prednisolone has been researched along with Infertility, Male in 39 studies
Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prednisolone (5 mg) was administered orally, daily for 3-6 months in men with significant antisperm antibodies." | 2.68 | Effect of low dose continuous corticosteroid therapy in men with antisperm antibodies on spermatozoal quality and conception rate. ( Abdul Hamada, B; al-Qattan, F; Omu, AE, 1996) |
| "Prednisolone was given orally at a dose of 1 mg/kg/day for 9 days repeated over 3 cycles (their wives' menstrual cycles)." | 2.66 | Steroid therapy for male infertility associated with antisperm antibodies. Results of a small randomized clinical trial. ( De Almeida, M; Feneux, D; Jouannet, P; Rigaud, C, 1985) |
| "A normal pregnancy was achieved." | 1.31 | Primary infertility in 45-year-old man with untreated 21-hydroxylase deficiency: successful outcome with glucocorticoid therapy. ( Tiitinen, A; Välimäki, M, 2002) |
| "Of these, 50 had severe oligozoospermia or azoospermia, and another 30 had oligozoospermia; 67 had significantly raised serum antisperm antibody titres." | 1.29 | Unilateral testicular obstruction: orchidectomy or reconstruction? ( Hendry, WF; Lowe, DG; Parkinson, MC; Parslow, JM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (28.21) | 18.7374 |
| 1990's | 23 (58.97) | 18.2507 |
| 2000's | 3 (7.69) | 29.6817 |
| 2010's | 2 (5.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Siristatidis, C | 1 |
| Dafopoulos, K | 1 |
| El-Khayat, W | 1 |
| Salamalekis, G | 1 |
| Anifandis, G | 1 |
| Vrantza, T | 1 |
| Elsadek, M | 1 |
| Papantoniou, N | 1 |
| Taiyeb, AM | 1 |
| Ridha-Albarzanchi, MT | 1 |
| Taiyeb, SM | 1 |
| Kanan, ZA | 1 |
| Alatrakchi, SK | 1 |
| Kjelland, ME | 1 |
| Muhsen-Alanssari, SA | 1 |
| Yoshida, C | 1 |
| Kojima, H | 1 |
| Ishigaki, T | 1 |
| Katsura, Y | 1 |
| Kaneko, S | 1 |
| Suzukawa, K | 1 |
| Hasegawa, Y | 1 |
| Kawachi, Y | 1 |
| Otsuka, F | 1 |
| Nagasawa, T | 1 |
| Skinner, JA | 1 |
| Mann, BS | 1 |
| Carrington, RW | 1 |
| Hashems-Nejad, A | 1 |
| Bentley, G | 1 |
| Baker, HW | 2 |
| Clarke, GN | 1 |
| Hudson, B | 1 |
| McBain, JC | 1 |
| McGowan, MP | 1 |
| Pepperell, RJ | 1 |
| Ekwere, PD | 1 |
| Sharma, KK | 1 |
| Barratt, CL | 1 |
| Pearson, MJ | 1 |
| Cooke, ID | 1 |
| Lähteenmäki, A | 3 |
| Veilahti, J | 1 |
| Hovatta, O | 3 |
| Robinson, JN | 1 |
| Forman, RG | 1 |
| Nicholson, SC | 1 |
| Maciocia, LR | 1 |
| Barlow, DH | 1 |
| Räsänen, M | 2 |
| Saarikoski, S | 2 |
| Penttilä, I | 1 |
| Agrawal, YP | 2 |
| Hendry, WF | 8 |
| Parslow, JM | 2 |
| Parkinson, MC | 1 |
| Lowe, DG | 1 |
| Shafford, EA | 1 |
| Kingston, JE | 1 |
| Malpas, JS | 2 |
| Plowman, PN | 1 |
| Pritchard, J | 1 |
| Savage, MO | 1 |
| Eden, OB | 1 |
| Haas, GG | 1 |
| Shulman, S | 1 |
| Grigoriou, O | 1 |
| Konidaris, S | 1 |
| Antonaki, V | 1 |
| Papadias, C | 1 |
| Antoniou, G | 1 |
| Gargaropoulos, A | 1 |
| Räs anen, M | 1 |
| Omu, AE | 1 |
| al-Qattan, F | 1 |
