prednisolone has been researched along with Leprosy, Cutaneous in 37 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We followed the urinary levels of the metabolites of NO [nitrite (NO2-) and nitrate (NO3-)] and the clinical response to prednisolone treatment in leprosy patients (n = 9) admitted to ALERT leprosy hospital Addis Ababa, Ethiopia, because of reversal reaction (RR) or erythema nodosum leprosum (ENL)." | 9.09 | High dose prednisolone treatment of leprosy patients undergoing reactions is associated with a rapid decrease in urinary nitric oxide metabolites and clinical improvement. ( Bizuneh, E; Britton, S; Gebre, N; Leekassa, R; Schön, T; Sundqvist, T, 2000) |
| " She was referred to our clinic with painful nodules and pustules on the upper limbs, diffuse facial infiltration with pustules and fever, after initiating minocycline with the intention of treating acne." | 7.78 | Erythema nodosum leprosum associated with minocycline. ( Almeida, LS; Antunes, J; Filipe, P; Marques, MS; Pacheco, D; Travassos, AR, 2012) |
| " These two pilot studies compare the efficacy and side effect profile of ciclosporin plus prednisolone against prednisolone alone in the treatment of patients with either new ENL or chronic and recurrent ENL." | 6.82 | Comparison of Efficacy and Safety of Ciclosporin to Prednisolone in the Treatment of Erythema Nodosum Leprosum: Two Randomised, Double Blind, Controlled Pilot Studies in Ethiopia. ( Alembo, DT; Idriss, MH; Lambert, SM; Lockwood, DN; Nicholls, PG; Nigusse, SD; Walker, SL; Yamuah, LK, 2016) |
| " We followed the urinary levels of the metabolites of NO [nitrite (NO2-) and nitrate (NO3-)] and the clinical response to prednisolone treatment in leprosy patients (n = 9) admitted to ALERT leprosy hospital Addis Ababa, Ethiopia, because of reversal reaction (RR) or erythema nodosum leprosum (ENL)." | 5.09 | High dose prednisolone treatment of leprosy patients undergoing reactions is associated with a rapid decrease in urinary nitric oxide metabolites and clinical improvement. ( Bizuneh, E; Britton, S; Gebre, N; Leekassa, R; Schön, T; Sundqvist, T, 2000) |
| " She was referred to our clinic with painful nodules and pustules on the upper limbs, diffuse facial infiltration with pustules and fever, after initiating minocycline with the intention of treating acne." | 3.78 | Erythema nodosum leprosum associated with minocycline. ( Almeida, LS; Antunes, J; Filipe, P; Marques, MS; Pacheco, D; Travassos, AR, 2012) |
| " These two pilot studies compare the efficacy and side effect profile of ciclosporin plus prednisolone against prednisolone alone in the treatment of patients with either new ENL or chronic and recurrent ENL." | 2.82 | Comparison of Efficacy and Safety of Ciclosporin to Prednisolone in the Treatment of Erythema Nodosum Leprosum: Two Randomised, Double Blind, Controlled Pilot Studies in Ethiopia. ( Alembo, DT; Idriss, MH; Lambert, SM; Lockwood, DN; Nicholls, PG; Nigusse, SD; Walker, SL; Yamuah, LK, 2016) |
| "Clofazimine treatment was superior to prednisolone (more treatment successes; RR 3." | 2.45 | Interventions for erythema nodosum leprosum. ( Lockwood, DN; Ramirez, J; Richardus, JH; van Brakel, WH; Van Veen, NH, 2009) |
| "Clofazimine treatment was superior to prednisolone (more treatment successes; RR 3." | 2.45 | Interventions for erythema nodosum leprosum. A Cochrane review. ( Lockwood, DN; Ramirez, J; Richardus, JH; Van Brakel, WH; Van Veen, NH, 2009) |
