prednisolone has been researched along with Muscle Weakness in 79 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Muscle Weakness: A vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases. (From Wyngaarden et al., Cecil Textbook of Medicine, 19th ed, p2251)
Excerpt | Relevance | Reference |
---|---|---|
"An 11-year-old girl with a calpain-3 gene (CAPN-3) mutation and eosinophilic myositis on muscle biopsy had high serum CK levels and eosinophil counts which showed spontaneous fluctuations." | 7.75 | Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease? ( Dincer, P; Gundesli, H; Oflazer, PS; Sabuncu, T; Zorludemir, S, 2009) |
" He visited a rheumatologist in an outpatient clinic, and according to proximal muscle weakness and heliotrope rash (based on the rheumatologist's notes) with the impression of dermatomyositis, prednisolone and azathioprine were prescribed for him that did not improve his clinical status and he was gradually wheelchair dependent." | 4.12 | Proximal muscle weakness as the sole manifestation of Cushing's disease, misdiagnosed as dermatomyositis: a case report. ( Jeddi, M; Shams, M, 2022) |
" Ten and 15 days respectively after initiation of prednisolone treatment both patients experienced exacerbation of sensory symptoms and emerging of muscle weakness." | 3.81 | Pure sensory chronic inflammatory polyneuropathy: rapid deterioration after steroid treatment. ( Chroni, E; Gavanozi, E; Papathanasopoulos, P; Polychronopoulos, P; Veltsista, D; Vlachou, T, 2015) |
"An 11-year-old girl with a calpain-3 gene (CAPN-3) mutation and eosinophilic myositis on muscle biopsy had high serum CK levels and eosinophil counts which showed spontaneous fluctuations." | 3.75 | Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease? ( Dincer, P; Gundesli, H; Oflazer, PS; Sabuncu, T; Zorludemir, S, 2009) |
"Prednisolone treatment significantly improved her myositis." | 1.56 | Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease. ( Akagi, M; Endo, Y; Fukui, S; Hara, K; Hashisako, M; Ichinose, K; Igawa, T; Iwamoto, N; Kawakami, A; Kawashiri, SY; Koga, T; Nakamura, H; Niino, D; Origuchi, T; Shimizu, T; Takatani, A; Tamai, M; Tsuji, S; Umeda, M, 2020) |
"Excessive weight gain is a potential risk." | 1.51 | Twice-weekly glucocorticosteroids in infants and young boys with Duchenne muscular dystrophy. ( Alfano, LN; Anand, P; Connolly, AM; Cradock, MM; Finkel, RS; Flanigan, KM; Florence, JM; Golumbek, PT; Iannaccone, ST; Johnson, LB; Kuntz, NL; Lowes, LP; McDonald, CM; Mendell, JR; Nelson, LL; Nicorici, A; Siener, CA; Zaidman, CM, 2019) |
"Its presentation with interstitial lung disease alters its prognosis." | 1.51 | Antisynthetase syndrome presenting as interstitial lung disease: a case report. ( Badshah, A; Haider, I; Humayun, M; Pervez, S, 2019) |
"A 66-year-old woman with a history of interstitial lung disease presented with a 3-month history of dropped head syndrome (DHS), followed by camptocormia and extremity weakness." | 1.48 | Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-polymyositis Overlap Syndrome Associated with Anti-Ku Antibody. ( Higuchi, I; Jonosono, M; Mitsuyo, K; Yoshida, M; Yoshida, T, 2018) |
"In contrast, cholecystitis is a rare complication." | 1.48 | Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Complicated by Perforation of the Small Intestine and Cholecystitis. ( Inomoto, C; Mizuma, A; Moriya, Y; Nakamura, N; Nakayama, T; Ohnuki, Y; Takizawa, S; Uda, S; Yamamoto, S; Yutani, S, 2018) |
"Dermatomyositis is a humoral-mediated inflammatory myopathy with symmetrical proximal muscle weakness and dermatological manifestations such as Gottron's papules, heliotrope rash, periungual abnormalities, and flagellate erythema." | 1.48 | Erythroderma and extensive poikiloderma - a rare initial presentation of dermatomyositis: a case report. ( Gunasekera, CN; Herath, HMMTB; Janappriya, GHCC; Keragala, BSDP; Kulatunga, A; Pahalagamage, SP, 2018) |
