 - decrease below 5% baseline level and definition 2 - decrease below 0.04 x 109/L. B-cell recovery was defined in two ways: definition 1 - return to at least 50% of baseline level and definition 2 - return to at least 0.08 x 109/L. (NCT00517530)
Timeframe: by the end of Phase II (within 3 years, 4 months)

,,,,
Interventionparticipants (Number)
within 6 months (n=11,19,11,12,13)within 9 months (n=8,17,6,5,10)within 12 months (n=5,16,4,5,9)within 18 months (n=4,13,3,3,8)within 24 months (n=3,10,2,3,5)after 24 months (n=3,4,1,2,0)
1000/1000 mg - Phase II, CLL303220
1600/800 mg - Phase II, aNHL010101
1600/800 mg - Phase II, iNHL002120
400/400 mg - Phase II, aNHL001010
400/400 mg - Phase II, iNHL000021

Reviews

12 reviews available for prednisolone and Opportunistic Infections

ArticleYear
[Serious organ damage and intractable clinical conditions in rheumatic and connective tissue disease--progress in pathophysiology and treatment. Topics: II. Clinical conditions special attention needed to be paid to; 3. Opportunistic infections].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2013, Oct-10, Volume: 102, Issue:10

    Topics: Antirheumatic Agents; Aspergillosis; Biological Factors; Collagen Diseases; Cryptococcosis; Cytomega

2013
[Therapy and prognosis of medium and small vessel vasculitis].
    Nihon Jinzo Gakkai shi, 2014, Volume: 56, Issue:2

    Topics: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Cyclophosphamide; Drug Therapy, Combinat

2014
Infections and biologic therapy in rheumatoid arthritis: our changing understanding of risk and prevention.
    Rheumatic diseases clinics of North America, 2012, Volume: 38, Issue:4

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Biological Therapy; Humans; Opportunistic Infection

2012
[Collagen diseases with opportunistic infections].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2004, Volume: 27, Issue:3

    Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheu

2004
Aspergillus endocarditis in a native valve after amphotericin B treatment.
    The Annals of thoracic surgery, 2004, Volume: 78, Issue:4

    Topics: Amphotericin B; Anti-Infective Agents; Aspergillosis; Aspergillus fumigatus; Candidiasis; Drug Resis

2004
[Corticosteroids for treatment of rheumatoid arthritis].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 1

    Topics: Arthritis, Rheumatoid; Drug Resistance; Femur Head Necrosis; Glucocorticoids; Humans; Methylpredniso

2005
[Pneumocystis carinii pneumonia in patients with connective tissue diseases].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2002, Volume: 25, Issue:4

    Topics: Anti-Infective Agents; Connective Tissue Diseases; Drug Therapy, Combination; Humans; Molecular Diag

2002
Invasive fungal infection in systemic lupus erythematosus: an analysis of 15 cases and a literature review.
    Rheumatology (Oxford, England), 2007, Volume: 46, Issue:3

    Topics: Adult; Cryptococcosis; Cryptococcus neoformans; Drug Administration Schedule; Epidemiologic Methods;

2007
Cutaneous alternariosis: role of corticosteroid-induced cutaneous fragility.
    Dermatology (Basel, Switzerland), 1996, Volume: 193, Issue:4

    Topics: Aged; Alternaria; Biopsy, Needle; Dermatomycoses; Dermatomyositis; Female; Follow-Up Studies; Glucoc

1996
[Immunodeficiency induced by immunosuppressive agents].
    Ryoikibetsu shokogun shirizu, 2000, Issue:32

    Topics: Azathioprine; Cyclophosphamide; Cyclosporine; Diagnosis, Differential; Humans; Immunologic Deficienc

2000
[Pulmonary nocardiosis associated with nephrotic syndrome].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2001, Volume: 39, Issue:5

    Topics: Aged; Humans; Male; Nephrotic Syndrome; Nocardia asteroides; Nocardia Infections; Opportunistic Infe