| Abdul Hamada, B | 1 |
| Pearce, G | 1 |
| Tabensky, DA | 1 |
| Delmas, PD | 1 |
| Seeman, E | 1 |
| Tiitinen, A | 1 |
| Välimäki, M | 1 |
| Chapman, RM | 1 |
| Sutcliffe, SB | 1 |
| Rees, LH | 1 |
| Edwards, CR | 1 |
| Baumgarten, SR | 1 |
| Lindsay, GK | 1 |
| Wise, GJ | 1 |
| Bals-Pratsch, M | 1 |
| Dören, M | 1 |
| Karbowski, B | 1 |
| Schneider, HP | 1 |
| Nieschlag, E | 1 |
| Tsatsoulis, A | 1 |
| Shalet, SM | 2 |
| Hughes, L | 2 |
| Scammell, G | 1 |
| Pryor, JP | 1 |
| Hargreave, TB | 1 |
| Parkhouse, H | 1 |
| Charak, BS | 1 |
| Gupta, R | 1 |
| Mandrekar, P | 1 |
| Sheth, NA | 1 |
| Banavali, SD | 1 |
| Saikia, TK | 1 |
| Gopal, R | 1 |
| Dinshaw, KA | 1 |
| Advani, SH | 1 |
| Cohen, J | 1 |
| Malter, H | 1 |
| Elsner, C | 1 |
| Kort, H | 1 |
| Massey, J | 1 |
| Mayer, MP | 1 |
| Papa, FO | 1 |
| Alvarenga, MA | 1 |
| Lopes, MD | 1 |
| Campos Filho, EP | 1 |
| Elstein, M | 1 |
| Vaughan Williams, CA | 1 |
| De Almeida, M | 1 |
| Feneux, D | 1 |
| Rigaud, C | 1 |
| Jouannet, P | 1 |
| Treehuba, K | 1 |
| Stedronska, J | 1 |
| Wass, JA | 1 |
| Besser, GM | 1 |
| Bandhauer, K | 1 |
| Lingardh, G | 1 |
| Andersson, L | 1 |
| Osterman, B | 1 |
| Halim, A | 1 |
| Antoniou, D | 1 |
| Lane, J | 1 |
| Blandy, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Improvement in Pregnancy Outcomes in Immunologically Infertile Male Patients Undergoing Prednisolone Treatment and Conventional IVF Preceded by Sperm Penetration Assay: A Randomized Controlled Trial[NCT02935738] | 241 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Live birth rates in treated and control patients undergoing conventional IVF or ICSI cycles as determined by the sperm penetration assay (SPA) of hamster zone free ova (NCT02935738)
Timeframe: Nine months (pregnancy term) after the in vitro fertilization.
| Intervention | participants (Number) |
|---|---|
| Prednisolone Treated Men / Positive SPA / IVF | 18 |
| Prednisolone Treated Men / Negative SPA / ICSI | 13 |
| Control Men / Positive SPA / IVF | 8 |
| Control Men / Negative SPA / ICSI | 9 |
3 reviews available for prednisolone and Infertility, Male
| Article | Year |
|---|---|
Corticosteroid-induced bone loss in men.
Topics: Absorptiometry, Photon; Adult; Androgens; Antibodies; Bone and Bones; Bone Density; Bone Remodeling; | 1998 |
The significance of antisperm antibodies: measurement and management.
Topics: Autoantibodies; Female; Humans; Immunoglobulin G; Infertility, Male; Male; Prednisolone; Sperm-Ovum | 1992 |
Detection and treatment of antispermatozoal antibodies in men.
Topics: Autoantibodies; Female; Humans; Infertility, Male; Male; Methylprednisolone; Prednisolone; Spermatoz | 1989 |
16 trials available for prednisolone and Infertility, Male
| Article | Year |
|---|---|
Improvement in pregnancy outcomes in couples with immunologically male infertility undergoing prednisolone treatment and conventional in vitro fertilization preceded by sperm penetration assay: a randomized controlled trial.