"Investigations revealed interstitial lung disease, inflammatory myopathy and an immunology profile consistent with PL-12 antisynthetase syndrome." | 1.48 | Interstitial lung disease and inflammatory myopathy in antisynthetase syndrome with PL-12 antibody. ( Jubber, A; Taylor, J; Tripathi, M, 2018) |
"Polymyositis is an inflammatory myopathy which, like SCD, may present with myalgia but is usually associated with proximal muscle weakness." | 1.42 | Juvenile polymyositis with unremitting pain and progressive loss of motor and bulbar function on a background of sickle cell disease. ( Bali, S; D'Cruz, D; Inusa, BP; Lazaro, M, 2015) |
"Bell's palsy is a non-life threatening disorder with important functional and psychosocial effects." | 1.39 | Medium term outcome in Bell's palsy in children. ( Babl, FE; Doyle, J; Keenan, P; Mc Kay, M; McNamara, R, 2013) |
"Diagnosis of Becker muscular dystrophy (BMD) was confirmed by genetic testing." | 1.37 | Unusual presentation as an adult onset painful myopathy in a Thai patient with Becker muscular dystrophy. ( Pithukpakorn, M, 2011) |
"Eosinophilia has been reported previously in patients with Calpainopathy and Becker Muscular Dystrophy and might be an early, but transient feature of a wider range of muscular dystrophies." | 1.35 | Eosinophilic myositis as presenting symptom in gamma-sarcoglycanopathy. ( Baumeister, SK; Dekomien, G; Lochmüller, H; Milić-Rasić, V; Todorovic, S; Walter, MC, 2009) |
"The patient was diagnosed with breast carcinoma 4 months after initial presentation and underwent resective surgery, radiotherapy, and hormonotherapy." | 1.35 | Steroid-responsive paraneoplastic demyelinating neuropathy and myelopathy associated with breast carcinoma. ( Abbott, RJ; Qaddoura, B; Rajabally, YA, 2008) |
"Generally, sarcoidosis is identified clinically in patients with foggy vision or mediastinal lymphadenopathy, but muscular weakness may be an infrequently observed initial symptom." | 1.34 | Sarcoid myositis with muscle weakness as a presenting symptom. ( Goto, D; Ishii, W; Ito, S; Iwanami, K; Mamura, M; Matsumoto, I; Ogishima, H; Sumida, T; Suzuki, T; Tsutsumi, A; Yamada, H, 2007) |
"However, Devic's neuromyelitis optica has also been seen in children." | 1.34 | Devic's neuromyelitis optica in an infant case. ( Senbil, N; Yavuz Gurer, YK; Yilmaz, D; Yuksel, D, 2007) |
" High dosage steroid should be started before there is biopsy confirmation of the disease." | 1.32 | [Excessive hyperferritinemia as an indication of a reactive hemophagocytosis syndrome]. ( Brunner, J; Dinser, R; Engel, A, 2003) |
"Hypogonadism has been established as a cause of osteoporosis in males, and in this case would explain the occurrence of fractures in the absence of other major risk factors." | 1.31 | Osteoporosis with underlying connective tissue disease: an unusual case. ( De Silva, M; Prasad, R, 2002) |
" On Day 8, the nerve-evoked peak twitch tensions, tetanic tensions, and fatigability, and the dose-response curves of d-tubocurarine in the tibialis cranialis muscle were measured in vivo and related to muscle mass or expression of AChRs." | 1.31 | Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression. ( Fink, H; Ibebunjo, C; Khiroya, R; Martyn, J; Shin, YS, 2000) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (2.53) | 18.2507 |
2000's | 31 (39.24) | 29.6817 |
2010's | 34 (43.04) | 24.3611 |
2020's | 12 (15.19) | 2.80 |
Authors | Studies |
---|---|
Mekmangkonthong, A | 1 |
Amornvit, J | 1 |
Numkarunarunrote, N | 1 |
Veeravigrom, M | 1 |
Khaosut, P | 1 |
Kuroda, H | 1 |
Yamaguchi, A | 1 |
Sugata, S | 1 |
Hamada, T | 1 |
Moriuchi, R | 1 |
Wada, K | 1 |
Tamaru, Y | 1 |
Kusunoki, R | 1 |
Kuwai, T | 1 |
Kouno, H | 1 |
Kurashige, T | 1 |
Torii, T | 1 |
Saito, A | 2 |
Kuraoka, K | 1 |
Kohno, H | 1 |
Jeddi, M | 1 |
Shams, M | 1 |
Loghman, M | 1 |
Rahmanian, E | 1 |
Alikhani, M | 1 |