2001
Case report. Phaeohyphomycosis caused by Phialophora verrucosa developed in a patient with non-HIV acquired immunodeficiency syndrome.
    Mycoses, 2002, Volume: 45, Issue:1-2

    Topics: Acquired Immunodeficiency Syndrome; Anti-Inflammatory Agents; Dermatomycoses; Fatal Outcome; Female;

2002

Trials

4 trials available for prednisolone and Opportunistic Infections

ArticleYear
Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma.
    Haematologica, 2016, Volume: 101, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antigens, CD20; Antineoplastic Ag

2016
Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma.
    Haematologica, 2016, Volume: 101, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antigens, CD20; Antineoplastic Ag

2016
Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma.
    Haematologica, 2016, Volume: 101, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antigens, CD20; Antineoplastic Ag

2016
Rationale for optimal obinutuzumab/GA101 dosing regimen in B-cell non-Hodgkin lymphoma.
    Haematologica, 2016, Volume: 101, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antigens, CD20; Antineoplastic Ag

2016
[Effects of fluconazole on onychomycosis in the patients with collagen diseases].
    Ryumachi. [Rheumatism], 1995, Volume: 35, Issue:1

    Topics: Adult; Collagen Diseases; Female; Fluconazole; Humans; Male; Middle Aged; Onychomycosis; Opportunist

1995
Comparison of the safety and efficacy of mycophenolate mofetil, prednisolone and cyclosporine and conventional cyclosporine and prednisolone in kidney transplantation.
    Transplantation proceedings, 2000, Volume: 32, Issue:7

    Topics: Adrenal Cortex Hormones; Biopsy; Cyclosporine; Drug Therapy, Combination; Female; Gastrointestinal D

2000
Mycofenolate mofetil-cyclosporine immunosuppression of kidney transplantation recipients with two different corticosteroid doses.
    Transplantation proceedings, 2001, Volume: 33, Issue:3

    Topics: Adrenal Cortex Hormones; Cyclosporine; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug The

2001

Other Studies

84 other studies available for prednisolone and Opportunistic Infections

ArticleYear
Ulcerative colitis successfully treated with vedolizumab in the presence of comorbid opportunistic infections: a case report.
    Journal of medical case reports, 2023, May-31, Volume: 17, Issue:1

    Topics: Colitis, Ulcerative; Cytomegalovirus Infections; Fluconazole; Humans; Inflammatory Bowel Diseases; M

2023
A Decade of Varicella Screening Within a Paediatric Inflammatory Bowel Disease Population.
    Journal of Crohn's & colitis, 2020, Jun-19, Volume: 14, Issue:5

    Topics: Anti-Inflammatory Agents; Antibodies, Viral; Chickenpox; Child; Female; Hospitalization; Humans; Imm

2020
Recurrent Phaeohyphomycosis due to Phaeoacremonium alvesii Identified with Internal Transcribed Spacer and Beta-tubulin Gene Sequencing.
    Acta dermato-venereologica, 2020, Jan-30, Volume: 100, Issue:1

    Topics: Aged, 80 and over; Antifungal Agents; Ascomycota; Dermatomycoses; DNA, Fungal; DNA, Ribosomal Spacer

2020
[Neurological symptoms in a patient on anti-TNF therapy, methotrexate and prednisolone for rheumatoid arthritis].
    Der Internist, 2020, Volume: 61, Issue:3

    Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Brain; Diagnosis, Differential; Drug Therapy, Com

2020
Immunological risk stratification and tailored minimisation of immunosuppression in renal transplant recipients.
    BMC nephrology, 2020, 03-11, Volume: 21, Issue:1

    Topics: Adult; Aged; Azathioprine; Basiliximab; Drug Administration Schedule; Female; Glucocorticoids; Graft