Topics: Adult; Animals; Cricetinae; Female; Fertility Agents, Male; Fertilization in Vitro; Humans; Infertil | 2017 |
Immunological infertility among Nigerian men: incidence of circulating antisperm auto-antibodies and some clinical observations: a preliminary report.
Topics: Adult; Agglutination Tests; Autoantibodies; Glucocorticoids; Humans; Incidence; Infertility, Male; M | 1995 |
Oral steroid therapy for subfertile males with antisperm antibodies in the semen: prediction of the responders.
Topics: Administration, Oral; Adult; Autoantibodies; Female; Humans; Immunoglobulin A; Immunoglobulin G; Inf | 1995 |
Intra-uterine insemination versus cyclic, low-dose prednisolone in couples with male antisperm antibodies.
Topics: Adult; Autoantibodies; Cross-Over Studies; Drug Administration Schedule; Female; Humans; Immunoglobu | 1995 |
A comparison of intrauterine insemination in superovulated cycles to intercourse in couples where the male is receiving steroids for the treatment of autoimmune infertility.
Topics: Autoantibodies; Autoimmunity; Coitus; Cross-Over Studies; Female; Humans; Infertility, Male; Insemin | 1995 |
A flow cytometric study on the effect of low dose cyclic prednisolone treatment on sperm-bound antibody levels.
Topics: Autoantibodies; Drug Administration Schedule; Female; Flow Cytometry; Humans; Immunoglobulin A; Immu | 1994 |
Corticosteroid treatment does not improve the results of intrauterine insemination in male subfertility caused by antisperm antibodies.
Topics: Adult; Autoantibodies; Autoimmune Diseases; Female; Glucocorticoids; Humans; Immunosuppressive Agent | 1996 |
Low-dose prednisolone does not improve the outcome of in-vitro fertilization in male immunological infertility.
Topics: Adult; Anti-Inflammatory Agents; Autoantibodies; Embryo Transfer; Female; Fertilization in Vitro; Hu | 1995 |
A placebo-controlled flow cytometric study of the effect of low-dose prednisolone treatment on sperm-bound antibody levels.
Topics: Antibodies; Double-Blind Method; Flow Cytometry; Humans; Immunoglobulin A; Immunoglobulin G; Inferti | 1996 |
Effect of low dose continuous corticosteroid therapy in men with antisperm antibodies on spermatozoal quality and conception rate.
Topics: Adult; Autoantibodies; Cohort Studies; Female; Glucocorticoids; Humans; Infertility, Male; Male; Pre | 1996 |
Corticosteroid-induced bone loss in men.
Topics: Absorptiometry, Photon; Adult; Androgens; Antibodies; Bone and Bones; Bone Density; Bone Remodeling; | 1998 |
Cyclic corticosteroid immunosuppression is unsuccessful in the treatment of sperm antibody-related male infertility: a controlled study.
Topics: Adult; Antibodies; Autoimmune Diseases; Female; Fertilization; Follow-Up Studies; Humans; Infertilit | 1992 |
Comparison of prednisolone and placebo in subfertile men with antibodies to spermatozoa.
Topics: Agglutination Tests; Autoantibodies; Double-Blind Method; Drug Administration Schedule; Drug Evaluat | 1990 |
Corticoid therapy--risk/benefit?
Topics: Autoantibodies; Double-Blind Method; Humans; Infertility, Male; Male; Prednisolone; Spermatozoa | 1991 |
Immunosuppression supports implantation of zona pellucida dissected human embryos.
Topics: Clinical Trials as Topic; Embryo Implantation; Embryo Transfer; Female; Fertilization in Vitro; Huma | 1990 |
Steroid therapy for male infertility associated with antisperm antibodies. Results of a small randomized clinical trial.
Topics: Adult; Autoantibodies; Clinical Trials as Topic; Double-Blind Method; Humans; Infertility, Male; Mal | 1985 |
21 other studies available for prednisolone and Infertility, Male
| Article | Year |
|---|---|
Administration of prednisolone and low molecular weight heparin in patients with repeated implantation failures: a cohort study.