Saffar, H | 1 |
Beikmohamadi Hezaveh, S | 1 |
Nekooeian, M | 1 |
Shahriarirad, R | 1 |
Faezi, ST | 1 |
Akagi, M | 1 |
Umeda, M | 1 |
Hashisako, M | 1 |
Hara, K | 2 |
Tsuji, S | 1 |
Endo, Y | 1 |
Takatani, A | 1 |
Shimizu, T | 1 |
Fukui, S | 1 |
Koga, T | 2 |
Kawashiri, SY | 1 |
Iwamoto, N | 1 |
Igawa, T | 1 |
Ichinose, K | 2 |
Tamai, M | 1 |
Nakamura, H | 1 |
Origuchi, T | 1 |
Niino, D | 1 |
Kawakami, A | 1 |
Guess, KE | 1 |
Harada, Y | 1 |
Hill, A | 1 |
Ferry, J | 1 |
Veerapandiyan, A | 1 |
Nagiah, S | 1 |
Saranapala, DMM | 1 |
Finsterer, J | 1 |
Scorza, CA | 1 |
Fiorini, AC | 1 |
Scorza, FA | 1 |
Beck, G | 1 |
Yamashita, R | 1 |
Saeki, C | 1 |
Ogawa, T | 1 |
Shimizu, M | 1 |
Mochizuki, H | 2 |
Cavallasca, JA | 1 |
Cousillas, JE | 1 |
Takahashi, F | 1 |
Sawada, J | 1 |
Minoshima, A | 1 |
Sakamoto, N | 1 |
Ono, T | 1 |
Akasaka, K | 1 |
Takei, H | 1 |
Nishino, I | 1 |
Hasebe, N | 1 |
Ueda, R | 1 |
Imai, K | 1 |
Yamamoto, A | 1 |
Ioku, T | 1 |
Kadoya, M | 1 |
Hamanaka, M | 1 |
Iida, H | 1 |
Hanaoka, H | 1 |
Asari, Y | 1 |
Ishimori, K | 1 |
Kiyokawa, T | 1 |
Takakuwa, Y | 1 |
Yamasaki, Y | 1 |
Yamada, H | 2 |
Okazaki, T | 1 |
Doi, M | 1 |
Ozaki, S | 1 |
Yoshida, T | 1 |
Yoshida, M | 1 |
Mitsuyo, K | 1 |
Jonosono, M | 1 |
Higuchi, I | 1 |
Ohnuki, Y | 2 |
Moriya, Y | 1 |
Yutani, S | 1 |
Mizuma, A | 1 |
Nakayama, T | 1 |
Uda, S | 1 |
Inomoto, C | 1 |
Yamamoto, S | 1 |
Nakamura, N | 1 |
Takizawa, S | 1 |
Ojima, Y | 1 |
Sawada, K | 1 |
Fujii, H | 1 |
Shirai, T | 1 |
Kagaya, S | 1 |
Aoki, S | 1 |
Takeuchi, Y | 1 |
Ishii, T | 1 |
Nagasawa, T | 1 |
Herath, HMMTB | 1 |
Keragala, BSDP | 1 |
Pahalagamage, SP | 1 |
Janappriya, GHCC | 1 |
Kulatunga, A | 1 |
Gunasekera, CN | 1 |
Chawla, D | 1 |
Mishra, D | 1 |
Singh, S | 1 |
Juneja, M | 1 |
Jubber, A | 1 |
Tripathi, M | 1 |
Taylor, J | 1 |
Connolly, AM | 2 |
Zaidman, CM | 1 |
Golumbek, PT | 2 |
Cradock, MM | 1 |
Flanigan, KM | 1 |
Kuntz, NL | 1 |
Finkel, RS | 1 |
McDonald, CM | 1 |
Iannaccone, ST | 1 |
Anand, P | 1 |
Siener, CA | 1 |
Florence, JM | 1 |
Lowes, LP | 1 |
Alfano, LN | 1 |
Johnson, LB | 1 |
Nicorici, A | 1 |
Nelson, LL | 1 |
Mendell, JR | 1 |
Badshah, A | 1 |
Haider, I | 1 |
Pervez, S | 1 |
Humayun, M | 1 |
Steggink, LC | 1 |
Hettema, ME | 1 |
Delsing, CE | 1 |
Janssen, PM | 1 |
Murray, JD | 1 |
Schill, KE | 1 |
Rastogi, N | 1 |
Schultz, EJ | 1 |
Tran, T | 1 |
Raman, SV | 1 |
Rafael-Fortney, JA | 1 |
Yoshida, S | 2 |
Kikuchi, A | 1 |
Tateyama, M | 1 |
Tano, O | 1 |
Nishiyama, A | 1 |
Akaishi, T | 1 |
Kato, M | 1 |
Aoki, M | 1 |
Constable, H | 1 |
Wood, F | 1 |
Jones, K | 1 |
Malkan, A | 1 |
Cappelen-Smith, C | 1 |
Beran, R | 1 |
Griffith, N | 1 |
Toong, C | 1 |
Wang, MX | 1 |
Cordato, D | 1 |
Vinay, K | 1 |
Dogra, S | 1 |
Bali, S | 1 |
D'Cruz, D | 1 |
Lazaro, M | 1 |
Inusa, BP | 1 |
Chroni, E | 1 |
Veltsista, D | 1 |
Gavanozi, E | 1 |
Vlachou, T | 1 |
Polychronopoulos, P | 1 |
Papathanasopoulos, P | 1 |
Theofilos, D | 1 |
Triantafillidou, C | 1 |
Zetos, A | 1 |
Bisirtzoglou, D | 1 |
Konstantinou, F | 1 |
Marketos, C | 1 |
Politis, G | 1 |
Chamarthi, VS | 1 |
Chamarthi, S | 1 |
Johansson, BE | 1 |
Ong, SG | 1 |
Ding, HJ | 1 |
Lynch, RW | 1 |
Soane, T | 1 |
Gibson, R | 1 |
Pal, S | 1 |
Lees, CW | 1 |
Anantharajah, A | 1 |
Vucic, S | 1 |
Tarafdar, S | 1 |
Vongsuvanh, R | 1 |
Wilcken, N | 1 |
Swaminathan, S | 1 |
Cekinmez, EK | 1 |
Cengiz, N | 1 |
Erol, I | 1 |
Kizilkiliç, O | 1 |
Uslu, Y | 1 |
Yoshimoto, M | 1 |
Kawaguchi, S | 1 |
Takebayashi, T | 1 |
Isogai, S | 1 |
Nonaka, S | 1 |
Kosukegawa, I | 1 |
Yamashita, T | 1 |
Nishikawa, T | 1 |
Kawakami, K | 1 |
Kumamoto, T | 2 |
Tonooka, S | 1 |
Abe, A | 1 |
Hayasaka, K | 1 |
Okamoto, Y | 1 |
Kawano, Y | 1 |
Baumeister, SK | 1 |
Todorovic, S | 1 |
Milić-Rasić, V | 1 |
Dekomien, G | 1 |
Lochmüller, H | 1 |
Walter, MC | 1 |
Rajabally, YA | 1 |
Qaddoura, B | 1 |
Abbott, RJ | 1 |
Oflazer, PS | 1 |
Gundesli, H | 1 |
Zorludemir, S | 1 |
Sabuncu, T | 1 |
