prednisolone and Keratitis, Herpetic studies

Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Keratitis, Herpetic: A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)

Research Excerpts

Excerpt	Relevance	Reference
"To assess the benefit of adding oral acyclovir to a regimen of topical prednisolone phosphate and trifluridine for the treatment of iridocyclitis caused by herpes simplex virus (HSV)."	9.08	A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group. ( , 1996)
"To report a case of herpes simplex virus reactivation after starting bimatoprost treatment for glaucoma."	7.71	Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma. ( Kroll, DM; Schuman, JS, 2002)
"To assess the benefit of adding oral acyclovir to a regimen of topical prednisolone phosphate and trifluridine for the treatment of iridocyclitis caused by herpes simplex virus (HSV)."	5.08	A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group. ( , 1996)
"To report a case of herpes simplex virus reactivation after starting bimatoprost treatment for glaucoma."	3.71	Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma. ( Kroll, DM; Schuman, JS, 2002)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (15.38)	18.7374
1990's	10 (25.64)	18.2507
2000's	11 (28.21)	29.6817
2010's	8 (20.51)	24.3611
2020's	4 (10.26)	2.80

Authors	Studies
Richardson-May, J	1
Rothwell, A	1
Rashid, M	1
Wilhelmus, KR	6
Gee, L	4
Hauck, WW	3
Kurinij, N	3
Dawson, CR	6
Jones, DB	5
Barron, BA	4
Kaufman, HE	4
Sugar, J	4
Hyndiuk, RA	4
Laibson, PR	3
Stulting, RD	2
Asbell, PA	2
Ozturk, T	1
Arikan, G	1
Oner, H	1
Porcar Plana, CA	1
Matarredona Muñoz, J	1
Moya Roca, J	1
Campos Mollo, E	1
Peyman, A	1
Nayebzadeh, M	1
Peyman, M	1
Afshari, NA	1
Pourazizi, M	1
Albietz, JM	1
Lenton, LM	1
Eriş, E	1
Yüksel, N	1
Pirhan, D	1
Karadenizli, A	1
Aslan, M	1
Gacar, G	1
Erman, G	1
Subaş, C	1
Uzuner, H	1
Yldz, DK	1
Karaöz, E	1
Gondchawar, A	1
Biswas, J	1
Murali, S	1
Eawaran, LM	1
Patel, NN	1
Teng, CC	1
Sperber, LT	1
Dodick, JM	1
Jain, V	1
Pineda, R	1
Garcia, DD	1
Shtein, RM	1
Musch, DC	1
Elner, VM	1
Patel, DV	1
McGhee, CN	1
Chiang, CC	1
Lin, TH	1
Tien, PT	1
Tsai, YY	1
Mitchell, BM	1
Praidou, A	1
Androudi, S	1
Kanonidou, E	1
Konidaris, V	1
Alexandridis, A	1
Brazitikos, P	1
Baltatzis, S	1
Romero-Rangel, T	1
Foster, CS	1
Barker, NH	3
KIMURA, SJ	2
OKUMOTO, M	3
DIAZ-BONNET, V	1
HOGAN, MJ	1
CROMPTON, DO	1
DOHLMAN, CH	1
ZUCKER, BB	1
JAWETZ, E	1
SONNE, M	1
Lanier, JD	1
Whitcher, JP	1
Oh, JO	1
Rao, SN	1
Shen, YC	1
Wang, CY	1
Chen, YC	1
Lee, YF	1
Epstein, RJ	1
Beck, R	1
Cohen, EJ	1
O'Brien, WJ	1
Segundo, AP	1
Guy, J	1
Dorn, EM	1
Taylor, JL	1
Bacchetti, P	1
Dayan, M	1
McGhee, C	1
Anastas, C	1
Sudesh, S	1
Pandit, RT	1
Halgren, JT	1
Sutphin, JE	1
Wagoner, MD	1
Kroll, DM	1
Schuman, JS	1
Lesher, MP	1
Lohman, LE	1
Yeakley, W	1
Lass, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
[NCT00000138]	Phase 3	0 participants	Interventional	1989-05-31	Active, not recruiting
[NCT00000139]	Phase 3	0 participants	Interventional	1992-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Ocular herpes simplex. Clinical evidence, 2003, Issue:9 Topics: Acyclovir; Administration, Oral; Antiviral Agents; Corneal Transplantation; Debridement; Humans; Int	2003
Ocular herpes simplex. Clinical evidence, 2004, Issue:11 Topics: Acyclovir; Antiviral Agents; Debridement; Humans; Interferons; Keratitis, Herpetic; Prednisolone; Se	2004
Ocular herpes simplex. Clinical evidence, 2005, Issue:14 Topics: Acyclovir; Antiviral Agents; Debridement; Humans; Interferons; Keratitis, Herpetic; Prednisolone; Se	2005
Herpetic eye disease study. You can help. Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:1 Topics: Acyclovir; Administration, Oral; Anti-Inflammatory Agents; Antiviral Agents; Clinical Trials as Topi	1996
The impact of the herpetic eye disease studies on the management of herpes simplex virus ocular infections. Current opinion in ophthalmology, 1999, Volume: 10, Issue:4 Topics: Acyclovir; Administration, Oral; Antiviral Agents; Corneal Stroma; Humans; Iritis; Keratitis, Herpet	1999