| " Steroids were found to be beneficial and safe, in the dosage that we prescribed." | 1.28 | Treatment of recent facial nerve damage with lagophthalmos, using a semistandardized steroid regimen. ( Hogeweg, M; Kiran, KU; Suneetha, S, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.70) | 18.7374 |
| 1990's | 10 (27.03) | 18.2507 |
| 2000's | 16 (43.24) | 29.6817 |
| 2010's | 7 (18.92) | 24.3611 |
| 2020's | 3 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Negera, E | 3 |
| Bobosha, K | 3 |
| Aseffa, A | 3 |
| Dockrell, HM | 3 |
| Lockwood, DNJ | 1 |
| Walker, SL | 5 |
| Bathula, S | 1 |
| Sardana, K | 1 |
| Mathachan, SR | 1 |
| Khurana, A | 1 |
| Ahuja, A | 1 |
| Paliwal, P | 1 |
| de Barros, B | 1 |
| Lambert, SM | 3 |
| Shah, M | 1 |
| Pai, VV | 1 |
| Darlong, J | 1 |
| Rozario, BJ | 1 |
| Alinda, MD | 1 |
| Sales, AM | 1 |
| Doni, S | 1 |
| Hagge, DA | 1 |
| Shrestha, D | 1 |
| Listiawan, MY | 1 |
| Yitaye, AM | 1 |
| Nery, JAC | 1 |
| Neupane, KD | 1 |
| Dias, VLA | 1 |
| Butlin, CR | 2 |
| Nicholls, PG | 3 |
| Lockwood, D | 1 |
| Bekele, Y | 1 |
| Endale, B | 1 |
| Tarekegn, A | 1 |
| Abebe, M | 1 |
| Lockwood, DN | 8 |
| Tilahun, M | 1 |
| Spencer, JS | 1 |
| Ghorpade, A | 1 |
| Nigusse, SD | 1 |
| Alembo, DT | 1 |
| Idriss, MH | 1 |
| Yamuah, LK | 1 |
| Ganesan, V | 1 |
| Mandal, J | 1 |
| Feuth, M | 1 |
| Brandsma, JW | 1 |
| Faber, WR | 2 |
| Bhattarai, B | 1 |
| Feuth, T | 1 |
| Anderson, AM | 1 |
| Benard, G | 1 |
| Sakai-Valente, NY | 1 |
| Bianconcini Trindade, MA | 1 |
| Van Veen, NH | 2 |
| van Brakel, WH | 2 |
| Ramirez, J | 2 |
| Richardus, JH | 2 |
| Kaur, I | 2 |
| Dogra, S | 2 |
| Narang, T | 1 |
| De, D | 1 |
| Eickelmann, M | 1 |
| Steinhoff, M | 1 |
| Metze, D | 1 |
| Tomimori-Yamashita, J | 1 |
| Sunderkötter, C | 1 |
| Travassos, AR | 1 |
| Antunes, J | 1 |
| Pacheco, D | 1 |
| Almeida, LS | 1 |
| Filipe, P | 1 |
| Marques, MS | 1 |
| Kumar, B | 1 |
| Rosenberg, NR | 1 |
| Vermeulen, M | 1 |
| Atkinson, SE | 1 |
| Khanolkar-Young, S | 1 |
| Marlowe, S | 1 |
| Jain, S | 1 |
| Reddy, RG | 1 |
| Suneetha, S | 2 |
| Marlowe, SN | 1 |
| Hawksworth, RA | 1 |
| Kar, BR | 1 |
| Babu, R | 1 |
| Rai, VM | 1 |
| Shenoi, S | 1 |
| Rao, SN | 1 |
| van Hal, SJ | 1 |
| Hudson, BJ | 1 |
| Sharma, NL | 1 |
| Mahajan, VK | 1 |
| Sharma, VC | 1 |
| Sarin, S | 1 |
| Sharma, RC | 1 |
| Pandhi, D | 1 |
| Mehta, S | 1 |
| Agrawal, S | 1 |
| Singal, A | 1 |
| Thaipisuttikul, Y | 1 |
| Kateruttanakul, P | 1 |
| Dhar, S | 1 |
| Kanwar, AJ | 1 |
| Kaur, S | 1 |
| Bhattacharya, SN | 1 |
| Chattopadhaya, D | 1 |
| Saha, K | 1 |
| Vinayakumar, S | 1 |
| Stanley, JN | 1 |
| McAdam, KP | 1 |
| Colston, MJ | 1 |
| Croft, R | 1 |
| Cross, R | 1 |
| Naafs, B | 1 |
| Arunthathi, S | 1 |
| Ebenezer, L | 1 |
| Kumuda, C | 1 |
| Roul-Bouriat, S | 1 |
| Léauté-Labrèze, C | 1 |
| Bobin, P | 1 |
| Tamisier, JM | 1 |
| Vernhes, P | 1 |
| Geniaux, M | 1 |
| Amenu, A | 1 |
| Saunderson, P | 1 |
| Schön, T | 1 |
| Leekassa, R | 1 |
| Gebre, N | 1 |
| Sundqvist, T | 1 |
| Bizuneh, E | 1 |
| Britton, S | 1 |
| Becx-Bleumink, M | 1 |
| Berhe, D | 1 |
| Kiran, KU | 1 |
| Hogeweg, M | 1 |
| Chaudhary, SD | 1 |
| Sen, R | 1 |
| Jain, VK | 1 |
| Dixit, VB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum (MaPS in ENL[NCT03775460] | 550 participants (Anticipated) | Interventional | 2023-01-15 | Recruiting | |||
| A Pilot Study to Evaluate the Efficacy and Safety of Apremilast in Patients of Chronic and Recurrent Erythema Nodosum Leprosum[NCT04822909] | Phase 4 | 10 participants (Actual) | Interventional | 2019-09-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for prednisolone and Leprosy, Cutaneous
| Article | Year |
|---|---|
Interventions for erythema nodosum leprosum.