Dincer, P | 1 |
Saidha, S | 1 |
Mok, TH | 1 |
Butler, M | 1 |
Keohane, C | 1 |
Harrington, H | 1 |
Nishigori, K | 1 |
Yamamoto, T | 1 |
Yokozeki, H | 1 |
Migita, K | 1 |
Ueda-Nakata, R | 1 |
Masuda, T | 1 |
Miyashita, T | 1 |
Izumi, Y | 1 |
Ezaki, H | 1 |
Ito, M | 1 |
Motomura, M | 2 |
Eguchi, K | 1 |
Na, SJ | 1 |
Kim, SM | 1 |
Sunwoo, IN | 1 |
Choi, YC | 1 |
Franciotta, D | 1 |
Zardini, E | 1 |
Caporali, R | 1 |
Piccolo, L | 1 |
Alberici, E | 1 |
Romani, A | 1 |
Bergamaschi, R | 1 |
Marchioni, E | 1 |
Ceroni, M | 1 |
Piccolo, G | 1 |
Li, HZ | 1 |
Guo, J | 1 |
Lin, H | 1 |
Li, Z | 1 |
Yamashita, S | 1 |
Ueda, A | 1 |
Hirahara, T | 1 |
Kimura, E | 1 |
Hirano, T | 1 |
Uchino, M | 1 |
Pithukpakorn, M | 1 |
Tzermpos, FH | 1 |
Cocos, A | 1 |
Kleftogiannis, M | 1 |
Zarakas, M | 1 |
Iatrou, I | 1 |
Rehman, HU | 1 |
Azzopardi, L | 1 |
Quirk, J | 1 |
McNamara, R | 1 |
Doyle, J | 1 |
Mc Kay, M | 1 |
Keenan, P | 1 |
Babl, FE | 1 |
Yoshihara, N | 1 |
Okuda, M | 1 |
Takano, K | 1 |
Wada, T | 1 |
Osaka, H | 1 |
Hejazi, SM | 1 |
Engkasan, JP | 1 |
Qomi, MS | 1 |
Zach, H | 1 |
Cetin, H | 1 |
Hilger, E | 1 |
Paul, A | 1 |
Wuschitz, B | 1 |
Jung, R | 1 |
Auff, E | 1 |
Zimprich, F | 1 |
Prasad, R | 1 |
De Silva, M | 1 |
Johnson, RW | 1 |
Williams, FM | 1 |
Kazi, S | 1 |
Dimachkie, MM | 1 |
Reveille, JD | 1 |
Inoue, N | 1 |
Kunishige, M | 1 |
Oshima, Y | 1 |
Ohnishi, Y | 1 |
Kuroda, Y | 1 |
Asano, A | 1 |
Yoshino, H | 1 |
Matsumoto, T | 1 |
Mitsui, T | 1 |
Dinser, R | 1 |
Brunner, J | 1 |
Engel, A | 1 |
Paus, S | 1 |
Prömse, A | 1 |
Schmidt, S | 1 |
Klockgether, T | 1 |
Yilmaz, O | 1 |
Karaduman, A | 1 |
Topaloğlu, H | 1 |
Yang, YW | 1 |
Liu, CH | 1 |
Tsai, CH | 1 |
Lee, CC | 1 |
Jou, SB | 1 |
Sharma, BK | 1 |
Daga, MK | 1 |
Sharma, M | 1 |
McIlwain, KL | 1 |
DiCarlo, JB | 1 |
Miller, SB | 1 |
Lim, S | 1 |
Rodriguez-Casero, MV | 1 |
Shield, LK | 1 |
Kornberg, AJ | 1 |
de Carvalho, M | 1 |
Geraldes, R | 1 |
Keeling, RM | 1 |
Streif, EM | 1 |
Needham, M | 1 |
Fabian, V | 1 |
Knezevic, W | 1 |
Panegyres, P | 1 |
Zilko, P | 1 |
Mastaglia, FL | 1 |
Mashima, T | 1 |
Matsuda, A | 1 |
Tanaka, K | 1 |
Tomita, M | 1 |
Shiraishi, H | 1 |
Nishizawa, M | 1 |
Ishii, W | 1 |
Ito, S | 1 |
Iwanami, K | 1 |
Ogishima, H | 1 |
Suzuki, T | 1 |
Mamura, M | 1 |
Goto, D | 1 |
Matsumoto, I | 1 |
Tsutsumi, A | 1 |
Sumida, T | 1 |
Yuksel, D | 1 |
Senbil, N | 1 |
Yilmaz, D | 1 |
Yavuz Gurer, YK | 1 |
Kastrup, A | 1 |
Gdynia, HJ | 1 |
Nägele, T | 1 |
Riecker, A | 1 |
Ueyama, H | 1 |
Johno, M | 1 |
Mita, S | 1 |
Tsuda, T | 1 |
Peris, P | 1 |
Font, J | 1 |
Grau, JM | 1 |
Martínez de Osaba, MJ | 1 |
Filella, X | 1 |
Muñoz-Gómez, J | 1 |
Ryan, MM | 1 |
Grattan-Smith, PJ | 1 |
Procopis, PG | 1 |
Morgan, G | 1 |
Ouvrier, RA | 1 |
Shin, YS | 1 |
Fink, H | 1 |
Khiroya, R | 1 |
Ibebunjo, C | 1 |
Martyn, J | 1 |
Vitali, N | 1 |
Tondeur, M | 1 |
Hermans, P | 1 |
Deweerdt, S | 1 |
Clumeck, N | 1 |
Kamakura, K | 1 |
Masaki, T | 1 |
Hirata, A | 1 |
Nakamura, R | 1 |
Motoyoshi, K | 1 |
Plumley, SG | 1 |
Rubio, R | 1 |
Alasfar, S | 1 |
Jasin, HE | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Phase 2 Historically Controlled Trial of Corticosteroids in Young Boys With Duchenne Muscular Dystrophy[NCT02167217] | Phase 2 | 25 participants (Actual) | Interventional | 2014-04-17 | Completed | ||
A Randomized Open Label Trial of Spironolactone Versus Prednisolone in Corticosteroid-naïve Boys With DMD[NCT03777319] | Phase 1 | 2 participants (Actual) | Interventional | 2018-12-05 | Terminated (stopped due to Inability to recruit participants.) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Bayley III Gross Motor Scaled Score measures motor development. This is normed for typically developing children and follow a bell shaped curve. The scale has mean of 10 +/-3 for children at all ages and is bell shaped. Therefore the two standard deviation range is 16 to 4 with higher values indicated better performance. Lower values have been shown to be common in boys with DMD and it this study the baseline average score was 4.2. (NCT02167217)
