Page last updated: 2024-11-06

prednisolone and Metabolic Syndrome

prednisolone has been researched along with Metabolic Syndrome in 11 studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.

Research Excerpts

ExcerptRelevanceReference
"Chronic prednisolone treatment in renal transplant recipients (RTR) causes metabolic abnormalities, which cluster in the metabolic syndrome (MS)."7.85Twenty-four hour urinary cortisol excretion and the metabolic syndrome in prednisolone-treated renal transplant recipients. ( Bakker, SJL; Berger, SP; de Jong, WHA; de Vries, LV; Kema, IP; Navis, G; Touw, DJ, 2017)
"Men with the metabolic syndrome but without diabetes received prednisolone 30  mg once daily plus sitagliptin 100  mg once daily (n=14), prednisolone (n=12) or sitagliptin alone (n=14) or placebo (n=12) for 14 days in a double-blind 2 × 2 randomized-controlled study."5.19Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial. ( Diamant, M; Heymans, MW; Mari, A; Muskiet, MH; Ouwens, DM; Pouwels, PJ; van Genugten, RE; van Raalte, DH, 2014)
"Chronic prednisolone treatment in renal transplant recipients (RTR) causes metabolic abnormalities, which cluster in the metabolic syndrome (MS)."3.85Twenty-four hour urinary cortisol excretion and the metabolic syndrome in prednisolone-treated renal transplant recipients. ( Bakker, SJL; Berger, SP; de Jong, WHA; de Vries, LV; Kema, IP; Navis, G; Touw, DJ, 2017)
"Treatment of children with congenital adrenal hyperplasia (CAH) with corticosteroids (CS) may increase the risk for developing different components of metabolic syndrome (MetS)."1.72Growth and Metabolic Syndrome (MetS) criteria in young children with classic Congenital Adrenal Hyperplasia (CAH) treated with corticosteroids (CS). ( Abdel Meguid, SE; Abougabal, AMS; Ahmed, S; De Sanctis, V; Hamed, N; Hassan, M; Ramadan, MAEF; Soliman, AT, 2022)
"Non-alcoholic fatty liver disease (NAFLD) is nowadays the most common liver disease worldwide."1.56Non-alcoholic steatohepatitis or autoimmune hepatitis? Sometimes a closer look under the surface is needed. ( Dalekos, GN; Gatselis, NK; Koukoulis, GK, 2020)
"Prednisolone dosage was increased from 10 to 60 mg/day."1.36Type B insulin resistance syndrome with systemic lupus erythematosus. ( Gohda, T; Horikoshi, S; Ohsawa, I; Sato, N; Shirato, I; Takagi, M; Tomino, Y; Yamaguchi, Y, 2010)
"Obesity is increasingly prevalent in affluent societies and portends considerable morbidity."1.36Growth in children with acute lymphoblastic leukemia during treatment. ( Barr, RD; Collins, L; Nayiager, T; Pollock, BH; Zarzabal, LA, 2010)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's7 (63.64)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Abdel Meguid, SE1
Soliman, AT2
De Sanctis, V2
Abougabal, AMS1
Ramadan, MAEF1
Hassan, M1
Hamed, N2
Ahmed, S1
Elbaba, M1
Alyafei, F1
Alaaraj, N1
Ahmad, S1
Itani, M1
Al-Naimi, F1
Khater, D1
Dalekos, GN1
Gatselis, NK1
Koukoulis, GK1
de Vries, LV1
de Jong, WHA1
Touw, DJ1
Berger, SP1
Navis, G1
Kema, IP1
Bakker, SJL1
Jung, SY1
Shim, HS1
Hah, YM1
Kim, SH1
Yeo, SG1
Wang, B1
Smyl, C1
Chen, CY1
Li, XY1
Huang, W1
Zhang, HM1
Pai, VJ1
Kang, JX1
van Genugten, RE1
van Raalte, DH1
Muskiet, MH1
Heymans, MW1
Pouwels, PJ1
Ouwens, DM1
Mari, A1
Diamant, M1
Taniguchi, A1
Sato, N1
Ohsawa, I1
Takagi, M1
Gohda, T1
Horikoshi, S1
Shirato, I1
Yamaguchi, Y1
Tomino, Y1
Collins, L1
Zarzabal, LA1
Nayiager, T1
Pollock, BH1
Barr, RD1
Sahebari, M1
Goshayeshi, L1
Mirfeizi, Z1
Rezaieyazdi, Z1
Hatef, MR1
Ghayour-Mobarhan, M1
Akhlaghi, S1
Sahebkar, A1
Ferns, GA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism and Beta-Cell Dysfunction in Males With the Metabolic Syndrome X: A Randomized, Placebo-controlled, Double-blind Intervention Study With a 2x2 Factorial Design[NCT00721552]82 participants (Actual)Interventional2008-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for prednisolone and Metabolic Syndrome