2020
Atypical presentation of a central nervous system aspergillosis in a peripheral T cell lymphoma patient.
    Annals of hematology, 2020, Volume: 99, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Brown-Sequard Syndrome; Cyclophos

2020
Induction of Severe Chronic Hyperplastic Candidiasis in Rat by Opportunistic Infection of C. albicans through Combination of Diabetes and Intermittent Prednisolone Administration.
    Toxicologic pathology, 2017, Volume: 45, Issue:6

    Topics: Animals; Candida albicans; Candidiasis; Carcinogenesis; Diabetes Mellitus, Experimental; Drug Admini

2017
[Infections during glucocorticoid use].
    Nederlands tijdschrift voor geneeskunde, 2018, 08-30, Volume: 162

    Topics: Animals; Comorbidity; Glucocorticoids; Humans; Medical History Taking; Opportunistic Infections; Pne

2018
[Complete elimination of cytomegalovirus without antiviral therapy after systemic mesenchymal stromal cell transplantation in a patient with ulcerative colitis (a clinical case)].
    Terapevticheskii arkhiv, 2012, Volume: 84, Issue:12

    Topics: Adult; Anti-Inflammatory Agents; Antibodies, Viral; Biopsy; Colitis, Ulcerative; Cytomegalovirus; Cy

2012
T cell non-Hodgkin's lymphoma with colesional mucormycosis presenting as palatal perforation: a case report.
    Journal of the Indian Medical Association, 2012, Volume: 110, Issue:7

    Topics: Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Combined Modality

2012
Induction of molecular remission by using anti-CC-chemokine receptor 4 (anti-CCR4) antibodies for adult T cell leukemia: a risk of opportunistic infection after treatment with anti-CCR4 antibodies.
    Annals of hematology, 2014, Volume: 93, Issue:1

    Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antibody-Dependent Cell Cytotoxicity; An

2014
[Case report; Disseminated Mycobacterium abscessus infection with hemophagocytic syndrome during treatment of chronic lymphocytic leukemia].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2014, Mar-10, Volume: 103, Issue:3

    Topics: Amikacin; Anemia, Hemolytic, Autoimmune; Anti-Bacterial Agents; Clarithromycin; Cyclophosphamide; Hu

2014
The development of pulmonary aspergillosis and pneumothorax in a patient with neutropenic systemic lupus erythematosus and successful treatment of the first case.
    BMJ case reports, 2014, May-21, Volume: 2014

    Topics: Anti-Inflammatory Agents; Antifungal Agents; Aspergillus fumigatus; Drainage; Female; Humans; Lupus

2014
Catastrophic gastrointestinal complication of systemic immunosuppression.
    World journal of gastroenterology, 2015, Feb-28, Volume: 21, Issue:8

    Topics: Aged; Antiviral Agents; Biopsy; Cyclophosphamide; Cytomegalovirus Infections; Duodenitis; Endoscopy,

2015
Efficacy and Safety of High-Dose Mizoribine Combined With Cyclosporine, Basiliximab, and Corticosteroids in Renal Transplantation: A Japanese Multicenter Study.
    Transplantation proceedings, 2016, Volume: 48, Issue:3

    Topics: Adult; Aged; Anemia; Antibodies, Monoclonal; Basiliximab; Case-Control Studies; Cyclosporine; Cytome

2016
Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli.
    Transplantation, 2017, Volume: 101, Issue:1

    Topics: Animals; Antimicrobial Cationic Peptides; Drug Therapy, Combination; Escherichia coli Infections; Fe

2017
Risk factors of Pneumocystis jeroveci pneumonia in patients with systemic lupus erythematosus.
    Rheumatology international, 2009, Volume: 29, Issue:5

    Topics: Adult; Case-Control Studies; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Female; Humans; Immun

2009
[Acquired hemophilia complicated with multiple muscle abscess by Nocardia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2009, Volume: 50, Issue:6