Timeframe: One year
Intervention | units on a scale (Mean) |
---|---|
Oral Prednisolone | 4.8 |
The determination of whether spironolactone has similar efficacy to glucocorticoids in improving muscle strength in steroid naïve DMD patients. This will be determined by measuring the time to complete a 100 meter timed test (100M). (NCT03777319)
Timeframe: 6 months
Intervention | sec (Number) |
---|---|
Spironolactone | -0.6 |
Prednisolone | -5.3 |
Secondary outcome measures will be Dynamometry score, which is a summation of maximum voluntary isometric contraction test values for knee flexion, knee extension, elbow flexion, and elbow extension (NCT03777319)
Timeframe: 6 months
Intervention | kg (Number) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Elbow Flexion (Right)-Baseline | Elbow Flexion (Left)-Baseline | Elbow Extension (Right)-Baseline | Elbow Extension (Left)-Baseline | Knee Flexion (Right)-Baseline | Knee Flexion (Left)-Baseline | Knee Extension (Right)-Baseline | Knee Extension (Left)-Baseline | Elbow Flexion (Right)-Month 6 | Elbow Flexion (Left)-Month 6 | Elbow Extension (Right)-Month 6 | Elbow Extension (Left)-Month 6 | Knee Flexion (Right)-Month 6 | Knee Flexion (Left)-Month 6 | Knee Extension (Right)-Month 6 | Knee Extension (Left)-Month 6 | |
Prednisolone | 3.6 | 4.1 | 5.3 | 4.1 | 3.3 | 3.4 | 4.8 | 5.2 | 2.9 | 3.4 | 4.3 | 3.8 | 4.1 | 3.9 | 6 | 5.1 |
Spironolactone | 0 | 0 | 0 | 0 | 4.1 | 2.8 | 3.8 | 5.9 | 3.1 | 3.5 | 2.4 | 2.5 | 4.3 | 4.1 | 7.2 | 8.3 |
Electrolytes (Sodium, Potassium, Cloride and Carbon dioxide, mmol/L) will be measured on a monthly basis following initiation of either spironolactone or prednisolone. (NCT03777319)
Timeframe: 6 months
Intervention | mmol/L (Number) | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-Baseline | Sodium-Month 1 | Sodium-Month 2 | Sodium-Month 3 | Sodium-Month 4 | Sodium-Month 5 | Sodium-Month 6 | Potassium-Baseline | Potassium-Month 1 | Potassium-Month 2 | Potassium-Month 3 | Potassium-Month 4 | Potassium-Month 5 | Potassium-Month 6 | Chloride-Baseline | Chloride-Month 1 | Chloride-Month 2 | Chloride-Month 3 | Chloride-Month 4 | Chloride-Month 5 | Chloride-Month 6 | CO2-Baseline | CO2-Month 1 | CO2-Month 2 | CO2-Month 3 | CO2-Month 4 | CO2-Month 5 | CO2-Month 6 | |
Prednisolone | 140 | 140 | 139 | 141 | 139 | 139 | 143 | 3.8 | 4 | 4.5 | 3.9 | 4.6 | 4.2 | 3.9 | 105 | 105 | 104 | 105 | 105 | 106 | 105 | 22 | 24 | 24 | 24 | 25 | 26 | 26 |
Spironolactone | 142 | 142 | 141 | 142 | 139 | 139 | 140 | 4.5 | 4.7 | 4.2 | 4.1 | 4.5 | 4.5 | 4.3 | 103 | 109 | 107 | 103 | 103 | 103 | 101 | 29 | 22 | 25 | 27 | 28 | 28 | 26 |
3 reviews available for prednisolone and Muscle Weakness
Article | Year |
---|---|
Dengue infection triggered immune mediated necrotizing myopathy in children: a case report and literature review.
Topics: Autoantibodies; Autoimmune Diseases; Child; Dengue; Humans; Male; Muscle Weakness; Muscular Diseases | 2022 |
Advanced gallbladder cancer accompanied with cancer-associated dermatomyositis: A case report and literature review.
Topics: Aged; Deglutition Disorders; Dermatomyositis; Female; Gallbladder Neoplasms; Humans; Muscle Weakness | 2022 |
[Polymyositis associated with HIV immunodeficiency: clinical case and literature review].
Topics: Adult; Anti-Inflammatory Agents; Biopsy; Deglutition Disorders; Diagnosis, Differential; Female; HIV | 2001 |
3 trials available for prednisolone and Muscle Weakness
Article | Year |
---|---|
Human immunodeficiency virus-associated polymyositis: a longitudinal study of outcome.
Topics: Adult; Aged; Anti-HIV Agents; Anti-Inflammatory Agents; Biopsy; CD4-CD8 Ratio; Creatine Kinase; Elec | 2003 |
Prednisolone therapy in Duchenne muscular dystrophy prolongs ambulation and prevents scoliosis.