Topics: Adult; Anticoagulants; Cohort Studies; Combined Modality Therapy; Drug Therapy, Combination; Egypt; | 2018 |
Association of pyoderma gangrenosum and sterile osteomyelitis in a patient having myelodysplastic syndrome with der(1;7)(q10;q10).
Topics: Aged; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pa | 2004 |
Male infertility and avascular necrosis of the femoral head.
Topics: Adult; Femur Head Necrosis; Glucocorticoids; Humans; Infertility, Male; Male; Prednisolone | 2004 |
Treatment of sperm autoimmunity in men.
Topics: Adult; Autoantibodies; Autoimmune Diseases; Female; Follow-Up Studies; Humans; Immunosuppressive Age | 1983 |
Unilateral testicular obstruction: orchidectomy or reconstruction?
Topics: Adult; Autoantibodies; Female; Humans; Infections; Infertility, Male; Male; Middle Aged; Oligospermi | 1994 |
Testicular function following the treatment of Hodgkin's disease in childhood.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Combined Modality Therapy; | 1993 |
Antisperm antibodies in infertile men.
Topics: Antibodies; Glucocorticoids; Humans; Immunosuppression Therapy; Infertility, Male; Male; Methylpredn | 1996 |
Steroids and male immunological infertility.
Topics: Autoantibodies; Drug Administration Schedule; Female; Fertilization in Vitro; Humans; Infertility, M | 1996 |
Primary infertility in 45-year-old man with untreated 21-hydroxylase deficiency: successful outcome with glucocorticoid therapy.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Drug Therapy, Combination; Female; Glucocorticoids; Humans | 2002 |
Cyclical combination chemotherapy and gonadal function. Retrospective study in males.
Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination; Follow-Up Studies; | 1979 |
Fertility problems in the renal transplant patient.
Topics: Adult; Azathioprine; Follicle Stimulating Hormone; Humans; Infertility, Male; Kidney; Kidney Transpl | 1977 |
Antisperm antibodies in the polyglandular autoimmune (PGA) syndrome type I: response to cyclical steroid therapy.
Topics: Adult; Humans; Infertility, Male; Male; Polyendocrinopathies, Autoimmune; Prednisolone; Sperm Agglut | 1991 |
Vasal injuries during childhood and their effect on subsequent fertility.
Topics: Adult; Epididymis; Humans; Infertility, Male; Male; Oligospermia; Postoperative Complications; Predn | 1991 |
Testicular dysfunction after cyclophosphamide-vincristine-procarbazine-prednisolone chemotherapy for advanced Hodgkin's disease. A long-term follow-up study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Follicle Stimul | 1990 |
Infertility of autoimmune origin in a stallion.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Horse Diseases; Horses; Infertility, Male; Male; Orchi | 1990 |
Clinical algorithms: infertility.
Topics: Adrenal Cortex Hormones; Algorithms; Humans; Infertility, Male; Male; Prednisolone | 1987 |
Antisperm antibody treatment.
Topics: Antibodies; Antispermatogenic Agents; Female; Humans; Infertility, Male; Male; Prednisolone; Pregnan | 1988 |
Cyclic prednisolone therapy for male infertility associated with autoantibodies to spermatozoa.
Topics: Adult; Agglutination Tests; Autoantibodies; Drug Administration Schedule; Female; Humans; Infertilit | 1986 |
[Immunologic fertility disorders of the male].
Topics: Antibody Formation; Autoantibodies; Autoimmune Diseases; Epididymitis; Humans; Infertility, Male; Ma | 1972 |
Fertility in men after renal transplantation.
Topics: Adult; Atrophy; Azathioprine; Cushing Syndrome; Depression, Chemical; Erectile Dysfunction; Female; | 1974 |
The significance of antibodies to sperm in infertile men and their wives.
Topics: Agglutination; Autoantibodies; Cytotoxicity Tests, Immunologic; Female; Histocompatibility Antigens; | 1974 |