Article	Year
Herpetic Eye Disease Study: A Controlled Trial of Topical Corticosteroids for Herpes Simplex Stromal Keratitis. Ophthalmology, 2020, Volume: 127, Issue:4S Topics: Administration, Ophthalmic; Adult; Antiviral Agents; Corneal Stroma; Double-Blind Method; Eye Infect	2020
Topical cyclosporine-A versus prednisolone for herpetic stromal keratitis: a randomized controlled trial. Acta ophthalmologica, 2019, Volume: 97, Issue:2 Topics: Administration, Topical; Adolescent; Adult; Aged; Corneal Stroma; Cyclosporine; Dose-Response Relati	2019
Herpetic Eye Disease Study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. Ophthalmology, 1994, Volume: 101, Issue:12 Topics: Acyclovir; Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Double-Blind Meth	1994
Herpetic Eye Disease Study. A controlled trial of topical corticosteroids for herpes simplex stromal keratitis. Ophthalmology, 1994, Volume: 101, Issue:12 Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Double	1994
A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:9 Topics: Acyclovir; Administration, Oral; Administration, Topical; Anti-Inflammatory Agents; Antiviral Agents	1996
Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group. The British journal of ophthalmology, 1996, Volume: 80, Issue:11 Topics: Acyclovir; Anti-Inflammatory Agents; Antiviral Agents; Drug Therapy, Combination; Endothelium, Corne	1996