Topics: Adolescent; Ankle; Anti-Inflammatory Agents; Calcium; Case-Control Studies; Child; Child, Preschool; | 2004 |
Childhood chronic inflammatory demyelinating polyneuropathy: clinical course and long-term outcome.
Topics: Adolescent; Child; Child, Preschool; Disease Progression; Electromyography; Female; Humans; Immunogl | 2000 |
73 other studies available for prednisolone and Muscle Weakness
Article | Year |
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Proximal muscle weakness as the sole manifestation of Cushing's disease, misdiagnosed as dermatomyositis: a case report.
Topics: Adult; Cushing Syndrome; Dermatomyositis; Diagnostic Errors; Humans; Iran; Male; Muscle Weakness; Pi | 2022 |
Necrotizing autoimmune myositis following coronavirus disease 2019 infection: a case report.
Topics: Aged; Autoimmune Diseases; COVID-19; Humans; Male; Muscle Weakness; Myositis; Prednisolone; SARS-CoV | 2022 |
Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease.
Topics: Antibodies, Antinuclear; Creatine Kinase; Female; Glucocorticoids; Humans; Middle Aged; Mixed Connec | 2020 |
A Toddler With Bilateral Facial Weakness.
Topics: Diagnosis, Differential; Epstein-Barr Virus Infections; Facial Paralysis; Glucocorticoids; Humans; I | 2020 |
Severe proximal muscle weakness with normal CK as a presenting feature of ANCA-associated vasculitis.
Topics: Aged, 80 and over; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Biopsy; Delayed Diagn | 2020 |
"Initial deterioration" upon intravenous methyl-prednisolon in myasthenia is multifactorial.
Topics: Administration, Intravenous; Humans; Immunosuppressive Agents; Methylprednisolone; Muscle Weakness; | 2020 |
C1-inhibitor Deficiency Induces Myositis-like Symptoms Via the Deposition of the Membrane Attack Complex in the Muscle.
Topics: Adult; Angioedemas, Hereditary; Anti-Inflammatory Agents; Asian People; Complement Membrane Attack C | 2020 |
Numbness and Weakness in a Patient With Systemic Lupus Erythematosus.
Topics: Electromyography; Female; Glucocorticoids; Humans; Hypesthesia; Lupus Erythematosus, Systemic; Methy | 2021 |
Antimitochondrial Antibody-associated Myopathy with Slowly Progressive Cardiac Dysfunction.
Topics: Autoantibodies; Cardiomyopathies; Female; Humans; Middle Aged; Muscle Weakness; Muscular Diseases; P | 2021 |
[Eosinophilic granulomatosis with polyangiitis presenting with Guillain-Barré syndrome-like acute course. A case report].
Topics: Antibodies, Antineutrophil Cytoplasmic; Churg-Strauss Syndrome; Granulomatosis with Polyangiitis; Gu | 2021 |
Rhabdomyolysis in a Patient with Polyarteritis Nodosa.
Topics: Aged; Anti-Inflammatory Agents; Antibodies, Antineutrophil Cytoplasmic; Antirheumatic Agents; Cyclop | 2018 |
Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-polymyositis Overlap Syndrome Associated with Anti-Ku Antibody.
Topics: Aged; Anti-Inflammatory Agents; Autoantibodies; Azathioprine; Female; Head Movements; Humans; Immuno | 2018 |
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Complicated by Perforation of the Small Intestine and Cholecystitis.
Topics: Adrenal Cortex Hormones; Aged; Asthma; Cholecystitis; Granulomatosis with Polyangiitis; Humans; Hype | 2018 |
Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis (AAV) Restricted to the Limbs.
Topics: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; | 2018 |
Erythroderma and extensive poikiloderma - a rare initial presentation of dermatomyositis: a case report.
Topics: Dermatologic Agents; Dermatomyositis; Electromyography; Female; Fever; Humans; Methotrexate; Middle | 2018 |
Longitudinally Extensive Transverse Myelitis.
Topics: Anti-Inflammatory Agents; Child, Preschool; Fever; Humans; Magnetic Resonance Imaging; Methylprednis | 2019 |
Interstitial lung disease and inflammatory myopathy in antisynthetase syndrome with PL-12 antibody.
Topics: Aged, 80 and over; Amino Acyl-tRNA Synthetases; Autoantibodies; Deglutition Disorders; Humans; Lung | 2018 |
Twice-weekly glucocorticosteroids in infants and young boys with Duchenne muscular dystrophy.
Topics: Case-Control Studies; Child, Preschool; Cohort Studies; Disease Progression; Glucocorticoids; Humans | 2019 |
Antisynthetase syndrome presenting as interstitial lung disease: a case report.
Topics: Adult; Antibodies, Antinuclear; Autoantibodies; Azathioprine; Creatine Kinase; Diagnosis, Differenti | 2019 |
[A woman with skin abnormalities and muscle weakness].
Topics: Anti-Inflammatory Agents; Dermatomyositis; Female; Humans; Middle Aged; Muscle Weakness; Paresis; Pr | 2013 |
Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Diuretics; Dystrophin; Female; Gene Expression; | 2014 |
A case of steroid-responsive MADSAM with late appearance of a partial conduction block in the forearm.
Topics: Anti-Inflammatory Agents; Forearm; Hereditary Central Nervous System Demyelinating Diseases; Humans; | 2014 |
The patient with acute muscular weakness.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents; Creatine Kinase; Cyclosporine; Dermatomyositis; Diag | 2014 |
Anti-synthetase syndrome associated with anti PL-12 and anti-Signal recognition particle antibodies and a necrotizing auto-immune myositis.