    Topics: Abscess; Aged, 80 and over; Biopsy, Fine-Needle; Cyclosporine; Hemophilia A; Humans; Immunocompromis

2009
[MRSA infection of the hand in immunodeficient patients].
    Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V..., 2009, Volume: 41, Issue:5

    Topics: Aged; Amputation, Surgical; Anti-Bacterial Agents; Antineoplastic Agents, Hormonal; Combined Modalit

2009
[A case of disseminated nocardiosis followed by pneumocystis pneumonia in a patient prescribed corticosteroid and cyclosporin A and having elevated blood (1-->3)-beta-D-glucan].
    Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases, 2009, Volume: 83, Issue:5

    Topics: Aged; beta-Glucans; Cyclosporine; Humans; Male; Nocardia Infections; Opportunistic Infections; Pemph

2009
Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2010, Volume: 29, Issue:5

    Topics: Adenosine Triphosphate; Adult; Aged; Biopsy; CD4-Positive T-Lymphocytes; Drug Therapy, Combination;

2010
Development of Candida albicans colitis in a child undergoing steroid therapy for ulcerative colitis.
    Journal of pediatric gastroenterology and nutrition, 2010, Volume: 51, Issue:1

    Topics: Adolescent; Betamethasone; Candida albicans; Candidiasis; Colitis; Colitis, Ulcerative; Glucocortico

2010
[Unilateral odynophagia in rheumatoid arthritis].
    Laryngo- rhino- otologie, 2011, Volume: 90, Issue:8

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cooperative Behavior; Deglutition Disorders; Diagnosis,

2011
Young male with systemic lupus erythematosus presenting with sensorineural deafness with immune suppression induced miliary tuberculosis.
    The Journal of the Association of Physicians of India, 2011, Volume: 59

    Topics: Adult; Antineoplastic Agents; Antitubercular Agents; Biopsy; Hearing Loss, Sensorineural; Humans; Im

2011
Cryptococcal cellulitis in a patient with bullous pemphigoid.
    Acta dermato-venereologica, 2013, Mar-27, Volume: 93, Issue:2

    Topics: Aged; Antifungal Agents; Cellulitis; Cryptococcosis; Cryptococcus neoformans; Dermatomycoses; Glucoc

2013
A possible novel mechanism of opportunistic infection in systemic lupus erythematosus, based on a case of toxoplasmic encephalopathy.
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:9

    Topics: Adult; Animals; Anti-Infective Agents; Antibodies, Protozoan; Cerebral Cortex; Drug Combinations; Fe

2002
Disseminated candidiasis following prednisolone therapy in systemic lupus erythematosus.
    Pediatrics international : official journal of the Japan Pediatric Society, 2002, Volume: 44, Issue:6

    Topics: Anti-Inflammatory Agents; Candidiasis; Child; Humans; Lupus Erythematosus, Systemic; Male; Multiple

2002
PCR-aided diagnosis of fungal chorioretinitis following ingestion of traditional Chinese medication.
    Retina (Philadelphia, Pa.), 2002, Volume: 22, Issue:6

    Topics: Aged; Amphotericin B; Antifungal Agents; Chorioretinitis; DNA, Fungal; Drug Therapy, Combination; Dr

2002
[Functional asplenia after severe varicella zoster-infection diagnosis by colour Doppler ultrasound].
    Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:4

    Topics: Adult; Atrophy; Azathioprine; Crohn Disease; Drug Therapy, Combination; Follow-Up Studies; Herpes Zo

2003
Cerebral toxoplasmosis after autologous peripheral blood stem cell transplantation.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2003, Volume: 22, Issue:9

    Topics: Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclop

2003
An overwhelming pulmonary fungus ball in a systemic lupus erythematosus patient.
    Zeitschrift fur Rheumatologie, 2003, Volume: 62, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Aspergillosis; Diagnosis, Differential; Female; Humans; Lung; Lupus

2003
[A case of left hemiplegia following erythema, fever, and gastrointestinal bleeding].
    No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:3