Topics: Aspirin; Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Prednisolo | 2009 |
Interventions for erythema nodosum leprosum. A Cochrane review.
Topics: Aspirin; Clofazimine; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Prednisolo | 2009 |
Bangkok Workshop on Leprosy Research. Treatment of reactions and nerve damage.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Clofazimine; Cyclosporine; Drug A | 1996 |
8 trials available for prednisolone and Leprosy, Cutaneous
| Article | Year |
|---|---|
Methotrexate and prednisolone study in erythema nodosum leprosum (MaPs in ENL) protocol: a double-blind randomised clinical trial.
Topics: Bangladesh; Brazil; Erythema Nodosum; Ethiopia; Humans; India; Indonesia; Leprostatic Agents; Lepros | 2020 |
The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions.
Topics: Adolescent; Adult; Case-Control Studies; Cholesterol; Erythema Nodosum; Female; Humans; Leprosy, Lep | 2018 |
Comparison of Efficacy and Safety of Ciclosporin to Prednisolone in the Treatment of Erythema Nodosum Leprosum: Two Randomised, Double Blind, Controlled Pilot Studies in Ethiopia.
Topics: Adolescent; Adult; Aged; Cyclosporine; Double-Blind Method; Erythema Nodosum; Ethiopia; Female; Huma | 2016 |
Erythema nodosum leprosum in Nepal: a retrospective study of clinical features and response to treatment with prednisolone or thalidomide.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Child; Erythema Nodosum; Female; Humans; Leprosta | 2008 |
Comparative efficacy of thalidomide and prednisolone in the treatment of moderate to severe erythema nodosum leprosum: a randomized study.
Topics: Administration, Oral; Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythem | 2009 |
Detection of IL-13, IL-10, and IL-6 in the leprosy skin lesions of patients during prednisolone treatment for type 1 (T1R) reactions.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Biopsy; Female; Humans; Immunohistochemistry; | 2004 |
Clinical outcomes in a randomized controlled study comparing azathioprine and prednisolone versus prednisolone alone in the treatment of severe leprosy type 1 reactions in Nepal.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Drug Therapy, | 2004 |
High dose prednisolone treatment of leprosy patients undergoing reactions is associated with a rapid decrease in urinary nitric oxide metabolites and clinical improvement.
Topics: Adolescent; Adult; Biomarkers; Dose-Response Relationship, Drug; Erythema Nodosum; Female; Humans; L | 2000 |
26 other studies available for prednisolone and Leprosy, Cutaneous
| Article | Year |
|---|---|
Regulatory T cells in erythema nodosum leprosum maintain anti-inflammatory function.
Topics: Anti-Inflammatory Agents; Drug Therapy, Combination; Erythema Nodosum; Humans; Interleukin-10; Lepro | 2022 |
A real-world study of low-dose thalidomide in severe erythema nodosum leprosum highlighting its mechanistic rationale in a resource-constrained target population.
Topics: Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Leprosy, Multibacillary; Pannicu | 2023 |
The Effects of Prednisolone Treatment on Cytokine Expression in Patients with Erythema Nodosum Leprosum Reactions.
Topics: Adolescent; Adult; Biopsy; Case-Control Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Eryth | 2018 |
Reactive perforating leprosy: pustular erythema nodosum leprosum with epidermal perforation and liberation of Mycobacterium leprae.
Topics: Anti-Inflammatory Agents; Erythema Nodosum; Humans; Leprostatic Agents; Leprosy, Lepromatous; Male; | 2014 |
Primary oral tuberculosis in a patient with lepromatous leprosy: Diagnostic dilemma.