prednisolone and Keratitis, Herpetic

Research Excerpts

Research

Studies (39)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Reactivation of herpes simplex keratitis following vaccination for COVID-19. BMJ case reports, 2021, Sep-07, Volume: 14, Issue:9 Topics: Acyclovir; Aged, 80 and over; Antiviral Agents; COVID-19; Humans; Keratitis, Herpetic; Male; Prednis	2021
Herpetic Keratouveitis following Intravitreal Ranibizumab Injection in a Case with Diabetic Macular Edema. Ocular immunology and inflammation, 2021, Nov-17, Volume: 29, Issue:7-8 Topics: Angiogenesis Inhibitors; Antiviral Agents; Diabetic Retinopathy; Drug Therapy, Combination; Drug-Rel	2021
Moraxella nonliquefaciens superinfecting herpes simplex keratitis. European journal of ophthalmology, 2022, Volume: 32, Issue:6 Topics: Acyclovir; Aged, 80 and over; Anti-Bacterial Agents; Ceftazidime; Ciprofloxacin; Cyclopentolate; Fem	2022
Late reactivation of herpes zoster keratitis results in band keratopathy. Optometry and vision science : official publication of the American Academy of Optometry, 2014, Volume: 91, Issue:6 Topics: Aged, 80 and over; Combined Modality Therapy; Corneal Dystrophies, Hereditary; Corneal Topography; E	2014
Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. Eye & contact lens, 2016, Volume: 42, Issue:3 Topics: Administration, Topical; Animals; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocyte	2016
A case of herpes simplex keratouveitis diagnosed by real time polymerase chain reaction. Indian journal of ophthalmology, 2015, Volume: 63, Issue:11 Topics: Acyclovir; Antiviral Agents; Aqueous Humor; DNA, Viral; Drug Therapy, Combination; Eye Infections, V	2015
New-onset herpes simplex virus keratitis after cataract surgery. Cornea, 2009, Volume: 28, Issue:1 Topics: Acyclovir; Administration, Oral; Adult; Anti-Inflammatory Agents; Antifungal Agents; Antiviral Agent	2009
Reactivated herpetic keratitis following laser in situ keratomileusis. Journal of cataract and refractive surgery, 2009, Volume: 35, Issue:5 Topics: Acyclovir; Adult; Antiviral Agents; Astigmatism; Cornea; Corneal Topography; Drug Therapy, Combinati	2009
Herpes simplex virus keratitis: histopathologic neovascularization and corneal allograft failure. Cornea, 2009, Volume: 28, Issue:9 Topics: Acyclovir; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; Child, Preschool; Co	2009
Laser scanning in vivo confocal microscopy demonstrating significant alteration of human corneal nerves following herpes zoster ophthalmicus. Archives of neurology, 2010, Volume: 67, Issue:5 Topics: Acyclovir; Antiviral Agents; Cornea; Female; Herpes Zoster Ophthalmicus; Humans; Keratitis, Herpetic	2010
Atypical presentation of cytomegalovirus endotheliitis: a case report. Ocular immunology and inflammation, 2011, Volume: 19, Issue:1 Topics: Acyclovir; Aged; Antiviral Agents; Corneal Edema; Cytomegalovirus; Cytomegalovirus Infections; DNA,	2011
Photographic monitoring of herpes simplex virus keratitis during anti-inflammatory treatment. Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:2 Topics: Antiviral Agents; Cohort Studies; Corneal Stroma; Drug Therapy, Combination; Endothelium, Corneal; G	2011
Bilateral herpes simplex keratitis presenting as peripheral ulcerative keratitis. Cornea, 2012, Volume: 31, Issue:5 Topics: Acyclovir; Antigens, Viral; Antiviral Agents; Corneal Ulcer; Diagnosis, Differential; Drug Therapy,	2012
Sectorial keratitis and uveitis: differential diagnosis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003, Volume: 241, Issue:1 Topics: Acyclovir; Administration, Topical; Adult; Anti-Inflammatory Agents; Antiviral Agents; Corneal Strom	2003
The effect of corticosteroids on experimental herpes simplex keratoconjunctivitis in the rabbit. American journal of ophthalmology, 1957, Volume: 43, Issue:4 Part 2 Topics: Adrenal Cortex Hormones; Animals; Herpesviridae Infections; Hydrocortisone; Keratitis, Herpetic; Ker	1957
The effect of corticosteroid hormones on experimental herpes simplex keratitis. A clinical, histopathologic, and histochemical study. American journal of ophthalmology, 1961, Volume: 51 Topics: Adrenal Cortex Hormones; Herpesviridae Infections; Humans; Keratitis, Herpetic; Prednisolone	1961
CORTICOSTEROIDS EXACERBATE OCULAR HERPES SIMPLEX. The Medical journal of Australia, 1964, Dec-12, Volume: 2 Topics: Administration, Topical; Adolescent; Adrenal Cortex Hormones; Betamethasone; Corneal Ulcer; Drug The	1964
LONG-TERM TREATMENT WITH IDOXURIDINE AND STEROIDS: A COMPLICATION IN HERPETIC KERATITIS. Archives of ophthalmology (Chicago, Ill. : 1960), 1965, Volume: 74 Topics: Acetazolamide; Administration, Topical; Blindness; Dexamethasone; Drug Therapy; Erythromycin; Geriat	1965
Studies on herpes simplex. X. The effect of corticosteroids on herpetic keratitis in the rabbit. Journal of immunology (Baltimore, Md. : 1950), 1959, Volume: 83 Topics: Adrenal Cortex Hormones; Animals; Glucocorticoids; Herpes Simplex; Herpesviridae Infections; Hydroco	1959
Proflavine and light in the treatment of experimental herpetic ocular infections. Antimicrobial agents and chemotherapy, 1974, Volume: 6, Issue:5 Topics: Animals; Corneal Ulcer; Drug Therapy, Combination; Idoxuridine; Keratitis, Herpetic; Male; Photochem	1974
Treatment of herpes simplex virus stromal keratitis unresponsive to topical prednisolone 1% with topical cyclosporine 0.05%. American journal of ophthalmology, 2006, Volume: 141, Issue:4 Topics: Administration, Topical; Adult; Corneal Stroma; Cyclosporine; Humans; Immunosuppressive Agents; Kera	2006
Progressive herpetic linear endotheliitis. Cornea, 2007, Volume: 26, Issue:3 Topics: Acyclovir; Aged; Antibodies, Viral; Aqueous Humor; Disease Progression; DNA, Viral; Drug Therapy, Co	2007
Band keratopathy secondary to herpes simplex or topical corticosteroid? Archives of ophthalmology (Chicago, Ill. : 1960), 1994, Volume: 112, Issue:5 Topics: Calcinosis; Corneal Diseases; Humans; Keratitis, Herpetic; Prednisolone	1994
Herpetic stromal disease: response to acyclovir/steroid therapy. Acta ophthalmologica Scandinavica, 1996, Volume: 74, Issue:3 Topics: Acyclovir; Animals; Antiviral Agents; Corneal Stroma; DNA, Viral; Drug Therapy, Combination; Glucoco	1996
Idiopathic sectoral corneal endotheliitis. Australian and New Zealand journal of ophthalmology, 1996, Volume: 24, Issue:4 Topics: Acyclovir; Adult; Antiviral Agents; Drug Therapy, Combination; Endothelium, Corneal; Glucocorticoids	1996
Triple anterior stromal ring infiltrate associated with presumed HSV keratitis. Cornea, 2001, Volume: 20, Issue:8 Topics: Acyclovir; Anti-Infective Agents; Antiviral Agents; Ciprofloxacin; Corneal Stroma; Drug Therapy, Com	2001
Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma. American journal of ophthalmology, 2002, Volume: 133, Issue:3 Topics: Acyclovir; Aged; Amides; Anti-Infective Agents; Anti-Inflammatory Agents; Antihypertensive Agents; A	2002
Recurrence of herpetic stromal keratitis after a conjunctival flap surgical procedure. American journal of ophthalmology, 1992, Aug-15, Volume: 114, Issue:2 Topics: Aged; Cataract Extraction; Conjunctiva; Corneal Stroma; Corneal Ulcer; Eye Infections, Viral; Female	1992