    Topics: Adult; Anti-Inflammatory Agents; Cyclophosphamide; Diagnosis, Differential; Disseminated Intravascul

2004
Disseminated cutaneous infection with Mycobacterium chelonae in a patient with steroid-dependent rheumatoid arthritis.
    Clinical and experimental dermatology, 2004, Volume: 29, Issue:3

    Topics: Arthritis, Rheumatoid; Fatal Outcome; Glucocorticoids; Humans; Immunocompromised Host; Male; Middle

2004
[Fatal opportunistic infection following disappearance of antibodies by immunosuppressive therapy in a patient with acquired factor VIII inhibitor].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2004, Volume: 45, Issue:9

    Topics: Aged; Aged, 80 and over; Autoantibodies; Cyclophosphamide; Cyclosporine; Cytomegalovirus Infections;

2004
Cerebral toxoplasmosis in a patient with common variable immunodeficiency.
    Neurology, 2004, Dec-14, Volume: 63, Issue:11

    Topics: Anemia, Hemolytic, Autoimmune; Antibodies, Protozoan; Antiprotozoal Agents; Biopsy; Brain; Central N

2004
Fatal fulminant legionnaires' disease in a patient with severe erythodermic psoriasis treated with infliximab after long-term steroid therapy.
    The British journal of dermatology, 2005, Volume: 152, Issue:3

    Topics: Antibodies, Monoclonal; Dermatologic Agents; Fatal Outcome; Glucocorticoids; Humans; Infliximab; Leg

2005
[A case of chronic renal failure complicated with tuberculous meningitis successfully diagnosed by nested polymerase chain reaction (PCR)].
    Nihon Jinzo Gakkai shi, 2005, Volume: 47, Issue:2

    Topics: Adult; DNA, Bacterial; Female; Glomerulonephritis; Humans; Immunocompromised Host; Kidney Failure, C

2005
A case of tuberculous meningoencephalitis in a patient with Behçet's disease.
    Clinical rheumatology, 2006, Volume: 25, Issue:1

    Topics: Adult; Antitubercular Agents; Behcet Syndrome; Colchicine; Cyclosporine; DNA, Bacterial; Drug Therap

2006
[Pulmonary nocardiosis complicated with multiple brain abscess].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2005, Volume: 43, Issue:6

    Topics: Anemia, Hemolytic, Autoimmune; Brain Abscess; Female; Humans; Lung Diseases; Middle Aged; Nocardia I

2005
Cytomegalovirus-induced interstitial pneumonitis in a patient with dermatomyositis.
    Clinical rheumatology, 2006, Volume: 25, Issue:5

    Topics: Adult; Antiviral Agents; Azathioprine; Cyclosporine; Cytomegalovirus; Cytomegalovirus Infections; De

2006
Fatal varicella infection in a girl with systemic lupus erythematosus after oral acyclovir prophylaxis.
    European journal of pediatrics, 2006, Volume: 165, Issue:4

    Topics: Acyclovir; Adolescent; Antiviral Agents; Aspergillosis; Azathioprine; Brain; Chickenpox; Disseminate

2006
[Effective treatment for a methotrexate-associated lymphoproliferative disorder with R-CHOP following administration of rituximab].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2005, Volume: 46, Issue:7

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemot

2005
[Pneumocystis jiroveci pneumonia as a complication of glucocorticoid therapy for interstitial pneumonia].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2005, Volume: 43, Issue:12

    Topics: Aged; Anti-Infective Agents; Drug Administration Schedule; Female; Glucocorticoids; Humans; Lung Dis

2005
[Gas gangrene with ulcerative colitis under immunosuppressive therapy: report of a case].
    Zentralblatt fur Chirurgie, 2006, Volume: 131, Issue:1

    Topics: Adult; Amputation, Surgical; Buttocks; Colitis, Ulcerative; Debridement; Diagnosis, Differential; Fa