Topics: Adult; Anti-Inflammatory Agents; Autoantibodies; Autoimmune Diseases; Cyclophosphamide; Female; Huma | 2015 |
Palmar Gottron papules and Gottron sign.
Topics: Dermatomyositis; Erythema; Female; Glucocorticoids; Hand; Humans; Middle Aged; Muscle Weakness; Pred | 2015 |
Juvenile polymyositis with unremitting pain and progressive loss of motor and bulbar function on a background of sickle cell disease.
Topics: Adolescent; Adrenal Cortex Hormones; Anemia, Sickle Cell; Anti-Inflammatory Agents; Autoimmunity; Az | 2015 |
Pure sensory chronic inflammatory polyneuropathy: rapid deterioration after steroid treatment.
Topics: Disease Progression; Female; Glucocorticoids; Humans; Immunoglobulins, Intravenous; Immunologic Fact | 2015 |
A 44-Year-Old Man With Chronic Cough, Weakness, and a Mediastinum Mass.
Topics: Adult; Biopsy; Cough; Diagnosis, Differential; Glucocorticoids; Humans; Immunoglobulin G; Male; Medi | 2015 |
Case 3: Acute Onset of Headache, Fever, and Right Arm Weakness in 12-year-old Boy.
Topics: Anti-Inflammatory Agents; Arm; Child; Diagnosis, Differential; Encephalomyelitis, Acute Disseminated | 2015 |
Patient with statin-associated immune-mediated necrotizing myopathy presenting with subcutaneous edema, persistent bulbar weakness and absent anti-HMGCR.
Topics: Aged; Autoantibodies; Azathioprine; Biopsy; Bulbar Palsy, Progressive; Edema; Glucocorticoids; Human | 2017 |
Bilateral lower limb weakness in acute severe ulcerative colitis.
Topics: Colitis, Ulcerative; Cyclosporine; Epidural Space; Glucocorticoids; Humans; Immunosuppressive Agents | 2016 |
Prominent subcutaneous oedema as a masquerading symptom of an underlying inflammatory myopathy.
Topics: Aged; Creatine Kinase; Edema; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Muscle | 2017 |
Unusual cause of acute neurologic deficit in childhood: primary central nervous system vasculitis presenting with basilar arterial occlusion.
Topics: Anti-Inflammatory Agents; Arterial Occlusive Diseases; Cerebral Angiography; Child; Diagnosis, Diffe | 2009 |
Morphological changes of the dorsal root ganglion in a patient with herpes zoster seen by magnetic resonance imaging.
Topics: Aged; Anti-Inflammatory Agents; Ganglia, Spinal; Herpes Zoster; Humans; Magnetic Resonance Imaging; | 2008 |
Severe neurotoxicities in a case of Charcot-Marie-Tooth disease type 2 caused by vincristine for acute lymphoblastic leukemia.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aspar | 2008 |
Eosinophilic myositis as presenting symptom in gamma-sarcoglycanopathy.
Topics: Anti-Inflammatory Agents; Biopsy; Disease Progression; DNA Mutational Analysis; Eosinophilia; Female | 2009 |
Steroid-responsive paraneoplastic demyelinating neuropathy and myelopathy associated with breast carcinoma.
Topics: Anti-Inflammatory Agents; Breast Neoplasms; Carcinoma; Disease Progression; Female; Humans; Immunogl | 2008 |
Eosinophilic myositis in calpainopathy: could immunosuppression of the eosinophilic myositis alter the early natural course of the dystrophic disease?
Topics: Azathioprine; Calpain; Child; Creatine Kinase; Disease Progression; Dose-Response Relationship, Drug | 2009 |
Bilateral brachial neuropathy and acute aortic dissection due to giant cell arteritis.
Topics: Anti-Inflammatory Agents; Aorta; Aortic Aneurysm; Aortic Dissection; Biopsy; Brachial Plexus; Brachi | 2009 |
Vesiculo-bullous dermatomyositis: report of three cases.
Topics: Anti-Inflammatory Agents; Breast Neoplasms; Dermatomyositis; Fatigue; Female; Follow-Up Studies; Hum | 2009 |
Macrophagic myofascitis associated with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biopsy; Fascia; Female; Gait Disorders, Neurologic; Humans; Immunosuppressive | 2010 |
Clinical characteristics and outcomes of juvenile and adult dermatomyositis.
Topics: Adolescent; Adult; Age of Onset; Aged; Anti-Inflammatory Agents; Calcification, Physiologic; Dermato | 2009 |
Systemic sclerosis in aquaporin-4 antibody-positive longitudinally extensive transverse myelitis.
Topics: Anti-Inflammatory Agents; Aquaporin 4; Autoantibodies; Brain; Facial Nerve Diseases; Female; Humans; | 2011 |
Silk road occlusion.
Topics: Abdominal Pain; Anorexia; Arterial Occlusive Diseases; Behcet Syndrome; Blood Sedimentation; Brain I | 2011 |
Fulminant myelopathy following neurogenic proximal weakness associated with human T-cell lymphotropic virus type I infection.
Topics: Aged; Glucocorticoids; Humans; Magnetic Resonance Imaging; Male; Muscle Weakness; Muscular Atrophy; | 2011 |
Unusual presentation as an adult onset painful myopathy in a Thai patient with Becker muscular dystrophy.
Topics: Adult; Age of Onset; Asian People; Creatine Kinase; Dystrophin; Electromyography; Genetic Diseases, | 2011 |
Transient delayed facial nerve palsy after inferior alveolar nerve block anesthesia.