Topics: Anti-Inflammatory Agents; Clofazimine; Coinfection; Female; Humans; Leprostatic Agents; Leprosy, Lep | 2016 |
Concomitant lucio phenomenon and erythema nodosum in a leprosy patient: clues for their distinct pathogeneses.
Topics: Adult; Anti-Inflammatory Agents; Biopsy; Drug Therapy, Combination; Erythema Nodosum; Female; Humans | 2009 |
Erythema leprosum--after treatment of Lepromatous Leprosy.
Topics: Adult; Anti-Inflammatory Agents; Drug Administration Schedule; Drug Eruptions; Erythema Nodosum; Fem | 2010 |
Erythema nodosum leprosum associated with minocycline.
Topics: Acne Vulgaris; Biopsy, Needle; Drug Therapy, Combination; Erythema Nodosum; Female; Follow-Up Studie | 2012 |
Bullous reaction in leprosy: a rare phenomenon.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blister; Clofazimine; Cloxacillin; Humans; India; Le | 2002 |
Unexplained delayed nerve impairment in leprosy after treatment.
Topics: Adult; Aged; Disability Evaluation; Drug Therapy, Combination; Electrophysiology; Erythema Nodosum; | 2003 |
Methotrexate in resistant ENL.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Drug Synergism; Erythema Nodosum; Humans; Immunos | 2004 |
Guillain-Barré syndrome-like presentation in borderline leprosy with type-2 reaction.
Topics: Drug Therapy, Combination; Glucocorticoids; Guillain-Barre Syndrome; Humans; Leprostatic Agents; Lep | 2006 |
Leprosy: an uncommon infection with varied presentations.
Topics: Adult; Anti-Inflammatory Agents; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy, Lepr | 2006 |
Erythema nodosum leprosum and HIV infection: A therapeutic experience.
Topics: Adult; Anti-HIV Agents; Colchicine; Erythema Nodosum; HIV Infections; Humans; Ibuprofen; Leprostatic | 2005 |
Erythema nodosum leprosum necroticans in a child--an unusual manifestation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Diclofenac; Drug Therapy, Combination; Erythema Nodo | 2005 |
Sarcoidosis mimics lepromatous leprosy: a case report.
Topics: Adult; Glucocorticoids; Humans; Leprosy, Lepromatous; Male; Prednisolone; Sarcoidosis; Skin Diseases | 2007 |
Autoaggressive lepromatous leprosy.
Topics: Autoantibodies; Autoimmune Diseases; Drug Therapy, Combination; Female; Humans; Leprostatic Agents; | 1993 |
Tumor necrosis factor: status in reactions in leprosy before and after treatment.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chloroquine; Clofazimine; Eryt | 1993 |
Clinical features and outcome of reversal (type 1) reactions in Hyderabad, India.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Child; Erythema; Female; Humans; India; Leprosy; | 1993 |
Development of life-threatening thrombocytopaenia in a patient on MDT and prednisolone.
Topics: Adult; Anti-Inflammatory Agents; Drug Therapy, Combination; Epistaxis; Humans; Leprostatic Agents; L | 1996 |
Reversal reaction, nerve damage and steroid therapy in three multibacillary HIV positive patients.
Topics: Adult; Female; HIV Infections; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Leprosy, Tuberculo | 1998 |
[Leprosy disclosed by polyarthritis].
Topics: Aged; Antimalarials; Arthritis; Connective Tissue Diseases; Diagnosis, Differential; Female; Glucoco | 1998 |
Use of prednisolone blister packs in the field.
Topics: Administration, Topical; Anti-Inflammatory Agents; Drug Delivery Systems; Drug Packaging; Ethiopia; | 1999 |
Occurrence of reactions, their diagnosis and management in leprosy patients treated with multidrug therapy; experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia.
Topics: Drug Therapy, Combination; Erythema Nodosum; Ethiopia; Humans; Hypersensitivity, Delayed; Immunity, | 1992 |
Treatment of recent facial nerve damage with lagophthalmos, using a semistandardized steroid regimen.
Topics: Eyelid Diseases; Facial Nerve Diseases; Humans; Leprosy, Borderline; Leprosy, Lepromatous; Prednisol | 1991 |
Leukemoid reaction in erythema nodosum leprosum in a leprosy patient.
Topics: Adult; Clofazimine; Erythema Nodosum; Ferritins; Humans; Leprosy, Lepromatous; Leukemoid Reaction; M | 1988 |