2006
[Pulmonary infection of Pneumocystis carinii and Cytomegalo virus in the treatment of cholesterol crystal embolism].
    Nihon Jinzo Gakkai shi, 2006, Volume: 48, Issue:5

    Topics: Angioplasty, Balloon, Coronary; Cytomegalovirus Infections; Embolism, Cholesterol; Humans; Male; Mid

2006
Clinical features, prognostic and risk factors of central nervous system infections in patients with systemic lupus erythematosus.
    Clinical rheumatology, 2007, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Central Nervous System Infections; China; Cohort Studies; Dose-Response Relations

2007
[Radiological findings in initial pulmonary alveolar proteinosis detected in the post-treatment course of nocardiosis].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2006, Volume: 44, Issue:10

    Topics: Anemia, Hemolytic, Autoimmune; Female; Humans; Middle Aged; Nocardia Infections; Opportunistic Infec

2006
[Successful treatment by voliconazole for pulmonary and adductor magnus muscle aspergillosis induced by immunosuppressive therapy for hypersensitivity pneumonia].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2006, Volume: 44, Issue:10

    Topics: Aged; Alveolitis, Extrinsic Allergic; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Cyclo

2006
Cytomegalovirus infection complicating immunosuppressive therapy for dermatomyositis.
    Acta dermato-venereologica, 2006, Volume: 86, Issue:6

    Topics: Aged; Antiviral Agents; Cyclophosphamide; Cytomegalovirus Infections; Dermatomyositis; Fatal Outcome

2006
Antibody-mediated acquired pure red cell aplasia (PRCA) after treatment with darbepoetin.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:5

    Topics: Aged; Anemia; Antibodies; Chronic Disease; Cyclophosphamide; Darbepoetin alfa; Erythropoietin; Fatal

2007
Soft tissue manifestations of mycobacterial infection in patients with rheumatic diseases.
    Annals of the Academy of Medicine, Singapore, 2007, Volume: 36, Issue:2

    Topics: Adult; Fatal Outcome; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Middle Aged;

2007
[A case of pulmonary nocardiosis cured by early sulfamethoxazole-trimethoprim therapy].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2007, Volume: 45, Issue:8

    Topics: Anti-Infective Agents; Humans; Lung Diseases; Lupus Erythematosus, Systemic; Lupus Nephritis; Male;

2007
Pneumocystis carinii pneumonia in infant treated with oral steroids for hemangioma.
    Archives of dermatology, 2007, Volume: 143, Issue:9

    Topics: Administration, Oral; Antineoplastic Agents, Hormonal; Facial Neoplasms; Female; Hemangioma; Humans;

2007
[Atypical ocular toxoplasmosis with concomitant ocular reactivation of varicella-zoster virus and cytomegalovirus in an immunocompromised host].
    Klinische Monatsblatter fur Augenheilkunde, 2008, Volume: 225, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Blindness; Chlorambucil; Chorioretinitis; Como

2008
[Mycotic retrobulbar neuritis].
    Klinische Monatsblatter fur Augenheilkunde, 1994, Volume: 204, Issue:4

    Topics: Aged; Anemia, Aplastic; Diagnosis, Differential; Female; Humans; Lymphoma, Non-Hodgkin; Opportunisti

1994
Nephrotic syndrome in the elderly--clinicopathological study.
    Nihon Jinzo Gakkai shi, 1994, Volume: 36, Issue:1

    Topics: Aged; Female; Humans; Kidney; Male; Middle Aged; Nephrotic Syndrome; Opportunistic Infections; Predn

1994
Disseminated subcutaneous Nocardia asteroides abscesses in a patient after bone marrow transplantation.
    Bone marrow transplantation, 1993, Volume: 11, Issue:4