Topics: Anesthesia, Dental; Anesthetics, Local; Anti-Inflammatory Agents; Carticaine; Dental Restoration, Pe | 2012 |
A 90 year old man with difficulty swallowing and proximal muscle weakness.
Topics: Aged, 80 and over; Cholinesterase Inhibitors; Deglutition Disorders; Diagnosis, Differential; Fatal | 2012 |
An acquired source of seizures.
Topics: Adult; Albendazole; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antiparasitic Agents; Develo | 2012 |
Medium term outcome in Bell's palsy in children.
Topics: Bell Palsy; Child; Cohort Studies; Emergency Medical Services; Follow-Up Studies; Glucocorticoids; H | 2013 |
Idiopathic cranial polyneuropathy with unilateral IX and X and contralateral XI nerve palsy in a 4-year-old boy.
Topics: Accessory Nerve Diseases; Anti-Inflammatory Agents; Child, Preschool; Functional Laterality; Glossop | 2012 |
Intensive exercise and a patient in acute phase of polymyositis.
Topics: Acute Disease; Combined Modality Therapy; Electromyography; Exercise Therapy; Female; Humans; Muscle | 2012 |
The effect of early prednisolone treatment on the generalization rate in ocular myasthenia gravis.
Topics: Adult; Age of Onset; Aged; Anti-Inflammatory Agents; Autoantibodies; Blepharoptosis; Cholinesterase | 2013 |
Osteoporosis with underlying connective tissue disease: an unusual case.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Accidental Falls; Adult; Anti-Ulcer Agents; Antibodies, Ant | 2002 |
Dissociation between titer of anti-ganglioside antibody and severity of symptoms in a case of Guillain-Barré syndrome with treatment-related fluctuation.
Topics: Adult; Anti-Inflammatory Agents; Antibodies; Cerebrospinal Fluid Proteins; Combined Modality Therapy | 2003 |
[Excessive hyperferritinemia as an indication of a reactive hemophagocytosis syndrome].
Topics: Adolescent; Alanine Transaminase; Anti-Inflammatory Agents; Arthritis; Aspartate Aminotransferases; | 2003 |
Treatment of steroid-unresponsive tumefactive demyelinating disease with plasma exchange.
Topics: Adult; Combined Modality Therapy; Demyelinating Diseases; Disease Progression; Female; Gadolinium; H | 2003 |
Multifocal acquired demyelinating sensory and motor neuropathy: report of a case and review of the literature.
Topics: Adult; Anti-Inflammatory Agents; Demyelinating Diseases; Diagnosis, Differential; Electric Stimulati | 2004 |
A limited form of Churg-Strauss syndrome presenting without asthma and eosinophilia.
Topics: Adult; Amputation, Surgical; Anti-Inflammatory Agents; Antibodies, Antineutrophil Cytoplasmic; Asthm | 2004 |
Multicentric reticulohistiocytosis with prominent cutaneous lesions and proximal muscle weakness masquerading as dermatomyositis.
Topics: Dermatomyositis; Diagnosis, Differential; Drug Therapy, Combination; Female; Histiocytosis; Humans; | 2005 |
Subacute inflammatory demyelinating polyneuropathy in children.
Topics: Adolescent; Age Factors; Anti-Inflammatory Agents; Child; Child, Preschool; Chronic Disease; Disease | 2005 |
Longstanding right-hand weakness in a patient with myasthenia gravis.
Topics: Adult; Anti-Inflammatory Agents; Autoantibodies; Chronic Disease; Disease Progression; Electric Stim | 2006 |
Weekly oral prednisolone improves survival and strength in male mdx mice.
Topics: Administration, Oral; Age Factors; Animals; Anti-Inflammatory Agents; Body Weight; Disease Models, A | 2007 |
Progressive myopathy with up-regulation of MHC-I associated with statin therapy.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Atorvastatin; Creatine Kinase; Female; Folic Acid | 2007 |
Vocal cord paralysis in myasthenia gravis with anti-MuSK antibodies.
Topics: Autoantibodies; Biomarkers; Bulbar Palsy, Progressive; Deglutition Disorders; Facial Muscles; Humans | 2007 |
Sarcoid myositis with muscle weakness as a presenting symptom.
Topics: Anti-Inflammatory Agents; Female; Humans; Middle Aged; Muscle Weakness; Polymyositis; Prednisolone; | 2007 |
Devic's neuromyelitis optica in an infant case.
Topics: Atrophy; Demyelinating Autoimmune Diseases, CNS; Humans; Immunosuppressive Agents; Infant; Male; Mus | 2007 |
Dropped-head syndrome due to steroid responsive focal myositis: a case report and review of the literature.
Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Azathioprine; Biopsy; Di | 2008 |
Localized muscle wasting as an initial symptom of skeletal muscle lymphoma.
Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Hormonal; Diagnosis, Differential; Humans; I | 1998 |
Calcitriol-mediated hypercalcaemia and increased interleukins in a patient with sarcoid myopathy.
Topics: Antirheumatic Agents; Calcitonin; Calcitriol; Chloroquine; Clodronic Acid; Female; Humans; Hypercalc | 1999 |
Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Glucocorticoids; Hindlimb; Male; Mu | 2000 |
Motor dominant neuropathy in Sjögren's syndrome: report of two cases.
Topics: Aged; Autoimmune Diseases; Biopsy; Diagnosis, Differential; Female; Guillain-Barre Syndrome; Humans; | 2002 |
Polyarteritis nodosa presenting as polymyositis.
Topics: Adult; Antirheumatic Agents; Creatine Kinase; Diagnosis, Differential; Drug Therapy, Combination; Hu | 2002 |