ArticleYear
[Therapy for gout and pseudogout].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2008, Oct-10, Volume: 97, Issue:10

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Calcium Pyrophosphate; Chondrocal

2008

Trials

1 trial available for prednisolone and Metabolic Syndrome

ArticleYear
Does dipeptidyl peptidase-4 inhibition prevent the diabetogenic effects of glucocorticoids in men with the metabolic syndrome? A randomized controlled trial.
    European journal of endocrinology, 2014, Volume: 170, Issue:3

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; F

2014

Other Studies

9 other studies available for prednisolone and Metabolic Syndrome

ArticleYear
Growth and Metabolic Syndrome (MetS) criteria in young children with classic Congenital Adrenal Hyperplasia (CAH) treated with corticosteroids (CS).
    Acta bio-medica : Atenei Parmensis, 2022, 10-26, Volume: 93, Issue:5

    Topics: Adrenal Hyperplasia, Congenital; Carotid Intima-Media Thickness; Child; Child, Preschool; Cholestero

2022
The long-term (five years) effects of prednisone therapy in children with frequently relapsing nephrotic syndrome: A controlled study of anthropometric parameters and metabolic abnormalities.
    Acta bio-medica : Atenei Parmensis, 2022, 10-26, Volume: 93, Issue:5

    Topics: Child; Cholesterol; Glucose; Humans; Metabolic Syndrome; Nephrotic Syndrome; Obesity; Prednisolone;

2022
Non-alcoholic steatohepatitis or autoimmune hepatitis? Sometimes a closer look under the surface is needed.
    BMJ case reports, 2020, Dec-21, Volume: 13, Issue:12

    Topics: Adult; Antibodies, Antinuclear; Biopsy; Diagnosis, Differential; Diagnostic Errors; Elasticity Imagi

2020
Twenty-four hour urinary cortisol excretion and the metabolic syndrome in prednisolone-treated renal transplant recipients.
    Steroids, 2017, Volume: 127

    Topics: Female; Humans; Hydrocortisone; Hypothalamus; Kidney Transplantation; Male; Metabolic Syndrome; Midd

2017
Association of Metabolic Syndrome With Sudden Sensorineural Hearing Loss.
    JAMA otolaryngology-- head & neck surgery, 2018, 04-01, Volume: 144, Issue:4

    Topics: Administration, Oral; Audiometry, Pure-Tone; Cholesterol, HDL; Diabetes Complications; Female; Gluco

2018
Suppression of Postprandial Blood Glucose Fluctuations by a Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of Gluconeogenesis.
    International journal of molecular sciences, 2018, Jun-21, Volume: 19, Issue:7

    Topics: Alanine; Alanine Transaminase; Animals; Blood Glucose; Carbon Isotopes; Diabetes Mellitus, Experimen

2018
Type B insulin resistance syndrome with systemic lupus erythematosus.
    Clinical nephrology, 2010, Volume: 73, Issue:2

    Topics: Biopsy; Dose-Response Relationship, Drug; Follow-Up Studies; Glucocorticoids; Humans; Insulin; Insul

2010
Growth in children with acute lymphoblastic leukemia during treatment.
    Journal of pediatric hematology/oncology, 2010, Volume: 32, Issue:8

    Topics: Antineoplastic Agents, Hormonal; Body Mass Index; Child; Child, Preschool; Combined Modality Therapy

2010
Investigation of the association between metabolic syndrome and disease activity in rheumatoid arthritis.
    TheScientificWorldJournal, 2011, Jun-09, Volume: 11

    Topics: Adult; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Femal

2011