    Topics: Abscess; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Marro

1993
Induction toxicity of a modified Memorial Sloan-Kettering-New York II Protocol in children with relapsed acute lymphoblastic leukemia: a single institution study.
    Medical and pediatric oncology, 1996, Volume: 27, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Daunorubicin;

1996
[Pneumocystis carinii and aspergillus pneumonia in immunosuppression in rapidly progressing glomerulonephritis of the anti-glomerular basement membrane type].
    Medizinische Klinik (Munich, Germany : 1983), 1996, Sep-15, Volume: 91, Issue:9

    Topics: Adult; Aspergillosis; Autoimmune Diseases; Basement Membrane; Cyclophosphamide; Drug Therapy, Combin

1996
[A case of allergic bronchopulmonary aspergillosis following active pulmonary tuberculosis].
    Arerugi = [Allergy], 1996, Volume: 45, Issue:11

    Topics: Aged; Anti-Inflammatory Agents; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Aspergi

1996
[Invasive disseminated aspergillosis in combined immunosuppressive therapy in systemic lupus erythematosus].
    Medizinische Klinik (Munich, Germany : 1983), 1996, Dec-15, Volume: 91, Issue:12

    Topics: Aged; Aspergillosis; Cyclophosphamide; Drug Therapy, Combination; Fatal Outcome; Female; Fungemia; H

1996
An unusual complication of immunosuppressive therapy in inflammatory bowel disease.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:9

    Topics: Aged; Aminosalicylic Acids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antim

1997
[Recurrent fever in a patient treated with immunosuppressive therapy for Takayasu arteritis].
    Der Internist, 1997, Volume: 38, Issue:8

    Topics: Abdominal Abscess; Adult; Cyclophosphamide; Diagnosis, Differential; Dose-Response Relationship, Dru

1997
Immunosuppression and incidence of opportunistic pneumonias after liver transplantation.
    Transplantation proceedings, 1998, Volume: 30, Issue:4

    Topics: Adolescent; Adult; Aged; Antibodies, Monoclonal; Azathioprine; Child; Child, Preschool; Cyclosporine

1998
Cardiac transplant-related cutaneous malignancies in an Australian recipient: immunosuppression, friend or foe?
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1998, Volume: 10, Issue:3

    Topics: Adult; Australia; Azathioprine; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cy

1998
Rhodococcus equi lung abscess complicating Evan's syndrome treated with corticosteroid.
    Respiration; international review of thoracic diseases, 1998, Volume: 65, Issue:4

    Topics: Actinomycetales Infections; Aged; Anemia, Hemolytic, Autoimmune; Anti-Bacterial Agents; Drug Therapy

1998
Influence of anti-rejection therapy on the timing of cytomegalovirus disease and other infections in renal transplant recipients.
    Clinical transplantation, 2000, Volume: 14, Issue:1

    Topics: Acute Disease; Adult; Antilymphocyte Serum; Cytomegalovirus Infections; Female; Glucocorticoids; Gra

2000
[A case of pityriasis rubra pilaris associated with unclassified connective tissue disease and sepsis in clinical course].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 1998, Volume: 21, Issue:5

    Topics: Adult; Antibodies, Antinuclear; Bacteremia; Biomarkers; Carrier State; Connective Tissue Diseases; E

1998
[A case of systemic lupus erythematosus with pure red cell aplasia possibly caused by persistent infection of human parvovirus B 19].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 1998, Volume: 21, Issue:5

    Topics: Aged; Antiphospholipid Syndrome; Female; Humans; Immunocompromised Host; Lupus Erythematosus, System

1998
Strongyloides hyperinfection syndrome--an unappreciated opportunistic infection.
    The Journal of the Association of Physicians of India, 2000, Volume: 48, Issue:10

    Topics: Animals; Follow-Up Studies; Glomerulonephritis; Humans; Male; Middle Aged; Opportunistic Infections;

2000
Sarcoidosis and opportunistic infections.
    Southern medical journal, 2001, Volume: 94, Issue:1

    Topics: Aged; Anti-Inflammatory Agents; Biopsy; Diagnosis, Differential; Histoplasmosis; Humans; Immunity, C

2001
Early onset Pneumocystis carinii pneumonia after allogeneic peripheral blood stem cell transplantation.
    American journal of hematology, 2001, Volume: 67, Issue:3

    Topics: Antibiotic Prophylaxis; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Combined Modal

2001
Pulmonary nocardiosis in a patient treated with corticosteroid therapy.
    Respirology (Carlton, Vic.), 2002, Volume: 7, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Cilastatin; Cilastatin, Imipenem Drug Combination; Diagnosis, Different

2002
Pneumonia and pneumonitis in childhood malignancy.
    Acta paediatrica (Oslo, Norway : 1992), 1992, Volume: 81, Issue:3

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; C

1992
[Cryptococcal meningoencephalitis following immunosuppressive therapy].
    Zeitschrift fur arztliche Fortbildung, 1992, May-11, Volume: 86, Issue:9

    Topics: Adult; Azathioprine; Brain; Cryptococcus neoformans; Female; Humans; Immune Tolerance; Lupus Erythem

1992
Cytomegalovirus pneumonia in a patient with rheumatoid arthritis treated with low dose methotrexate and prednisone.
    Annals of the rheumatic diseases, 1991, Volume: 50, Issue:1

    Topics: Arthritis, Rheumatoid; Cytomegalovirus Infections; Humans; Male; Methotrexate; Middle Aged; Opportun

1991
Opportunistic Listeria pericardial effusion.
    Postgraduate medical journal, 1990, Volume: 66, Issue:773

    Topics: Arthritis, Rheumatoid; Carcinoma, Squamous Cell; Female; Humans; Listeriosis; Middle Aged; Opportuni

1990
[Results of conversion from conventional immunosuppressive therapy to cyclosporin A in complications following kidney transplantation].
    Zeitschrift fur Urologie und Nephrologie, 1990, Volume: 83, Issue:2

    Topics: Adolescent; Adult; Azathioprine; Creatinine; Cyclosporins; Female; Follow-Up Studies; Graft Rejectio

1990
Trichosporon beigelii pneumonia in a neutropenic patient.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1989, Volume: 8, Issue:7

    Topics: Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Lung Diseases, Fungal; Mal

1989
[Pulmonary opportunistic infections in patients with autoimmune diseases].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1989, Volume: 78, Issue:9

    Topics: Adult; Aged; Autoimmune Diseases; Female; Humans; Isoniazid; Lung Diseases, Fungal; Male; Middle Age

1989
[Dynamics of Mycoplasma infection in patients with glomerulo- nephritis during pathogenetic therapy].
    Klinicheskaia meditsina, 1989, Volume: 67, Issue:11

    Topics: Cyclophosphamide; Drug Resistance, Microbial; Glomerulonephritis; Humans; Immune Tolerance; Mycoplas

1989
[Corticosteroid tuberculosis].
    Klinicheskaia meditsina, 1988, Volume: 66, Issue:12

    Topics: Asthma; Bronchopneumonia; Female; Humans; Immune Tolerance; Male; Middle Aged; Opportunistic Infecti

1988
Triple drug immunosuppression (cyclosporine, azathioprine and low-dose prednisolone): a safe and effective regimen in first-cadaver kidney transplantation.
    Transplantation proceedings, 1987, Volume: 19, Issue:5

    Topics: Azathioprine; Bacterial Infections; Cadaver; Cyclosporins; Drug Therapy, Combination; Graft Rejectio

1987
[Complications caused by fungi of the genus Candida in patients with glomerulonephritis during pathogenetic therapy].
    Vrachebnoe delo, 1988, Issue:6

    Topics: Candidiasis; Cyclophosphamide; Glomerulonephritis; Humans; Immunosuppressive Agents; Opportunistic I

1988